IMP

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2 genes annotated in human

microglial cell activation

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

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Known genes in the process in human Include functional analogs

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Name	Description	Probability	Func Analog Organism
ATF3	activating transcription factor 3	0.657
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.333
NLRC4	NLR family, CARD domain containing 4	0.246
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.152
APP	amyloid beta (A4) precursor protein	0.135
LY96	lymphocyte antigen 96	0.100
MAPK8	mitogen-activated protein kinase 8	0.049
MYD88	myeloid differentiation primary response gene (88)	0.048
TICAM2	toll-like receptor adaptor molecule 2	0.045
JUNB	jun B proto-oncogene	0.043
DUSP1	dual specificity phosphatase 1	0.028
DOCK7	dedicator of cytokinesis 7	0.027
JUND	jun D proto-oncogene	0.025
MPO	myeloperoxidase	0.025
BCL2L1	BCL2-like 1	0.024
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.023
SNCAIP	synuclein, alpha interacting protein	0.021
RIPK2	receptor-interacting serine-threonine kinase 2	0.020
HSPA1B	heat shock 70kDa protein 1B	0.018
PYCARD	PYD and CARD domain containing	0.017
ELANE	elastase, neutrophil expressed	0.016	Human
MAPT	microtubule-associated protein tau	0.016
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.014
TPPP	tubulin polymerization promoting protein	0.014
IER2	immediate early response 2	0.012
LRRK2	leucine-rich repeat kinase 2	0.012
ATF2	activating transcription factor 2	0.011
TLR1	toll-like receptor 1	0.011
CTSG	cathepsin G	0.010
APLP1	amyloid beta (A4) precursor-like protein 1	0.010