IMP

Process View

Homo sapiens

3 genes annotated in human

negative regulation of multicellular organismal metabolic process

Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of multicellular organismal metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of multicellular organismal metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
S100B	S100 calcium binding protein B	0.985
IL6R	interleukin 6 receptor	0.984
IL6	interleukin 6 (interferon, beta 2)	0.968
IL8	interleukin 8	0.808
CXCL2	chemokine (C-X-C motif) ligand 2	0.755
JAK1	Janus kinase 1	0.563
CST2	cystatin SA	0.548	Human
GRN	granulin	0.443
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.426
CST4	cystatin S	0.408	Human
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.314
CXCL3	chemokine (C-X-C motif) ligand 3	0.277
CTSA	cathepsin A	0.267
PLD3	phospholipase D family, member 3	0.208
TTR	transthyretin	0.189
CCL20	chemokine (C-C motif) ligand 20	0.179
CTSB	cathepsin B	0.148
GAA	glucosidase, alpha; acid	0.142
S100A1	S100 calcium binding protein A1	0.141
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.116
IL1B	interleukin 1, beta	0.108
CFD	complement factor D (adipsin)	0.106
CST1	cystatin SN	0.092	Human
CTSD	cathepsin D	0.058
HRH1	histamine receptor H1	0.057
CCL2	chemokine (C-C motif) ligand 2	0.057
CD81	CD81 molecule	0.056
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.055
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.045
NPC2	Niemann-Pick disease, type C2	0.045
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.045
CD151	CD151 molecule (Raph blood group)	0.039
ADRB2	adrenergic, beta-2-, receptor, surface	0.037
CCL22	chemokine (C-C motif) ligand 22	0.036
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.036
S100P	S100 calcium binding protein P	0.035
CD63	CD63 molecule	0.032
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.030
TNP1	transition protein 1 (during histone to protamine replacement)	0.026
PTX3	pentraxin 3, long	0.025
CCL8	chemokine (C-C motif) ligand 8	0.025
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.024
TIMP1	TIMP metallopeptidase inhibitor 1	0.024
CSF3	colony stimulating factor 3 (granulocyte)	0.022
CST5	cystatin D	0.022	Human
SMAD9	SMAD family member 9	0.022
CCL7	chemokine (C-C motif) ligand 7	0.020
CCL17	chemokine (C-C motif) ligand 17	0.020
ZC3H12A	zinc finger CCCH-type containing 12A	0.020
PPARA	peroxisome proliferator-activated receptor alpha	0.019
S100A3	S100 calcium binding protein A3	0.019
PSAP	prosaposin	0.019
TSPO	translocator protein (18kDa)	0.019
ICAM1	intercellular adhesion molecule 1	0.018
RARA	retinoic acid receptor, alpha	0.018
SLC22A2	solute carrier family 22 (organic cation transporter), member 2	0.018
G0S2	G0/G1switch 2	0.017
SPACA4	sperm acrosome associated 4	0.017
CCIN	calicin	0.017
ANGPTL4	angiopoietin-like 4	0.017
PLAU	plasminogen activator, urokinase	0.017
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.017
SELE	selectin E	0.016
IL18R1	interleukin 18 receptor 1	0.016
CD68	CD68 molecule	0.015
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.014
FAM46A	family with sequence similarity 46, member A	0.014
CD79B	CD79b molecule, immunoglobulin-associated beta	0.014
IL1R1	interleukin 1 receptor, type I	0.014
RXRA	retinoid X receptor, alpha	0.013
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.013
COMP	cartilage oligomeric matrix protein	0.013
TCN2	transcobalamin II	0.012
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.012
PDCD1LG2	programmed cell death 1 ligand 2	0.012
CRYL1	crystallin, lambda 1	0.012
THBD	thrombomodulin	0.012
SOD2	superoxide dismutase 2, mitochondrial	0.012
CCL4	chemokine (C-C motif) ligand 4	0.012
STC1	stanniocalcin 1	0.012
MT3	metallothionein 3	0.012
LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	0.011
INHBA	inhibin, beta A	0.011
CXCL5	chemokine (C-X-C motif) ligand 5	0.011
RRAD	Ras-related associated with diabetes	0.011
NCOR2	nuclear receptor corepressor 2	0.011
SIX1	SIX homeobox 1	0.011
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.011
CCL24	chemokine (C-C motif) ligand 24	0.011
GRINA	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.011
IER3	immediate early response 3	0.011
MDFI	MyoD family inhibitor	0.011
TFPI2	tissue factor pathway inhibitor 2	0.011
PHLDA2	pleckstrin homology-like domain, family A, member 2	0.011
CSTB	cystatin B (stefin B)	0.011
GRK1	G protein-coupled receptor kinase 1	0.011
CATSPER1	cation channel, sperm associated 1	0.010
HMOX1	heme oxygenase (decycling) 1	0.010
C1orf162	chromosome 1 open reading frame 162	0.010
LRP10	low density lipoprotein receptor-related protein 10	0.010