Homo sapiens

45 known processes

CASP1

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

(Aliases: P45,IL1BC,ICE)

CASP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of interleukin 1 beta secretion GO:0050718 11 1.000
Mouse Rat
regulation of interleukin 1 beta secretion GO:0050706 12 1.000
Mouse Rat
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.999
cytokine production GO:0001816 247 0.998
Mouse Rat
defense response to bacterium GO:0042742 63 0.998
Fly
interleukin 1 beta secretion GO:0050702 15 0.998
Mouse Rat
innate immune response GO:0045087 178 0.997
Fly
regulation of peptidase activity GO:0052547 180 0.997
Human Fly
activation of innate immune response GO:0002218 55 0.997
defense response to virus GO:0051607 71 0.997
Fly
positive regulation of defense response GO:0031349 87 0.997
Fly
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.996
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.996
Fly
defense response to other organism GO:0098542 129 0.996
Fly
positive regulation of interleukin 1 production GO:0032732 14 0.996
Mouse Rat
response to cytokine GO:0034097 232 0.995
Human
immune response GO:0006955 307 0.995
Fly
response to biotic stimulus GO:0009607 276 0.994
Mouse Rat Fly
pyroptosis GO:0070269 1 0.994
Mouse
i kappab kinase nf kappab signaling GO:0007249 166 0.994
defense response GO:0006952 315 0.994
Mouse Fly
response to external biotic stimulus GO:0043207 261 0.993
Mouse Rat Fly
positive regulation of cell death GO:0010942 263 0.992
Human Zebrafish Rat Fly
response to virus GO:0009615 126 0.992
Fly
regulation of cytokine production GO:0001817 232 0.991
Mouse Rat
regulation of innate immune response GO:0045088 97 0.991
Fly
interleukin 1 secretion GO:0050701 18 0.988
Mouse Rat
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.988
positive regulation of interleukin 1 beta production GO:0032731 13 0.987
Mouse Rat
positive regulation of immune system process GO:0002684 283 0.984
Human Fly
positive regulation of innate immune response GO:0045089 79 0.982
Fly
protein processing GO:0016485 226 0.981
Human Mouse Fly
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.979
Fly
interleukin 1 production GO:0032612 26 0.978
Mouse Rat
secretion GO:0046903 254 0.976
Mouse Rat
cytokine secretion GO:0050663 64 0.970
Mouse Rat
regulation of apoptotic signaling pathway GO:2001233 175 0.968
Fly
protein maturation GO:0051604 233 0.965
Human Mouse Fly
regulation of immune response GO:0050776 201 0.962
Fly
positive regulation of immune response GO:0050778 159 0.962
Fly
protein secretion GO:0009306 98 0.952
Mouse Rat
positive regulation of programmed cell death GO:0043068 249 0.951
Human Zebrafish Rat Fly
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.951
detection of external biotic stimulus GO:0098581 19 0.948
response to bacterium GO:0009617 144 0.947
Mouse Rat Fly
detection of stimulus GO:0051606 85 0.947
regulation of endopeptidase activity GO:0052548 170 0.943
Human Fly
activation of immune response GO:0002253 114 0.942
response to other organism GO:0051707 261 0.941
Mouse Rat Fly
protein oligomerization GO:0051259 173 0.940
Fly
detection of biotic stimulus GO:0009595 21 0.939
positive regulation of apoptotic process GO:0043065 246 0.939
Human Zebrafish Rat Fly
regulation of proteolysis GO:0030162 293 0.934
Human Fly
cellular response to molecule of bacterial origin GO:0071219 62 0.934
mononuclear cell proliferation GO:0032943 71 0.934
regulation of cysteine type endopeptidase activity GO:2000116 127 0.932
Human Fly
t cell activation GO:0042110 99 0.925
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.922
Human
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.904
Fly
regulation of defense response GO:0031347 154 0.897
Mouse Fly
positive regulation of proteolysis GO:0045862 142 0.894
Human Fly
positive regulation of mapk cascade GO:0043410 190 0.883
regulation of leukocyte activation GO:0002694 115 0.880
developmental programmed cell death GO:0010623 3 0.874
Fly
positive regulation of leukocyte proliferation GO:0070665 48 0.873
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.853
Fly
regulation of lymphocyte proliferation GO:0050670 64 0.852
zymogen activation GO:0031638 70 0.845
Human Fly
positive regulation of leukocyte activation GO:0002696 80 0.842
