The network for 'protein folding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CPR6 Cpr6p 0.997
STI1 Sti1p 0.989
SIS1 Sis1p 0.988
HSP82 Hsp82p 0.968
KAR2 Kar2p 0.960
BTN2 Btn2p 0.955
CCT2 Cct2p 0.942
CCT4 Cct4p 0.936
SSC1 Ssc1p 0.924
SSA4 Ssa4p 0.917
HSP60 Hsp60p 0.913
CIN1 Cin1p 0.909
SCJ1 Scj1p 0.908
MDJ1 Mdj1p 0.905
SSE1 Sse1p 0.900
SGT2 Sgt2p 0.898
YDJ1 Ydj1p 0.895
CCT6 Cct6p 0.892
AHA1 Aha1p 0.876
CCT8 Cct8p 0.872
HSP104 Hsp104p 0.871
TCP1 Tcp1p 0.784
CCT3 Cct3p 0.731
SSA3 Ssa3p 0.728
SBA1 Sba1p 0.726
HSC82 Hsc82p 0.722
SSA1 Ssa1p 0.700
CUR1 Cur1p 0.682
PHB2 Phb2p 0.669
SSA2 Ssa2p 0.641
SIL1 Sil1p 0.576
CCT7 Cct7p 0.565
PDI1 Pdi1p 0.565
STE24 Ste24p 0.529
HSP10 Hsp10p 0.515
FES1 Fes1p 0.503
GIM4 Gim4p 0.503
PLP2 Plp2p 0.503
APJ1 Apj1p 0.481
FPR2 Fpr2p 0.471
PIH1 Pih1p 0.439
ERV41 Erv41p 0.427
HSP78 Hsp78p 0.373
KEG1 Keg1p 0.343
PAC2 Pac2p 0.337
ERV46 Erv46p 0.318
CPR7 Cpr7p 0.309
CUE1 Cue1p 0.309
VMA11 Vma11p 0.306
YGR130C hypothetical protein 0.299
UBC4 Ubc4p 0.286
TIM44 Tim44p 0.281
GET1 Get1p 0.274
AHP1 Ahp1p 0.261
PMT3 Pmt3p 0.227
SSE2 Sse2p 0.217
SLP1 Slp1p 0.198
ERV29 Erv29p 0.198
LHS1 Lhs1p 0.196
HSP42 Hsp42p 0.195
ADR1 Adr1p 0.191
TAH1 Tah1p 0.191
TSA1 Tsa1p 0.190
SEC28 Sec28p 0.188
ACP1 Acp1p 0.188
TRX1 Trx1p 0.187
MTG1 Mtg1p 0.184
TIM17 Tim17p 0.179
JEM1 Jem1p 0.179
YMR130W hypothetical protein 0.178
SOD1 Sod1p 0.177
DOG2 Dog2p 0.174
LTP1 Ltp1p 0.173
NTA1 Nta1p 0.173
VPH2 Vph2p 0.168
EXG2 Exg2p 0.160
CAF130 Caf130p 0.159
HCH1 Hch1p 0.158
CDC37 Cdc37p 0.148
YBL029C-A hypothetical protein 0.147
TIM23 Tim23p 0.143
CUE4 Cue4p 0.141
DDI1 Ddi1p 0.139
SRP54 Srp54p 0.135
YRB2 Yrb2p 0.134
LPP1 Lpp1p 0.133
PPX1 Ppx1p 0.130
PHO86 Pho86p 0.128
NAT5 Nat5p 0.125
CCT5 Cct5p 0.124
YER163C hypothetical protein 0.121
MIM1 Mim1p 0.111
YER140W hypothetical protein 0.111
YHB1 Yhb1p 0.111
CRH1 Crh1p 0.108
AIM29 Aim29p 0.107
MGR2 Mgr2p 0.106
EGD2 Egd2p 0.106
YDL121C hypothetical protein 0.106
HNT1 Hnt1p 0.105
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
hsp-1 Protein HSP-1 0.829
cct-2 Protein CCT-2 0.309
hsp-4 Protein HSP-4 0.220
dnj-19 Protein DNJ-19 0.196
C30C11.4 Protein C30C11.4 0.134
hsp-3 Protein HSP-3 0.132
tag-320 Protein TAG-320 0.124
ZC395.10 Protein ZC395.10 0.121
cct-6 Protein CCT-6 0.111
CELE_C01G10.8 Protein C01G10.8 0.103
pdi-1 Protein PDI-1 0.076
fkb-6 Protein FKB-6 0.074
daf-21 Protein DAF-21 0.072
cct-1 Protein CCT-1 0.064
dnj-12 Protein DNJ-12 0.057
tbb-2 Protein TBB-2 0.047
cct-5 Protein CCT-5 0.043
dnj-13 Protein DNJ-13 0.037
ahcy-1 Protein AHCY-1 0.029
pdi-3 Protein PDI-3 0.026
gars-1 Protein GARS-1 0.025
ttll-12 Protein TTLL-12 0.024
gdi-1 Protein GDI-1 0.021
CELE_T05E11.3 Protein T05E11.3 0.019
cct-4 Protein CCT-4 0.018
hel-1 Protein HEL-1 0.018
sti-1 Protein STI-1 0.015
dars-1 Protein DARS-1 0.015
cars-1 Protein CARS-1 0.015
R107.5 Protein R107.5 0.014
hke-4.2 Protein HKE-4.2 0.014
par-5 Protein PAR-5 0.014
stt-3 Protein STT-3 0.013
T16G1.9 Protein T16G1.9 0.013
eif-3.J Protein EIF-3.J 0.013
sgt-1 Protein SGT-1 0.011
D2085.3 Protein D2085.3 0.011
nra-2 Protein NRA-2 0.011
ubc-9 Protein UBC-9 0.011
hip-1 Protein HIP-1 0.010
pfn-1 Protein PFN-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.000
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.000
HSPA8 heat shock 70kDa protein 8 1.000
FKBP4 FK506 binding protein 4, 59kDa 1.000
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 1.000
TCP1 t-complex 1 1.000
PDIA4 protein disulfide isomerase family A, member 4 0.999
STIP1 stress-induced-phosphoprotein 1 0.999
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.997
HSPH1 heat shock 105kDa/110kDa protein 1 0.997
P4HB prolyl 4-hydroxylase, beta polypeptide 0.997
PPID peptidylprolyl isomerase D 0.994
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.993
HSPA4 heat shock 70kDa protein 4 0.990
PDIA6 protein disulfide isomerase family A, member 6 0.985
