Homo sapiens

142 known processes

ELANE

elastase, neutrophil expressed

(Aliases: HNE,PMN-E,ELA2,NE,GE,SCN1,HLE)

ELANE biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
interleukin 1 beta biosynthetic process GO:0050720 2 0.626
Human
interleukin 1 biosynthetic process GO:0042222 2 0.473
Human
defense response to bacterium GO:0042742 63 0.332
defense response GO:0006952 315 0.311
cellular amine metabolic process GO:0044106 41 0.292
response to other organism GO:0051707 261 0.285
interleukin 1 beta production GO:0032611 22 0.270
Human
response to oxygen containing compound GO:1901700 369 0.249
Mouse
positive regulation of cytokine production GO:0001819 167 0.230
cellular amino acid metabolic process GO:0006520 116 0.216
response to external biotic stimulus GO:0043207 261 0.192
immune response GO:0006955 307 0.187
Mouse
response to bacterium GO:0009617 144 0.186
response to biotic stimulus GO:0009607 276 0.186
defense response to other organism GO:0098542 129 0.162
lipid metabolic process GO:0006629 381 0.161
positive regulation of transport GO:0051050 336 0.138
Human
cellular ketone metabolic process GO:0042180 80 0.136
biological adhesion GO:0022610 331 0.132
Human
cytokine production GO:0001816 247 0.130
regulation of cellular amino acid metabolic process GO:0006521 6 0.122
response to lipid GO:0033993 206 0.122
Mouse
cellular lipid metabolic process GO:0044255 303 0.114
amine metabolic process GO:0009308 44 0.112
positive regulation of cell motility GO:2000147 177 0.109
system process GO:0003008 349 0.107
negative regulation of protein metabolic process GO:0051248 391 0.102
innate immune response GO:0045087 178 0.102
defense response to gram positive bacterium GO:0050830 29 0.100
regulation of cell differentiation GO:0045595 393 0.098
positive regulation of cell proliferation GO:0008284 301 0.095
positive regulation of cellular amine metabolic process GO:0033240 7 0.092
regulation of cellular amine metabolic process GO:0033238 11 0.092
regulation of cellular component movement GO:0051270 334 0.091
cell adhesion GO:0007155 325 0.091
Human
mature dendritic cell differentiation GO:0097029 2 0.081
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.081
regulation of cellular ketone metabolic process GO:0010565 50 0.080
regulation of cell migration GO:0030334 289 0.077
cellular response to oxygen containing compound GO:1901701 276 0.076
positive regulation of cellular component movement GO:0051272 181 0.076
positive regulation of phosphorylation GO:0042327 394 0.075
oxidation reduction process GO:0055114 396 0.075
positive regulation of immune response GO:0050778 159 0.074
Mouse
regulation of cell motility GO:2000145 299 0.074
cell activation GO:0001775 213 0.073
Human
regulation of cytokine production GO:0001817 232 0.073
positive regulation of cell migration GO:0030335 172 0.073
regulation of proteolysis GO:0030162 293 0.071
response to abiotic stimulus GO:0009628 336 0.070
negative regulation of catalytic activity GO:0043086 335 0.069
chemical homeostasis GO:0048878 306 0.068
small molecule biosynthetic process GO:0044283 157 0.068
positive regulation of protein phosphorylation GO:0001934 313 0.067
positive regulation of immune system process GO:0002684 283 0.067
Mouse
positive regulation of apoptotic process GO:0043065 246 0.065
positive regulation of programmed cell death GO:0043068 249 0.062
positive regulation of cell death GO:0010942 263 0.061
lipid biosynthetic process GO:0008610 177 0.060
regulation of locomotion GO:0040012 329 0.059
post embryonic development GO:0009791 2 0.057
hematopoietic or lymphoid organ development GO:0048534 186 0.054
Human
carbohydrate derivative biosynthetic process GO:1901137 207 0.054
organonitrogen compound biosynthetic process GO:1901566 200 0.053
positive regulation of locomotion GO:0040017 186 0.053
vesicle mediated transport GO:0016192 371 0.053
Human Mouse