regulation of secretion by cell GO:1903530 177 0.835
Mouse Rat
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.831
signal transduction by phosphorylation GO:0023014 297 0.829
response to lipopolysaccharide GO:0032496 70 0.826
Mouse Rat
positive regulation of protein transport GO:0051222 135 0.825
Mouse Rat
immune effector process GO:0002252 159 0.822
Fly
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.820
Human Fly
response to tumor necrosis factor GO:0034612 76 0.813
Human
positive regulation of lymphocyte activation GO:0051251 73 0.807
cellular response to oxygen containing compound GO:1901701 276 0.803
positive regulation of endopeptidase activity GO:0010950 84 0.802
Human Fly
regulation of defense response to virus GO:0050688 33 0.798
Fly
positive regulation of myeloid cell differentiation GO:0045639 39 0.792
Human
pattern recognition receptor signaling pathway GO:0002221 48 0.768
immune system development GO:0002520 195 0.767
Human
adaptive immune response GO:0002250 49 0.765
lymphocyte activation GO:0046649 133 0.763
regulation of secretion GO:0051046 194 0.763
Mouse Rat
cellular response to lipid GO:0071396 127 0.762
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.749
positive regulation of apoptotic signaling pathway GO:2001235 70 0.748
Fly
regulation of autophagy GO:0010506 52 0.741
Mouse Fly
extrinsic apoptotic signaling pathway GO:0097191 119 0.739
Human
regulation of protein secretion GO:0050708 86 0.732
Mouse Rat
apoptotic signaling pathway GO:0097190 268 0.724
Human Fly
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.710
Human
regulation of interleukin 6 production GO:0032675 37 0.707
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.706
regulation of interleukin 1 secretion GO:0050704 14 0.705
Mouse Rat
positive regulation of humoral immune response GO:0002922 3 0.705
Fly
regulation of tumor necrosis factor production GO:0032680 43 0.705
positive regulation of interferon gamma production GO:0032729 26 0.692
leukocyte activation GO:0045321 164 0.691
Rat
positive regulation of transport GO:0051050 336 0.687
Mouse Rat
positive regulation of cell differentiation GO:0045597 211 0.666
Human Fly
regulation of establishment of protein localization GO:0070201 242 0.664
Mouse Rat
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.664
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.658
Human
positive regulation of hydrolase activity GO:0051345 331 0.657
Human Fly
positive regulation of response to external stimulus GO:0032103 88 0.648
Fly
regulation of immune effector process GO:0002697 91 0.644
Fly
protein catabolic process GO:0030163 325 0.644
Human
regulation of cytokine secretion GO:0050707 57 0.643
Mouse Rat
regulation of cellular response to stress GO:0080135 244 0.637
Human
positive regulation of cell activation GO:0050867 81 0.625
positive regulation of leukocyte differentiation GO:1902107 37 0.616
Human
interleukin 1 beta production GO:0032611 22 0.610
Mouse Rat
cytokine mediated signaling pathway GO:0019221 109 0.608
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.606
regulation of interferon gamma production GO:0032649 36 0.585
positive regulation of t cell proliferation GO:0042102 33 0.565
positive regulation of mhc class i biosynthetic process GO:0045345 4 0.553
regulation of leukocyte differentiation GO:1902105 61 0.548
Human
organic hydroxy compound metabolic process GO:1901615 147 0.548
Fly
mapk cascade GO:0000165 288 0.546
detection of bacterium GO:0016045 13 0.539
immune response activating signal transduction GO:0002757 90 0.531
regulation of inflammatory response GO:0050727 46 0.528
Mouse
regulation of chemokine production GO:0032642 31 0.527
response to oxygen containing compound GO:1901700 369 0.521
Mouse Rat
production of molecular mediator of immune response GO:0002440 37 0.509
Fly
regulation of cell activation GO:0050865 125 0.508
regulation of t cell activation GO:0050863 77 0.507
regulation of lymphocyte activation GO:0051249 103 0.505
regulation of protein transport GO:0051223 213 0.496
Mouse Rat
cellular response to triacyl bacterial lipopeptide GO:0071727 2 0.483
negative regulation of cell proliferation GO:0008285 228 0.483
Fly
secretion by cell GO:0032940 226 0.478
Mouse Rat
