Homo sapiens

94 known processes

PCNA

proliferating cell nuclear antigen

(Aliases: MGC8367)

PCNA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 198 1.000
cellular response to dna damage stimulus GO:0006974 379 1.000
double strand break repair via homologous recombination GO:0000724 50 0.999
meiosis i GO:0007127 4 0.999
double strand break repair GO:0006302 101 0.998
postreplication repair GO:0006301 12 0.997
dna recombination GO:0006310 77 0.997
dna replication GO:0006260 116 0.994
Fly
translesion synthesis GO:0019985 8 0.992
dna strand elongation involved in dna replication GO:0006271 3 0.992
negative regulation of meiotic cell cycle GO:0051447 2 0.992
dna integrity checkpoint GO:0031570 71 0.988
mitotic dna integrity checkpoint GO:0044774 30 0.978
dna damage checkpoint GO:0000077 68 0.970
post embryonic development GO:0009791 2 0.968
chromatin modification GO:0016568 298 0.957
nucleotide excision repair GO:0006289 31 0.955
leading strand elongation GO:0006272 1 0.939
base excision repair GO:0006284 21 0.935
Mouse
dna biosynthetic process GO:0071897 40 0.932
anatomical structure homeostasis GO:0060249 100 0.908
apoptotic signaling pathway GO:0097190 268 0.905
mismatch repair GO:0006298 15 0.900
mitotic g2 m transition checkpoint GO:0044818 9 0.892
dna synthesis involved in dna repair GO:0000731 6 0.876
dna strand elongation GO:0022616 5 0.872
g2 dna damage checkpoint GO:0031572 26 0.864
vesicle mediated transport GO:0016192 371 0.859
response to uv GO:0009411 73 0.853
cell cycle checkpoint GO:0000075 117 0.800
mitotic cell cycle GO:0000278 326 0.799
Fly
recombinational repair GO:0000725 50 0.797
covalent chromatin modification GO:0016569 254 0.789
cellular amino acid metabolic process GO:0006520 116 0.775
chromatin organization GO:0006325 351 0.765
negative regulation of dna metabolic process GO:0051053 57 0.746
nucleotide biosynthetic process GO:0009165 109 0.742
negative regulation of cell cycle phase transition GO:1901988 89 0.723
regulation of cell cycle GO:0051726 393 0.717
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.716
dna dependent dna replication GO:0006261 44 0.669
chromatin remodeling GO:0006338 55 0.666
mitotic dna damage checkpoint GO:0044773 28 0.560
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.556
response to radiation GO:0009314 151 0.551
response to abiotic stimulus GO:0009628 336 0.547
asymmetric stem cell division GO:0098722 1 0.542
regulation of cell cycle phase transition GO:1901987 126 0.537
mitotic g2 dna damage checkpoint GO:0007095 7 0.535
cellular macromolecule catabolic process GO:0044265 380 0.531
peptidyl lysine modification GO:0018205 144 0.525
reciprocal meiotic recombination GO:0007131 4 0.510
chromatin silencing GO:0006342 12 0.497
regulation of response to dna damage stimulus GO:2001020 94 0.452
negative regulation of catalytic activity GO:0043086 335 0.451
internal protein amino acid acetylation GO:0006475 101 0.423
negative regulation of programmed cell death GO:0043069 321 0.423
negative regulation of gene expression epigenetic GO:0045814 19 0.419
gene silencing GO:0016458 49 0.411
regulation of gene expression epigenetic GO:0040029 73 0.410
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.408
regulation of mitotic cell cycle GO:0007346 189 0.402
negative regulation of cell cycle GO:0045786 193 0.393
sex differentiation GO:0007548 45 0.378
ribonucleoside biosynthetic process GO:0042455 25 0.363
dna packaging GO:0006323 77 0.355
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.353
regulation of dna methylation GO:0044030 2 0.351
mitotic cell cycle phase transition GO:0044772 162 0.351
protein modification by small protein conjugation GO:0032446 342 0.343
oxidation reduction process GO:0055114 396 0.330
intrinsic apoptotic signaling pathway GO:0097193 127 0.324
regulation of cellular ketone metabolic process GO:0010565 50 0.324
