IMP

Process View

Homo sapiens

38 genes annotated in human

protein k48 linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein k48 linked ubiquitination"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein k48 linked ubiquitination" (in gray)

Name	Description	Probability	Func Analog Organism
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	1.000
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	1.000
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	1.000
RNF11	ring finger protein 11	1.000
XIAP	X-linked inhibitor of apoptosis	1.000	Human
UBE2N	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	1.000
RNF5	ring finger protein 5	1.000
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	1.000
ZNRF1	zinc and ring finger 1	0.997	Mouse
RNF111	ring finger protein 111	0.991
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.991	Human
RNF14	ring finger protein 14	0.985
TRIM39	tripartite motif containing 39	0.984
FBXW11	F-box and WD repeat domain containing 11	0.980
BIRC2	baculoviral IAP repeat containing 2	0.979
DZIP3	DAZ interacting protein 3, zinc finger	0.974	Human
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.973
TRAF6	TNF receptor-associated factor 6	0.955
UBE3A	ubiquitin protein ligase E3A	0.916
UBE2W	ubiquitin-conjugating enzyme E2W (putative)	0.911
RNF4	ring finger protein 4	0.903	Rat
UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.894
ARIH2	ariadne homolog 2 (Drosophila)	0.874
MARCH7	membrane-associated ring finger (C3HC4) 7	0.870
CUL3	cullin 3	0.837
CUL1	cullin 1	0.824
MARCH5	membrane-associated ring finger (C3HC4) 5	0.820
UBE2E3	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)	0.803
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.803
UBE2E2	ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)	0.775
RNF114	ring finger protein 114	0.762
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.743
OPTN	optineurin	0.740
UBA1	ubiquitin-like modifier activating enzyme 1	0.739
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.724
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.722	Human
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.714
RNF38	ring finger protein 38	0.706
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.629
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.628
TRIM43	tripartite motif containing 43	0.616
SKP1	S-phase kinase-associated protein 1	0.611
SIAH1	seven in absentia homolog 1 (Drosophila)	0.589
TRIM23	tripartite motif containing 23	0.587
BTRC	beta-transducin repeat containing	0.582
BIRC3	baculoviral IAP repeat containing 3	0.567	Human
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.558
KLHL12	kelch-like 12 (Drosophila)	0.535	Human
UBE2H	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	0.526
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.489	Human
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.480
CHFR	checkpoint with forkhead and ring finger domains	0.467	Human
ZNF746	zinc finger protein 746	0.462
RNF26	ring finger protein 26	0.452
RNF168	ring finger protein 168	0.425
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.403
RNF2	ring finger protein 2	0.396
PJA2	praja ring finger 2	0.391
RNF10	ring finger protein 10	0.364
UBC	ubiquitin C	0.364
TRIM32	tripartite motif containing 32	0.363
MIB1	mindbomb homolog 1 (Drosophila)	0.347
DTX3L	deltex 3-like (Drosophila)	0.340
RNF130	ring finger protein 130	0.331
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.328
AMFR	autocrine motility factor receptor	0.327
ANKRD13A	ankyrin repeat domain 13A	0.308
RNF185	ring finger protein 185	0.286	Human
ZFAND5	zinc finger, AN1-type domain 5	0.282
UBQLN2	ubiquilin 2	0.282
WNK4	WNK lysine deficient protein kinase 4	0.278
KLHL2	kelch-like 2, Mayven (Drosophila)	0.278	Human
TRIM27	tripartite motif containing 27	0.238
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.233
RNF146	ring finger protein 146	0.220
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.214
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.213
RLIM	ring finger protein, LIM domain interacting	0.211
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.205
DAPK1	death-associated protein kinase 1	0.192
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.184
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.172
UBOX5	U-box domain containing 5	0.162
BFAR	bifunctional apoptosis regulator	0.161
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.158	Human