positive regulation of stress activated mapk cascade GO:0032874 60 0.475
regulation of transferase activity GO:0051338 355 0.458
cellular response to cytokine stimulus GO:0071345 181 0.453
positive regulation of phosphorylation GO:0042327 394 0.442
protein homooligomerization GO:0051260 100 0.438
autophagy GO:0006914 88 0.436
Mouse Fly
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.418
regulation of myeloid leukocyte differentiation GO:0002761 39 0.417
Human
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.416
positive regulation of developmental process GO:0051094 314 0.415
Human Fly
innate immune response activating signal transduction GO:0002758 48 0.411
negative regulation of protein maturation GO:1903318 142 0.409
cellular response to lipopolysaccharide GO:0071222 57 0.409
regulation of cytokine biosynthetic process GO:0042035 35 0.407
angiogenesis GO:0001525 147 0.404
regulation of interleukin 8 secretion GO:2000482 13 0.403
interleukin 8 production GO:0032637 51 0.402
regulation of adaptive immune response GO:0002819 33 0.396
regulation of kinase activity GO:0043549 314 0.376
cellular response to dna damage stimulus GO:0006974 379 0.368
Human
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.356
negative regulation of catalytic activity GO:0043086 335 0.355
negative regulation of protein processing GO:0010955 142 0.352
organonitrogen compound biosynthetic process GO:1901566 200 0.346
Fly
melanin metabolic process GO:0006582 1 0.341
Fly
positive regulation of secretion GO:0051047 116 0.340
Mouse Rat
cellular macromolecule catabolic process GO:0044265 380 0.331
Human
activation of cysteine type endopeptidase activity GO:0097202 57 0.330
Human Fly
jnk cascade GO:0007254 80 0.329
signal transduction by p53 class mediator GO:0072331 72 0.328
Human
detection of muramyl dipeptide GO:0032498 1 0.328
regulation of protein processing GO:0070613 150 0.326
positive regulation of secretion by cell GO:1903532 108 0.322
Mouse Rat
positive regulation of tumor necrosis factor production GO:0032760 21 0.320
response to triacyl bacterial lipopeptide GO:0071725 2 0.316
inflammatory response GO:0006954 79 0.313
Mouse
hemopoiesis GO:0030097 180 0.307
Human
response to molecule of bacterial origin GO:0002237 82 0.305
Mouse Rat
negative regulation of programmed cell death GO:0043069 321 0.303
Fly
positive regulation of mononuclear cell proliferation GO:0032946 47 0.298
positive regulation of cytokine production GO:0001819 167 0.296
Mouse Rat
regulation of antimicrobial humoral response GO:0002759 1 0.293
Fly
detection of other organism GO:0098543 13 0.287
regulation of multi organism process GO:0043900 157 0.285
Fly
response to diacyl bacterial lipopeptide GO:0071724 2 0.284
leukocyte proliferation GO:0070661 74 0.280
positive regulation of interleukin 8 biosynthetic process GO:0045416 8 0.277
execution phase of apoptosis GO:0097194 32 0.263
Human
leukocyte differentiation GO:0002521 98 0.259
Human
regulation of protein localization GO:0032880 296 0.256
Mouse Rat
nitrogen compound transport GO:0071705 191 0.256
positive regulation of cell proliferation GO:0008284 301 0.255
regulation of cell cycle process GO:0010564 266 0.250
Human
cellular response to mechanical stimulus GO:0071260 39 0.241
regulation of leukocyte proliferation GO:0070663 67 0.240
cellular response to external stimulus GO:0071496 111 0.239
amide biosynthetic process GO:0043604 15 0.237
Fly
response to abiotic stimulus GO:0009628 336 0.230
positive regulation of macrophage differentiation GO:0045651 7 0.227
Human
regulation of response to external stimulus GO:0032101 222 0.217
Mouse Fly
negative regulation of intracellular signal transduction GO:1902532 183 0.215
Human
positive regulation of antimicrobial humoral response GO:0002760 1 0.211
Fly
negative regulation of apoptotic process GO:0043066 316 0.211
determination of adult lifespan GO:0008340 2 0.209
Fly
positive regulation of interleukin 1 secretion GO:0050716 11 0.206
Mouse Rat
t cell proliferation GO:0042098 45 0.206
regulation of protein kinase activity GO:0045859 289 0.205
cellular response to biotic stimulus GO:0071216 71 0.204
signal transduction involved in mitotic g1 dna damage checkpoint GO:0072431 10 0.202
Human
erk1 and erk2 cascade GO:0070371 104 0.202
