|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.713
|
Mouse Rat |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.710
|
|
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
43 |
0.691
|
|
|
|
adenylate cyclase activating g protein coupled receptor signaling pathway
|
GO:0007189 |
18 |
0.686
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.638
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.636
|
Human Yeast Mouse Rat Fly |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.618
|
Human Yeast Mouse Rat Fly |
|
|
positive regulation of rap gtpase activity
|
GO:0032854 |
8 |
0.554
|
Rat |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.543
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.535
|
Fly |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.511
|
Human Mouse Rat |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.507
|
Human Mouse Rat |
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.499
|
Human Yeast Mouse Rat Fly |
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
43 |
0.491
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.480
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.475
|
Human Yeast Mouse Rat Fly |
|
|
regulation of rap protein signal transduction
|
GO:0032487 |
9 |
0.472
|
Rat |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.469
|
Human Yeast Mouse Rat Fly |
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.456
|
Rat |
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.433
|
Human Yeast Mouse Rat Fly |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.433
|
Mouse Rat |
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.426
|
Human Yeast Mouse Rat Fly |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.424
|
Human |
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.417
|
Rat |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.400
|
Human Mouse Rat |
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.391
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.374
|
Rat |
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.357
|
Human Yeast Mouse Rat Fly |
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.356
|
Rat |
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.342
|
Human Yeast Mouse Rat Fly |
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.340
|
Human Yeast Mouse Rat Fly |
|
|
rap protein signal transduction
|
GO:0032486 |
7 |
0.337
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.320
|
Rat |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.317
|
Rat |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.303
|
Human Yeast Mouse Rat Fly |
|
|
positive regulation of cytoskeleton organization
|
GO:0051495 |
83 |
0.297
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.297
|
Rat |
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.293
|
Rat |
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.291
|
Rat |
|
|
blood vessel development
|
GO:0001568 |
172 |
0.286
|
Mouse |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.285
|
Mouse Rat |
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.278
|
Rat |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.277
|
Human Yeast Mouse Rat Fly |
|
|
regulation of dendritic cell apoptotic process
|
GO:2000668 |
4 |
0.275
|
|
|
|
positive regulation of camp dependent protein kinase activity
|
GO:2000481 |
4 |
0.273
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.268
|
Human Yeast Mouse Rat Fly |
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.268
|
Human Yeast Mouse Rat Fly |
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.262
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.262
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.254
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.252
|
Human Yeast Mouse Rat Fly |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.243
|
Human Mouse Rat |
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.237
|
Mouse |
|
|
oogenesis
|
GO:0048477 |
2 |
0.236
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.234
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.233
|
Human |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.227
|
Mouse Rat |
|
|
forebrain generation of neurons
|
GO:0021872 |
3 |
0.225
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.223
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.222
|
Rat |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.219
|
Rat |
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.218
|
Human Mouse Fly |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.217
|
Rat |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.217
|
Mouse |
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.212
|
Rat |
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.210
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.209
|
Rat |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.208
|
|
|
|
response to camp
|
GO:0051591 |
25 |
0.205
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.205
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.199
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.193
|
Human Fly |
|
|
circulatory system development
|
GO:0072359 |
262 |
0.192
|
Zebrafish Mouse |
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.191
|
Mouse |
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.190
|
Human Yeast Mouse Rat Fly |
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.189
|
Human Yeast Mouse Rat Fly |
|
|
actin filament organization
|
GO:0007015 |
128 |
0.182
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.182
|
Rat |
|
|
angiogenesis
|
GO:0001525 |
147 |
0.182
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.177
|
Zebrafish Mouse |
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.173
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.171
|
Human Yeast Mouse Rat Fly |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.166
|
Human Yeast Mouse Rat Fly |
|
|
cellular response to camp
|
GO:0071320 |
21 |
0.164
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.162
|
Rat |
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.160
|
|
|
|
establishment of endothelial barrier
|
GO:0061028 |
16 |
0.159
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.156
|
Human Yeast Mouse Rat Fly |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.155
|
Mouse Rat |
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.153
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.151
|
Human Yeast Mouse Rat Fly |
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.150
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.147
|
Rat |
|
|
vasculature development
|
GO:0001944 |
181 |
0.145
|
Mouse |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.142
|
|
|
|
positive regulation of dendritic cell apoptotic process
|
GO:2000670 |
1 |
0.141
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.141
|
|
|
|
regulation of vasculogenesis
|
GO:2001212 |
3 |
0.139
|
Mouse |
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.139
|
Rat |
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.138
|
Rat |
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.137
|
Fly |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.136
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.135
|
Human Fly |
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.134
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.133
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.133
|
Mouse |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.131
|
Rat |
|
|
negative regulation of rho gtpase activity
|
GO:0034259 |
4 |
0.128
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.127
|
Human |
|
|
cell junction organization
|
GO:0034330 |
79 |
0.120
