Homo sapiens

86 known processes

AURKA

aurora kinase A

(Aliases: AIK,BTAK,STK15,AURORA2,AURA,MGC34538,STK7,STK6,ARK1)

AURKA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spindle assembly involved in mitosis GO:0090307 12 0.982
Yeast Worm
meiotic chromosome segregation GO:0045132 4 0.972
Yeast
nuclear division GO:0000280 128 0.930
Yeast Zebrafish Mouse Worm
organelle fission GO:0048285 149 0.921
Yeast Zebrafish Mouse Worm
spindle assembly GO:0051225 29 0.909
Yeast Mouse Worm
cytokinesis GO:0000910 96 0.849
Yeast Worm
protein polymerization GO:0051258 71 0.826
regulation of microtubule based process GO:0032886 74 0.823
microtubule based process GO:0007017 210 0.808
histone serine phosphorylation GO:0035404 4 0.795
Mouse
microtubule nucleation GO:0007020 6 0.694
spindle organization GO:0007051 53 0.688
microtubule cytoskeleton organization GO:0000226 176 0.666
mitotic spindle midzone assembly GO:0051256 4 0.640
Worm
regulation of spindle organization GO:0090224 10 0.618
sister chromatid segregation GO:0000819 54 0.549
Yeast
cellular protein complex assembly GO:0043623 188 0.543
Worm
single organism cellular localization GO:1902580 332 0.485
Yeast
microtubule anchoring GO:0034453 24 0.469
Yeast
mitotic sister chromatid segregation GO:0000070 53 0.450
maintenance of location in cell GO:0051651 62 0.412
Yeast
regulation of mitotic spindle organization GO:0060236 6 0.412
Yeast
cell development GO:0048468 328 0.412
Mouse
protein maturation GO:0051604 233 0.408
protein processing GO:0016485 226 0.402
microtubule polymerization GO:0046785 18 0.393
cellular macromolecular complex assembly GO:0034622 324 0.368
Worm
chromosome segregation GO:0007059 114 0.353
Yeast Worm
spindle midzone assembly GO:0051255 4 0.343
Worm
negative regulation of cellular component organization GO:0051129 235 0.333
positive regulation of proteolysis GO:0045862 142 0.317
Mouse
positive regulation of protein phosphorylation GO:0001934 313 0.311
cellular response to dna damage stimulus GO:0006974 379 0.283
regulation of proteolysis GO:0030162 293 0.276
Mouse
protein localization to chromosome GO:0034502 30 0.274
organelle assembly GO:0070925 176 0.259
Yeast Mouse Worm
regeneration GO:0031099 4 0.245
microtubule polymerization or depolymerization GO:0031109 37 0.240
peptidyl serine phosphorylation GO:0018105 101 0.200
Mouse Worm
establishment of organelle localization GO:0051656 59 0.192
regulation of cell cycle GO:0051726 393 0.188
regulation of transferase activity GO:0051338 355 0.169
dephosphorylation GO:0016311 209 0.164
mitotic spindle elongation GO:0000022 4 0.154
Worm
determination of adult lifespan GO:0008340 2 0.150
protein depolymerization GO:0051261 30 0.142
centrosome duplication GO:0051298 28 0.140
positive regulation of cellular component organization GO:0051130 376 0.136
oogenesis GO:0048477 2 0.136
Mouse
negative regulation of protein metabolic process GO:0051248 391 0.134
posttranscriptional regulation of gene expression GO:0010608 213 0.133
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.130
mitotic spindle organization GO:0007052 27 0.126
Yeast Mouse Worm
regulation of intracellular transport GO:0032386 195 0.122
Yeast
positive regulation of transferase activity GO:0051347 227 0.122
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.120
mitotic nuclear division GO:0007067 119 0.117
Yeast Zebrafish Mouse Worm
chromatin modification GO:0016568 298 0.116
Mouse
regulation of protein complex assembly GO:0043254 147 0.113
Yeast
regulation of endopeptidase activity GO:0052548 170 0.107
centrosome cycle GO:0007098 32 0.105
Mouse
mitotic centrosome separation GO:0007100 1 0.100
Mouse
meiosis i GO:0007127 4 0.099
Yeast Mouse
nucleus localization GO:0051647 1 0.099
regulation of peptidase activity GO:0052547 180 0.097
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.094
negative regulation of cellular protein metabolic process GO:0032269 353 0.093
organelle localization GO:0051640 84 0.093
