|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
1.000
|
Human |
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
1.000
|
Human |
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
1.000
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
1.000
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
1.000
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
1.000
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
1.000
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
1.000
|
Human |
|
|
negative regulation of neurological system process
|
GO:0031645 |
2 |
0.999
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.998
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.997
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.997
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.996
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.996
|
|
|
|
positive regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903557 |
22 |
0.995
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.993
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.992
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.991
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.989
|
|
|
|
positive regulation of tumor necrosis factor production
|
GO:0032760 |
21 |
0.989
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.985
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.983
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.982
|
Human |
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.979
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.977
|
Human |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.976
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.974
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.972
|
|
|
|
positive regulation of cdc42 gtpase activity
|
GO:0043089 |
6 |
0.969
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.969
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.968
|
|
|
|
cdc42 protein signal transduction
|
GO:0032488 |
4 |
0.966
|
|
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
2 |
0.964
|
|
|
|
negative regulation of myelination
|
GO:0031642 |
1 |
0.960
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.959
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.958
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.952
|
|
|
|
neuronal action potential
|
GO:0019228 |
9 |
0.951
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.948
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.946
|
|
|
|
regulation of protein homodimerization activity
|
GO:0043496 |
9 |
0.946
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.943
|
Human |
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.930
|
Human |
|
|
regulation of cdc42 protein signal transduction
|
GO:0032489 |
14 |
0.929
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.925
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.924
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.923
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
0.922
|
Mouse |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.922
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.910
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.893
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.889
|
Human |
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.887
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.882
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.882
|
Human |
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.879
|
|
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
9 |
0.877
|
Human |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.876
|
Human |
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
4 |
0.874
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.850
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
11 |
0.846
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.845
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.841
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.840
|
|
|
|
positive regulation of protein kinase c signaling
|
GO:0090037 |
5 |
0.838
|
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
9 |
0.838
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.838
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.832
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.831
|
Human |
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.829
|
|
|
|
regulation of myelination
|
GO:0031641 |
1 |
0.829
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.821
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.806
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.790
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.789
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.786
|
|
|
|
regulation of t cell cytokine production
|
GO:0002724 |
10 |
0.781
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.779
|
Human |
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
4 |
0.751
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.744
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.742
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.741
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.740
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.739
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.738
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.727
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.719
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
19 |
0.712
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.709
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.707
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.697
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.670
|
|
|
|
membrane protein ectodomain proteolysis
|
GO:0006509 |
33 |
0.662
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.654
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.652
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.639
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001240 |
16 |
0.635
|
|
|
|
action potential
|
GO:0001508 |
34 |
0.635
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.633
|
Mouse |
|
|
tnfsf11 mediated signaling pathway
|
GO:0071847 |
2 |
0.627
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.623
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.616
|
Human |
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.614
|
|
|
|
cellular response to muramyl dipeptide
|
GO:0071225 |
3 |
0.603
|
|
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
18 |
0.598
|
Human |
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.598
|
|
|
|
positive regulation of transcription regulatory region dna binding
|
GO:2000679 |
8 |
0.595
|
Human |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.590
|
Human |
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
30 |
0.581
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.578
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.575
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
11 |
0.565
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.564
|
|
|
|
regulation of protein kinase c signaling
|
GO:0090036 |
8 |
0.563
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
11 |
0.560
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.556
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.551
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.547
|
|
|
|
carbohydrate derivative transport
|
GO:1901264 |
20 |
0.545
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.542
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.538
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.537