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.984
EPRS glutamyl-prolyl-tRNA synthetase 0.982
HSPA1B heat shock 70kDa protein 1B 0.979
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.978
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.978
PDIA3 protein disulfide isomerase family A, member 3 0.940
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.937
CACYBP calcyclin binding protein 0.926
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.898
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.878
PPP5C protein phosphatase 5, catalytic subunit 0.875
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.857
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.815
BAG3 BCL2-associated athanogene 3 0.799
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.750
IARS isoleucyl-tRNA synthetase 0.747
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.740
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.706
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.656
HSPA1A heat shock 70kDa protein 1A 0.635
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.634
HSPB8 heat shock 22kDa protein 8 0.621
ARL2 ADP-ribosylation factor-like 2 0.612
NUB1 negative regulator of ubiquitin-like proteins 1 0.590
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.587
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.497
BAG1 BCL2-associated athanogene 0.426
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.425
ERO1L ERO1-like (S. cerevisiae) 0.421
HSPE1 heat shock 10kDa protein 1 (chaperonin 10) 0.420
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.420
BAG2 BCL2-associated athanogene 2 0.420
CALR calreticulin 0.410
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 0.406
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.389
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.339
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.323
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.307
NUDC nuclear distribution gene C homolog (A. nidulans) 0.273
SOD1 superoxide dismutase 1, soluble 0.267
HLA-DMB major histocompatibility complex, class II, DM beta 0.235
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.231
MARS methionyl-tRNA synthetase 0.217
GADD45A growth arrest and DNA-damage-inducible, alpha 0.199
UBQLN1 ubiquilin 1 0.161
TBCD tubulin folding cofactor D 0.155
GARS glycyl-tRNA synthetase 0.141
TOR1A torsin family 1, member A (torsin A) 0.133
CCDC117 coiled-coil domain containing 117 0.122
KARS lysyl-tRNA synthetase 0.122
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.120
CANX calnexin 0.114
PLOD1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 0.112
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.111
BCL2L1 BCL2-like 1 0.111
SARS seryl-tRNA synthetase 0.110
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) 0.110
COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) 0.108
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.101
SMAD9 SMAD family member 9 0.101
TBK1 TANK-binding kinase 1 0.100
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.099
PSEN1 presenilin 1 0.098
CRYAA crystallin, alpha A 0.095
NARS asparaginyl-tRNA synthetase 0.094
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.092
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.087
CHUK conserved helix-loop-helix ubiquitous kinase 0.082
TOR1AIP2 torsin A interacting protein 2 0.080
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.079
TMED5 transmembrane emp24 protein transport domain containing 5 0.076
CRYBB2 crystallin, beta B2 0.075
LDHA lactate dehydrogenase A 0.074
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.072
HSPA13 heat shock protein 70kDa family, member 13 0.072
TTC4 tetratricopeptide repeat domain 4 0.066
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.063