carbohydrate derivative biosynthetic process GO:1901137 207 0.323
dna conformation change GO:0071103 113 0.304
embryo development GO:0009790 123 0.300
glycosyl compound biosynthetic process GO:1901659 27 0.299
negative regulation of apoptotic process GO:0043066 316 0.283
regulation of cellular response to stress GO:0080135 244 0.271
histone modification GO:0016570 251 0.269
regulation of dna repair GO:0006282 47 0.265
response to oxygen containing compound GO:1901700 369 0.263
response to metal ion GO:0010038 84 0.256
negative regulation of mitotic cell cycle GO:0045930 102 0.241
double strand break repair via nonhomologous end joining GO:0006303 10 0.235
leukocyte mediated immunity GO:0002443 59 0.228
regeneration GO:0031099 4 0.228
response to light stimulus GO:0009416 87 0.224
meiotic cell cycle process GO:1903046 8 0.222
positive regulation of transport GO:0051050 336 0.216
regulation of transferase activity GO:0051338 355 0.203
regulation of cellular amino acid metabolic process GO:0006521 6 0.201
cellular response to external stimulus GO:0071496 111 0.201
mrna metabolic process GO:0016071 175 0.191
dna double strand break processing GO:0000729 10 0.190
regulation of dna metabolic process GO:0051052 153 0.190
negative regulation of cell death GO:0060548 345 0.190
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.188
Mouse
nucleoside monophosphate metabolic process GO:0009123 191 0.176
gonad development GO:0008406 34 0.173
nucleoside monophosphate catabolic process GO:0009125 159 0.173
protein monoubiquitination GO:0006513 39 0.164
amine metabolic process GO:0009308 44 0.162
protein alkylation GO:0008213 74 0.161
cellular amine metabolic process GO:0044106 41 0.160
purine nucleotide biosynthetic process GO:0006164 84 0.159
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.156
cell cycle phase transition GO:0044770 173 0.154
nuclear transport GO:0051169 179 0.153
regulation of double strand break repair via homologous recombination GO:0010569 11 0.152
chromatin assembly GO:0031497 61 0.151
internal peptidyl lysine acetylation GO:0018393 97 0.150
embryo development ending in birth or egg hatching GO:0009792 34 0.150
telomere maintenance GO:0000723 32 0.146
cellular macromolecular complex assembly GO:0034622 324 0.145
determination of adult lifespan GO:0008340 2 0.143
dna catabolic process GO:0006308 49 0.139
negative regulation of cell cycle process GO:0010948 121 0.138
positive regulation of cellular amine metabolic process GO:0033240 7 0.138
regulation of dna replication GO:0006275 68 0.134
ribonucleoside catabolic process GO:0042454 406 0.129
non recombinational repair GO:0000726 14 0.128
regulation of double strand break repair GO:2000779 22 0.125
rna interference GO:0016246 4 0.124
single organism reproductive process GO:0044702 98 0.123
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.122
meiotic nuclear division GO:0007126 10 0.121
development of primary sexual characteristics GO:0045137 35 0.119
regulation of mitotic cell cycle phase transition GO:1901990 118 0.115
response to ionizing radiation GO:0010212 65 0.113
atp dependent chromatin remodeling GO:0043044 25 0.113
regulation of peptidase activity GO:0052547 180 0.109
protein dna complex assembly GO:0065004 64 0.108
protein acetylation GO:0006473 116 0.107
regulation of chromatin organization GO:1902275 56 0.107
response to inorganic substance GO:0010035 127 0.106
reproductive process GO:0022414 106 0.105
response to purine containing compound GO:0014074 40 0.102
regulation of meiotic cell cycle GO:0051445 4 0.101
cellular protein complex assembly GO:0043623 188 0.101
purine nucleoside triphosphate metabolic process GO:0009144 412 0.099
generation of precursor metabolites and energy GO:0006091 68 0.095
somatic diversification of immune receptors via somatic mutation GO:0002566 1 0.093