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.155
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.155
TRIM8	tripartite motif containing 8	0.152
PCGF2	polycomb group ring finger 2	0.143
TRAF1	TNF receptor-associated factor 1	0.142
RNF103	ring finger protein 103	0.140
BIRC8	baculoviral IAP repeat containing 8	0.136	Human
UBE2G1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.134
SCAMP1	secretory carrier membrane protein 1	0.131
ZMYND11	zinc finger, MYND-type containing 11	0.131
USP15	ubiquitin specific peptidase 15	0.123
SQSTM1	sequestosome 1	0.120
PTTG1	pituitary tumor-transforming 1	0.118
MED28	mediator complex subunit 28	0.116
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.115
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.114
IRAK1	interleukin-1 receptor-associated kinase 1	0.113
RNF7	ring finger protein 7	0.110
UBXN7	UBX domain protein 7	0.105
DAXX	death-domain associated protein	0.105
ZRANB1	zinc finger, RAN-binding domain containing 1	0.104	Human
BTBD10	BTB (POZ) domain containing 10	0.104
TNIP2	TNFAIP3 interacting protein 2	0.100
ARIH1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)	0.099	Human
TRAF2	TNF receptor-associated factor 2	0.090
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.090
MID1	midline 1 (Opitz/BBB syndrome)	0.089
G3BP2	GTPase activating protein (SH3 domain) binding protein 2	0.085
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.084
CKS2	CDC28 protein kinase regulatory subunit 2	0.081
UBASH3B	ubiquitin associated and SH3 domain containing B	0.080
PLK1	polo-like kinase 1	0.077
ING2	inhibitor of growth family, member 2	0.077
POLH	polymerase (DNA directed), eta	0.075
BAK1	BCL2-antagonist/killer 1	0.072
RIPK2	receptor-interacting serine-threonine kinase 2	0.069
RHOA	ras homolog gene family, member A	0.066
TRIM5	tripartite motif containing 5	0.066
MDC1	mediator of DNA-damage checkpoint 1	0.065
UBQLN1	ubiquilin 1	0.063
PFN2	profilin 2	0.062
RNF115	ring finger protein 115	0.060	Mouse
CNOT4	CCR4-NOT transcription complex, subunit 4	0.060
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.060
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.059
KLF5	Kruppel-like factor 5 (intestinal)	0.059
FAF2	Fas associated factor family member 2	0.054
UBE2M	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	0.054
ANAPC11	anaphase promoting complex subunit 11	0.053
FBXL15	F-box and leucine-rich repeat protein 15	0.053
INF2	inverted formin, FH2 and WH2 domain containing	0.052
NBR1	neighbor of BRCA1 gene 1	0.052
WDR26	WD repeat domain 26	0.052
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.052
FBXW5	F-box and WD repeat domain containing 5	0.051
CCDC50	coiled-coil domain containing 50	0.048
RAB5A	RAB5A, member RAS oncogene family	0.048
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.047
RYBP	RING1 and YY1 binding protein	0.047
EPS15	epidermal growth factor receptor pathway substrate 15	0.046
RCHY1	ring finger and CHY zinc finger domain containing 1	0.045
YTHDF3	YTH domain family, member 3	0.042
SPOP	speckle-type POZ protein	0.042
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.042
CLCN3	chloride channel 3	0.041
DCTN4	dynactin 4 (p62)	0.041
MTMR6	myotubularin related protein 6	0.040
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.040
PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	0.039
VCP	valosin containing protein	0.039
DTX3	deltex homolog 3 (Drosophila)	0.038
RNF113B	ring finger protein 113B	0.038
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.037
RNF166	ring finger protein 166	0.037
IRAK4	interleukin-1 receptor-associated kinase 4	0.037
POLI	polymerase (DNA directed) iota	0.036
BCL2L12	BCL2-like 12 (proline rich)	0.036
WNK1	WNK lysine deficient protein kinase 1	0.036
HN1	hematological and neurological expressed 1	0.036
AUP1	ancient ubiquitous protein 1	0.035
ANXA1	annexin A1	0.035
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.035
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.035
TRAF3	TNF receptor-associated factor 3	0.034
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.033
PHF17	PHD finger protein 17	0.033
ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	0.032
DNAJA2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.031
ACBD3	acyl-CoA binding domain containing 3	0.031
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.031
UBE2S	ubiquitin-conjugating enzyme E2S	0.031