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.535
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.535
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.532
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.523
|
Human |
|
|
positive regulation of nik nf kappab signaling
|
GO:1901224 |
10 |
0.521
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.512
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.507
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.503
|
Human Mouse |
|
|
regulation of transcription regulatory region dna binding
|
GO:2000677 |
15 |
0.495
|
Human |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.487
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.474
|
Human |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.472
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.466
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.463
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
11 |
0.463
|
|
|
|
regulation of dna binding
|
GO:0051101 |
37 |
0.463
|
Human |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.463
|
|
|
|
positive regulation of interleukin 8 biosynthetic process
|
GO:0045416 |
8 |
0.460
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.450
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.447
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
20 |
0.445
|
|
|
|
positive regulation of protein homodimerization activity
|
GO:0090073 |
5 |
0.443
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.441
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.431
|
Human |
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.431
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
26 |
0.426
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.424
|
Mouse |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.396
|
Human |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.391
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.388
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.387
|
Mouse |
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.384
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.383
|
Human |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.377
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.373
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.371
|
Human |
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.368
|
|
|
|
t cell cytokine production
|
GO:0002369 |
12 |
0.358
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.358
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.356
|
|
|
|
myelination
|
GO:0042552 |
6 |
0.348
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.347
|
Human |
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.341
|
|
|
|
regulation of neurological system process
|
GO:0031644 |
6 |
0.340
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.336
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.333
|
|
|
|
positive regulation of endothelial cell apoptotic process
|
GO:2000353 |
8 |
0.328
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.319
|
Human |
|
|
response to virus
|
GO:0009615 |
126 |
0.315
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.307
|
|
|
|
trail activated apoptotic signaling pathway
|
GO:0036462 |
4 |
0.303
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
27 |
0.294
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.293
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.291
|
|
|
|
positive regulation of membrane protein ectodomain proteolysis
|
GO:0051044 |
13 |
0.288
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.283
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.279
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.277
|
|
|
|
positive regulation of cytokine secretion involved in immune response
|
GO:0002741 |
2 |
0.276
|
|
|
|
translation
|
GO:0006412 |
132 |
0.274
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.271
|
|
|
|
positive regulation of tyrosine phosphorylation of stat protein
|
GO:0042531 |
28 |
0.265
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.258
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.258
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.256
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.244
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.244
|
Human Mouse |
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.240
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.237
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.235
|
|
|
|
negative regulation of nervous system development
|
GO:0051961 |
28 |
0.232
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.231
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.231
|
|
|
|
regulation of tor signaling
|
GO:0032006 |
30 |
0.231
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.228
|
|
|
|
positive regulation of dna binding
|
GO:0043388 |
17 |
0.226
|
Human |
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.221
|
|
|
|
regulation of interferon beta production
|
GO:0032648 |
22 |
0.221
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.220
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
25 |
0.220
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.217
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.214
|
Human |
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.209
|
|
|
|
positive regulation of interleukin 8 production
|
GO:0032757 |
36 |
0.206
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.205
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.205
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.202
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
6 |
0.201
|
|
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.193
|
Human |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.192
|
Human |
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.191
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
23 |
0.190
|
|
|
|
serine phosphorylation of stat protein
|
GO:0042501 |
4 |
0.187
|
|
|
|
membrane protein proteolysis
|
GO:0033619 |
38 |
0.187
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.185
|
|
|
|
positive regulation of hair follicle development
|
GO:0051798 |
3 |
0.183
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.182
|
Human |
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.180
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.177
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.177
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.175
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.174
|
|
|
|
immunoglobulin secretion
|
GO:0048305 |
1 |
0.174
|
Mouse |
|
|
positive regulation of erk1 and erk2 cascade via tnfsf11 mediated signaling
|
GO:0071848 |
2 |
0.173
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.169
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.166
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.165
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.165
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.163
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.162
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.160
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.160
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.159
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
21 |
0.149
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.148
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.146
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.145
|
Mouse |
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.144
|
Mouse |
|
|
multicellular organismal signaling
|
GO:0035637 |
34 |
0.143
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.140