mhc class ii biosynthetic process GO:0045342 4 0.052
Human
protein processing GO:0016485 226 0.052
positive regulation of hydrolase activity GO:0051345 331 0.052
organic acid biosynthetic process GO:0016053 97 0.052
defense response to fungus GO:0050832 4 0.051
Mouse
organic anion transport GO:0015711 103 0.051
negative regulation of cellular protein metabolic process GO:0032269 353 0.050
regulation of endopeptidase activity GO:0052548 170 0.050
response to inorganic substance GO:0010035 127 0.050
negative regulation of multicellular organismal process GO:0051241 317 0.050
growth of symbiont in host GO:0044117 1 0.048
Mouse
positive regulation of interleukin 8 production GO:0032757 36 0.047
regulation of protein kinase activity GO:0045859 289 0.047
negative regulation of hydrolase activity GO:0051346 182 0.047
regulation of peptidase activity GO:0052547 180 0.046
nervous system development GO:0007399 293 0.046
Human
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.046
negative regulation of cell death GO:0060548 345 0.045
monocarboxylic acid metabolic process GO:0032787 185 0.045
regulation of kinase activity GO:0043549 314 0.045
anion transport GO:0006820 161 0.045
hemopoiesis GO:0030097 180 0.045
Human
reactive oxygen species metabolic process GO:0072593 75 0.044
fatty acid metabolic process GO:0006631 115 0.043
protein maturation GO:0051604 233 0.042
regulation of protein maturation GO:1903317 150 0.042
regulation of hormone levels GO:0010817 125 0.042
regulation of cell adhesion GO:0030155 166 0.041
Human
immune system development GO:0002520 195 0.041
Human
myeloid cell differentiation GO:0030099 117 0.040
actin filament based process GO:0030029 224 0.040
determination of adult lifespan GO:0008340 2 0.040
regulation of anatomical structure morphogenesis GO:0022603 286 0.039
cellular response to oxidative stress GO:0034599 85 0.039
positive regulation of organelle organization GO:0010638 195 0.039
response to lipopolysaccharide GO:0032496 70 0.038
Mouse
disruption by host of symbiont cells GO:0051852 2 0.038
Mouse
organophosphate catabolic process GO:0046434 430 0.038
ribonucleoside triphosphate metabolic process GO:0009199 412 0.038
tissue migration GO:0090130 119 0.038
epithelial cell migration GO:0010631 119 0.037
g protein coupled receptor signaling pathway GO:0007186 207 0.037
enzyme linked receptor protein signaling pathway GO:0007167 303 0.037
positive regulation of interleukin 8 biosynthetic process GO:0045416 8 0.037
positive regulation of aldosterone metabolic process GO:0032346 2 0.037
actin cytoskeleton organization GO:0030036 207 0.036
apoptotic signaling pathway GO:0097190 268 0.036
regulation of branching involved in ureteric bud morphogenesis GO:0090189 3 0.036
single organism cell adhesion GO:0098602 179 0.036
nucleoside phosphate catabolic process GO:1901292 412 0.036
nucleoside triphosphate metabolic process GO:0009141 422 0.035
regulation of protein processing GO:0070613 150 0.035
response to hormone GO:0009725 175 0.035
multicellular organismal aging GO:0010259 3 0.035
single organismal cell cell adhesion GO:0016337 148 0.035
ras protein signal transduction GO:0007265 73 0.035
regulation of establishment of protein localization GO:0070201 242 0.035
negative regulation of transport GO:0051051 176 0.034
Human
ion homeostasis GO:0050801 230 0.034
negative regulation of protein maturation GO:1903318 142 0.033
leukocyte differentiation GO:0002521 98 0.033
Human
regulation of oxidoreductase activity GO:0051341 43 0.033
regulation of epithelial cell migration GO:0010632 93 0.033
negative regulation of protein processing GO:0010955 142 0.032
negative regulation of phosphorus metabolic process GO:0010563 267 0.032
cellular divalent inorganic cation homeostasis GO:0072503 128 0.032
endothelial cell migration GO:0043542 86 0.032
cellular response to growth factor stimulus GO:0071363 197 0.032
nucleoside triphosphate catabolic process GO:0009143 394 0.032