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.030
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.030
UBASH3A	ubiquitin associated and SH3 domain containing A	0.030
ZFYVE9	zinc finger, FYVE domain containing 9	0.030
SNIP1	Smad nuclear interacting protein 1	0.029
CORO7	coronin 7	0.028
CCDC127	coiled-coil domain containing 127	0.028
MAGEA2	melanoma antigen family A, 2	0.028
PIAS4	protein inhibitor of activated STAT, 4	0.027
USP9X	ubiquitin specific peptidase 9, X-linked	0.027
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.027
STAMBP	STAM binding protein	0.026
SLC25A36	solute carrier family 25, member 36	0.026
ARRDC3	arrestin domain containing 3	0.026
AKIRIN1	akirin 1	0.025
TCF19	transcription factor 19	0.025
RNF165	ring finger protein 165	0.025
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.025
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.025
ANXA7	annexin A7	0.025
DPP3	dipeptidyl-peptidase 3	0.025
SETD7	SET domain containing (lysine methyltransferase) 7	0.024
RIPK3	receptor-interacting serine-threonine kinase 3	0.024
AURKA	aurora kinase A	0.024
RNF13	ring finger protein 13	0.023
RNF144A	ring finger protein 144A	0.023
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.023
HECTD1	HECT domain containing 1	0.023
MBNL2	muscleblind-like 2 (Drosophila)	0.023
NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2	0.022
SP100	SP100 nuclear antigen	0.022
PCBP1	poly(rC) binding protein 1	0.022
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.022
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.022
ISCA1	iron-sulfur cluster assembly 1 homolog (S. cerevisiae)	0.022
DTX1	deltex homolog 1 (Drosophila)	0.022
HERC2	hect domain and RLD 2	0.022
PELI3	pellino homolog 3 (Drosophila)	0.021
NDFIP2	Nedd4 family interacting protein 2	0.021
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.020
MND1	meiotic nuclear divisions 1 homolog (S. cerevisiae)	0.020
RFFL	ring finger and FYVE-like domain containing 1	0.020
WDR47	WD repeat domain 47	0.020
TRIM11	tripartite motif containing 11	0.020
RNF20	ring finger protein 20	0.020
ZBTB41	zinc finger and BTB domain containing 41	0.019
RAD23B	RAD23 homolog B (S. cerevisiae)	0.019
KIAA0174	KIAA0174	0.019
ARPP19	cAMP-regulated phosphoprotein, 19kDa	0.019
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.019
AFTPH	aftiphilin	0.019
CHD4	chromodomain helicase DNA binding protein 4	0.019
SNX16	sorting nexin 16	0.019
ATXN3	ataxin 3	0.019
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.019
PELI1	pellino homolog 1 (Drosophila)	0.019	Mouse
FTH1	ferritin, heavy polypeptide 1	0.018
CDCA3	cell division cycle associated 3	0.018
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.018
CUL5	cullin 5	0.018
TSC22D4	TSC22 domain family, member 4	0.018
KPNA1	karyopherin alpha 1 (importin alpha 5)	0.017
SRPK2	SRSF protein kinase 2	0.017
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.017
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.017
ERN1	endoplasmic reticulum to nucleus signaling 1	0.017
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.017
TRIM2	tripartite motif containing 2	0.017
KPNA4	karyopherin alpha 4 (importin alpha 3)	0.017
LNX1	ligand of numb-protein X 1	0.017
C7orf25	chromosome 7 open reading frame 25	0.017
USP2	ubiquitin specific peptidase 2	0.016
FBXW2	F-box and WD repeat domain containing 2	0.016
PUM1	pumilio homolog 1 (Drosophila)	0.016
FBXO7	F-box protein 7	0.016
RNF181	ring finger protein 181	0.016
ENSA	endosulfine alpha	0.016
PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A	0.016
BICD2	bicaudal D homolog 2 (Drosophila)	0.016
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.016
GSPT1	G1 to S phase transition 1	0.016
USP38	ubiquitin specific peptidase 38	0.015
PNPLA2	patatin-like phospholipase domain containing 2	0.015
SNX13	sorting nexin 13	0.015
TRADD	TNFRSF1A-associated via death domain	0.015
IRAK2	interleukin-1 receptor-associated kinase 2	0.015
RAB21	RAB21, member RAS oncogene family	0.015
RSPRY1	ring finger and SPRY domain containing 1	0.015
FBXW7	F-box and WD repeat domain containing 7	0.015
UBE4A	ubiquitination factor E4A (UFD2 homolog, yeast)	0.015
CDK16	cyclin-dependent kinase 16	0.015
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.015
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.014
PINK1	PTEN induced putative kinase 1	0.014
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.014	Human