extrinsic apoptotic signaling pathway GO:0097191 119 0.092
oocyte maturation GO:0001556 1 0.092
mrna processing GO:0006397 133 0.091
nervous system development GO:0007399 293 0.091
Fly
reproduction GO:0000003 63 0.089
response to steroid hormone GO:0048545 80 0.087
alpha amino acid metabolic process GO:1901605 72 0.086
posttranscriptional regulation of gene expression GO:0010608 213 0.085
single organism carbohydrate metabolic process GO:0044723 193 0.083
response to hormone GO:0009725 175 0.083
glycosyl compound catabolic process GO:1901658 413 0.082
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.081
meiotic cell cycle GO:0051321 13 0.080
cellular response to ionizing radiation GO:0071479 32 0.078
regulation of apoptotic signaling pathway GO:2001233 175 0.076
receptor mediated endocytosis GO:0006898 84 0.076
peptidyl serine phosphorylation GO:0018105 101 0.074
regulation of binding GO:0051098 111 0.072
immune effector process GO:0002252 159 0.069
development of primary male sexual characteristics GO:0046546 23 0.068
negative regulation of phosphorus metabolic process GO:0010563 267 0.067
purine nucleoside monophosphate metabolic process GO:0009126 186 0.066
regulation of establishment of protein localization GO:0070201 242 0.065
protein ubiquitination GO:0016567 314 0.065
ribonucleoside triphosphate metabolic process GO:0009199 412 0.063
developmental process involved in reproduction GO:0003006 66 0.063
response to lipid GO:0033993 206 0.063
methylation GO:0032259 106 0.062
somatic hypermutation of immunoglobulin genes GO:0016446 1 0.062
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.059
cellular response to organic cyclic compound GO:0071407 127 0.058
hemopoiesis GO:0030097 180 0.057
ribonucleotide catabolic process GO:0009261 405 0.057
regulation of chromatin modification GO:1903308 51 0.056
atp metabolic process GO:0046034 176 0.056
posttranscriptional gene silencing by rna GO:0035194 25 0.054
response to organic cyclic compound GO:0014070 204 0.053
atp catabolic process GO:0006200 157 0.053
mitotic cell cycle checkpoint GO:0007093 68 0.053
anion transport GO:0006820 161 0.052
response to other organism GO:0051707 261 0.051
Zebrafish Fly
nucleoside catabolic process GO:0009164 408 0.051
response to alcohol GO:0097305 64 0.049
positive regulation of developmental process GO:0051094 314 0.048
gene conversion GO:0035822 1 0.048
multi organism cellular process GO:0044764 156 0.047
negative regulation of apoptotic signaling pathway GO:2001234 97 0.046
regulation of nucleotide metabolic process GO:0006140 269 0.046
cellular response to acid chemical GO:0071229 44 0.046
viral process GO:0016032 146 0.044
interstrand cross link repair GO:0036297 3 0.043
spermatid development GO:0007286 4 0.042
purine ribonucleoside monophosphate biosynthetic process GO:0009168 16 0.042
positive regulation of dna templated transcription elongation GO:0032786 18 0.042
peptidyl lysine acetylation GO:0018394 101 0.042
purine containing compound biosynthetic process GO:0072522 88 0.041
cellular response to oxidative stress GO:0034599 85 0.041
telomere organization GO:0032200 33 0.039
cell projection organization GO:0030030 252 0.038
multicellular organismal aging GO:0010259 3 0.038
histone acetylation GO:0016573 93 0.037
regulation of gene silencing GO:0060968 24 0.037
lymphocyte proliferation GO:0046651 70 0.037
mature ribosome assembly GO:0042256 5 0.036
secretion GO:0046903 254 0.036
cellular ketone metabolic process GO:0042180 80 0.036
nitrogen compound transport GO:0071705 191 0.036
mitotic sister chromatid segregation GO:0000070 53 0.035
positive regulation of programmed cell death GO:0043068 249 0.035
chordate embryonic development GO:0043009 34 0.035
response to virus GO:0009615 126 0.035
nucleobase biosynthetic process GO:0046112 4 0.035
ribonucleotide biosynthetic process GO:0009260 81 0.035