cytokine biosynthetic process GO:0042089 37 0.032
purine nucleoside triphosphate catabolic process GO:0009146 392 0.032
epithelium development GO:0060429 227 0.032
negative regulation of cellular component organization GO:0051129 235 0.032
Human
positive regulation of cell differentiation GO:0045597 211 0.031
response to growth factor GO:0070848 205 0.031
lipid modification GO:0030258 84 0.031
positive regulation of cellular component biogenesis GO:0044089 158 0.031
regulation of mapk cascade GO:0043408 262 0.031
cellular response to cytokine stimulus GO:0071345 181 0.031
nucleotide catabolic process GO:0009166 408 0.030
negative regulation of cell proliferation GO:0008285 228 0.030
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.030
positive regulation of cellular component organization GO:0051130 376 0.030
Human
negative regulation of apoptotic process GO:0043066 316 0.030
regulation of interleukin 8 production GO:0032677 49 0.030
positive regulation of kinase activity GO:0033674 204 0.030
negative regulation of deoxyribonuclease activity GO:0032076 1 0.029
cellular chemical homeostasis GO:0055082 180 0.029
response to cytokine GO:0034097 232 0.029
lipid localization GO:0010876 106 0.029
cytoplasmic transport GO:0016482 379 0.029
interleukin 1 production GO:0032612 26 0.029
Human
regulation of transferase activity GO:0051338 355 0.029
sulfur compound metabolic process GO:0006790 101 0.029
glycerolipid metabolic process GO:0046486 107 0.029
leukocyte activation GO:0045321 164 0.029
Human
epithelium migration GO:0090132 119 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.028
response to radiation GO:0009314 151 0.028
regulation of cell cycle process GO:0010564 266 0.028
negative regulation of cytokine production GO:0001818 82 0.028
regulation of apoptotic signaling pathway GO:2001233 175 0.028
regulation of nucleotide metabolic process GO:0006140 269 0.028
cellular component morphogenesis GO:0032989 314 0.028
regulation of reactive oxygen species metabolic process GO:2000377 41 0.028
response to molecule of bacterial origin GO:0002237 82 0.028
Mouse
cellular macromolecule catabolic process GO:0044265 380 0.028
regulation of cellular component biogenesis GO:0044087 281 0.028
protein catabolic process GO:0030163 325 0.028
mapk cascade GO:0000165 288 0.028
cellular metal ion homeostasis GO:0006875 146 0.028
negative regulation of developmental process GO:0051093 247 0.027
regulation of response to external stimulus GO:0032101 222 0.027
purine ribonucleoside catabolic process GO:0046130 398 0.027
chemokine biosynthetic process GO:0042033 4 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.027
positive regulation of developmental process GO:0051094 314 0.027
single organism membrane organization GO:0044802 268 0.027
lipid catabolic process GO:0016042 84 0.027
nucleoside catabolic process GO:0009164 408 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.027
purine ribonucleotide catabolic process GO:0009154 404 0.026
purine nucleoside triphosphate metabolic process GO:0009144 412 0.026
activation of immune response GO:0002253 114 0.026
anatomical structure formation involved in morphogenesis GO:0048646 284 0.026
purine ribonucleoside metabolic process GO:0046128 437 0.026
purine containing compound catabolic process GO:0072523 411 0.026
organic hydroxy compound metabolic process GO:1901615 147 0.026
regulation of epithelial cell proliferation GO:0050678 113 0.026
cardiovascular system development GO:0072358 262 0.026
cellular homeostasis GO:0019725 196 0.026
ribonucleoside catabolic process GO:0042454 406 0.026
oogenesis GO:0048477 2 0.026
ribonucleotide catabolic process GO:0009261 405 0.026
maintenance of location GO:0051235 112 0.026
ossification GO:0001503 121 0.025
regulation of intracellular transport GO:0032386 195 0.025
regulation of protein localization GO:0032880 296 0.025