Mouse
maintenance of location GO:0051235 112 0.093
Yeast
positive regulation of phosphorylation GO:0042327 394 0.092
immune system development GO:0002520 195 0.088
cell division GO:0051301 168 0.088
Yeast Worm
negative regulation of catalytic activity GO:0043086 335 0.086
response to abiotic stimulus GO:0009628 336 0.085
negative regulation of protein processing GO:0010955 142 0.085
response to organic cyclic compound GO:0014070 204 0.078
Rat
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.077
positive regulation of protein kinase activity GO:0045860 190 0.077
single fertilization GO:0007338 11 0.076
negative regulation of cytoskeleton organization GO:0051494 45 0.075
cellular response to organic cyclic compound GO:0071407 127 0.075
meiotic nuclear division GO:0007126 10 0.074
Yeast Mouse Worm
regulation of protein kinase activity GO:0045859 289 0.072
positive regulation of cellular component biogenesis GO:0044089 158 0.071
regulation of cell differentiation GO:0045595 393 0.066
Mouse
tissue regeneration GO:0042246 3 0.066
negative regulation of phosphorus metabolic process GO:0010563 267 0.064
cellular amino acid metabolic process GO:0006520 116 0.064
response to radiation GO:0009314 151 0.063
regulation of attachment of spindle microtubules to kinetochore GO:0051988 9 0.062
negative regulation of proteolysis GO:0045861 132 0.061
regulation of microtubule cytoskeleton organization GO:0070507 61 0.061
spindle stabilization GO:0043146 4 0.060
regulation of viral process GO:0050792 103 0.059
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.059
protein localization to organelle GO:0033365 280 0.058
Yeast Mouse
single organism reproductive process GO:0044702 98 0.056
Mouse Worm
dna recombination GO:0006310 77 0.055
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.055
Mouse
regulation of cellular response to stress GO:0080135 244 0.054
regulation of cytoplasmic transport GO:1903649 149 0.053
Yeast
regulation of cytoskeleton organization GO:0051493 177 0.053
protein polyubiquitination GO:0000209 110 0.052
segmentation GO:0035282 4 0.051
regulation of proteasomal protein catabolic process GO:0061136 87 0.050
Mouse
nervous system development GO:0007399 293 0.047
Mouse
histone modification GO:0016570 251 0.047
Mouse
attachment of spindle microtubules to kinetochore GO:0008608 17 0.047
Yeast
regulation of dephosphorylation GO:0035303 96 0.047
negative regulation of binding GO:0051100 57 0.047
cell morphogenesis GO:0000902 296 0.046
Mouse
nuclear migration GO:0007097 1 0.046
negative regulation of hydrolase activity GO:0051346 182 0.045
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.045
embryo development GO:0009790 123 0.044
Worm
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.044
negative regulation of apoptotic process GO:0043066 316 0.043
Mouse
regulation of protein localization GO:0032880 296 0.042
Yeast
post embryonic development GO:0009791 2 0.042
regulation of protein polymerization GO:0032271 63 0.041
mitotic cell cycle process GO:1903047 286 0.041
Yeast Zebrafish Mouse Worm
regulation of intracellular protein transport GO:0033157 123 0.039
Yeast
peptidyl serine modification GO:0018209 106 0.039
Mouse Worm
establishment of nucleus localization GO:0040023 1 0.038
regulation of cardiac muscle tissue growth GO:0055021 4 0.038
fertilization GO:0009566 12 0.036
negative regulation of endopeptidase activity GO:0010951 84 0.036
modification dependent macromolecule catabolic process GO:0043632 212 0.035
Mouse
regulation of chromosome segregation GO:0051983 44 0.035
negative regulation of cell cycle GO:0045786 193 0.035
Yeast Mouse
histone phosphorylation GO:0016572 16 0.034
Mouse
oocyte maturation GO:0001556 1 0.033
Mouse
heart development GO:0007507 95 0.033
protein autophosphorylation GO:0046777 123 0.032
Worm
protein ubiquitination GO:0016567 314 0.032
activation of protein kinase activity GO:0032147 90 0.031
regulation of protein processing GO:0070613 150 0.031