negative regulation of proteolysis GO:0045861 132 0.199
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.198
positive regulation of cell cycle GO:0045787 140 0.194
Human
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.193
positive regulation of nf kappab import into nucleus GO:0042346 13 0.191
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 10 0.190
Human
detection of molecule of bacterial origin GO:0032490 10 0.187
hematopoietic or lymphoid organ development GO:0048534 186 0.186
Human
circulatory system development GO:0072359 262 0.181
autophagic cell death GO:0048102 3 0.178
Fly
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.178
vasculature development GO:0001944 181 0.178
positive regulation of peptidase activity GO:0010952 88 0.176
Human Fly
cellular response to uv GO:0034644 32 0.174
Human
regulation of response to biotic stimulus GO:0002831 55 0.174
Fly
regulation of myeloid cell differentiation GO:0045637 81 0.174
Human
positive regulation of cell cycle process GO:0090068 106 0.174
Human
humoral immune response GO:0006959 49 0.174
Fly
cellular protein catabolic process GO:0044257 261 0.171
Human
myeloid leukocyte differentiation GO:0002573 60 0.171
Human
stress activated protein kinase signaling cascade GO:0031098 94 0.169
positive regulation of interleukin 6 production GO:0032755 21 0.167
positive regulation of cytokine secretion GO:0050715 42 0.164
Mouse Rat
spermatid differentiation GO:0048515 4 0.164
Fly
detection of chemical stimulus GO:0009593 55 0.164
negative regulation of protein metabolic process GO:0051248 391 0.162
response to mechanical stimulus GO:0009612 51 0.160
cell activation GO:0001775 213 0.159
Rat
regulation of interleukin 8 production GO:0032677 49 0.158
myeloid leukocyte activation GO:0002274 34 0.157
Rat
oogenesis GO:0048477 2 0.157
Fly
tumor necrosis factor production GO:0032640 43 0.156
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.154
Human
compound eye development GO:0048749 1 0.149
Fly
activated t cell proliferation GO:0050798 13 0.144
regulation of cell cycle phase transition GO:1901987 126 0.144
Human
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.143
regulation of intracellular transport GO:0032386 195 0.141
nk t cell proliferation GO:0001866 3 0.140
regulation of protein maturation GO:1903317 150 0.140
intrinsic apoptotic signaling pathway GO:0097193 127 0.139
Human
response to interferon gamma GO:0034341 39 0.135
intracellular protein transport GO:0006886 270 0.132
cellular amide metabolic process GO:0043603 69 0.131
Fly
purine nucleoside triphosphate catabolic process GO:0009146 392 0.131
regulation of erk1 and erk2 cascade GO:0070372 99 0.130
negative regulation of cellular protein metabolic process GO:0032269 353 0.127
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.125
cytoplasmic transport GO:0016482 379 0.121
ion transmembrane transport GO:0034220 338 0.121
negative regulation of cell cycle phase transition GO:1901988 89 0.120
Human
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.118
Human
negative regulation of peptidase activity GO:0010466 91 0.115
regulation of mitochondrion organization GO:0010821 54 0.114
regulation of cellular amino acid metabolic process GO:0006521 6 0.114
mitotic cell cycle checkpoint GO:0007093 68 0.114
Human
regulation of production of molecular mediator of immune response GO:0002700 25 0.113
Fly
negative regulation of hydrolase activity GO:0051346 182 0.111
cell cycle checkpoint GO:0000075 117 0.107
Human
negative regulation of cell cycle GO:0045786 193 0.107
Human
protein heterooligomerization GO:0051291 16 0.105
Fly
response to radiation GO:0009314 151 0.105
Human
cell activation involved in immune response GO:0002263 30 0.104
cell type specific apoptotic process GO:0097285 125 0.103
Fly
positive regulation of chemokine production GO:0032722 22 0.103
negative regulation of cell death GO:0060548 345 0.103
Fly
interleukin 17 production GO:0032620 12 0.102
positive regulation of adaptive immune response GO:0002821 21 0.102
regulation of t cell proliferation GO:0042129 42 0.101
positive regulation of organelle organization GO:0010638 195 0.101
positive regulation of t cell activation GO:0050870 54 0.101
g1 dna damage checkpoint GO:0044783 18 0.101