antibacterial humoral response GO:0019731 24 0.025
membrane organization GO:0061024 292 0.025
positive regulation of catabolic process GO:0009896 310 0.025
growth GO:0040007 202 0.025
Mouse
regulation of cell development GO:0060284 161 0.025
single organism cellular localization GO:1902580 332 0.025
negative regulation of cell cycle GO:0045786 193 0.024
purine nucleoside catabolic process GO:0006152 398 0.024
purine nucleotide catabolic process GO:0006195 405 0.024
regeneration GO:0031099 4 0.024
smooth muscle cell proliferation GO:0048659 28 0.024
glycosyl compound catabolic process GO:1901658 413 0.024
ribonucleoside triphosphate catabolic process GO:0009203 391 0.024
regulation of immune response GO:0050776 201 0.024
Mouse
regulation of actin filament based process GO:0032970 141 0.024
female gamete generation GO:0007292 2 0.024
lipid transport GO:0006869 90 0.024
negative regulation of peptidase activity GO:0010466 91 0.024
ameboidal type cell migration GO:0001667 135 0.024
mitotic cell cycle GO:0000278 326 0.024
negative regulation of nuclease activity GO:0032074 2 0.023
cellular protein catabolic process GO:0044257 261 0.023
positive regulation of cell adhesion GO:0045785 84 0.023
Human
response to hypoxia GO:0001666 96 0.023
positive regulation of transferase activity GO:0051347 227 0.023
negative regulation of phosphate metabolic process GO:0045936 267 0.023
cell development GO:0048468 328 0.023
peptidyl tyrosine modification GO:0018212 170 0.023
negative regulation of neurotrophin trk receptor signaling pathway GO:0051387 2 0.023
detection of stimulus GO:0051606 85 0.023
negative regulation of proteolysis GO:0045861 132 0.023
carboxylic acid biosynthetic process GO:0046394 97 0.023
positive regulation of cytokine biosynthetic process GO:0042108 25 0.023
cellular response to lipid GO:0071396 127 0.023
regulation of secretion GO:0051046 194 0.023
signal transduction by phosphorylation GO:0023014 297 0.023
nucleoside phosphate biosynthetic process GO:1901293 109 0.022
regulation of innate immune response GO:0045088 97 0.022
negative regulation of cell differentiation GO:0045596 171 0.022
intracellular protein transport GO:0006886 270 0.022
negative regulation of cellular amine metabolic process GO:0033239 3 0.022
regulation of vesicle mediated transport GO:0060627 130 0.022
Human
organophosphate biosynthetic process GO:0090407 163 0.022
interleukin 8 production GO:0032637 51 0.022
regulation of endothelial cell migration GO:0010594 67 0.022
regulation of multi organism process GO:0043900 157 0.022
Mouse
modulation of growth of symbiont involved in interaction with host GO:0044144 2 0.022
Mouse
growth of symbiont involved in interaction with host GO:0044116 2 0.022
Mouse
regulation of cysteine type endopeptidase activity GO:2000116 127 0.022
cation homeostasis GO:0055080 189 0.022
response to organonitrogen compound GO:0010243 156 0.021
interspecies interaction between organisms GO:0044419 156 0.021
Mouse
nitrogen compound transport GO:0071705 191 0.021
positive regulation of protein kinase activity GO:0045860 190 0.021
positive regulation of cytoskeleton organization GO:0051495 83 0.021
single organism carbohydrate metabolic process GO:0044723 193 0.021
regulation of cytoskeleton organization GO:0051493 177 0.021
regulation of growth of symbiont in host GO:0044126 1 0.021
Mouse
regulation of dna metabolic process GO:0051052 153 0.021
small gtpase mediated signal transduction GO:0007264 78 0.021
modification of morphology or physiology of other organism GO:0035821 43 0.021
Mouse
negative regulation of growth of symbiont in host GO:0044130 1 0.021
Mouse
negative regulation of catabolic process GO:0009895 104 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
oocyte differentiation GO:0009994 2 0.021
myeloid leukocyte activation GO:0002274 34 0.021
Human
positive regulation of proteolysis GO:0045862 142 0.021
chromatin organization GO:0006325 351 0.021