FAM64A	family with sequence similarity 64, member A	0.014
PIAS3	protein inhibitor of activated STAT, 3	0.014
TP53BP1	tumor protein p53 binding protein 1	0.014
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.014
KBTBD2	kelch repeat and BTB (POZ) domain containing 2	0.014
ZNF148	zinc finger protein 148	0.014
DDIT4	DNA-damage-inducible transcript 4	0.014
ADAM17	ADAM metallopeptidase domain 17	0.014
VPS13B	vacuolar protein sorting 13 homolog B (yeast)	0.014
AP1G1	adaptor-related protein complex 1, gamma 1 subunit	0.014
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	0.014
MID2	midline 2	0.014
EID1	EP300 interacting inhibitor of differentiation 1	0.014
FNDC3A	fibronectin type III domain containing 3A	0.013
TRAF4	TNF receptor-associated factor 4	0.013
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.013
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.013
MEX3B	mex-3 homolog B (C. elegans)	0.013
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.013
RNF25	ring finger protein 25	0.013
TRIM35	tripartite motif containing 35	0.013
KLHL20	kelch-like 20 (Drosophila)	0.013	Human
EIF1	eukaryotic translation initiation factor 1	0.013
FBXO33	F-box protein 33	0.013
CCNK	cyclin K	0.013
ANKRD17	ankyrin repeat domain 17	0.013
USP49	ubiquitin specific peptidase 49	0.013
GSK3B	glycogen synthase kinase 3 beta	0.013
ADRBK1	adrenergic, beta, receptor kinase 1	0.013
RAD18	RAD18 homolog (S. cerevisiae)	0.013
MKRN1	makorin ring finger protein 1	0.013
NUDCD3	NudC domain containing 3	0.013
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.013
CSDE1	cold shock domain containing E1, RNA-binding	0.013
MAEA	macrophage erythroblast attacher	0.012
FBXO28	F-box protein 28	0.012
ZFAND3	zinc finger, AN1-type domain 3	0.012
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.012
YAP1	Yes-associated protein 1	0.012
KIAA0232	KIAA0232	0.012
EDEM3	ER degradation enhancer, mannosidase alpha-like 3	0.012
RNF125	ring finger protein 125	0.012
KCMF1	potassium channel modulatory factor 1	0.012
TRPS1	trichorhinophalangeal syndrome I	0.012
BCL10	B-cell CLL/lymphoma 10	0.012
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.012
CNNM3	cyclin M3	0.012
USP42	ubiquitin specific peptidase 42	0.012
OXR1	oxidation resistance 1	0.012
RLF	rearranged L-myc fusion	0.012
RIOK3	RIO kinase 3 (yeast)	0.012
WDFY3	WD repeat and FYVE domain containing 3	0.012
TSG101	tumor susceptibility gene 101	0.012
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.012
UBE2G2	ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)	0.012
WSB2	WD repeat and SOCS box containing 2	0.011
ZYG11B	zyg-11 homolog B (C. elegans)	0.011
DYNC1LI1	dynein, cytoplasmic 1, light intermediate chain 1	0.011
HERC3	hect domain and RLD 3	0.011	Human
NPEPPS	aminopeptidase puromycin sensitive	0.011
CROCC	ciliary rootlet coiled-coil, rootletin	0.011
TMEM188	transmembrane protein 188	0.011
STMN1	stathmin 1	0.011
RNF34	ring finger protein 34	0.011
FBXO21	F-box protein 21	0.011
ABHD16A	abhydrolase domain containing 16A	0.011
SIRT6	sirtuin 6	0.011
CHN2	chimerin (chimaerin) 2	0.011
SGMS1	sphingomyelin synthase 1	0.011
PACRG	PARK2 co-regulated	0.011
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.011
ZKSCAN1	zinc finger with KRAB and SCAN domains 1	0.011
CDKN3	cyclin-dependent kinase inhibitor 3	0.011
WSB1	WD repeat and SOCS box containing 1	0.011
MKRN3	makorin ring finger protein 3	0.011
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.011
ZFR	zinc finger RNA binding protein	0.011
USO1	USO1 vesicle docking protein homolog (yeast)	0.011
GNAS	GNAS complex locus	0.011
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.011
RMND5A	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.011
SERINC1	serine incorporator 1	0.011
CXXC5	CXXC finger protein 5	0.011
HBS1L	HBS1-like (S. cerevisiae)	0.011
FGFR1OP2	FGFR1 oncogene partner 2	0.011
HIST1H4C	histone cluster 1, H4c	0.010
ANKRD50	ankyrin repeat domain 50	0.010
HJURP	Holliday junction recognition protein	0.010
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.010
C16orf61	chromosome 16 open reading frame 61	0.010
PCYOX1	prenylcysteine oxidase 1	0.010
USP46	ubiquitin specific peptidase 46	0.010
SH3RF3	SH3 domain containing ring finger 3	0.010
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.010
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.010
EIF5	eukaryotic translation initiation factor 5	0.010