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.140
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.139
|
|
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.135
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.134
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.133
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.129
|
|
|
|
positive regulation of t cell mediated immunity
|
GO:0002711 |
12 |
0.128
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.123
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.123
|
|
|
|
endocytic recycling
|
GO:0032456 |
12 |
0.123
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.122
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.117
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.117
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.116
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.115
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.115
|
|
|
|
cellular response to hyperoxia
|
GO:0071455 |
4 |
0.114
|
|
|
|
ripoptosome assembly
|
GO:0097343 |
1 |
0.113
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.113
|
|
|
|
positive regulation of binding
|
GO:0051099 |
45 |
0.113
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.112
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.111
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.110
|
Mouse |
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
22 |
0.110
|
|
|
|
positive regulation of interleukin 6 production
|
GO:0032755 |
21 |
0.108
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
56 |
0.108
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.107
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.106
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.105
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.105
|
Human |
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.105
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.104
|
|
|
|
endothelial cell apoptotic process
|
GO:0072577 |
26 |
0.104
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.101
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.098
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.098
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.098
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.097
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.096
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.096
|
Human |
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.093
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.092
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.092
|
|
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.090
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.089
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.088
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.087
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.086
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.086
|
|
|
|
positive regulation of interferon beta production
|
GO:0032728 |
17 |
0.084
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.083
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
33 |
0.083
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.083
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.082
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.082
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.082
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.081
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.081
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.081
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.080
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.080
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.080
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.079
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.078
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.078
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.078
|
|
|
|
regulation of protein monoubiquitination
|
GO:1902525 |
1 |
0.076
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.075
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.074
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.073
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.073
|
|
|
|
protein kinase c signaling
|
GO:0070528 |
17 |
0.073
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.072
|
|
|
|
interferon beta production
|
GO:0032608 |
23 |
0.071
|
|
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.070
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.069
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.069
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.068
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.067
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.067
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.067
|
|
|
|
neuron remodeling
|
GO:0016322 |
2 |
0.065
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.064
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.064
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.063
|
|
|
|
regulation of cdc42 gtpase activity
|
GO:0043088 |
10 |
0.063
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.061
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.060
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.060
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.060
|
|
|
|
ensheathment of neurons
|
GO:0007272 |
6 |
0.059
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.059
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.059
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
24 |
0.057
|
|
|
|
regulation of type i interferon production
|
GO:0032479 |
26 |
0.057
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.057
|
|
|
|
negative regulation of alpha beta t cell proliferation
|
GO:0046642 |
1 |
0.056
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.056
|
Human |
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.055
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.055
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
37 |
0.054
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.053
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.053
|
Human |
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.053
|
|
|
|
positive regulation of cytokine production involved in immune response
|
GO:0002720 |
6 |
0.053
|
|
|
|
negative regulation of multi organism process
|
GO:0043901 |
92 |
0.052
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.052
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.051
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.051
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.051
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.051
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.050
|
Human |
|
|
defense response to gram positive bacterium
|
GO:0050830 |
29 |
0.050
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
38 |
0.049
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.049
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.048
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.047
|
|
|
|
protein heterooligomerization
|
GO:0051291 |
16 |
0.047
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.047
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.046
|
|
|
|
fat soluble vitamin metabolic process
|
GO:0006775 |
19 |
0.046
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.045
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.045
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.045
|
|
|
|
protein monoubiquitination
|
GO:0006513 |
39 |
0.045
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.044