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.120
|
Human |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.119
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.118
|
Human |
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.117
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.117
|
Human Yeast Mouse Rat Fly |
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.110
|
Human |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.110
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.107
|
Mouse |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.107
|
Human Mouse Rat Fly |
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.104
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.103
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.102
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.101
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.101
|
Human Mouse Rat |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.101
|
|
|
|
positive regulation of neuron migration
|
GO:2001224 |
1 |
0.100
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.097
|
Human Yeast Mouse Rat Fly |
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.096
|
Rat |
|
|
brain derived neurotrophic factor receptor signaling pathway
|
GO:0031547 |
1 |
0.096
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.095
|
Human |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.095
|
Mouse Rat |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.094
|
|
|
|
response to purine containing compound
|
GO:0014074 |
40 |
0.093
|
|
|
|
cyclic purine nucleotide metabolic process
|
GO:0052652 |
60 |
0.093
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.092
|
Fly |
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.091
|
Human |
|
|
cell development
|
GO:0048468 |
328 |
0.091
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.091
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.088
|
Mouse |
|
|
melanin biosynthetic process
|
GO:0042438 |
1 |
0.086
|
|
|
|
exocytosis
|
GO:0006887 |
71 |
0.085
|
Mouse |
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.085
|
|
|
|
endothelial cell development
|
GO:0001885 |
18 |
0.084
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.083
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.082
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.081
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.080
|
|
|
|
forebrain neuron differentiation
|
GO:0021879 |
3 |
0.080
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.079
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.079
|
Zebrafish |
|
|
dendritic cell apoptotic process
|
GO:0097048 |
4 |
0.079
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.079
|
Rat |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.079
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.077
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.076
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.076
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.075
|
Rat |
|
|
cell projection organization
|
GO:0030030 |
252 |
0.075
|
Human Mouse Rat Fly |
|
|
cell junction assembly
|
GO:0034329 |
67 |
0.075
|
|
|
|
positive regulation of angiogenesis
|
GO:0045766 |
51 |
0.075
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.074
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.073
|
|
|
|
response to organophosphorus
|
GO:0046683 |
41 |
0.071
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.071
|
Human Yeast Mouse Rat Fly |
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.070
|
Human Mouse Rat |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.070
|
Human Fly |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.069
|
|
|
|
regulation of stress fiber assembly
|
GO:0051492 |
32 |
0.069
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.067
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.067
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.066
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.064
|
Human Mouse Rat |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.064
|
Human Rat |
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.064
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.063
|
Human Mouse Rat |
|
|
neuron projection development
|
GO:0031175 |
106 |
0.063
|
Human Mouse Rat |
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.063
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.063
|
Mouse |
|
|
positive regulation of actin filament bundle assembly
|
GO:0032233 |
25 |
0.062
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.062
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.062
|
Human |
|
|
generation of neurons
|
GO:0048699 |
152 |
0.062
|
Human Mouse Rat |
|
|
forebrain neuron development
|
GO:0021884 |
2 |
0.062
|
|
|
|
regulation of neuron migration
|
GO:2001222 |
3 |
0.061
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.061
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.060
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.060
|
Mouse |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.060
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.060
|
Human Fly |
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.059
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.059
|
Mouse |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.059
|
Mouse Rat |
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.058
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.058
|
Human Yeast Mouse Rat Fly |
|
|
stem cell development
|
GO:0048864 |
69 |
0.057
|
Fly |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.057
|
Rat |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.057
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.057
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.057
|
Human |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.057
|
|
|
|
cellular response to cgmp
|
GO:0071321 |
5 |
0.056
|
|
|
|
adenylate cyclase activating adrenergic receptor signaling pathway
|
GO:0071880 |
3 |
0.055
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.055
|
Zebrafish |
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.055
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
109 |
0.054
|
|
|
|
secondary metabolite biosynthetic process
|
GO:0044550 |
2 |
0.054
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.054
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.054
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.053
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.052
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.052
|
Human |
|
|
visual learning
|
GO:0008542 |
1 |
0.051
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.051
|
Human Mouse Rat |
|
|
stress fiber assembly
|
GO:0043149 |
40 |
0.050
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.050
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.050
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.048
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.048
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
54 |
0.047
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.047
|
Fly |
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.046
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.046
|
Human Mouse Rat |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.045
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.045
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.045
|
Human |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.045
|
|
|
|
melanin metabolic process
|
GO:0006582 |
1 |
0.044
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.044
|
Rat |
|
|
neurogenesis
|
GO:0022008 |
169 |
0.044
|
Human Mouse Rat |
|
|
positive regulation of stress fiber assembly
|
