IMP

Process View

Homo sapiens

13 genes annotated in human

dendritic cell differentiation

The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dendritic cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dendritic cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
HLA-G	major histocompatibility complex, class I, G	1.000
HLA-C	major histocompatibility complex, class I, C	1.000	Human
B2M	beta-2-microglobulin	1.000
HLA-B	major histocompatibility complex, class I, B	1.000
HLA-A	major histocompatibility complex, class I, A	0.996	Human
HLA-F	major histocompatibility complex, class I, F	0.994	Human
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.947
HLA-E	major histocompatibility complex, class I, E	0.944	Human
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.854
GAS6	growth arrest-specific 6	0.811
PILRA	paired immunoglobin-like type 2 receptor alpha	0.551
AXL	AXL receptor tyrosine kinase	0.490
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.409	Human
TAPBP	TAP binding protein (tapasin)	0.396
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.338	Human
NOTCH1	notch 1	0.308
IL4R	interleukin 4 receptor	0.226
ENG	endoglin	0.198
CAV1	caveolin 1, caveolae protein, 22kDa	0.172
FSTL1	follistatin-like 1	0.113
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.096
JAG1	jagged 1	0.089
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.079
SIGLEC7	sialic acid binding Ig-like lectin 7	0.069
PEX14	peroxisomal biogenesis factor 14	0.067
PKP4	plakophilin 4	0.062
TGFB3	transforming growth factor, beta 3	0.062
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.062
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.056
IL2RG	interleukin 2 receptor, gamma	0.056
JUNB	jun B proto-oncogene	0.052
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.050
MPO	myeloperoxidase	0.048
TGFBR1	transforming growth factor, beta receptor 1	0.047
NLRP3	NLR family, pyrin domain containing 3	0.044
PSEN2	presenilin 2 (Alzheimer disease 4)	0.043
PTAFR	platelet-activating factor receptor	0.042
BTN3A3	butyrophilin, subfamily 3, member A3	0.039
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.038
HK3	hexokinase 3 (white cell)	0.036
CD40	CD40 molecule, TNF receptor superfamily member 5	0.034
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.033	Human
CCR7	chemokine (C-C motif) receptor 7	0.033	Mouse
IRAK1	interleukin-1 receptor-associated kinase 1	0.032
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.029
ATXN1L	ataxin 1-like	0.029
TAL1	T-cell acute lymphocytic leukemia 1	0.025
PRTN3	proteinase 3	0.024
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.024
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.023
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.022
AOAH	acyloxyacyl hydrolase (neutrophil)	0.021
XIAP	X-linked inhibitor of apoptosis	0.020
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.020	Human
GAB1	GRB2-associated binding protein 1	0.019
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.019
TYMP	thymidine phosphorylase	0.019
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.019
RNASE3	ribonuclease, RNase A family, 3	0.018
NRP1	neuropilin 1	0.018
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.018
TMEM176B	transmembrane protein 176B	0.017
CD300C	CD300c molecule	0.017
HCK	hemopoietic cell kinase	0.017
IL21R	interleukin 21 receptor	0.016
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.016
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.016
CTSG	cathepsin G	0.016
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.016
CTNND1	catenin (cadherin-associated protein), delta 1	0.016
AZU1	azurocidin 1	0.016	Human
CCL22	chemokine (C-C motif) ligand 22	0.015
ELANE	elastase, neutrophil expressed	0.015	Human
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.015
PLXNB1	plexin B1	0.015
CD163	CD163 molecule	0.014
CCL19	chemokine (C-C motif) ligand 19	0.014	Mouse
BATF	basic leucine zipper transcription factor, ATF-like	0.014	Mouse
CFP	complement factor properdin	0.014
ITM2B	integral membrane protein 2B	0.014
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.014
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.014	Mouse
PLEK	pleckstrin	0.014
CMKLR1	chemokine-like receptor 1	0.013
CAV2	caveolin 2	0.013
MAML1	mastermind-like 1 (Drosophila)	0.013
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.013
IL2RA	interleukin 2 receptor, alpha	0.013
EGFR	epidermal growth factor receptor	0.013
IL32	interleukin 32	0.013
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.013
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.013
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.012
SIGLEC9	sialic acid binding Ig-like lectin 9	0.012
PDGFC	platelet derived growth factor C	0.012
PEX5	peroxisomal biogenesis factor 5	0.011
CHIT1	chitinase 1 (chitotriosidase)	0.011
TLR7	toll-like receptor 7	0.011
SIRPB1	signal-regulatory protein beta 1	0.011
TREM1	triggering receptor expressed on myeloid cells 1	0.011
EBI3	Epstein-Barr virus induced 3	0.011
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.011
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.011
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.010
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.010
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.010
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.010
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.010
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.010	Human
CIITA	class II, major histocompatibility complex, transactivator	0.010
CAMP	cathelicidin antimicrobial peptide	0.010
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.010