|
|
|
|
nucleobase containing compound transport
|
GO:0015931 |
51 |
0.044
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.044
|
Human |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.044
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.043
|
|
|
|
regulation of membrane protein ectodomain proteolysis
|
GO:0051043 |
17 |
0.043
|
|
|
|
tor signaling
|
GO:0031929 |
39 |
0.043
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.043
|
|
|
|
necrotic cell death
|
GO:0070265 |
21 |
0.042
|
Mouse |
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.042
|
|
|
|
positive regulation of interferon alpha production
|
GO:0032727 |
11 |
0.042
|
|
|
|
chemokine production
|
GO:0032602 |
32 |
0.041
|
|
|
|
positive regulation of cell size
|
GO:0045793 |
3 |
0.041
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.041
|
Human |
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.041
|
|
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.041
|
|
|
|
amyloid fibril formation
|
GO:1990000 |
3 |
0.041
|
|
|
|
negative regulation of interleukin 6 production
|
GO:0032715 |
13 |
0.040
|
|
|
|
positive regulation of tor signaling
|
GO:0032008 |
11 |
0.040
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.040
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.040
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.040
|
|
|
|
positive regulation of necroptotic process
|
GO:0060545 |
2 |
0.039
|
|
|
|
viral process
|
GO:0016032 |
146 |
0.039
|
|
|
|
type i interferon production
|
GO:0032606 |
27 |
0.039
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.038
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.038
|
|
|
|
positive regulation of protein linear polyubiquitination
|
GO:1902530 |
2 |
0.038
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.038
|
|
|
|
regulation of immunoglobulin production
|
GO:0002637 |
4 |
0.038
|
Mouse |
|
|
positive regulation of lymphocyte migration
|
GO:2000403 |
16 |
0.038
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.038
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.038
|
Human |
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.038
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.037
|
Mouse |
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
11 |
0.037
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.036
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.036
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.036
|
Mouse |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.036
|
|
|
|
regulation of nucleoside transport
|
GO:0032242 |
1 |
0.035
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.035
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.035
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.035
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.035
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.034
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.033
|
|
|
|
t helper 1 cell differentiation
|
GO:0045063 |
1 |
0.033
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.033
|
|
|
|
response to hyperoxia
|
GO:0055093 |
4 |
0.033
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.033
|
|
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
15 |
0.033
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.033
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.033
|
|
|
|
positive regulation of protein polyubiquitination
|
GO:1902916 |
3 |
0.033
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.033
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.033
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.032
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.032
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.032
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
25 |
0.032
|
|
|
|
protein homotrimerization
|
GO:0070207 |
9 |
0.032
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.032
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.032
|
|
|
|
regulation of hair cycle
|
GO:0042634 |
10 |
0.032
|
|
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
3 |
0.031
|
|
|
|
growth
|
GO:0040007 |
202 |
0.031
|
|
|
|
chemokine metabolic process
|
GO:0050755 |
4 |
0.031
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.031
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.031
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.031
|
|
|
|
activation of jnkk activity
|
GO:0007256 |
1 |
0.031
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.031
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.031
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.031
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.030
|
Human |
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.030
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.030
|
|
|
|
positive regulation of tumor necrosis factor biosynthetic process
|
GO:0042535 |
5 |
0.030
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.030
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.030
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.029
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.029
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.029
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.029
|
|
|
|
fibril organization
|
GO:0097435 |
10 |
0.028
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.028
|
|
|
|
release of cytoplasmic sequestered nf kappab
|
GO:0008588 |
4 |
0.028
|
|
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
31 |
0.027
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.027
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.027
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.027
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.026
|
|
|
|
regulation of isotype switching
|
GO:0045191 |
2 |
0.026
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.026
|
|
|
|
positive regulation of immunoglobulin production
|
GO:0002639 |
4 |
0.026
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.026
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.026
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.026
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.025
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.025
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.025
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.025
|
|
|
|
cellular response to increased oxygen levels
|
GO:0036295 |
4 |
0.025
|
|
|
|
regulation of chemokine production
|
GO:0032642 |
31 |
0.025
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.024
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.024
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.024
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.024
|
|
|
|
positive regulation of chemokine production
|
GO:0032722 |
22 |
0.024
|
|
|
|
interferon alpha production
|
GO:0032607 |
11 |
0.024
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.023
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.023
|
|
|
|
axon ensheathment
|
GO:0008366 |
6 |
0.023
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.023
|
Mouse |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.023
|
|
|
|
somatic recombination of immunoglobulin gene segments
|
GO:0016447 |
4 |
0.023
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
24 |
0.023
|
Human |
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.022
|
Mouse |
|
|
regulation of protein linear polyubiquitination
|
GO:1902528 |
2 |
0.022
|
|
|
|
regulation of phosphatase activity
|
GO:0010921 |
81 |
0.022
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.022
|
|
|
|
positive regulation of type i interferon mediated signaling pathway
|
GO:0060340 |
4 |
0.022
|
|
