Homo sapiens

6 known processes

GRN

granulin

(Aliases: PEPI,GP88,GEP,PCDGF,PGRN)

GRN biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neurological system process GO:0050877 163 0.876
vacuole organization GO:0007033 44 0.835
epithelium development GO:0060429 227 0.650
response to other organism GO:0051707 261 0.633
protein catabolic process GO:0030163 325 0.627
neuromuscular process GO:0050905 15 0.616
single organism carbohydrate catabolic process GO:0044724 33 0.604
multicellular organismal aging GO:0010259 3 0.583
system process GO:0003008 349 0.569
carbohydrate metabolic process GO:0005975 207 0.550
determination of adult lifespan GO:0008340 2 0.547
regulation of blood vessel remodeling GO:0060312 2 0.480
anatomical structure homeostasis GO:0060249 100 0.446
negative regulation of multicellular organismal metabolic process GO:0044252 3 0.443
retina homeostasis GO:0001895 42 0.423
multicellular organismal homeostasis GO:0048871 67 0.405
signal transduction by phosphorylation GO:0023014 297 0.384
cellular amine metabolic process GO:0044106 41 0.358
single organism carbohydrate metabolic process GO:0044723 193 0.349
regulation of cellular ketone metabolic process GO:0010565 50 0.346
positive regulation of cytokine production GO:0001819 167 0.335
regulation of elastin catabolic process GO:0060310 1 0.327
negative regulation of elastin catabolic process GO:0060311 1 0.320
membrane lipid metabolic process GO:0006643 53 0.315
carbohydrate catabolic process GO:0016052 36 0.311
chemical homeostasis GO:0048878 306 0.311
cellular amide metabolic process GO:0043603 69 0.307
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.295
sensory perception of bitter taste GO:0050913 28 0.287
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.283
protein maturation GO:0051604 233 0.265
antigen processing and presentation of peptide antigen GO:0048002 18 0.254
locomotory behavior GO:0007626 1 0.250
negative regulation of collagen catabolic process GO:0010711 1 0.233
nervous system development GO:0007399 293 0.223
Zebrafish
cellular amino acid metabolic process GO:0006520 116 0.200
cytokine production GO:0001816 247 0.191
response to bacterium GO:0009617 144 0.191
protein localization to organelle GO:0033365 280 0.176
protein processing GO:0016485 226 0.170
regulation of lipid metabolic process GO:0019216 96 0.167
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.164
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.162
circulatory system development GO:0072359 262 0.158
leukocyte mediated immunity GO:0002443 59 0.150
cellular ion homeostasis GO:0006873 168 0.149
regulation of cellular amino acid metabolic process GO:0006521 6 0.146
antigen processing and presentation GO:0019882 33 0.145
lipid metabolic process GO:0006629 381 0.144
innate immune response GO:0045087 178 0.136
involuntary skeletal muscle contraction GO:0003011 1 0.132
neuromuscular process controlling balance GO:0050885 7 0.130
organ morphogenesis GO:0009887 147 0.121
post embryonic development GO:0009791 2 0.115
tissue homeostasis GO:0001894 63 0.100
sensory perception of taste GO:0050909 36 0.098
retina development in camera type eye GO:0060041 15 0.098
immune response GO:0006955 307 0.098
cellular metal ion homeostasis GO:0006875 146 0.096
positive regulation of developmental process GO:0051094 314 0.087
peptide catabolic process GO:0043171 10 0.082
positive regulation of cellular amine metabolic process GO:0033240 7 0.082
cellular homeostasis GO:0019725 196 0.081
regulation of defense response GO:0031347 154 0.080
collagen catabolic process GO:0030574 10 0.079
g protein coupled receptor signaling pathway GO:0007186 207 0.077
regulation of leukocyte mediated immunity GO:0002703 38 0.071
regulation of peptidase activity GO:0052547 180 0.070
sensory perception of chemical stimulus GO:0007606 38 0.070
cartilage development involved in endochondral bone morphogenesis GO:0060351 2 0.070
positive regulation of defense response GO:0031349 87 0.070
regulation of purine nucleotide metabolic process GO:1900542 264 0.070
central nervous system development GO:0007417 123 0.067
