The network for 'translesion synthesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

translesion synthesis

The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
REV1 Rev1p 0.862
RAD5 Rad5p 0.757
REV7 Rev7p 0.744
REV3 Rev3p 0.262
RAD9 Rad9p 0.171
POL2 Pol2p 0.167
POL32 Pol32p 0.159
DPB2 Dpb2p 0.103
RFC2 Rfc2p 0.102
RAD24 Rad24p 0.101
RAD30 Rad30p 0.096
POL3 Pol3p 0.083
PIF1 Pif1p 0.074
MGS1 Mgs1p 0.068
PSF1 Psf1p 0.059
POL12 Pol12p 0.057
POL30 Pol30p 0.057
RAD17 Rad17p 0.055
RNH201 Rnh201p 0.053
SHU1 Shu1p 0.051
PMS1 Pms1p 0.045
RNH203 Rnh203p 0.043
RAD57 Rad57p 0.043
SRD1 Srd1p 0.037
UBC13 Ubc13p 0.036
DLS1 Dls1p 0.036
RFC4 Rfc4p 0.035
SMC6 Smc6p 0.032
YLR264C-A hypothetical protein 0.032
MSH3 Msh3p 0.032
LEU2 Leu2p 0.030
CUP1-1 Cup1-1p 0.030
APN1 Apn1p 0.030
CRP1 Crp1p 0.030
URA3 Ura3p 0.029
MER1 Mer1p 0.029
YOL038C-A hypothetical protein 0.028
CDC9 Cdc9p 0.028
HXT3 Hxt3p 0.028
MSH6 Msh6p 0.028
YLR162W hypothetical protein 0.028
YNL155W hypothetical protein 0.026
ARG8 Arg8p 0.024
EST2 Est2p 0.024
RAD18 Rad18p 0.024
ARP10 Arp10p 0.023
YLR126C hypothetical protein 0.023
WSS1 Wss1p 0.023
TIP1 Tip1p 0.023
RLF2 Rlf2p 0.023
MPT5 Mpt5p 0.023
HO Hop 0.023
YLR042C hypothetical protein 0.022
ATP6 Atp6p 0.022
RAD55 Rad55p 0.022
YPR157W hypothetical protein 0.022
YAR068W hypothetical protein 0.022
YPL168W hypothetical protein 0.022
PRS2 Prs2p 0.022
SWC7 Swc7p 0.021
ZPS1 Zps1p 0.021
PTI1 Pti1p 0.021
OPT2 Opt2p 0.021
AUA1 Aua1p 0.020
IRC5 Irc5p 0.020
HLR1 Hlr1p 0.020
YBR013C hypothetical protein 0.020
POP6 Pop6p 0.020
PEX15 Pex15p 0.020
YIL151C hypothetical protein 0.020
SPL2 Spl2p 0.020
HPF1 Hpf1p 0.020
NTG2 Ntg2p 0.019
APT2 Apt2p 0.019
XRS2 Xrs2p 0.019
CSM2 Csm2p 0.019
MF(ALPHA)2 Mf(alpha)2p 0.019
MET8 Met8p 0.019
PRI2 Pri2p 0.019
IZH4 Izh4p 0.019
FMT1 Fmt1p 0.018
YDR222W hypothetical protein 0.018
YER137C hypothetical protein 0.018
INM1 Inm1p 0.018
TYE7 Tye7p 0.018
BSC1 Bsc1p 0.018
TAF4 Taf4p 0.018
YOL013W-A hypothetical protein 0.018
RAD1 Rad1p 0.018
CPD1 Cpd1p 0.018
RAD23 Rad23p 0.017
DUN1 Dun1p 0.017
YAR066W hypothetical protein 0.017
RPB3 Rpb3p 0.017
CUP1-2 Cup1-2p 0.017
UPS3 Ups3p 0.017
YLR040C hypothetical protein 0.017
YGR126W hypothetical protein 0.017
YAR029W hypothetical protein 0.016
CHZ1 Chz1p 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
mus101 mutagen-sensitive 101 0.819
rad50 CG6339 gene product from transcript CG6339-RD 0.658
mus205 mutagen-sensitive 205 0.645
mus308 mutagen-sensitive 308 0.606
RecQ5 homolog of RecQ 0.555
CG5524 CG5524 gene product from transcript CG5524-RA 0.494
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.484
lok loki 0.411
Mcm3 Minichromosome maintenance 3 0.374
nbs CG6754 gene product from transcript CG6754-RC 0.220
Brca2 Breast cancer 2, early onset homolog 0.162
mus209 mutagen-sensitive 209 0.117
mi minus 0.100
hay haywire 0.094
mus210 mutagen-sensitive 210 0.093
mus201 mutagen-sensitive 201 0.078
mus309 mutagen-sensitive 309 0.072
spn-A spindle A 0.068
Smc5 CG32438 gene product from transcript CG32438-RE 0.061
Spc105R Spc105-related 0.056
RecQ4 CG7487 gene product from transcript CG7487-RA 0.055
RnrL Ribonucleoside diphosphate reductase large subunit 0.050
mei-9 meiotic 9 0.049
dmt dalmatian 0.040
CG5290 CG5290 gene product from transcript CG5290-RA 0.036
dpa disc proliferation abnormal 0.031
mre11 meiotic recombination 11 0.029
mus304 mutagen-sensitive 304 0.028
ncd non-claret disjunctional 0.027
CDC45L CG3658 gene product from transcript CG3658-RA 0.026
Irbp Inverted repeat-binding protein 0.024
CG5931 CG5931 gene product from transcript CG5931-RA 0.020
wds will die slowly 0.020
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.019
Lig4 Ligase4 0.016
Ercc1 CG10215 gene product from transcript CG10215-RA 0.015
l(1)G0095 lethal (1) G0095 0.015
CG3065 CG3065 gene product from transcript CG3065-RA 0.015
lid little imaginal discs 0.015
Rev1 CG12189 gene product from transcript CG12189-RA 0.014
Orc2 Origin recognition complex subunit 2 0.014
CG9576 CG9576 gene product from transcript CG9576-RA 0.014
Cap-G CG34438 gene product from transcript CG34438-RF 0.014
okr okra 0.013