regulation of spindle checkpoint GO:0090231 12 0.031
Yeast Mouse
establishment or maintenance of cell polarity GO:0007163 31 0.031
cellular response to iron ion GO:0071281 1 0.031
mitotic cell cycle GO:0000278 326 0.031
Yeast Zebrafish Mouse Worm
positive regulation of peptidase activity GO:0010952 88 0.030
chemical homeostasis GO:0048878 306 0.030
regulation of protein catabolic process GO:0042176 155 0.029
Mouse
aging GO:0007568 66 0.029
negative regulation of programmed cell death GO:0043069 321 0.028
Mouse
regulation of cardiac muscle cell proliferation GO:0060043 4 0.028
meiotic cell cycle GO:0051321 13 0.027
Yeast Mouse Worm
negative regulation of phosphatase activity GO:0010923 61 0.027
cardiovascular system development GO:0072358 262 0.027
response to decreased oxygen levels GO:0036293 96 0.026
regulation of cellular protein catabolic process GO:1903362 96 0.025
Mouse
response to oxygen levels GO:0070482 100 0.025
reproduction GO:0000003 63 0.024
Yeast Mouse Worm
ribosome assembly GO:0042255 9 0.024
protein k48 linked ubiquitination GO:0070936 38 0.024
negative regulation of cell death GO:0060548 345 0.024
Mouse
establishment of spindle localization GO:0051293 12 0.024
brain development GO:0007420 97 0.023
secretion GO:0046903 254 0.023
regulation of protein transport GO:0051223 213 0.023
Yeast
mitotic cytokinesis GO:0000281 19 0.023
regulation of kinase activity GO:0043549 314 0.023
establishment of protein localization to organelle GO:0072594 172 0.023
Yeast
cellular response to abiotic stimulus GO:0071214 117 0.022
cellular response to radiation GO:0071478 65 0.022
negative regulation of dephosphorylation GO:0035305 63 0.022
microtubule based movement GO:0007018 32 0.022
chromatin organization GO:0006325 351 0.021
Mouse
positive regulation of response to dna damage stimulus GO:2001022 43 0.021
positive regulation of programmed cell death GO:0043068 249 0.020
male meiosis GO:0007140 1 0.020
protein modification by small protein conjugation GO:0032446 342 0.020
protein import GO:0017038 130 0.020
Yeast
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
dna repair GO:0006281 198 0.020
negative regulation of cytoplasmic transport GO:1903650 46 0.020
Yeast
neurogenesis GO:0022008 169 0.020
Mouse
cell projection organization GO:0030030 252 0.020
Mouse
regulation of establishment of protein localization GO:0070201 242 0.020
Yeast
negative regulation of peptidase activity GO:0010466 91 0.019
cellular macromolecule catabolic process GO:0044265 380 0.019
Mouse
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.019
anatomical structure formation involved in morphogenesis GO:0048646 284 0.019
myosin filament assembly GO:0031034 2 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
Yeast
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.019
positive regulation of endopeptidase activity GO:0010950 84 0.018
regulation of protein maturation GO:1903317 150 0.018
regulation of cell division GO:0051302 116 0.017
Yeast Worm
oocyte development GO:0048599 1 0.017
Mouse
spermatid development GO:0007286 4 0.017
cellular component disassembly GO:0022411 92 0.016
meiotic cell cycle process GO:1903046 8 0.016
Yeast Mouse
positive regulation of spindle checkpoint GO:0090232 7 0.016
Yeast
regulation of muscle organ development GO:0048634 27 0.016
spermatid differentiation GO:0048515 4 0.016
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.016
blastocyst development GO:0001824 3 0.016
protein localization to chromosome centromeric region GO:0071459 12 0.016
cellular homeostasis GO:0019725 196 0.016
establishment of chromosome localization GO:0051303 20 0.016
negative regulation of protein modification process GO:0031400 200 0.016
regulation of phosphatase activity GO:0010921 81 0.016
negative regulation of protein maturation GO:1903318 142 0.016
metaphase plate congression GO:0051310 18 0.016
positive regulation of kinase activity GO:0033674 204 0.015
generation of neurons GO:0048699 152 0.015