Human
negative regulation of protein phosphorylation GO:0001933 140 0.101
positive regulation of natural killer cell proliferation GO:0032819 3 0.100
cellular response to abiotic stimulus GO:0071214 117 0.097
cell cycle phase transition GO:0044770 173 0.097
Human
regulation of type i interferon production GO:0032479 26 0.097
protein targeting GO:0006605 187 0.096
dna integrity checkpoint GO:0031570 71 0.096
Human
regulation of protein localization to nucleus GO:1900180 85 0.096
regulation of metal ion transport GO:0010959 120 0.095
interferon gamma production GO:0032609 39 0.095
positive regulation of map kinase activity GO:0043406 80 0.093
macrophage differentiation GO:0030225 11 0.091
Human
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.090
positive regulation of lymphocyte proliferation GO:0050671 46 0.090
cellular amino acid metabolic process GO:0006520 116 0.090
regulation of mononuclear cell proliferation GO:0032944 65 0.089
regulation of b cell activation GO:0050864 24 0.088
defense response to gram negative bacterium GO:0050829 14 0.088
Fly
regulation of protein targeting GO:1903533 91 0.086
response to lipid GO:0033993 206 0.086
Mouse Rat
interleukin 2 production GO:0032623 20 0.085
regulation of cytoplasmic transport GO:1903649 149 0.085
regulation of mapk cascade GO:0043408 262 0.084
spermatid development GO:0007286 4 0.084
Fly
mitotic dna damage checkpoint GO:0044773 28 0.084
Human
antigen receptor mediated signaling pathway GO:0050851 38 0.083
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.079
Human
cellular response to tumor necrosis factor GO:0071356 63 0.079
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 2 0.079
Fly
maintenance of location GO:0051235 112 0.079
activation of protein kinase activity GO:0032147 90 0.078
regulation of interleukin 2 production GO:0032663 19 0.077
positive regulation of cellular component organization GO:0051130 376 0.077
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.076
regulation of cellular component biogenesis GO:0044087 281 0.075
negative regulation of cell cycle process GO:0010948 121 0.074
Human
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.074
multi organism cellular process GO:0044764 156 0.074
positive regulation of release of cytochrome c from mitochondria GO:0090200 18 0.073
positive regulation of interleukin 8 production GO:0032757 36 0.073
regulation of response to cytokine stimulus GO:0060759 46 0.073
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.071
stress activated mapk cascade GO:0051403 93 0.071
regulation of interleukin 17 production GO:0032660 12 0.070
negative regulation of endopeptidase activity GO:0010951 84 0.070
regulation of defense response to bacterium GO:1900424 2 0.069
Fly
positive regulation of protein secretion GO:0050714 60 0.068
Mouse Rat
interspecies interaction between organisms GO:0044419 156 0.068
positive regulation of protein localization to nucleus GO:1900182 48 0.067
nucleocytoplasmic transport GO:0006913 176 0.067
positive regulation of intracellular protein transport GO:0090316 76 0.065
positive regulation of intracellular transport GO:0032388 104 0.064
negative regulation of viral transcription GO:0032897 23 0.064
apoptotic mitochondrial changes GO:0008637 57 0.063
positive regulation of protein phosphorylation GO:0001934 313 0.063
positive regulation of protein complex assembly GO:0031334 86 0.063
negative regulation of calcium ion import GO:0090281 1 0.063
regulation of protein serine threonine kinase activity GO:0071900 179 0.062
response to uv GO:0009411 73 0.062
Human
dna damage checkpoint GO:0000077 68 0.062
Human
negative regulation of mitotic cell cycle GO:0045930 102 0.061
Human
immune response regulating signaling pathway GO:0002764 97 0.060
system process GO:0003008 349 0.060
Rat
regulation of cytokine mediated signaling pathway GO:0001959 41 0.060
regulation of stress activated mapk cascade GO:0032872 84 0.059
positive regulation of protein kinase activity GO:0045860 190 0.059
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.058
Human
detection of bacterial lipopeptide GO:0070340 3 0.057
single organism nuclear import GO:1902593 104 0.057
positive regulation of cytoplasmic transport GO:1903651 82 0.057