regulation of neurotrophin trk receptor signaling pathway GO:0051386 2 0.021
regulation of binding GO:0051098 111 0.021
cell morphogenesis GO:0000902 296 0.021
response to organic cyclic compound GO:0014070 204 0.021
humoral immune response GO:0006959 49 0.021
alcohol metabolic process GO:0006066 114 0.021
vasculature development GO:0001944 181 0.020
regulation of purine nucleotide metabolic process GO:1900542 264 0.020
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.020
response to extracellular stimulus GO:0009991 85 0.020
cation transport GO:0006812 331 0.020
negative regulation of programmed cell death GO:0043069 321 0.020
secretion GO:0046903 254 0.020
multicellular organismal metabolic process GO:0044236 34 0.020
blood circulation GO:0008015 113 0.020
cellular response to endogenous stimulus GO:0071495 336 0.020
regulation of cytokine biosynthetic process GO:0042035 35 0.020
cellular macromolecular complex assembly GO:0034622 324 0.020
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.020
organ morphogenesis GO:0009887 147 0.019
pattern recognition receptor signaling pathway GO:0002221 48 0.019
leukotriene metabolic process GO:0006691 10 0.019
response to fungus GO:0009620 4 0.019
Mouse
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.019
Mouse
regulation of protein transport GO:0051223 213 0.019
immune response activating signal transduction GO:0002757 90 0.019
positive regulation of aldosterone biosynthetic process GO:0032349 2 0.019
plasma lipoprotein particle remodeling GO:0034369 16 0.019
protein localization to membrane GO:0072657 160 0.019
innate immune response activating signal transduction GO:0002758 48 0.019
negative regulation of cellular catabolic process GO:0031330 83 0.019
protein localization to organelle GO:0033365 280 0.019
response to oxidative stress GO:0006979 121 0.019
negative regulation of endopeptidase activity GO:0010951 84 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.019
cellular lipid catabolic process GO:0044242 65 0.019
response to wounding GO:0009611 168 0.019
chemokine production GO:0032602 32 0.019
negative regulation of immune system process GO:0002683 136 0.019
posttranscriptional regulation of gene expression GO:0010608 213 0.019
memory GO:0007613 3 0.019
carbohydrate metabolic process GO:0005975 207 0.019
modified amino acid transport GO:0072337 11 0.019
secretion by cell GO:0032940 226 0.019
thyroid hormone transport GO:0070327 2 0.019
activation of innate immune response GO:0002218 55 0.018
reactive nitrogen species metabolic process GO:2001057 3 0.018
regulation of vasculature development GO:1901342 97 0.018
cellular ion homeostasis GO:0006873 168 0.018
negative regulation of growth of symbiont involved in interaction with host GO:0044146 2 0.018
Mouse
regulation of cellular response to stress GO:0080135 244 0.018
purine ribonucleotide biosynthetic process GO:0009152 79 0.018
neuromuscular junction development GO:0007528 3 0.018
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.018
mucosal immune response GO:0002385 21 0.018
leukocyte migration GO:0050900 107 0.018
Mouse
negative regulation of intracellular signal transduction GO:1902532 183 0.018
positive regulation of mapk cascade GO:0043410 190 0.018
regulation of cell cycle GO:0051726 393 0.018
hindbrain development GO:0030902 3 0.018
blood coagulation GO:0007596 76 0.018
regulation of high density lipoprotein particle clearance GO:0010982 2 0.018
sequestering of metal ion GO:0051238 24 0.018
cellular response to reactive oxygen species GO:0034614 50 0.018
cellular response to hormone stimulus GO:0032870 125 0.018
response to nitrogen compound GO:1901698 184 0.018
gtp catabolic process GO:0006184 237 0.017
negative regulation of phosphorylation GO:0042326 174 0.017
myeloid leukocyte differentiation GO:0002573 60 0.017
cell division GO:0051301 168 0.017
response to decreased oxygen levels GO:0036293 96 0.017
