Homo sapiens

20 known processes

ITK

IL2-inducible T-cell kinase

(Aliases: MGC126258,EMT,MGC126257,PSCTK2,LYK)

ITK biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
leukocyte activation GO:0045321 164 0.891
Human Mouse
t cell activation GO:0042110 99 0.872
Mouse
lymphocyte activation GO:0046649 133 0.862
Mouse
leukocyte differentiation GO:0002521 98 0.802
Mouse
negative regulation of endodeoxyribonuclease activity GO:0032078 1 0.770
cell activation GO:0001775 213 0.766
Human Mouse
response to biotic stimulus GO:0009607 276 0.684
cytokine production GO:0001816 247 0.616
Mouse
cytokine mediated signaling pathway GO:0019221 109 0.588
Human
response to external biotic stimulus GO:0043207 261 0.558
positive regulation of immune response GO:0050778 159 0.538
Human Mouse
negative regulation of cellular amine metabolic process GO:0033239 3 0.513
positive regulation of t cell activation GO:0050870 54 0.508
phagocytosis recognition GO:0006910 3 0.490
response to cytokine GO:0034097 232 0.469
Human
regulation of nucleotide metabolic process GO:0006140 269 0.440
immune response regulating signaling pathway GO:0002764 97 0.402
Human Mouse
regulation of protein secretion GO:0050708 86 0.399
chemokine c c motif ligand 19 signaling pathway GO:0038115 1 0.394
positive regulation of lymphocyte activation GO:0051251 73 0.384
regulation of astrocyte chemotaxis GO:2000458 1 0.382
positive regulation of developmental process GO:0051094 314 0.380
Human
g protein coupled receptor signaling pathway GO:0007186 207 0.377
defense response GO:0006952 315 0.372
immune system development GO:0002520 195 0.370
Human Mouse
negative regulation of deoxyribonuclease activity GO:0032076 1 0.346
positive regulation of phosphorylation GO:0042327 394 0.336
memory GO:0007613 3 0.312
positive regulation of immune system process GO:0002684 283 0.305
Human Mouse
hematopoietic or lymphoid organ development GO:0048534 186 0.300
Human Mouse
positive regulation of cell activation GO:0050867 81 0.299
negative regulation of phosphorus metabolic process GO:0010563 267 0.293
secretion GO:0046903 254 0.288
Human
regulation of intracellular transport GO:0032386 195 0.288
Human
cellular divalent inorganic cation homeostasis GO:0072503 128 0.286
receptor metabolic process GO:0043112 81 0.285
cellular homeostasis GO:0019725 196 0.280
negative regulation of phosphate metabolic process GO:0045936 267 0.277
peptide transport GO:0015833 74 0.277
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.272
myeloid leukocyte migration GO:0097529 62 0.270
regulation of cellular amino acid metabolic process GO:0006521 6 0.267
positive regulation of cell death GO:0010942 263 0.263
anatomical structure formation involved in morphogenesis GO:0048646 284 0.261
regulation of immune response GO:0050776 201 0.260
Human Mouse
taxis GO:0042330 157 0.260
regulation of cell morphogenesis GO:0022604 153 0.256
Human
chemotaxis GO:0006935 157 0.253
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.252
cell morphogenesis GO:0000902 296 0.239
Human
glycosyl compound catabolic process GO:1901658 413 0.236
actin cytoskeleton organization GO:0030036 207 0.236
Human
cellular ketone metabolic process GO:0042180 80 0.234
protein polymerization GO:0051258 71 0.234
Human
positive regulation of proteolysis GO:0045862 142 0.229
positive regulation of transport GO:0051050 336 0.227
metal ion homeostasis GO:0055065 169 0.225
regulation of cellular amine metabolic process GO:0033238 11 0.224
regulation of kinase activity GO:0043549 314 0.223
regulation of anatomical structure morphogenesis GO:0022603 286 0.222
Human
regulation of ion homeostasis GO:2000021 73 0.220
regulation of cytoplasmic transport GO:1903649 149 0.217
amide transport GO:0042886 76 0.217
cellular response to cytokine stimulus GO:0071345 181 0.215
Human
regulation of reactive oxygen species metabolic process GO:2000377 41 0.212
response to other organism GO:0051707 261 0.203
positive regulation of programmed cell death GO:0043068 249 0.199
innate immune response GO:0045087 178 0.198
protein secretion GO:0009306 98 0.192