negative regulation of phosphate metabolic process GO:0045936 267 0.035
signal transduction by p53 class mediator GO:0072331 72 0.034
chromosome condensation GO:0030261 15 0.034
negative regulation of hydrolase activity GO:0051346 182 0.034
cellular component morphogenesis GO:0032989 314 0.034
regulation of meiosis GO:0040020 3 0.034
signal transduction in response to dna damage GO:0042770 57 0.034
response to transforming growth factor beta GO:0071559 94 0.033
male meiosis GO:0007140 1 0.033
regulation of histone modification GO:0031056 47 0.032
dephosphorylation GO:0016311 209 0.032
cellular response to endogenous stimulus GO:0071495 336 0.032
organophosphate biosynthetic process GO:0090407 163 0.032
purine nucleoside triphosphate catabolic process GO:0009146 392 0.031
adaptive immune response GO:0002250 49 0.031
carbohydrate metabolic process GO:0005975 207 0.031
regulation of cell cycle process GO:0010564 266 0.031
response to hypoxia GO:0001666 96 0.031
somatic diversification of immune receptors GO:0002200 8 0.031
negative regulation of intracellular signal transduction GO:1902532 183 0.030
sister chromatid cohesion GO:0007062 24 0.030
positive regulation of binding GO:0051099 45 0.029
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.028
negative regulation of chromatin modification GO:1903309 21 0.028
chemical homeostasis GO:0048878 306 0.028
immune system development GO:0002520 195 0.028
chromosome segregation GO:0007059 114 0.027
interspecies interaction between organisms GO:0044419 156 0.026
cellular response to organonitrogen compound GO:0071417 124 0.026
regulation of cellular amine metabolic process GO:0033238 11 0.026
behavior GO:0007610 112 0.025
pancreas development GO:0031016 19 0.025
response to estrogen GO:0043627 47 0.025
mitotic cell cycle process GO:1903047 286 0.025
Fly
regulation of viral process GO:0050792 103 0.024
sex determination GO:0007530 3 0.024
organ morphogenesis GO:0009887 147 0.024
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.024
response to reactive oxygen species GO:0000302 61 0.024
ribosome assembly GO:0042255 9 0.024
nucleoside phosphate catabolic process GO:1901292 412 0.024
cell cycle g1 s phase transition GO:0044843 80 0.023
protein acylation GO:0043543 138 0.023
regulation of kinase activity GO:0043549 314 0.022
protein dna complex subunit organization GO:0071824 80 0.022
circulatory system development GO:0072359 262 0.022
immune response GO:0006955 307 0.022
Fly
epithelial cell differentiation GO:0030855 141 0.022
nucleosome organization GO:0034728 66 0.022
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.022
response to extracellular stimulus GO:0009991 85 0.021
blastocyst development GO:0001824 3 0.021
aging GO:0007568 66 0.021
regulation of intracellular transport GO:0032386 195 0.021
regulation of chromatin silencing GO:0031935 8 0.021
regulation of chromosome organization GO:0033044 103 0.021
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.020
purine nucleoside biosynthetic process GO:0042451 23 0.020
positive regulation of growth GO:0045927 58 0.020
regulation of phosphatase activity GO:0010921 81 0.020
cellular response to oxygen containing compound GO:1901701 276 0.020
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.020
positive regulation of immune system process GO:0002684 283 0.020
polynucleotide dephosphorylation GO:0098501 3 0.020
ribonucleoside monophosphate metabolic process GO:0009161 187 0.019
urate metabolic process GO:0046415 11 0.019
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.019
meiotic chromosome segregation GO:0045132 4 0.019
regulation of protein kinase activity GO:0045859 289 0.019
v d j recombination GO:0033151 3 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.019
negative regulation of double strand break repair via nonhomologous end joining GO:2001033 1 0.019
meiotic chromosome separation GO:0051307 3 0.019
