IMP

Process View

Homo sapiens

3 genes annotated in human

amyloid fibril formation

GO:1990000

The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. An example of this is seen when human RIP1 and RIP3 kinases form a heterodimeric functional amyloid signaling complex (PMID:22817896).

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "amyloid fibril formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "amyloid fibril formation" (in gray)

Name	Description	Probability
BIRC3	baculoviral IAP repeat containing 3	0.799
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.503
BIRC2	baculoviral IAP repeat containing 2	0.485
TRAF1	TNF receptor-associated factor 1	0.439
TRAF3	TNF receptor-associated factor 3	0.073
TRAF2	TNF receptor-associated factor 2	0.041
TANK	TRAF family member-associated NFKB activator	0.028
TRADD	TNFRSF1A-associated via death domain	0.012