TOR1B torsin family 1, member B (torsin B) 0.062
TAPBP TAP binding protein (tapasin) 0.055
CSNK1A1 casein kinase 1, alpha 1 0.054
SDF2L1 stromal cell-derived factor 2-like 1 0.054
CRYGC crystallin, gamma C 0.053
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.053
HSPB2 heat shock 27kDa protein 2 0.053
MRPL18 mitochondrial ribosomal protein L18 0.053
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Mus musculus
Name Description Probability Func Analog Organism
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.917
Hspa8 heat shock protein 8 0.903
Hsph1 heat shock 105kDa/110kDa protein 1 0.895
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.859
Hsp90b1 heat shock protein 90, beta (Grp94), member 1 0.834
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.826
Rpgrip1l Rpgrip1-like 0.737
Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) 0.611
Cct7 chaperonin containing Tcp1, subunit 7 (eta) 0.543
Hspa5 heat shock protein 5 0.541
Hspd1 heat shock protein 1 (chaperonin) 0.426
H2-DMa histocompatibility 2, class II, locus DMa 0.411
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.411
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.374
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.374
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.361
Cct2 chaperonin containing Tcp1, subunit 2 (beta) 0.326
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.309
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.297
Stip1 stress-induced phosphoprotein 1 0.242
Cct4 chaperonin containing Tcp1, subunit 4 (delta) 0.231
Hbb-b2 hemoglobin, beta adult minor chain 0.212
H2-Aa histocompatibility 2, class II antigen A, alpha 0.209
Cacybp calcyclin binding protein 0.206
Tcp1 t-complex protein 1 0.190
Prnp prion protein 0.185
Ikbip IKBKB interacting protein 0.184
Hspa9 heat shock protein 9 0.178
H2-Eb1 histocompatibility 2, class II antigen E beta 0.172
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.171
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.154
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.135
Cct6a chaperonin containing Tcp1, subunit 6a (zeta) 0.125
Gars glycyl-tRNA synthetase 0.105
Nars asparaginyl-tRNA synthetase 0.094
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.081
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.075
Copz2 coatomer protein complex, subunit zeta 2 0.071
Ahi1 Abelson helper integration site 1 0.070
Lrrk2 leucine-rich repeat kinase 2 0.066
Kdelr2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.063
Tm9sf3 transmembrane 9 superfamily member 3 0.062
Eif2s3x eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked 0.062
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.061
H2-K1 histocompatibility 2, K1, K region 0.055
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.053
Vcp valosin containing protein 0.049
Ahsa1 AHA1, activator of heat shock protein ATPase homolog 1 (yeast) 0.049
Mta1 metastasis associated 1 0.048
Eprs glutamyl-prolyl-tRNA synthetase 0.048
P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide 0.048
Pcbp1 poly(rC) binding protein 1 0.048
Hspa1b heat shock protein 1B 0.047
Eed embryonic ectoderm development 0.047
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.046
Ppic peptidylprolyl isomerase C 0.043
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.043
H2-DMb2 histocompatibility 2, class II, locus Mb2 0.042
P4hb prolyl 4-hydroxylase, beta polypeptide 0.042
Ddx1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 0.038
Cops2 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) 0.038
Rpn2 ribophorin II 0.037
Dnajb2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.037
Spcs2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.037
Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.036
Calu calumenin 0.035
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.035