interleukin 1 beta biosynthetic process GO:0050720 2 0.191
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.187
vesicle mediated transport GO:0016192 371 0.178
Human
nucleoside triphosphate metabolic process GO:0009141 422 0.178
cytoplasmic transport GO:0016482 379 0.175
protein catabolic process GO:0030163 325 0.174
negative regulation of peptidase activity GO:0010466 91 0.172
purine nucleoside catabolic process GO:0006152 398 0.170
regulation of protein complex assembly GO:0043254 147 0.169
Human
positive regulation of cellular component organization GO:0051130 376 0.169
Human
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.167
regulation of proteolysis GO:0030162 293 0.165
actin filament organization GO:0007015 128 0.164
Human
nucleoside phosphate catabolic process GO:1901292 412 0.163
regulation of defense response GO:0031347 154 0.158
myeloid leukocyte differentiation GO:0002573 60 0.157
long term memory GO:0007616 2 0.156
receptor mediated endocytosis GO:0006898 84 0.155
regulation of transferase activity GO:0051338 355 0.154
cellular response to interferon gamma GO:0071346 24 0.154
negative regulation of protein oligomerization GO:0032460 8 0.153
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.152
negative regulation of cell death GO:0060548 345 0.151
protein localization to organelle GO:0033365 280 0.151
cytosolic calcium ion homeostasis GO:0051480 89 0.151
negative regulation of hydrolase activity GO:0051346 182 0.149
negative regulation of protein phosphorylation GO:0001933 140 0.147
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 20 0.147
negative regulation of protein metabolic process GO:0051248 391 0.147
positive regulation of cellular catabolic process GO:0031331 284 0.142
positive regulation of cytoskeleton organization GO:0051495 83 0.141
Human
positive regulation of leukocyte activation GO:0002696 80 0.137
divalent inorganic cation homeostasis GO:0072507 136 0.137
receptor internalization GO:0031623 43 0.135
actin filament based process GO:0030029 224 0.133
Human
negative regulation of catalytic activity GO:0043086 335 0.133
secretion by cell GO:0032940 226 0.133
Human
mapk cascade GO:0000165 288 0.132
regulation of protein kinase activity GO:0045859 289 0.131
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.131
positive regulation of interferon gamma mediated signaling pathway GO:0060335 2 0.131
regulation of lipid kinase activity GO:0043550 19 0.129
actin polymerization or depolymerization GO:0008154 56 0.129
Human
negative regulation of protein homooligomerization GO:0032463 4 0.128
ion homeostasis GO:0050801 230 0.128
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.127
positive regulation of innate immune response GO:0045089 79 0.126
positive regulation of endopeptidase activity GO:0010950 84 0.124
regulation of mapk cascade GO:0043408 262 0.123
positive regulation of mapk cascade GO:0043410 190 0.122
amine metabolic process GO:0009308 44 0.122
zymogen activation GO:0031638 70 0.122
negative regulation of multicellular organismal process GO:0051241 317 0.122
defense response to bacterium GO:0042742 63 0.121
reactive oxygen species metabolic process GO:0072593 75 0.121
negative regulation of proteolysis GO:0045861 132 0.121
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.121
astrocyte chemotaxis GO:0035700 1 0.120
regulation of protein maturation GO:1903317 150 0.119
positive regulation of leukocyte proliferation GO:0070665 48 0.118
positive regulation of lymphocyte proliferation GO:0050671 46 0.118
positive regulation of hydrolase activity GO:0051345 331 0.117
Mouse
regulation of peptidase activity GO:0052547 180 0.117
g protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 1 0.115
regulation of innate immune response GO:0045088 97 0.115
endocytosis GO:0006897 159 0.114
regulation of lymphocyte activation GO:0051249 103 0.112
phospholipid metabolic process GO:0006644 99 0.112
negative regulation of intracellular signal transduction GO:1902532 183 0.112
negative regulation of protein processing GO:0010955 142 0.110
zinc ion homeostasis GO:0055069 12 0.109
cell chemotaxis GO:0060326 112 0.109
positive regulation of response to interferon gamma GO:0060332 2 0.109
regulation of leukocyte mediated immunity GO:0002703 38 0.108
Human
regulation of protein homooligomerization GO:0032462 11 0.107
immune response GO:0006955 307 0.106
Human Mouse
regulation of endopeptidase activity GO:0052548 170 0.106
extrinsic apoptotic signaling pathway GO:0097191 119 0.106
jak stat cascade GO:0007259 46 0.105
Human
regulation of response to interferon gamma GO:0060330 7 0.104
cytokine secretion GO:0050663 64 0.104
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.104
positive regulation of defense response GO:0031349 87 0.103
wound healing GO:0042060 115 0.101
Human
organelle assembly GO:0070925 176 0.098
ribonucleoside triphosphate metabolic process GO:0009199 412 0.098
neuromuscular junction development GO:0007528 3 0.098
cellular defense response GO:0006968 2 0.098
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.096
regulation of cytokine production GO:0001817 232 0.096
regulation of calcium mediated signaling GO:0050848 17 0.095
response to oxygen containing compound GO:1901700 369 0.094
calcium mediated signaling GO:0019722 44 0.094
regulation of neuron projection development GO:0010975 57 0.094
Human
oogenesis GO:0048477 2 0.092
response to interleukin 1 GO:0070555 47 0.092
phosphatidylinositol mediated signaling GO:0048015 55 0.091
positive regulation of mononuclear cell proliferation GO:0032946 47 0.087
negative regulation of cell proliferation GO:0008285 228 0.087
cellular metal ion homeostasis GO:0006875 146 0.086
negative regulation of cellular component organization GO:0051129 235 0.086
apoptotic signaling pathway GO:0097190 268 0.085
cell projection organization GO:0030030 252 0.085
Human
regulation of protein oligomerization GO:0032459 26 0.085
hemopoiesis GO:0030097 180 0.084
Human Mouse
negative regulation of calcium mediated signaling GO:0050849 4 0.084
regulation of actin polymerization or depolymerization GO:0008064 56 0.084
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.084
positive regulation of nucleotide metabolic process GO:0045981 230 0.083
negative regulation of apoptotic signaling pathway GO:2001234 97 0.082
negative regulation of vasculature development GO:1901343 43 0.082
calcium ion transport GO:0006816 147 0.082
negative regulation of phosphorylation GO:0042326 174 0.081
interleukin 1 biosynthetic process GO:0042222 2 0.081
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.081
hormone secretion GO:0046879 65 0.080
positive regulation of secretion by cell GO:1903532 108 0.080
regulation of cell migration GO:0030334 289 0.080
Human
membrane protein proteolysis GO:0033619 38 0.079
immune response activating signal transduction GO:0002757 90 0.079
Human Mouse
leukocyte migration GO:0050900 107 0.079
cellular response to oxygen containing compound GO:1901701 276 0.079
regulation of secretion by cell GO:1903530 177 0.078
Human
regulation of apoptotic signaling pathway GO:2001233 175 0.078
positive regulation of interferon gamma production GO:0032729 26 0.078
plasma membrane raft assembly GO:0044854 4 0.078
regulation of purine nucleotide metabolic process GO:1900542 264 0.077
positive regulation of apoptotic process GO:0043065 246 0.076
cell killing GO:0001906 34 0.076
negative regulation of protein maturation GO:1903318 142 0.076
positive regulation of cell motility GO:2000147 177 0.076
Human
regulation of peptide transport GO:0090087 62 0.075
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.074
regulation of homeostatic process GO:0032844 121 0.074
positive regulation of lipid metabolic process GO:0045834 50 0.074
cell cell signaling GO:0007267 155 0.074
cellular macromolecular complex assembly GO:0034622 324 0.073
Human
lymphocyte differentiation GO:0030098 35 0.073
Mouse
protein maturation GO:0051604 233 0.072
melanin metabolic process GO:0006582 1 0.072
cellular ion homeostasis GO:0006873 168 0.072
negative regulation of programmed cell death GO:0043069 321 0.071
positive regulation of cell proliferation GO:0008284 301 0.071
negative regulation of cellular protein metabolic process GO:0032269 353 0.069
establishment of protein localization to organelle GO:0072594 172 0.069
membrane protein ectodomain proteolysis GO:0006509 33 0.069
cellular component morphogenesis GO:0032989 314 0.068
Human
neuron projection development GO:0031175 106 0.068
Human
second messenger mediated signaling GO:0019932 78 0.068
regulation of nervous system development GO:0051960 88 0.068
Human
cellular chemical homeostasis GO:0055082 180 0.068
cellular response to acid chemical GO:0071229 44 0.067
regulation of cysteine type endopeptidase activity GO:2000116 127 0.067
negative regulation of protein complex assembly GO:0031333 43 0.067
regulation of actin cytoskeleton organization GO:0032956 116 0.067
Human
positive regulation of peptidase activity GO:0010952 88 0.067
myeloid leukocyte activation GO:0002274 34 0.066
Human
regulation of sequestering of calcium ion GO:0051282 41 0.066
regulation of cell shape GO:0008360 48 0.065
Human
regulation of protein transport GO:0051223 213 0.064
female gamete generation GO:0007292 2 0.064
regulation of protein processing GO:0070613 150 0.064
negative regulation of developmental process GO:0051093 247 0.064
positive regulation of leukocyte chemotaxis GO:0002690 38 0.063
positive regulation of organelle organization GO:0010638 195 0.063
Human
regulation of cellular component biogenesis GO:0044087 281 0.062
Human
hormone transport GO:0009914 68 0.062
regulation of actin filament based process GO:0032970 141 0.062
Human
positive regulation of catabolic process GO:0009896 310 0.062
regulation of peptide hormone secretion GO:0090276 41 0.062
negative regulation of dna catabolic process GO:1903625 2 0.061
activation of immune response GO:0002253 114 0.060
Human Mouse
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.060
positive regulation of secretion GO:0051047 116 0.060
regulation of cytokine secretion GO:0050707 57 0.060
organophosphate catabolic process GO:0046434 430 0.059
purinergic nucleotide receptor signaling pathway GO:0035590 4 0.059
negative regulation of apoptotic process GO:0043066 316 0.059
regulation of myeloid leukocyte mediated immunity GO:0002886 4 0.059
Human
positive regulation of astrocyte chemotaxis GO:2000464 1 0.059
regulation of hormone levels GO:0010817 125 0.058
nervous system development GO:0007399 293 0.058
Human
chemokine c c motif ligand 11 production GO:0071954 1 0.058
positive regulation of actin cytoskeleton reorganization GO:2000251 9 0.058
Human
purine nucleoside triphosphate metabolic process GO:0009144 412 0.058
negative regulation of t cell cytokine production GO:0002725 4 0.057
positive regulation of homeostatic process GO:0032846 47 0.057
ribonucleotide catabolic process GO:0009261 405 0.056
sequestering of metal ion GO:0051238 24 0.056
cell projection morphogenesis GO:0048858 129 0.056
positive regulation of cellular component biogenesis GO:0044089 158 0.056
Human
caveolin mediated endocytosis GO:0072584 4 0.055
positive regulation of homotypic cell cell adhesion GO:0034112 4 0.055
associative learning GO:0008306 1 0.054
positive regulation of cytokine secretion GO:0050715 42 0.054
regulation of cell motility GO:2000145 299 0.054
Human
positive regulation of t cell proliferation GO:0042102 33 0.054
activation of cysteine type endopeptidase activity GO:0097202 57 0.053
regulation of leukocyte chemotaxis GO:0002688 46 0.053
regulation of ras protein signal transduction GO:0046578 155 0.053
defense response to other organism GO:0098542 129 0.053
system process GO:0003008 349 0.053
regulation of lymphocyte mediated immunity GO:0002706 33 0.053
intrinsic apoptotic signaling pathway GO:0097193 127 0.053
regulation of epithelial cell migration GO:0010632 93 0.053
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.053
regulation of purine nucleotide catabolic process GO:0033121 205 0.052
maintenance of location GO:0051235 112 0.052
gtp metabolic process GO:0046039 239 0.052
regulation of caveolin mediated endocytosis GO:2001286 2 0.052
purine ribonucleotide catabolic process GO:0009154 404 0.051
neurological system process GO:0050877 163 0.051
guanosine containing compound catabolic process GO:1901069 239 0.051
single organism cellular localization GO:1902580 332 0.051
Human
cell fate determination GO:0001709 3 0.050
cellular cation homeostasis GO:0030003 163 0.050
regulation of intracellular protein transport GO:0033157 123 0.050
positive regulation of protein complex assembly GO:0031334 86 0.050
Human
regulation of myeloid leukocyte differentiation GO:0002761 39 0.050
protein import into nucleus GO:0006606 104 0.050
regulation of cellular ketone metabolic process GO:0010565 50 0.049
small gtpase mediated signal transduction GO:0007264 78 0.049
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.049
negative regulation of kinase activity GO:0033673 106 0.049
divalent inorganic cation transport GO:0072511 158 0.049
transition metal ion homeostasis GO:0055076 31 0.049
positive regulation of cell differentiation GO:0045597 211 0.049
Human
positive regulation of response to cytokine stimulus GO:0060760 13 0.049
actin filament polymerization GO:0030041 45 0.048
Human
chemical homeostasis GO:0048878 306 0.048
positive regulation of cellular amine metabolic process GO:0033240 7 0.048
cellular response to endogenous stimulus GO:0071495 336 0.048
cellular lipid metabolic process GO:0044255 303 0.047
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.046
regulation of organelle assembly GO:1902115 40 0.046
regulation of establishment of protein localization GO:0070201 242 0.046
organ morphogenesis GO:0009887 147 0.046
cation transport GO:0006812 331 0.046
regulation of neurogenesis GO:0050767 82 0.046
Human
cell development GO:0048468 328 0.044
Human
endomembrane system organization GO:0010256 196 0.044
reactive nitrogen species metabolic process GO:2001057 3 0.044
regulation of cytokine mediated signaling pathway GO:0001959 41 0.044
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.044
peptidyl tyrosine modification GO:0018212 170 0.043
stress activated protein kinase signaling cascade GO:0031098 94 0.043
regulation of protein polymerization GO:0032271 63 0.043
Human
nuclear transport GO:0051169 179 0.043
neuron differentiation GO:0030182 138 0.043
Human
positive regulation of transferase activity GO:0051347 227 0.043
purine ribonucleoside catabolic process GO:0046130 398 0.042
protein import GO:0017038 130 0.042
granulocyte migration GO:0097530 40 0.042
myeloid dendritic cell chemotaxis GO:0002408 3 0.041
regulation of cellular component size GO:0032535 82 0.041
Human
positive regulation of nf kappab import into nucleus GO:0042346 13 0.041
regulation of cell differentiation GO:0045595 393 0.041
Human
microtubule based process GO:0007017 210 0.041
Human
negative regulation of endopeptidase activity GO:0010951 84 0.041
positive regulation of rho gtpase activity GO:0032321 56 0.040
single organismal cell cell adhesion GO:0016337 148 0.040
positive regulation of calcium ion transport GO:0051928 51 0.040
biological adhesion GO:0022610 331 0.040
Human
positive regulation of apoptotic signaling pathway GO:2001235 70 0.039
interleukin 1 production GO:0032612 26 0.039
signal transduction by phosphorylation GO:0023014 297 0.039
positive regulation of protein transport GO:0051222 135 0.039
anterior posterior axis specification GO:0009948 2 0.039
interleukin 1 beta production GO:0032611 22 0.038
positive regulation of intracellular protein transport GO:0090316 76 0.038
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.038
positive regulation of t cell receptor signaling pathway GO:0050862 2 0.038
negative regulation of transport GO:0051051 176 0.038
generation of neurons GO:0048699 152 0.038
Human
cellular response to peptide hormone stimulus GO:0071375 56 0.038
positive regulation of protein kinase activity GO:0045860 190 0.038
t cell differentiation GO:0030217 29 0.038
Mouse
reactive oxygen species biosynthetic process GO:1903409 4 0.038
growth GO:0040007 202 0.037
regulation of protein import into nucleus GO:0042306 78 0.037
positive regulation of lipid kinase activity GO:0090218 13 0.037
organic hydroxy compound metabolic process GO:1901615 147 0.037
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.037
Human
positive regulation of osteoclast differentiation GO:0045672 9 0.037
regulation of cell cycle GO:0051726 393 0.036
positive regulation of cytoplasmic transport GO:1903651 82 0.036
mononuclear cell proliferation GO:0032943 71 0.036
negative regulation of nuclease activity GO:0032074 2 0.036
cellular zinc ion homeostasis GO:0006882 10 0.036
nitrogen compound transport GO:0071705 191 0.036
endosomal transport GO:0016197 129 0.035
leukocyte chemotaxis GO:0030595 76 0.035
camp metabolic process GO:0046058 61 0.035
segmentation GO:0035282 4 0.035
tissue migration GO:0090130 119 0.035
regulation of membrane depolarization GO:0003254 19 0.035
epithelial cell proliferation GO:0050673 128 0.035
regulation of protein localization GO:0032880 296 0.035
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.034
regulation of endocytosis GO:0030100 72 0.034
response to bacterium GO:0009617 144 0.034
single organism cell adhesion GO:0098602 179 0.033
early endosome to late endosome transport GO:0045022 21 0.033
purine ribonucleoside metabolic process GO:0046128 437 0.033
interferon gamma production GO:0032609 39 0.033
Mouse
eosinophil mediated immunity GO:0002447 2 0.033
short term memory GO:0007614 1 0.033
positive regulation of peptide hormone secretion GO:0090277 15 0.033
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.032
single organism nuclear import GO:1902593 104 0.032
positive regulation of cell cycle GO:0045787 140 0.032
integrin mediated signaling pathway GO:0007229 32 0.032
Human
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.032
interleukin 8 mediated signaling pathway GO:0038112 2 0.032
dephosphorylation GO:0016311 209 0.031
positive regulation of chemotaxis GO:0050921 57 0.031
positive regulation of calcium ion transport into cytosol GO:0010524 20 0.031
sequestering of calcium ion GO:0051208 17 0.031
cell division GO:0051301 168 0.031
cellular response to tumor necrosis factor GO:0071356 63 0.031
regulation of leukocyte activation GO:0002694 115 0.031
Human
regulation of peptide secretion GO:0002791 42 0.031
regulation of cell killing GO:0031341 22 0.031
immune effector process GO:0002252 159 0.031
Human
negative regulation of protein tyrosine kinase activity GO:0061099 13 0.031
intracellular protein transport GO:0006886 270 0.030
eosinophil activation involved in immune response GO:0002278 2 0.030
regulation of anatomical structure size GO:0090066 101 0.030
Human
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.030
regulation of insulin secretion GO:0050796 33 0.030
i kappab kinase nf kappab signaling GO:0007249 166 0.030
regulation of mitochondrial membrane potential GO:0051881 23 0.030
regulation of gtp catabolic process GO:0033124 180 0.030
cellular response to growth factor stimulus GO:0071363 197 0.030
positive regulation of cytokine production GO:0001819 167 0.030
myoblast fusion GO:0007520 1 0.030
regulation of calcium ion transport into cytosol GO:0010522 33 0.029
regulation of immune effector process GO:0002697 91 0.029
Human
response to salt stress GO:0009651 3 0.029
response to interferon gamma GO:0034341 39 0.029
cell adhesion GO:0007155 325 0.029
Human
negative regulation of angiogenesis GO:0016525 39 0.029
nucleocytoplasmic transport GO:0006913 176 0.029
regulation of mitochondrial depolarization GO:0051900 6 0.029
regulation of cellular component movement GO:0051270 334 0.029
Human
protein kinase b signaling GO:0043491 69 0.029
tyrosine phosphorylation of stat5 protein GO:0042506 13 0.029
protein oligomerization GO:0051259 173 0.029
regulation of hormone secretion GO:0046883 57 0.029
microtubule cytoskeleton organization GO:0000226 176 0.028
Human
regulation of cell division GO:0051302 116 0.028
inositol lipid mediated signaling GO:0048017 55 0.028
regulation of nucleoside metabolic process GO:0009118 209 0.028
regulation of protein serine threonine kinase activity GO:0071900 179 0.028
interspecies interaction between organisms GO:0044419 156 0.028
positive regulation of protein kinase b signaling GO:0051897 42 0.028
regulation of protein catabolic process GO:0042176 155 0.028
lymphocyte mediated immunity GO:0002449 48 0.028
purine containing compound catabolic process GO:0072523 411 0.027
plasma membrane organization GO:0007009 115 0.027
t cell differentiation in thymus GO:0033077 4 0.027
cellular response to dna damage stimulus GO:0006974 379 0.027
peptide secretion GO:0002790 51 0.027
head development GO:0060322 108 0.027
positive regulation of protein catabolic process GO:0045732 75 0.027
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.027
positive regulation of ion transport GO:0043270 87 0.027
cell part morphogenesis GO:0032990 137 0.027
regulation of small gtpase mediated signal transduction GO:0051056 156 0.026
lipid metabolic process GO:0006629 381 0.026
neuron development GO:0048666 113 0.026
Human
guanosine containing compound metabolic process GO:1901068 244 0.026
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.026
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 11 0.026
positive regulation of nucleoside metabolic process GO:0045979 186 0.026
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.026
cellular response to lipid GO:0071396 127 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
response to lipopolysaccharide GO:0032496 70 0.026
interferon gamma mediated signaling pathway GO:0060333 7 0.025
regulation of nucleotide catabolic process GO:0030811 205 0.025
protein localization to nucleus GO:0034504 136 0.025
positive regulation of cell killing GO:0031343 19 0.025
blood vessel development GO:0001568 172 0.025
establishment of organelle localization GO:0051656 59 0.025
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.025
dna catabolic process GO:0006308 49 0.025
cellular response to abiotic stimulus GO:0071214 117 0.025
osteoclast differentiation GO:0030316 21 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.024
cellular protein catabolic process GO:0044257 261 0.024
multicellular organismal aging GO:0010259 3 0.024
negative regulation of catabolic process GO:0009895 104 0.024
cellular amino acid metabolic process GO:0006520 116 0.024
response to growth factor GO:0070848 205 0.024
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.024
regulation of cytoskeleton organization GO:0051493 177 0.024
Human
membrane tubulation GO:0097320 12 0.024
negative regulation of nervous system development GO:0051961 28 0.024
protein processing GO:0016485 226 0.024
monocyte chemotaxis GO:0002548 20 0.024
determination of adult lifespan GO:0008340 2 0.024
regulation of epithelial cell proliferation GO:0050678 113 0.024
positive regulation of stress activated mapk cascade GO:0032874 60 0.023
nucleoside catabolic process GO:0009164 408 0.023
leukocyte mediated cytotoxicity GO:0001909 27 0.023
positive regulation of protein phosphorylation GO:0001934 313 0.023
regulation of calcium ion transport GO:0051924 79 0.023
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.023
regulation of cell cell adhesion GO:0022407 57 0.023
response to peptide GO:1901652 65 0.023
insulin secretion GO:0030073 39 0.023
negative regulation of blood vessel morphogenesis GO:2000181 41 0.023
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.023
purine nucleoside triphosphate catabolic process GO:0009146 392 0.023
eosinophil activation GO:0043307 3 0.022
regulation of neuron differentiation GO:0045664 70 0.022
Human
regulation of camp metabolic process GO:0030814 52 0.022
regulation of cell projection organization GO:0031344 107 0.022
Human
protein targeting GO:0006605 187 0.022
ras protein signal transduction GO:0007265 73 0.022
caveola assembly GO:0070836 4 0.022

ITK disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.220
hypersensitivity reaction disease DOID:0060056 25 0.071
cancer DOID:162 167 0.066
disease of cellular proliferation DOID:14566 174 0.066
organ system cancer DOID:0050686 164 0.066
hematopoietic system disease DOID:74 100 0.026
disease by infectious agent DOID:0050117 34 0.024