spn-B spindle B 0.013
stwl stonewall 0.013
su(Hw) suppressor of Hairy wing 0.013
CG12155 CG12155 gene product from transcript CG12155-RA 0.012
Mes2 CG11100 gene product from transcript CG11100-RB 0.012
Orc5 Origin recognition complex subunit 5 0.012
CG10809 CG10809 gene product from transcript CG10809-RA 0.012
phr photorepair 0.012
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Homo sapiens
Name Description Probability Func Analog Organism
RAD18 RAD18 homolog (S. cerevisiae) 0.996
PCNA proliferating cell nuclear antigen 0.992
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.895
POLH polymerase (DNA directed), eta 0.888
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.689
MSH6 mutS homolog 6 (E. coli) 0.575
RFC2 replication factor C (activator 1) 2, 40kDa 0.545
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.335
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.296
RFC3 replication factor C (activator 1) 3, 38kDa 0.272
FANCD2 Fanconi anemia, complementation group D2 0.224
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.155
REV3L REV3-like, catalytic subunit of DNA polymerase zeta (yeast) 0.153
ING2 inhibitor of growth family, member 2 0.145
REV1 REV1 homolog (S. cerevisiae) 0.136
DTL denticleless homolog (Drosophila) 0.112
RPA2 replication protein A2, 32kDa 0.110
POLI polymerase (DNA directed) iota 0.108
ALDOA aldolase A, fructose-bisphosphate 0.106
RFC1 replication factor C (activator 1) 1, 145kDa 0.103
POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.100
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.099
POLE polymerase (DNA directed), epsilon 0.085
RPA3 replication protein A3, 14kDa 0.077
RPA1 replication protein A1, 70kDa 0.053
PGK1 phosphoglycerate kinase 1 0.052
CHRAC1 chromatin accessibility complex 1 0.048
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.044
POLK polymerase (DNA directed) kappa 0.043
CDT1 chromatin licensing and DNA replication factor 1 0.040
DZIP3 DAZ interacting protein 3, zinc finger 0.037
PGAM1 phosphoglycerate mutase 1 (brain) 0.036
EXO1 exonuclease 1 0.036
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.034
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.032
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 0.031
UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.029
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.028
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.028
BRCA1 breast cancer 1, early onset 0.027
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.027
FEN1 flap structure-specific endonuclease 1 0.026
GMNN geminin, DNA replication inhibitor 0.018
FANCL Fanconi anemia, complementation group L 0.017
SIVA1 SIVA1, apoptosis-inducing factor 0.016
ZNF302 zinc finger protein 302 0.016
MSH3 mutS homolog 3 (E. coli) 0.014
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.013
MCM3 minichromosome maintenance complex component 3 0.013
RBBP8 retinoblastoma binding protein 8 0.012
FANCI Fanconi anemia, complementation group I 0.012
LIG1 ligase I, DNA, ATP-dependent 0.011
POLE4 polymerase (DNA-directed), epsilon 4 (p12 subunit) 0.011
RFC4 replication factor C (activator 1) 4, 37kDa 0.011
PRPS1 phosphoribosyl pyrophosphate synthetase 1 0.011
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.011
RAD1 RAD1 homolog (S. pombe) 0.011
FANCA Fanconi anemia, complementation group A 0.010
ENO1 enolase 1, (alpha) 0.010
BLM Bloom syndrome, RecQ helicase-like 0.010
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Timeless timeless homolog (Drosophila) 0.764
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.727
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.693
Brca1 breast cancer 1 0.549
Nsfl1c NSFL1 (p97) cofactor (p47) 0.444
Cdt1 chromatin licensing and DNA replication factor 1 0.428
Ccna2 cyclin A2 0.413
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.399
Polh polymerase (DNA directed), eta (RAD 30 related) 0.370
Brca2 breast cancer 2 0.354
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.354
Cdk1 cyclin-dependent kinase 1 0.345
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.305