elastin catabolic process GO:0060309 1 0.067
defense response GO:0006952 315 0.067
cellular chemical homeostasis GO:0055082 180 0.067
lipid catabolic process GO:0016042 84 0.067
single organism membrane organization GO:0044802 268 0.066
regulation of intracellular transport GO:0032386 195 0.064
regulation of erk1 and erk2 cascade GO:0070372 99 0.063
peptide metabolic process GO:0006518 51 0.062
amino acid transport GO:0006865 28 0.061
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.061
response to hormone GO:0009725 175 0.060
negative regulation of cell death GO:0060548 345 0.060
multicellular organismal metabolic process GO:0044236 34 0.059
aging GO:0007568 66 0.058
regulation of angiotensin levels in blood GO:0002002 3 0.057
regulation of mapk cascade GO:0043408 262 0.057
cell projection organization GO:0030030 252 0.057
Zebrafish
regulation of secretion GO:0051046 194 0.056
posttranscriptional regulation of gene expression GO:0010608 213 0.056
ossification GO:0001503 121 0.055
muscle contraction GO:0006936 73 0.055
positive regulation of cell activation GO:0050867 81 0.055
ion homeostasis GO:0050801 230 0.054
glycogen catabolic process GO:0005980 4 0.054
ganglioside catabolic process GO:0006689 3 0.053
response to hypoxia GO:0001666 96 0.053
eye development GO:0001654 42 0.053
response to oxygen containing compound GO:1901700 369 0.053
erbb signaling pathway GO:0038127 44 0.052
chemical homeostasis within a tissue GO:0048875 3 0.051
intracellular protein transport GO:0006886 270 0.051
embryonic organ morphogenesis GO:0048562 24 0.051
negative regulation of cellular protein metabolic process GO:0032269 353 0.050
regulation of natural killer cell mediated immunity GO:0002715 16 0.050
cellular ketone metabolic process GO:0042180 80 0.049
nucleoside catabolic process GO:0009164 408 0.049
cellular lipid metabolic process GO:0044255 303 0.048
growth GO:0040007 202 0.048
Zebrafish
hexose metabolic process GO:0019318 55 0.048
response to biotic stimulus GO:0009607 276 0.047
regulation of nucleotide metabolic process GO:0006140 269 0.047
cellular cation homeostasis GO:0030003 163 0.046
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 11 0.046
maintenance of location GO:0051235 112 0.046
vesicle mediated transport GO:0016192 371 0.044
lipid localization GO:0010876 106 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.043
muscle tissue development GO:0060537 62 0.043
detection of chemical stimulus GO:0009593 55 0.042
regulation of systemic arterial blood pressure by hormone GO:0001990 12 0.042
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.042
extracellular matrix organization GO:0030198 41 0.041
negative regulation of peptidase activity GO:0010466 91 0.040
ribonucleoside catabolic process GO:0042454 406 0.040
regulation of blood pressure GO:0008217 30 0.039
negative regulation of dendritic cell differentiation GO:2001199 2 0.039
detection of stimulus involved in sensory perception GO:0050906 43 0.039
head development GO:0060322 108 0.038
neuronal action potential GO:0019228 9 0.036
gland development GO:0048732 48 0.036
Zebrafish
regulation of rho gtpase activity GO:0032319 66 0.035
negative regulation of multicellular organismal process GO:0051241 317 0.035
nuclear transport GO:0051169 179 0.034
negative regulation of catalytic activity GO:0043086 335 0.034
amine metabolic process GO:0009308 44 0.034
cellular response to hormone stimulus GO:0032870 125 0.034
response to external biotic stimulus GO:0043207 261 0.034
cytoplasmic transport GO:0016482 379 0.034
peripheral nervous system development GO:0007422 2 0.033
cellular macromolecule catabolic process GO:0044265 380 0.033
negative regulation of cellular component movement GO:0051271 106 0.033
cellular lipid catabolic process GO:0044242 65 0.033
behavior GO:0007610 112 0.032
protein localization to membrane GO:0072657 160 0.032
striated muscle contraction GO:0006941 52 0.032
heart development GO:0007507 95 0.032
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.031
lymphocyte activation GO:0046649 133 0.031