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.017
endomembrane system organization GO:0010256 196 0.017
epithelial cell proliferation GO:0050673 128 0.017
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
circulatory system development GO:0072359 262 0.017
dna catabolic process GO:0006308 49 0.017
reactive oxygen species biosynthetic process GO:1903409 4 0.017
organic acid transport GO:0015849 65 0.017
zymogen activation GO:0031638 70 0.017
fatty acid biosynthetic process GO:0006633 46 0.017
sequestering of calcium ion GO:0051208 17 0.017
cellular response to hydrogen peroxide GO:0070301 37 0.017
negative regulation of protein modification process GO:0031400 200 0.017
embryo development GO:0009790 123 0.017
glycerolipid biosynthetic process GO:0045017 51 0.017
positive regulation of cell development GO:0010720 92 0.017
regulation of body fluid levels GO:0050878 99 0.017
endothelial cell proliferation GO:0001935 65 0.017
cytokine metabolic process GO:0042107 38 0.016
immune response regulating signaling pathway GO:0002764 97 0.016
regulation of lipid metabolic process GO:0019216 96 0.016
regulation of secretion by cell GO:1903530 177 0.016
actomyosin structure organization GO:0031032 59 0.016
regulation of plasma lipoprotein particle levels GO:0097006 32 0.016
regulation of defense response GO:0031347 154 0.016
coagulation GO:0050817 78 0.016
wound healing GO:0042060 115 0.016
actin filament organization GO:0007015 128 0.016
regulation of smooth muscle cell proliferation GO:0048660 28 0.016
positive regulation of lipid metabolic process GO:0045834 50 0.016
oocyte development GO:0048599 1 0.016
muscle cell proliferation GO:0033002 35 0.016
microglial cell activation GO:0001774 2 0.016
Human
peptidyl tyrosine phosphorylation GO:0018108 170 0.016
metal ion transport GO:0030001 272 0.016
carboxylic acid transport GO:0046942 63 0.016
cell growth GO:0016049 160 0.016
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.016
spermatid differentiation GO:0048515 4 0.016
regulation of protein catabolic process GO:0042176 155 0.016
neurotrophin trk receptor signaling pathway GO:0048011 4 0.016
urogenital system development GO:0001655 65 0.016
negative regulation of multi organism process GO:0043901 92 0.016
Mouse
protein acylation GO:0043543 138 0.016
cell substrate adhesion GO:0031589 132 0.016
regulation of nucleoside metabolic process GO:0009118 209 0.015
cellular response to dna damage stimulus GO:0006974 379 0.015
blood vessel development GO:0001568 172 0.015
chromatin modification GO:0016568 298 0.015
negative regulation of dna metabolic process GO:0051053 57 0.015
renal system development GO:0072001 63 0.015
forelimb morphogenesis GO:0035136 4 0.015
tube morphogenesis GO:0035239 95 0.015
neurological system process GO:0050877 163 0.015
dephosphorylation GO:0016311 209 0.015
protein oligomerization GO:0051259 173 0.015
mitotic cell cycle process GO:1903047 286 0.015
positive regulation of ion transport GO:0043270 87 0.015
negative regulation of growth GO:0045926 97 0.015
Mouse
response to uv GO:0009411 73 0.015
segmentation GO:0035282 4 0.015
positive regulation of innate immune response GO:0045089 79 0.015
negative regulation of phagocytosis GO:0050765 4 0.015
Human
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.015
cellular cation homeostasis GO:0030003 163 0.015
metal ion homeostasis GO:0055065 169 0.015
regulation of ras gtpase activity GO:0032318 128 0.015
establishment of protein localization to membrane GO:0090150 121 0.015
small molecule catabolic process GO:0044282 92 0.015
protein acetylation GO:0006473 116 0.015
locomotory behavior GO:0007626 1 0.015
plasma lipoprotein particle organization GO:0071827 22 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.015
rho protein signal transduction GO:0007266 26 0.015
dendritic cell differentiation GO:0097028 13 0.015
Human
neurogenesis GO:0022008 169 0.015