GO:0051496 |
22 |
0.044
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.043
|
|
|
|
head development
|
GO:0060322 |
108 |
0.043
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.043
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.043
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.043
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.043
|
|
|
|
positive regulation of camp mediated signaling
|
GO:0043950 |
10 |
0.043
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.043
|
|
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
49 |
0.043
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.042
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.042
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.041
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.041
|
|
|
|
endothelium development
|
GO:0003158 |
33 |
0.041
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.041
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.041
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.041
|
Human |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.040
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.040
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.040
|
|
|
|
camp mediated signaling
|
GO:0019933 |
23 |
0.039
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.038
|
Human Fly |
|
|
regulation of camp metabolic process
|
GO:0030814 |
52 |
0.038
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.038
|
|
|
|
positive regulation of camp biosynthetic process
|
GO:0030819 |
35 |
0.038
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
64 |
0.037
|
Mouse Rat |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.037
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.037
|
Zebrafish |
|
|
reproductive process
|
GO:0022414 |
106 |
0.037
|
|
|
|
regulation of secondary metabolic process
|
GO:0043455 |
2 |
0.037
|
|
|
|
positive regulation of cyclic nucleotide biosynthetic process
|
GO:0030804 |
38 |
0.037
|
|
|
|
positive regulation of adenylate cyclase activity
|
GO:0045762 |
12 |
0.036
|
|
|
|
adherens junction organization
|
GO:0034332 |
36 |
0.036
|
Fly |
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.035
|
Fly |
|
|
epidermis development
|
GO:0008544 |
59 |
0.035
|
Worm |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.035
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.034
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.034
|
Rat |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.034
|
|
|
|
regulation of dendrite morphogenesis
|
GO:0048814 |
11 |
0.034
|
Human |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.034
|
Human Fly |
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.034
|
|
|
|
regulation of actin cytoskeleton reorganization
|
GO:2000249 |
12 |
0.033
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.033
|
Human Fly |
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.033
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.033
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.032
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.032
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.032
|
Mouse |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.032
|
|
|
|
response to starvation
|
GO:0042594 |
59 |
0.032
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.031
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.031
|
Rat |
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.031
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.031
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.031
|
|
|
|
actin cytoskeleton reorganization
|
GO:0031532 |
37 |
0.031
|
Human |
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.031
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.031
|
Fly |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.031
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.030
|
Zebrafish Fly |
|
|
ncrna metabolic process
|
GO:0034660 |
108 |
0.030
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.030
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.030
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.030
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.030
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.030
|
Fly |
|
|
macroautophagy
|
GO:0016236 |
39 |
0.030
|
|
|
|
endothelial cell differentiation
|
GO:0045446 |
26 |
0.029
|
|
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.029
|
|
|
|
growth
|
GO:0040007 |
202 |
0.029
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.029
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.029
|
|
|
|
regulation of cell shape
|
GO:0008360 |
48 |
0.028
|
Fly |
|
|
replicative cell aging
|
GO:0001302 |
3 |
0.028
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.028
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.028
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.028
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.028
|
|
|
|
camp metabolic process
|
GO:0046058 |
61 |
0.028
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.028
|
Human Mouse Rat |
|
|
negative regulation of cell projection organization
|
GO:0031345 |
22 |
0.027
|
|
|
|
lipid transport
|
GO:0006869 |
90 |
0.027
|
|
|
|
regulation of dendrite development
|
GO:0050773 |
18 |
0.027
|
Human |
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.027
|
|
|
|
cellular senescence
|
GO:0090398 |
34 |
0.027
|
|
|
|
actomyosin structure organization
|
GO:0031032 |
59 |
0.027
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.027
|
Rat |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.027
|
|
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
38 |
0.027
|
|
|
|
regulation of actin filament bundle assembly
|
GO:0032231 |
36 |
0.026
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.026
|
Fly |
|
|
negative regulation of dendrite development
|
GO:2000171 |
5 |
0.026
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.026
|
Mouse |
|
|
cell activation
|
GO:0001775 |
213 |
0.026
|
Human |
|
|
tor signaling
|
GO:0031929 |
39 |
0.026
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.025
|
Mouse Rat |
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.025
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.025
|
|
|
|
negative regulation of nucleotide catabolic process
|
GO:0030812 |
16 |
0.025
|
|
|
|
adherens junction assembly
|
GO:0034333 |
34 |
0.025
|
Fly |
|
|
regulation of cell junction assembly
|
GO:1901888 |
29 |
0.025
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.025
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.025
|
|
|
|
actin filament bundle organization
|
GO:0061572 |
54 |
0.025
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.025
|
Mouse Rat |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.025
|
|
|
|
negative regulation of cell morphogenesis involved in differentiation
|
GO:0010771 |
24 |
0.025
|
|
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
61 |
0.025
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.025
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.024
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.024
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.024
|
|
|
|
establishment or maintenance of bipolar cell polarity
|
GO:0061245 |
2 |
0.024
|
|
|
|
nerve growth factor signaling pathway
|
GO:0038180 |
4 |
0.024
|
Rat |
|
|
cyclic nucleotide mediated signaling
|
GO:0019935 |
26 |
0.024
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.024
|
Human Mouse Rat |
|
|
stem cell maintenance
|
GO:0019827 |
19 |
0.024
|
Fly |
|
|
regulation of synaptic vesicle exocytosis
|
GO:2000300 |
2 |
0.023
|
Mouse |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.023
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.023