leukocyte activation GO:0045321 164 0.031
cation transport GO:0006812 331 0.031
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.031
regulation of cytoplasmic transport GO:1903649 149 0.031
monosaccharide metabolic process GO:0005996 74 0.031
cellular response to thyroid hormone stimulus GO:0097067 9 0.030
surfactant homeostasis GO:0043129 3 0.029
regulation of cellular response to stress GO:0080135 244 0.029
cell projection assembly GO:0030031 126 0.028
negative regulation of proteolysis GO:0045861 132 0.028
negative regulation of cell motility GO:2000146 104 0.028
endochondral bone morphogenesis GO:0060350 3 0.028
liposaccharide metabolic process GO:1903509 27 0.028
modification dependent protein catabolic process GO:0019941 209 0.028
peptidyl tyrosine modification GO:0018212 170 0.028
organic hydroxy compound metabolic process GO:1901615 147 0.027
proteasomal protein catabolic process GO:0010498 176 0.027
gtp metabolic process GO:0046039 239 0.027
protein import GO:0017038 130 0.027
single organism nuclear import GO:1902593 104 0.027
extracellular structure organization GO:0043062 41 0.027
rho protein signal transduction GO:0007266 26 0.027
regulation of transferase activity GO:0051338 355 0.027
regulation of protein stability GO:0031647 87 0.027
negative regulation of blood vessel remodeling GO:0060313 1 0.026
actin filament based process GO:0030029 224 0.026
metal ion homeostasis GO:0055065 169 0.026
cell development GO:0048468 328 0.026
Zebrafish
response to wounding GO:0009611 168 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
epidermis development GO:0008544 59 0.025
lytic vacuole organization GO:0080171 24 0.025
angiotensin maturation GO:0002003 2 0.025
lysosome organization GO:0007040 24 0.025
regulation of rho protein signal transduction GO:0035023 79 0.025
positive regulation of cellular component organization GO:0051130 376 0.024
negative regulation of hydrolase activity GO:0051346 182 0.024
positive regulation of nucleoside metabolic process GO:0045979 186 0.024
epithelial cell differentiation GO:0030855 141 0.024
cellular carbohydrate metabolic process GO:0044262 84 0.024
response to organonitrogen compound GO:0010243 156 0.024
negative regulation of developmental process GO:0051093 247 0.023
t cell proliferation GO:0042098 45 0.023
negative regulation of glycoprotein metabolic process GO:1903019 8 0.023
neuromuscular process controlling posture GO:0050884 2 0.023
brain development GO:0007420 97 0.023
membrane protein proteolysis GO:0033619 38 0.023
regulation of cell differentiation GO:0045595 393 0.023
negative regulation of cellular response to oxidative stress GO:1900408 18 0.022
regulation of establishment of protein localization GO:0070201 242 0.022
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.022
renal system development GO:0072001 63 0.022
regulation of protein maturation GO:1903317 150 0.021
adaptive immune response GO:0002250 49 0.021
muscle cell cellular homeostasis GO:0046716 3 0.021
negative regulation of programmed cell death GO:0043069 321 0.021
regulation of osteoblast differentiation GO:0045667 38 0.021
glycosphingolipid metabolic process GO:0006687 13 0.021
nuclear import GO:0051170 106 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.020
respiratory system process GO:0003016 3 0.020
cellular protein complex assembly GO:0043623 188 0.020
hexose catabolic process GO:0019320 7 0.020
generation of neurons GO:0048699 152 0.019
Zebrafish
microtubule based process GO:0007017 210 0.019
divalent inorganic cation homeostasis GO:0072507 136 0.019
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 28 0.019
mannose metabolic process GO:0006013 1 0.019
purine containing compound catabolic process GO:0072523 411 0.019
tissue remodeling GO:0048771 16 0.019
membrane organization GO:0061024 292 0.019
bone resorption GO:0045453 6 0.019
cardiovascular system development GO:0072358 262 0.019
cognition GO:0050890 43 0.019
regulation of proteolysis GO:0030162 293 0.019
response to nitrogen compound GO:1901698 184 0.019
cdc42 protein signal transduction GO:0032488 4 0.018