Mouse
regulation of protein stability GO:0031647 87 0.015
regulation of binding GO:0051098 111 0.015
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.015
Yeast Worm
cellular response to oxygen levels GO:0071453 55 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.015
chordate embryonic development GO:0043009 34 0.015
regulation of dna metabolic process GO:0051052 153 0.015
regulation of cell motility GO:2000145 299 0.015
regulation of nervous system development GO:0051960 88 0.015
positive regulation of intracellular transport GO:0032388 104 0.015
regulation of cell cycle process GO:0010564 266 0.015
multi organism cellular process GO:0044764 156 0.015
mitotic sister chromatid separation GO:0051306 18 0.014
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.014
negative regulation of cellular catabolic process GO:0031330 83 0.014
centrosome separation GO:0051299 3 0.014
Mouse
regulation of protein localization to nucleus GO:1900180 85 0.014
Yeast
reactive oxygen species metabolic process GO:0072593 75 0.014
regulation of cellular respiration GO:0043457 4 0.014
positive regulation of cytoskeleton organization GO:0051495 83 0.014
regulation of heart growth GO:0060420 4 0.013
regulation of mitotic sister chromatid segregation GO:0033047 27 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
defense response GO:0006952 315 0.013
positive regulation of developmental process GO:0051094 314 0.013
Mouse
response to wounding GO:0009611 168 0.013
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.013
microtubule depolymerization GO:0007019 18 0.013
positive regulation of cell death GO:0010942 263 0.012
sister chromatid biorientation GO:0031134 2 0.012
anatomical structure homeostasis GO:0060249 100 0.012
multicellular organism reproduction GO:0032504 42 0.012
Mouse
spindle assembly checkpoint GO:0071173 17 0.012
positive regulation of organelle organization GO:0010638 195 0.012
development of primary sexual characteristics GO:0045137 35 0.012
Worm
centrosome organization GO:0051297 58 0.012
Mouse
positive regulation of chromosome organization GO:2001252 41 0.012
anterior posterior axis specification GO:0009948 2 0.012
Mouse
regulation of mrna metabolic process GO:1903311 53 0.012
negative regulation of intracellular protein transport GO:0090317 42 0.012
Yeast
response to hypoxia GO:0001666 96 0.012
response to ionizing radiation GO:0010212 65 0.012
regulation of cell activation GO:0050865 125 0.012
leukocyte activation GO:0045321 164 0.012
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
positive regulation of protein transport GO:0051222 135 0.011
neuromuscular junction development GO:0007528 3 0.011
tube morphogenesis GO:0035239 95 0.011
sexual reproduction GO:0019953 37 0.011
Mouse
hindbrain development GO:0030902 3 0.011
chromosome separation GO:0051304 23 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
hemopoiesis GO:0030097 180 0.011
mature ribosome assembly GO:0042256 5 0.011
mrna metabolic process GO:0016071 175 0.011
mitotic chromosome condensation GO:0007076 11 0.011
cell projection morphogenesis GO:0048858 129 0.011
Mouse
wound healing GO:0042060 115 0.011
neuron development GO:0048666 113 0.010
Mouse
vesicle mediated transport GO:0016192 371 0.010
protein complex disassembly GO:0043241 52 0.010
regulation of mitotic cell cycle GO:0007346 189 0.010
Yeast
apoptotic signaling pathway GO:0097190 268 0.010
positive regulation of apoptotic process GO:0043065 246 0.010
intracellular protein transport GO:0006886 270 0.010
Yeast

AURKA disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.074
cancer DOID:162 167 0.046
organ system cancer DOID:0050686 164 0.014
thoracic cancer DOID:5093 21 0.010
breast cancer DOID:1612 21 0.010
gastrointestinal system cancer DOID:3119 52 0.008
colon cancer DOID:219 25 0.002
large intestine cancer DOID:5672 29 0.002
intestinal cancer DOID:10155 29 0.002
colorectal cancer DOID:9256 29 0.002
colon carcinoma DOID:1520 25 0.000