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.056
regulation of protein import into nucleus GO:0042306 78 0.056
leukocyte mediated immunity GO:0002443 59 0.055
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.055
interleukin 8 secretion GO:0072606 14 0.055
lymphocyte proliferation GO:0046651 70 0.055
negative regulation of protein modification process GO:0031400 200 0.054
positive regulation of locomotion GO:0040017 186 0.054
transmembrane transport GO:0055085 399 0.054
positive regulation of immune effector process GO:0002699 40 0.054
Fly
regulation of cell cycle GO:0051726 393 0.054
Human
regulation of protein complex assembly GO:0043254 147 0.053
interleukin 6 production GO:0032635 37 0.053
post embryonic development GO:0009791 2 0.053
Fly
regulation of mitotic cell cycle GO:0007346 189 0.053
Human
purine containing compound catabolic process GO:0072523 411 0.053
negative regulation of transferase activity GO:0051348 124 0.052
maintenance of protein location GO:0045185 57 0.052
cell development GO:0048468 328 0.052
Fly
actin polymerization or depolymerization GO:0008154 56 0.052
generation of neurons GO:0048699 152 0.051
Fly
protein polyubiquitination GO:0000209 110 0.051
cellular response to light stimulus GO:0071482 34 0.050
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.050
positive regulation of transferase activity GO:0051347 227 0.050
positive regulation of kinase activity GO:0033674 204 0.050
anatomical structure homeostasis GO:0060249 100 0.049
cell cycle arrest GO:0007050 71 0.049
Human
pigment metabolic process GO:0042440 16 0.049
Fly
regulation of jnk cascade GO:0046328 73 0.048
response to oxygen levels GO:0070482 100 0.048
Mouse Rat
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.048
detection of triacyl bacterial lipopeptide GO:0042495 2 0.048
signal transduction involved in cell cycle checkpoint GO:0072395 16 0.048
Human
negative regulation of defense response GO:0031348 47 0.047
metal ion transport GO:0030001 272 0.047
interferon alpha biosynthetic process GO:0045349 4 0.047
negative regulation of multicellular organismal process GO:0051241 317 0.047
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.046
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.046
Human
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.046
multicellular organismal aging GO:0010259 3 0.046
Fly
regulation of interleukin 1 beta production GO:0032651 18 0.046
Mouse Rat
negative regulation of phosphate metabolic process GO:0045936 267 0.046
intracellular receptor signaling pathway GO:0030522 104 0.045
protein localization to organelle GO:0033365 280 0.045
positive regulation of cell cycle arrest GO:0071158 23 0.045
Human
cytokine metabolic process GO:0042107 38 0.045
response to extracellular stimulus GO:0009991 85 0.044
ribonucleotide catabolic process GO:0009261 405 0.044
nucleoside triphosphate catabolic process GO:0009143 394 0.044
epithelium development GO:0060429 227 0.044
response to lipoteichoic acid GO:0070391 3 0.043
blood vessel morphogenesis GO:0048514 162 0.043
vesicle mediated transport GO:0016192 371 0.042
mitotic cell cycle GO:0000278 326 0.042
Human
signal transduction involved in dna integrity checkpoint GO:0072401 15 0.042
Human
positive regulation of multi organism process GO:0043902 56 0.042
Fly
negative regulation of immune response GO:0050777 40 0.041
negative regulation of apoptotic signaling pathway GO:2001234 97 0.041
cytokine production involved in immune response GO:0002367 27 0.041
necroptotic process GO:0070266 16 0.040
protein targeting to nucleus GO:0044744 104 0.040
regulation of interleukin 10 secretion GO:2001179 4 0.040
positive regulation of cellular amine metabolic process GO:0033240 7 0.039
regulation of vesicle mediated transport GO:0060627 130 0.039
negative regulation of kinase activity GO:0033673 106 0.038
negative regulation of phosphorylation GO:0042326 174 0.038
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.038
Human
cell adhesion GO:0007155 325 0.037
positive regulation of response to biotic stimulus GO:0002833 18 0.037
Fly
positive regulation of cell motility GO:2000147 177 0.037
nuclear transport GO:0051169 179 0.037
response to light stimulus GO:0009416 87 0.036
Human
regulation of vasculature development GO:1901342 97 0.036
