The network for 'cellular response to osmotic stress' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to osmotic stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PBS2 Pbs2p 0.982
SSK2 Ssk2p 0.773
HOG1 Hog1p 0.723
SSK1 Ssk1p 0.448
PTP2 Ptp2p 0.429
GLN3 Gln3p 0.336
CBK1 Cbk1p 0.298
HOP1 Hop1p 0.243
HSP42 Hsp42p 0.235
YKR015C hypothetical protein 0.222
NBP2 Nbp2p 0.216
HAL5 Hal5p 0.202
STE5 Ste5p 0.193
YNL134C hypothetical protein 0.184
FPS1 Fps1p 0.181
STE7 Ste7p 0.172
BCK1 Bck1p 0.168
BEM3 Bem3p 0.158
HSL1 Hsl1p 0.157
MSN4 Msn4p 0.156
MET4 Met4p 0.149
SSK22 Ssk22p 0.142
CKB2 Ckb2p 0.134
ROG3 Rog3p 0.129
MKK1 Mkk1p 0.125
SPI1 Spi1p 0.118
ZAP1 Zap1p 0.116
MTH1 Mth1p 0.114
CNA1 Cna1p 0.113
CMD1 Cmd1p 0.112
PSP2 Psp2p 0.108
FAR11 Far11p 0.102
RLM1 Rlm1p 0.100
PSK2 Psk2p 0.099
MSN1 Msn1p 0.097
GAT2 Gat2p 0.096
CLA4 Cla4p 0.095
CKA2 Cka2p 0.094
HOT1 Hot1p 0.094
RSC9 Rsc9p 0.091
DDR48 Ddr48p 0.090
SCH9 Sch9p 0.088
KAP95 Kap95p 0.086
YMR291W hypothetical protein 0.086
RCK1 Rck1p 0.083
RHO1 Rho1p 0.082
STB5 Stb5p 0.081
SGN1 Sgn1p 0.081
LRE1 Lre1p 0.081
DOT6 Dot6p 0.079
SMP1 Smp1p 0.077
MIG1 Mig1p 0.075
MSG5 Msg5p 0.074
SKO1 Sko1p 0.072
HRK1 Hrk1p 0.070
EAR1 Ear1p 0.070
RPI1 Rpi1p 0.070
BEM1 Bem1p 0.070
YSP2 Ysp2p 0.069
HXT3 Hxt3p 0.069
VID24 Vid24p 0.068
TOS8 Tos8p 0.067
MSB2 Msb2p 0.067
STE11 Ste11p 0.067
YNR014W hypothetical protein 0.065
SNF1 Snf1p 0.063
YOL036W hypothetical protein 0.063
PTP3 Ptp3p 0.063
SLT2 Slt2p 0.062
ICL2 Icl2p 0.062
VHS1 Vhs1p 0.062
DSE3 Dse3p 0.062
YIR014W hypothetical protein 0.062
STE50 Ste50p 0.062
YKR075C hypothetical protein 0.061
RED1 Red1p 0.061
YNL144C hypothetical protein 0.060
TPS2 Tps2p 0.060
NDD1 Ndd1p 0.060
BEM4 Bem4p 0.060
LAP4 Lap4p 0.059
VAC7 Vac7p 0.059
CCH1 Cch1p 0.059
CYC8 Cyc8p 0.057
YEL073C hypothetical protein 0.057
CRZ1 Crz1p 0.057
PSR2 Psr2p 0.057
GLE1 Gle1p 0.057
CPR1 Cpr1p 0.056
LDB19 Ldb19p 0.056
DBF4 Dbf4p 0.056
CSR2 Csr2p 0.055
HKR1 Hkr1p 0.055
MPH1 Mph1p 0.055
YGR127W hypothetical protein 0.054
YIR007W hypothetical protein 0.053
GPD1 Gpd1p 0.053
PTC1 Ptc1p 0.053
PTC5 Ptc5p 0.053
SKN7 Skn7p 0.053
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
slc17a6b solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b 0.011
mef2a myocyte enhancer factor 2a 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CAB39 calcium binding protein 39 0.133
MAPK14 mitogen-activated protein kinase 14 0.091
MAPK1 mitogen-activated protein kinase 1 0.089
DUSP1 dual specificity phosphatase 1 0.074
HDAC4 histone deacetylase 4 0.062
MAP2K4 mitogen-activated protein kinase kinase 4 0.040
ATF2 activating transcription factor 2 0.024
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.022
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 0.022
ARRB2 arrestin, beta 2 0.021
USP9Y ubiquitin specific peptidase 9, Y-linked 0.014
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.014
ARAF v-raf murine sarcoma 3611 viral oncogene homolog 0.013
ARRB1 arrestin, beta 1 0.013
MAPK3 mitogen-activated protein kinase 3 0.011
JUN jun proto-oncogene 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Mapk14 mitogen-activated protein kinase 14 0.912
Atf2 activating transcription factor 2 0.839
Ryr2 ryanodine receptor 2, cardiac 0.750
Rac1 RAS-related C3 botulinum substrate 1 0.707
Ren1 renin 1 structural 0.631
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.571
Mapk9 mitogen-activated protein kinase 9 0.541
Mapkapk2 MAP kinase-activated protein kinase 2 0.524
Mef2c myocyte enhancer factor 2C 0.509
Hdac4 histone deacetylase 4 0.463
Wnk4 WNK lysine deficient protein kinase 4 0.404
Vcl vinculin 0.227
Hdac5 histone deacetylase 5 0.220
Slc12a2 solute carrier family 12, member 2 0.215
Gja1 gap junction protein, alpha 1 0.206
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.196
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.195