|
|
|
|
eye development
|
GO:0001654 |
42 |
0.023
|
Fly |
|
|
wound healing
|
GO:0042060 |
115 |
0.023
|
Human |
|
|
microtubule based process
|
GO:0007017 |
210 |
0.023
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.023
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.023
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.023
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.023
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.023
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.023
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.022
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.022
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.022
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.022
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.022
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.022
|
|
|
|
positive regulation of vasculogenesis
|
GO:2001214 |
1 |
0.022
|
Mouse |
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.022
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.022
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.022
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.022
|
|
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.022
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.022
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.022
|
|
|
|
negative regulation of neurogenesis
|
GO:0050768 |
26 |
0.022
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.021
|
|
|
|
positive regulation of binding
|
GO:0051099 |
45 |
0.021
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.021
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.021
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.021
|
|
|
|
membrane raft localization
|
GO:0051665 |
1 |
0.021
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.021
|
|
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
3 |
0.021
|
Mouse |
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.021
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.021
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.020
|
Human |
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.020
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.020
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.020
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.020
|
Mouse |
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.020
|
|
|
|
protein stabilization
|
GO:0050821 |
64 |
0.020
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
48 |
0.020
|
|
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
31 |
0.020
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.020
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.019
|
|
|
|
organic anion transport
|
GO:0015711 |
103 |
0.019
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.019
|
|
|
|
camp biosynthetic process
|
GO:0006171 |
47 |
0.019
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.019
|
Mouse Rat |
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.019
|
|
|
|
regulation of lipid biosynthetic process
|
GO:0046890 |
47 |
0.019
|
|
|
|
positive regulation of purine nucleotide biosynthetic process
|
GO:1900373 |
38 |
0.019
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.019
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.019
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.019
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.019
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.019
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.019
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.019
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.019
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.019
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.019
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.019
|
|
|
|
positive regulation of cyclic nucleotide metabolic process
|
GO:0030801 |
49 |
0.019
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.018
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.018
|
Human Mouse Rat |
|
|
regulation of camp biosynthetic process
|
GO:0030817 |
45 |
0.018
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.018
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
56 |
0.018
|
|
|
|
visual behavior
|
GO:0007632 |
2 |
0.018
|
|
|
|
coagulation
|
GO:0050817 |
78 |
0.018
|
Human |
|
|
regulation of tor signaling
|
GO:0032006 |
30 |
0.018
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.018
|
Mouse |
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.018
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.018
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.018
|
|
|
|
viral process
|
GO:0016032 |
146 |
0.018
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.018
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.018
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.018
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.018
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.018
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.018
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.018
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.018
|
|
|
|
regulation of synaptic vesicle transport
|
GO:1902803 |
3 |
0.018
|
Mouse |
|
|
organelle fission
|
GO:0048285 |
149 |
0.018
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.018
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.018
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.017
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.017
|
|
|
|
organelle inheritance
|
GO:0048308 |
2 |
0.017
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.017
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.017
|
Mouse Rat |
|
|
organelle assembly
|
GO:0070925 |
176 |
0.017
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.017
|
|
|
|
regulation of cyclase activity
|
GO:0031279 |
19 |
0.017
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.017
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.017
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.017
|
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.017
|
|
|
|
negative regulation of neuron differentiation
|
GO:0045665 |
21 |
0.017
|
|
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.017
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.017
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.017
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.017
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.017
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.016
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.016
|
|
|
|
positive regulation of ruffle assembly
|
GO:1900029 |
4 |
0.016
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.016
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.016
|
|
|
|
cellular response to calcium ion
|
GO:0071277 |
19 |
0.016
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.016
|
|
|
|
lipid localization
|
GO:0010876 |
106 |
0.016
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.016
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.016
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.016
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.016
|
Human |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.016
|
|
|
|
epithelial tube branching involved in lung morphogenesis
|
GO:0060441 |
4 |
0.016
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.016
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.016
|
|
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.016
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.016
|
Human |
|
|
response to calcium ion
|
GO:0051592 |
46 |
0.016
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.016
|
|