Hbb-b1 hemoglobin, beta adult major chain 0.033
St13 suppression of tumorigenicity 13 0.032
Creld2 cysteine-rich with EGF-like domains 2 0.032
Nphp1 nephronophthisis 1 (juvenile) homolog (human) 0.030
Txndc5 thioredoxin domain containing 5 0.030
Fstl1 follistatin-like 1 0.030
Pdia3 protein disulfide isomerase associated 3 0.028
Plrg1 pleiotropic regulator 1, PRL1 homolog (Arabidopsis) 0.028
Hspa4l heat shock protein 4 like 0.027
Lman1 lectin, mannose-binding, 1 0.027
Pdia6 protein disulfide isomerase associated 6 0.027
Stt3a STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) 0.027
Dnajb4 DnaJ (Hsp40) homolog, subfamily B, member 4 0.027
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.026
Tmed10 transmembrane emp24-like trafficking protein 10 (yeast) 0.026
Hspa1a heat shock protein 1A 0.026
Cct8 chaperonin containing Tcp1, subunit 8 (theta) 0.026
Set SET nuclear oncogene 0.026
Magt1 magnesium transporter 1 0.025
Tram1 translocating chain-associating membrane protein 1 0.025
Sars seryl-aminoacyl-tRNA synthetase 0.025
Ghitm growth hormone inducible transmembrane protein 0.024
Fam136a family with sequence similarity 136, member A 0.024
Pdia5 protein disulfide isomerase associated 5 0.023
Rpn1 ribophorin I 0.023
Tmem33 transmembrane protein 33 0.023
Iqcb1 IQ calmodulin-binding motif containing 1 0.022
Skp1a S-phase kinase-associated protein 1A 0.022
Hspa4 heat shock protein 4 0.022
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.021
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 0.021
Fbn1 fibrillin 1 0.021
Leprel4 leprecan-like 4 0.020
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hsph1 heat shock 105/110 protein 1 0.991
Hsp90b1 heat shock protein 90, beta, member 1 0.942
Hspd1 heat shock protein 1 (chaperonin) 0.927
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.793
Cct2 chaperonin containing TCP1, subunit 2 (beta) 0.678
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.632
Hspa8 heat shock protein 8 0.605
Stip1 stress-induced phosphoprotein 1 0.559
Hspa5 heat shock protein 5 0.556
Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) 0.397
Pdia6 protein disulfide isomerase family A, member 6 0.276
RT1-Da RT1 class II, locus Da 0.268
Cct4 chaperonin containing Tcp1, subunit 4 (delta) 0.221
Pdia3 protein disulfide isomerase family A, member 3 0.184
Canx calnexin 0.162
LOC681996 similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 1 0.158
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.133
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.069
Hspa1a heat shock 70kD protein 1A 0.051
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.049
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.048
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.033
Xpo1 exportin 1, CRM1 homolog (yeast) 0.033
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.030
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.028
Cct7 chaperonin containing Tcp1, subunit 7 (eta) 0.024
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.023
Ppid peptidylprolyl isomerase D (cyclophilin D) 0.022
Tcp1 t-complex 1 0.022
Manf mesencephalic astrocyte-derived neurotrophic factor 0.020
Pdia4 protein disulfide isomerase family A, member 4 0.019
Caprin1 cell cycle associated protein 1 0.017
Hyou1 hypoxia up-regulated 1 0.017
Snd1 staphylococcal nuclease and tudor domain containing 1 0.015
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.015
Hnrnpf heterogeneous nuclear ribonucleoprotein F 0.015
Lman2 lectin, mannose-binding 2 0.013
Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.013
Nsun2 NOL1/NOP2/Sun domain family, member 2 0.012
RT1-Bb RT1 class II, locus Bb 0.012
Lrrc59 leucine rich repeat containing 59 0.011
Cox6a2 cytochrome c oxidase, subunit VIa, polypeptide 2 0.011
Rpn2 ribophorin II 0.010
Ttc9c tetratricopeptide repeat domain 9C 0.010