Lig1 ligase I, DNA, ATP-dependent 0.293
Ncaph non-SMC condensin I complex, subunit H 0.287
Poli polymerase (DNA directed), iota 0.286
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.265
Cdca5 cell division cycle associated 5 0.253
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.244
Ttk Ttk protein kinase 0.218
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.218
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.212
Ccnb1 cyclin B1 0.199
Mki67 antigen identified by monoclonal antibody Ki 67 0.178
Ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 0.178
Polk polymerase (DNA directed), kappa 0.174
Rad51 RAD51 homolog (S. cerevisiae) 0.162
Eif4a2 eukaryotic translation initiation factor 4A2 0.146
Kif11 kinesin family member 11 0.132
Mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.124
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.124
Rad51ap1 RAD51 associated protein 1 0.121
Clk4 CDC like kinase 4 0.118
Ufd1l ubiquitin fusion degradation 1 like 0.116
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.109
Aurkb aurora kinase B 0.108
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.106
Paip2 polyadenylate-binding protein-interacting protein 2 0.105
Trip13 thyroid hormone receptor interactor 13 0.104
Prim1 DNA primase, p49 subunit 0.102
Hdac6 histone deacetylase 6 0.098
Prc1 protein regulator of cytokinesis 1 0.097
Birc5 baculoviral IAP repeat-containing 5 0.097
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.095
Tk1 thymidine kinase 1 0.095
Dna2 DNA replication helicase 2 homolog (yeast) 0.093
Rrm2 ribonucleotide reductase M2 0.092
Smc2 structural maintenance of chromosomes 2 0.087
Ptma prothymosin alpha 0.084
Hprt hypoxanthine guanine phosphoribosyl transferase 0.083
Tacc3 transforming, acidic coiled-coil containing protein 3 0.083
Ranbp1 RAN binding protein 1 0.077
Ckap2 cytoskeleton associated protein 2 0.073
Top2a topoisomerase (DNA) II alpha 0.070
Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.068
Cdc7 cell division cycle 7 (S. cerevisiae) 0.068
Ect2 ect2 oncogene 0.067
Kif4 kinesin family member 4 0.066
Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 - like 0.065
Parp2 poly (ADP-ribose) polymerase family, member 2 0.064
Hells helicase, lymphoid specific 0.064
Rfc3 replication factor C (activator 1) 3 0.064
Cdca8 cell division cycle associated 8 0.063
E2f8 E2F transcription factor 8 0.063
Orc1 origin recognition complex, subunit 1 0.063
Cenpk centromere protein K 0.061
Tia1 cytotoxic granule-associated RNA binding protein 1 0.059
Rev1 REV1 homolog (S. cerevisiae) 0.059
Cdca7l cell division cycle associated 7 like 0.058
Plk4 polo-like kinase 4 (Drosophila) 0.058
Kif23 kinesin family member 23 0.056
Stil Scl/Tal1 interrupting locus 0.056
Rrm1 ribonucleotide reductase M1 0.054
Ncapd2 non-SMC condensin I complex, subunit D2 0.052
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.050
Fam103a1 family with sequence similarity 103, member A1 0.050
Wee1 WEE 1 homolog 1 (S. pombe) 0.049
Cenph centromere protein H 0.049
Mms22l MMS22-like, DNA repair protein 0.048
Plk1 polo-like kinase 1 (Drosophila) 0.048
Racgap1 Rac GTPase-activating protein 1 0.047
Ube2t ubiquitin-conjugating enzyme E2T (putative) 0.047
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.045
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.044
Fbxo5 F-box protein 5 0.044
Melk maternal embryonic leucine zipper kinase 0.042
Blm Bloom syndrome, RecQ helicase-like 0.042
Cdk2 cyclin-dependent kinase 2 0.041
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.040
Slbp stem-loop binding protein 0.040
Kntc1 kinetochore associated 1 0.039
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.039
Clk1 CDC-like kinase 1 0.037
Hat1 histone aminotransferase 1 0.037
H2afz H2A histone family, member Z 0.037
Tipin timeless interacting protein 0.036
Zfand6 zinc finger, AN1-type domain 6 0.036
Cdca7 cell division cycle associated 7 0.034
Mis18bp1 MIS18 binding protein 1 0.034
Ccnb2 cyclin B2 0.034
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Rattus norvegicus
Name Description Probability Func Analog Organism