regulation of cellular amine metabolic process GO:0033238 11 0.018
segmentation GO:0035282 4 0.018
regulation of cell activation GO:0050865 125 0.018
prostate gland development GO:0030850 3 0.018
cellular response to extracellular stimulus GO:0031668 72 0.018
multicellular organismal signaling GO:0035637 34 0.018
peptidyl lysine modification GO:0018205 144 0.018
negative regulation of locomotion GO:0040013 118 0.018
positive regulation of hydrolase activity GO:0051345 331 0.017
secretion by cell GO:0032940 226 0.017
cellular response to endogenous stimulus GO:0071495 336 0.017
response to oxygen levels GO:0070482 100 0.017
response to reactive oxygen species GO:0000302 61 0.017
antigen processing and presentation of exogenous antigen GO:0019884 4 0.017
response to abiotic stimulus GO:0009628 336 0.017
mononuclear cell proliferation GO:0032943 71 0.017
hemopoiesis GO:0030097 180 0.017
response to thyroid hormone GO:0097066 9 0.017
negative regulation of catabolic process GO:0009895 104 0.017
erk1 and erk2 cascade GO:0070371 104 0.017
autophagy GO:0006914 88 0.017
anatomical structure formation involved in morphogenesis GO:0048646 284 0.017
regulation of gtp catabolic process GO:0033124 180 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.016
hematopoietic or lymphoid organ development GO:0048534 186 0.016
blastoderm segmentation GO:0007350 2 0.016
negative regulation of protein processing GO:0010955 142 0.016
nucleotide catabolic process GO:0009166 408 0.016
apoptotic signaling pathway GO:0097190 268 0.016
positive regulation of cell differentiation GO:0045597 211 0.016
regulation of protein import into nucleus GO:0042306 78 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.016
organelle assembly GO:0070925 176 0.016
decidualization GO:0046697 4 0.016
positive regulation of gtp catabolic process GO:0033126 166 0.016
musculoskeletal movement GO:0050881 17 0.016
response to oxidative stress GO:0006979 121 0.016
oxidation reduction process GO:0055114 396 0.016
maintenance of location in cell GO:0051651 62 0.016
regulation of cell killing GO:0031341 22 0.015
mapk cascade GO:0000165 288 0.015
ras protein signal transduction GO:0007265 73 0.015
circulatory system process GO:0003013 113 0.015
leukocyte proliferation GO:0070661 74 0.015
positive regulation of tolerance induction GO:0002645 2 0.015
neurogenesis GO:0022008 169 0.015
Zebrafish
positive regulation of rho gtpase activity GO:0032321 56 0.015
ribonucleotide catabolic process GO:0009261 405 0.015
generation of precursor metabolites and energy GO:0006091 68 0.015
negative regulation of cellular catabolic process GO:0031330 83 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
regulation of microtubule based process GO:0032886 74 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
negative regulation of endopeptidase activity GO:0010951 84 0.014
vasculature development GO:0001944 181 0.014
alcohol metabolic process GO:0006066 114 0.014
reactive oxygen species biosynthetic process GO:1903409 4 0.014
cellular calcium ion homeostasis GO:0006874 117 0.013
regulation of lymphocyte activation GO:0051249 103 0.013
cell adhesion GO:0007155 325 0.013
regulation of protein processing GO:0070613 150 0.013
cellular protein catabolic process GO:0044257 261 0.013
peptide hormone processing GO:0016486 9 0.013
rhythmic behavior GO:0007622 2 0.013
calcium independent cell matrix adhesion GO:0007161 1 0.013
regulation of lymphocyte mediated immunity GO:0002706 33 0.013
immune system development GO:0002520 195 0.013
muscle system process GO:0003012 81 0.013
negative regulation of transferase activity GO:0051348 124 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
Mouse
cellular response to reactive oxygen species GO:0034614 50 0.013
negative regulation of protein maturation GO:1903318 142 0.013
guanosine containing compound metabolic process GO:1901068 244 0.012
positive regulation of secretion GO:0051047 116 0.012
i kappab kinase nf kappab signaling GO:0007249 166 0.012
sensory perception GO:0007600 103 0.012
secretion GO:0046903 254 0.012
monovalent inorganic cation homeostasis GO:0055067 37 0.012