Nos1 nitric oxide synthase 1, neuronal 0.190
Slc12a1 solute carrier family 12, member 1 0.184
Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like 0.181
Mknk2 MAP kinase-interacting serine/threonine kinase 2 0.162
Tjp1 tight junction protein 1 0.141
Adora3 adenosine A3 receptor 0.134
Agtrap angiotensin II, type I receptor-associated protein 0.127
Mapk1 mitogen-activated protein kinase 1 0.126
Pten phosphatase and tensin homolog 0.120
Mapk8 mitogen-activated protein kinase 8 0.115
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.115
Flot1 flotillin 1 0.098
Umod uromodulin 0.098
Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.088
Hdac7 histone deacetylase 7 0.084
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.080
Map2k3 mitogen-activated protein kinase kinase 3 0.078
Agtr1a angiotensin II receptor, type 1a 0.072
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.070
Uox urate oxidase 0.069
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.068
Nfix nuclear factor I/X 0.066
Dlg1 discs, large homolog 1 (Drosophila) 0.063
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.062
Mknk1 MAP kinase-interacting serine/threonine kinase 1 0.061
Gpx1 glutathione peroxidase 1 0.057
Tbx5 T-box 5 0.053
Stk39 serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 0.053
Rgs12 regulator of G-protein signaling 12 0.052
Flii flightless I homolog (Drosophila) 0.052
Alb albumin 0.051
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.047
Klc1 kinesin light chain 1 0.046
Set SET nuclear oncogene 0.046
Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 0.046
Cys1 cystin 1 0.046
Gys1 glycogen synthase 1, muscle 0.046
Cd36 CD36 antigen 0.044
Mef2d myocyte enhancer factor 2D 0.044
Kif5c kinesin family member 5C 0.042
Bdkrb2 bradykinin receptor, beta 2 0.042
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.039
Cldn16 claudin 16 0.037
Scarb2 scavenger receptor class B, member 2 0.035
Hdac9 histone deacetylase 9 0.035
Mapk3 mitogen-activated protein kinase 3 0.034
Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.034
Gjd3 gap junction protein, delta 3 0.033
Aprt adenine phosphoribosyl transferase 0.033
Prkce protein kinase C, epsilon 0.032
Tgfb2 transforming growth factor, beta 2 0.032
Tgfbr1 transforming growth factor, beta receptor I 0.031
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.031
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.029
Pcsk1 proprotein convertase subtilisin/kexin type 1 0.029
Elavl4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 0.029
Mapk11 mitogen-activated protein kinase 11 0.028
Adrbk1 adrenergic receptor kinase, beta 1 0.028
Fbn1 fibrillin 1 0.028
Wdr26 WD repeat domain 26 0.028
Kl klotho 0.027
Chrne cholinergic receptor, nicotinic, epsilon polypeptide 0.026
Ptpn9 protein tyrosine phosphatase, non-receptor type 9 0.026
Mybph myosin binding protein H 0.026
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.025
Fgf13 fibroblast growth factor 13 0.025
Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 0.024
Sstr3 somatostatin receptor 3 0.023
Kif5b kinesin family member 5B 0.023
Mb myoglobin 0.022
Pou3f4 POU domain, class 3, transcription factor 4 0.021
Cit citron 0.021
Qk quaking 0.021
Kcnab3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 0.020
Tgfbr2 transforming growth factor, beta receptor II 0.020
Slc12a6 solute carrier family 12, member 6 0.020
Lnx1 ligand of numb-protein X 1 0.020
Aldoa aldolase A, fructose-bisphosphate 0.020
Rnpepl1 arginyl aminopeptidase (aminopeptidase B)-like 1 0.020
Ndp Norrie disease (pseudoglioma) (human) 0.020
Xirp1 xin actin-binding repeat containing 1 0.020
Clock circadian locomotor output cycles kaput 0.019
Map2k4 mitogen-activated protein kinase kinase 4 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism