IMP

Process View

Homo sapiens

19 genes annotated in human

Multi-species View

positive regulation of cell killing

GO:0031343

Any process that activates or increases the frequency, rate or extent of cell killing.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of cell killing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of cell killing" (in gray)

Name	Description	Probability	Func Analog Organism
B2M	beta-2-microglobulin	0.994	Mouse
HLA-C	major histocompatibility complex, class I, C	0.936	Human
HLA-A	major histocompatibility complex, class I, A	0.927
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.906
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.865
HLA-B	major histocompatibility complex, class I, B	0.668
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.652	Human
HLA-F	major histocompatibility complex, class I, F	0.585	Human
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.567
IL2RB	interleukin 2 receptor, beta	0.557
HLA-G	major histocompatibility complex, class I, G	0.477	Human
CCL4	chemokine (C-C motif) ligand 4	0.408	Human
SH2D1A	SH2 domain containing 1A	0.340	Mouse
HLA-E	major histocompatibility complex, class I, E	0.327	Human
SLAMF1	signaling lymphocytic activation molecule family member 1	0.309
CD84	CD84 molecule	0.258
IL8	interleukin 8	0.240
CCL5	chemokine (C-C motif) ligand 5	0.234	Human
CCR5	chemokine (C-C motif) receptor 5	0.232
NOSTRIN	nitric oxide synthase trafficker	0.208
IFNG	interferon, gamma	0.177
CXCL3	chemokine (C-X-C motif) ligand 3	0.173	Mouse
TAPBP	TAP binding protein (tapasin)	0.149
CXCL2	chemokine (C-X-C motif) ligand 2	0.137	Mouse
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.113
GBA	glucosidase, beta, acid	0.111
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.105	Mouse
IL6	interleukin 6 (interferon, beta 2)	0.091
CXCL9	chemokine (C-X-C motif) ligand 9	0.089
IL1B	interleukin 1, beta	0.081
IL23A	interleukin 23, alpha subunit p19	0.069	Mouse
CCR7	chemokine (C-C motif) receptor 7	0.063
DPP4	dipeptidyl-peptidase 4	0.056
BCL2	B-cell CLL/lymphoma 2	0.055
FASLG	Fas ligand (TNF superfamily, member 6)	0.054
CAV1	caveolin 1, caveolae protein, 22kDa	0.052
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.051
CCL8	chemokine (C-C motif) ligand 8	0.049	Human
GZMK	granzyme K (granzyme 3; tryptase II)	0.046
CCL13	chemokine (C-C motif) ligand 13	0.041	Human
KLRC3	killer cell lectin-like receptor subfamily C, member 3	0.040	Human
CCL19	chemokine (C-C motif) ligand 19	0.038	Human
ITM2B	integral membrane protein 2B	0.038
CCL20	chemokine (C-C motif) ligand 20	0.037	Human
IL18RAP	interleukin 18 receptor accessory protein	0.034
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.034
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.031
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.028
CXCR6	chemokine (C-X-C motif) receptor 6	0.028
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.028
CXCL10	chemokine (C-X-C motif) ligand 10	0.028
RNF13	ring finger protein 13	0.027
CCL2	chemokine (C-C motif) ligand 2	0.027	Human
CCL22	chemokine (C-C motif) ligand 22	0.026	Human
ITK	IL2-inducible T-cell kinase	0.025
PVRL4	poliovirus receptor-related 4	0.025
GPR171	G protein-coupled receptor 171	0.025
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.024
XCL2	chemokine (C motif) ligand 2	0.024	Human
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.024	Human
VCAM1	vascular cell adhesion molecule 1	0.024
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.024
BAX	BCL2-associated X protein	0.023
BID	BH3 interacting domain death agonist	0.022
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.022
KLRC2	killer cell lectin-like receptor subfamily C, member 2	0.022	Human
IL10	interleukin 10	0.021
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.021
CCL7	chemokine (C-C motif) ligand 7	0.021	Human
RGS1	regulator of G-protein signaling 1	0.021
IRF4	interferon regulatory factor 4	0.020
CXCL13	chemokine (C-X-C motif) ligand 13	0.020
STAT4	signal transducer and activator of transcription 4	0.020
CD2	CD2 molecule	0.019
PRF1	perforin 1 (pore forming protein)	0.019
CCR4	chemokine (C-C motif) receptor 4	0.019
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.019
CCL3	chemokine (C-C motif) ligand 3	0.018	Human
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.018
IL7R	interleukin 7 receptor	0.017
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.017	Mouse
UBD	ubiquitin D	0.016
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.016
CD48	CD48 molecule	0.015
CXCL5	chemokine (C-X-C motif) ligand 5	0.015
TNF	tumor necrosis factor	0.015
STAP2	signal transducing adaptor family member 2	0.015
IDE	insulin-degrading enzyme	0.015
ICOS	inducible T-cell co-stimulator	0.015
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.015
BCL2L1	BCL2-like 1	0.015
ICAM1	intercellular adhesion molecule 1	0.014
NKG7	natural killer cell group 7 sequence	0.014
SH2D1B	SH2 domain containing 1B	0.014	Mouse
ASAH1	N-acylsphingosine amidohydrolase (acid ceramidase) 1	0.014
SRGN	serglycin	0.014
GNLY	granulysin	0.014
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.013
NSF	N-ethylmaleimide-sensitive factor	0.013
SELE	selectin E	0.013
RAB14	RAB14, member RAS oncogene family	0.013
FPR3	formyl peptide receptor 3	0.012
CD8A	CD8a molecule	0.012
FYB	FYN binding protein	0.012
GPR65	G protein-coupled receptor 65	0.012
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.012
SNX3	sorting nexin 3	0.012
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.012
PSAP	prosaposin	0.012
CD1C	CD1c molecule	0.012
IL21R	interleukin 21 receptor	0.012
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.011
ADAMDEC1	ADAM-like, decysin 1	0.011
DNASE1L3	deoxyribonuclease I-like 3	0.011
MAPK1	mitogen-activated protein kinase 1	0.011
CD69	CD69 molecule	0.011
CD160	CD160 molecule	0.011
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.010
CTSW	cathepsin W	0.010
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.010
DARC	Duffy blood group, chemokine receptor	0.010
SLAMF7	SLAM family member 7	0.010
CD83	CD83 molecule	0.010