Human
ribose phosphate biosynthetic process GO:0046390 82 0.015
tube development GO:0035295 125 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
intrinsic apoptotic signaling pathway GO:0097193 127 0.015
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.015
Human
embryonic hemopoiesis GO:0035162 4 0.015
positive regulation of apoptotic signaling pathway GO:2001235 70 0.015
extrinsic apoptotic signaling pathway GO:0097191 119 0.015
purine containing compound biosynthetic process GO:0072522 88 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
guanosine containing compound catabolic process GO:1901069 239 0.014
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.014
positive regulation of mesonephros development GO:0061213 2 0.014
inflammatory response GO:0006954 79 0.014
Mouse
regulation of endothelial cell proliferation GO:0001936 56 0.014
fatty acid derivative metabolic process GO:1901568 35 0.014
regulation of actin cytoskeleton organization GO:0032956 116 0.014
cellular biogenic amine metabolic process GO:0006576 34 0.014
taxis GO:0042330 157 0.014
regulation of dna binding GO:0051101 37 0.014
cellular response to organic cyclic compound GO:0071407 127 0.014
response to oxygen levels GO:0070482 100 0.014
regulation of cell morphogenesis GO:0022604 153 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
response to axon injury GO:0048678 1 0.014
antimicrobial humoral response GO:0019730 26 0.014
cytosolic calcium ion homeostasis GO:0051480 89 0.014
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.014
actin filament bundle assembly GO:0051017 54 0.014
response to metal ion GO:0010038 84 0.014
ion transmembrane transport GO:0034220 338 0.014
camp metabolic process GO:0046058 61 0.014
cyclic nucleotide metabolic process GO:0009187 82 0.014
intracellular receptor signaling pathway GO:0030522 104 0.014
detection of chemical stimulus GO:0009593 55 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.014
erk1 and erk2 cascade GO:0070371 104 0.014
divalent inorganic cation homeostasis GO:0072507 136 0.014
response to steroid hormone GO:0048545 80 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
steroid metabolic process GO:0008202 94 0.013
regulation of homeostatic process GO:0032844 121 0.013
positive regulation of synaptic transmission GO:0050806 4 0.013
positive regulation of gtpase activity GO:0043547 166 0.013
positive regulation of secretion by cell GO:1903532 108 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
glycoprotein metabolic process GO:0009100 110 0.013
purine nucleotide biosynthetic process GO:0006164 84 0.013
regulation of chemokine production GO:0032642 31 0.013
regulation of cell substrate adhesion GO:0010810 68 0.013
macrophage activation GO:0042116 12 0.013
Human
positive regulation of endothelial cell migration GO:0010595 39 0.013
monocarboxylic acid biosynthetic process GO:0072330 67 0.013
protein secretion GO:0009306 98 0.013
positive regulation of hormone biosynthetic process GO:0046886 4 0.013
atp metabolic process GO:0046034 176 0.013
nuclear transport GO:0051169 179 0.013
regulation of wound healing GO:0061041 56 0.013
regulation of gtp catabolic process GO:0033124 180 0.013
epithelial cell differentiation GO:0030855 141 0.013

ELANE disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.134
inherited metabolic disorder DOID:655 242 0.134
immune system disease DOID:2914 155 0.030
musculoskeletal system disease DOID:17 223 0.025
cancer DOID:162 167 0.021
disease of cellular proliferation DOID:14566 174 0.021
central nervous system disease DOID:331 186 0.019
neurodegenerative disease DOID:1289 102 0.019
nervous system disease DOID:863 431 0.019
hematopoietic system disease DOID:74 100 0.019
organ system cancer DOID:0050686 164 0.017
disease of mental health DOID:150 70 0.016
amino acid metabolic disorder DOID:9252 50 0.014
sensory system disease DOID:0050155 203 0.014