response to organic cyclic compound GO:0014070 204 0.012
camera type eye development GO:0043010 25 0.012
protein import into nucleus GO:0006606 104 0.012
necrotic cell death GO:0070265 21 0.012
negative regulation of apoptotic process GO:0043066 316 0.012
regeneration GO:0031099 4 0.012
regulation of immune effector process GO:0002697 91 0.012
positive regulation of leukocyte differentiation GO:1902107 37 0.012
tube development GO:0035295 125 0.012
detection of biotic stimulus GO:0009595 21 0.012
regulation of dna replication GO:0006275 68 0.012
protein localization to nucleus GO:0034504 136 0.012
negative regulation of intracellular signal transduction GO:1902532 183 0.012
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.012
single organism behavior GO:0044708 28 0.012
regulation of cytokine production GO:0001817 232 0.012
respiratory gaseous exchange GO:0007585 3 0.012
regulation of kinase activity GO:0043549 314 0.011
skeletal system morphogenesis GO:0048705 24 0.011
cellular macromolecular complex assembly GO:0034622 324 0.011
regulation of gtpase activity GO:0043087 180 0.011
regulation of ras gtpase activity GO:0032318 128 0.011
positive regulation of t cell tolerance induction GO:0002666 2 0.011
lymphocyte mediated immunity GO:0002449 48 0.011
negative regulation of protein catabolic process GO:0042177 59 0.011
protein stabilization GO:0050821 64 0.011
single organism cellular localization GO:1902580 332 0.011
phosphatidylinositol metabolic process GO:0046488 53 0.011
monovalent inorganic cation transport GO:0015672 128 0.011
regulation of oxidative stress induced cell death GO:1903201 24 0.011
multicellular organismal movement GO:0050879 17 0.011
regulation of response to oxidative stress GO:1902882 26 0.011
detection of stimulus GO:0051606 85 0.011
sensory perception of pain GO:0019233 4 0.011
negative regulation of t cell activation GO:0050868 18 0.011
positive regulation of protein transport GO:0051222 135 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
regulation of protein localization to nucleus GO:1900180 85 0.011
hair cell differentiation GO:0035315 2 0.011
oligosaccharide metabolic process GO:0009311 13 0.011
regulation of neuron apoptotic process GO:0043523 35 0.011
sensory organ development GO:0007423 52 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
lymphocyte proliferation GO:0046651 70 0.010
long term memory GO:0007616 2 0.010
negative regulation of cell migration GO:0030336 102 0.010
purine ribonucleoside metabolic process GO:0046128 437 0.010
regulation of tolerance induction GO:0002643 4 0.010
neuron differentiation GO:0030182 138 0.010
Zebrafish
regulation of t cell activation GO:0050863 77 0.010
skeletal muscle contraction GO:0003009 16 0.010
regulation of collagen catabolic process GO:0010710 3 0.010
regulation of actin filament based process GO:0032970 141 0.010
regulation of immune response GO:0050776 201 0.010
response to peptide hormone GO:0043434 61 0.010
tissue regeneration GO:0042246 3 0.010

GRN disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 1.000
lysosomal storage disease DOID:3211 47 1.000
inherited metabolic disorder DOID:655 242 1.000
lipid storage disease DOID:9455 28 0.998
central nervous system disease DOID:331 186 0.978
nervous system disease DOID:863 431 0.978
neuronal ceroid lipofuscinosis DOID:14503 11 0.856
brain disease DOID:936 73 0.490
cerebral degeneration DOID:1443 16 0.213
leukodystrophy DOID:10579 8 0.182
sphingolipidosis DOID:1927 14 0.165
acquired metabolic disease DOID:0060158 58 0.083
neurodegenerative disease DOID:1289 102 0.081
immune system disease DOID:2914 155 0.046
mucopolysaccharidosis DOID:12798 11 0.045
glycogen storage disease DOID:2747 10 0.038
carbohydrate metabolic disorder DOID:2978 55 0.038
glycogen metabolism disorder DOID:0050728 10 0.038
sensory system disease DOID:0050155 203 0.014
eye and adnexa disease DOID:1492 150 0.014
eye disease DOID:5614 149 0.014
musculoskeletal system disease DOID:17 223 0.011
disease of mental health DOID:150 70 0.011
cognitive disorder DOID:1561 29 0.011