response to caffeine GO:0031000 3 0.019
negative regulation of dephosphorylation GO:0035305 63 0.019
reproductive system development GO:0061458 56 0.019
regulation of endopeptidase activity GO:0052548 170 0.018
positive regulation of cell proliferation GO:0008284 301 0.018
histone lysine methylation GO:0034968 50 0.018
regulation of cell cycle g1 s phase transition GO:1902806 42 0.018
mrna 3 end processing GO:0031124 24 0.017
ras protein signal transduction GO:0007265 73 0.017
organophosphate catabolic process GO:0046434 430 0.017
positive regulation of protein transport GO:0051222 135 0.017
muscle contraction GO:0006936 73 0.017
lagging strand elongation GO:0006273 3 0.017
carboxylic acid biosynthetic process GO:0046394 97 0.017
rna catabolic process GO:0006401 71 0.016
cell fate commitment GO:0045165 27 0.016
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.016
response to oxidative stress GO:0006979 121 0.016
organic acid biosynthetic process GO:0016053 97 0.016
maintenance of dna repeat elements GO:0043570 4 0.016
myosin filament organization GO:0031033 2 0.016
regulation of histone methylation GO:0031060 16 0.015
nucleotide catabolic process GO:0009166 408 0.015
nucleoside biosynthetic process GO:0009163 26 0.015
dna modification GO:0006304 27 0.015
cellular response to reactive oxygen species GO:0034614 50 0.015
retina development in camera type eye GO:0060041 15 0.015
regulation of growth GO:0040008 165 0.015
positive regulation of dna metabolic process GO:0051054 73 0.015
cell part morphogenesis GO:0032990 137 0.015
macromolecule methylation GO:0043414 97 0.015
multi organism reproductive process GO:0044703 54 0.015
cellular response to hormone stimulus GO:0032870 125 0.015
lymphocyte activation GO:0046649 133 0.014
neuron development GO:0048666 113 0.014
neurogenesis GO:0022008 169 0.014
Fly
negative regulation of transferase activity GO:0051348 124 0.014
cellular response to alcohol GO:0097306 29 0.013
mitotic g1 dna damage checkpoint GO:0031571 17 0.013
positive regulation of intracellular transport GO:0032388 104 0.013
small molecule biosynthetic process GO:0044283 157 0.013
regulation of protein serine threonine kinase activity GO:0071900 179 0.013
single organism carbohydrate catabolic process GO:0044724 33 0.013
ribonucleoside monophosphate catabolic process GO:0009158 158 0.013
mononuclear cell proliferation GO:0032943 71 0.013
hexose metabolic process GO:0019318 55 0.013
endocytosis GO:0006897 159 0.013
isotype switching GO:0045190 3 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
response to transition metal nanoparticle GO:1990267 29 0.012
regulation of glucose metabolic process GO:0010906 28 0.012
positive regulation of helicase activity GO:0051096 6 0.012
viral life cycle GO:0019058 132 0.012
regulation of cysteine type endopeptidase activity GO:2000116 127 0.012
purine ribonucleotide biosynthetic process GO:0009152 79 0.012
growth GO:0040007 202 0.012
histone exchange GO:0043486 3 0.012
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.012
response to decreased oxygen levels GO:0036293 96 0.011
regulation of developmental growth GO:0048638 30 0.011
histone methylation GO:0016571 60 0.011
dna templated transcription elongation GO:0006354 25 0.011
eye development GO:0001654 42 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
neutral lipid catabolic process GO:0046461 12 0.011
positive regulation of histone modification GO:0031058 29 0.011
regulation of dephosphorylation GO:0035303 96 0.011
reproductive structure development GO:0048608 55 0.010
purine ribonucleoside biosynthetic process GO:0046129 23 0.010
cellular modified amino acid metabolic process GO:0006575 64 0.010

PCNA disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.125
hematopoietic system disease DOID:74 100 0.125
disease of metabolism DOID:0014667 295 0.097