regulation of nucleocytoplasmic transport GO:0046822 98 0.035
negative regulation of secretion GO:0051048 58 0.035
leukocyte apoptotic process GO:0071887 31 0.035
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 13 0.035
Human
release of cytochrome c from mitochondria GO:0001836 35 0.034
regulation of protein catabolic process GO:0042176 155 0.034
carbohydrate derivative biosynthetic process GO:1901137 207 0.034
single organism reproductive process GO:0044702 98 0.034
Fly
nuclear import GO:0051170 106 0.034
chemotaxis GO:0006935 157 0.033
regulation of alpha beta t cell activation GO:0046634 13 0.033
neuron development GO:0048666 113 0.033
Fly
negative regulation of transport GO:0051051 176 0.033
peptide metabolic process GO:0006518 51 0.033
Fly
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.033
actin filament based process GO:0030029 224 0.033
positive regulation of interferon alpha biosynthetic process GO:0045356 4 0.033
cell morphogenesis involved in differentiation GO:0000904 144 0.033
Fly
neuron differentiation GO:0030182 138 0.033
Fly
negative regulation of protein transport GO:0051224 75 0.033
regulation of lymphocyte migration GO:2000401 22 0.032
cardiovascular system development GO:0072358 262 0.032
negative regulation of viral genome replication GO:0045071 35 0.032
peptide transport GO:0015833 74 0.032
modification dependent macromolecule catabolic process GO:0043632 212 0.032
leukocyte activation involved in immune response GO:0002366 30 0.032
organophosphate catabolic process GO:0046434 430 0.032
secondary metabolic process GO:0019748 17 0.032
Fly
purine ribonucleoside metabolic process GO:0046128 437 0.032
phenol containing compound metabolic process GO:0018958 12 0.031
Fly
neurological system process GO:0050877 163 0.031
Rat
g1 s transition of mitotic cell cycle GO:0000082 78 0.031
Human
regulation of release of cytochrome c from mitochondria GO:0090199 29 0.031
regulation of activated t cell proliferation GO:0046006 12 0.031
regulation of dna binding GO:0051101 37 0.031
cation transport GO:0006812 331 0.031
regulation of cell adhesion GO:0030155 166 0.030
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.030
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9 0.030
Human
establishment of protein localization to organelle GO:0072594 172 0.029
regulation of protein stability GO:0031647 87 0.029
regulation of anatomical structure size GO:0090066 101 0.029
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 3 0.029
viral gene expression GO:0019080 35 0.029
nucleotide catabolic process GO:0009166 408 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.029
response to nutrient levels GO:0031667 81 0.028
regulation of cell cycle g1 s phase transition GO:1902806 42 0.028
Human
organophosphate biosynthetic process GO:0090407 163 0.028
cell cycle g1 s phase transition GO:0044843 80 0.028
Human
regulation of peptide transport GO:0090087 62 0.028
positive regulation of mitochondrion organization GO:0010822 30 0.028
cellular protein complex assembly GO:0043623 188 0.028
viral process GO:0016032 146 0.028
protein import into nucleus GO:0006606 104 0.028
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.028
interferon gamma biosynthetic process GO:0042095 8 0.027
regulation of cell migration GO:0030334 289 0.027
protein import GO:0017038 130 0.027
negative regulation of protein secretion GO:0050709 29 0.027
mitotic cell cycle phase transition GO:0044772 162 0.027
Human
mitotic dna integrity checkpoint GO:0044774 30 0.027
Human
amide transport GO:0042886 76 0.026
positive regulation of cellular component biogenesis GO:0044089 158 0.026
positive regulation of protein import into nucleus GO:0042307 46 0.026
divalent inorganic cation transport GO:0072511 158 0.026
positive regulation of homeostatic process GO:0032846 47 0.026
single organismal cell cell adhesion GO:0016337 148 0.026
aging GO:0007568 66 0.026
Fly
cellular response to interferon gamma GO:0071346 24 0.026
regulation of anatomical structure morphogenesis GO:0022603 286 0.025
Fly
regulation of cellular component size GO:0032535 82 0.025

CASP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.038
Human
cancer DOID:162 167 0.030
Human
organ system cancer DOID:0050686 164 0.029
Human