Homo sapiens

113 known processes

HLA-A

major histocompatibility complex, class I, A

(Aliases: FLJ26655,HLAA)

HLA-A biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
detection of chemical stimulus involved in sensory perception GO:0050907 33 1.000
Human
antigen processing and presentation via mhc class ib GO:0002475 3 1.000
Human
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 1.000
Human
positive regulation of natural killer cell mediated immunity GO:0002717 12 1.000
Human
sensory perception of chemical stimulus GO:0007606 38 1.000
Human
antigen processing and presentation of endogenous antigen GO:0019883 7 1.000
detection of external biotic stimulus GO:0098581 19 1.000
regulation of dendritic cell differentiation GO:2001198 3 1.000
Human
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 1.000
sensory perception of taste GO:0050909 36 1.000
Human
antigen processing and presentation of peptide antigen GO:0048002 18 1.000
detection of biotic stimulus GO:0009595 21 1.000
detection of chemical stimulus GO:0009593 55 1.000
Human
positive regulation of regulatory t cell differentiation GO:0045591 3 1.000
Human
negative regulation of leukocyte mediated cytotoxicity GO:0001911 5 1.000
negative regulation of dendritic cell differentiation GO:2001199 2 1.000
Human
negative regulation of leukocyte mediated immunity GO:0002704 14 1.000
positive regulation of t cell tolerance induction GO:0002666 2 1.000
Human
negative regulation of t cell proliferation GO:0042130 8 0.999
Human
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 6 0.999
antigen processing and presentation of endogenous peptide antigen via mhc class i GO:0019885 5 0.999
regulation of regulatory t cell differentiation GO:0045589 4 0.999
Human
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 5 0.999
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.998
detection of stimulus GO:0051606 85 0.998
antigen processing and presentation of endogenous peptide antigen via mhc class ib GO:0002476 2 0.998
Human
tolerance induction GO:0002507 6 0.998
Human
t cell tolerance induction GO:0002517 4 0.997
Human
immune response inhibiting signal transduction GO:0002765 4 0.996
Human
dendritic cell differentiation GO:0097028 13 0.996
Human
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap independent GO:0002486 3 0.996
sensory perception of bitter taste GO:0050913 28 0.996
Human
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway GO:0002484 3 0.995
iron ion import into cell GO:0097459 2 0.995
Human
retina homeostasis GO:0001895 42 0.995
Human
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.995
Human
antigen processing and presentation of peptide antigen via mhc class ib GO:0002428 2 0.993
Human
positive regulation of leukocyte mediated cytotoxicity GO:0001912 16 0.993
detection of other organism GO:0098543 13 0.991
negative regulation of lymphocyte mediated immunity GO:0002707 12 0.988
regulation of t cell mediated immunity GO:0002709 18 0.986
cell killing GO:0001906 34 0.985
transition metal ion transport GO:0000041 23 0.985
Human
tissue homeostasis GO:0001894 63 0.984
Human
negative regulation of leukocyte differentiation GO:1902106 24 0.982
Human
positive regulation of lymphocyte differentiation GO:0045621 13 0.981
Human
regulation of leukocyte mediated immunity GO:0002703 38 0.981
regulation of lymphocyte mediated immunity GO:0002706 33 0.979
adaptive immune response GO:0002250 49 0.979
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.979
t cell mediated cytotoxicity GO:0001913 9 0.979
natural killer cell mediated cytotoxicity GO:0042267 23 0.976
cation transport GO:0006812 331 0.976
Human
positive regulation of leukocyte mediated immunity GO:0002705 24 0.975
regulation of cell killing GO:0031341 22 0.975
regulation of natural killer cell mediated immunity GO:0002715 16 0.975
positive regulation of interleukin 12 production GO:0032735 8 0.974
Human
import into cell GO:0098657 2 0.974
Human
natural killer cell mediated immunity GO:0002228 23 0.973
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.968
response to other organism GO:0051707 261 0.967
regulation of t cell mediated cytotoxicity GO:0001914 8 0.963
response to biotic stimulus GO:0009607 276 0.953
inorganic cation import into cell GO:0098659 2 0.951
Human
lymphocyte mediated immunity GO:0002449 48 0.950
multicellular organismal homeostasis GO:0048871 67 0.937
Human
interferon gamma production GO:0032609 39 0.937
response to external biotic stimulus GO:0043207 261 0.935
type i interferon signaling pathway GO:0060337 11 0.935
regulation of adaptive immune response GO:0002819 33 0.931
positive regulation of t cell mediated immunity GO:0002711 12 0.929
positive regulation of cell killing GO:0031343 19 0.927
regulation of t cell tolerance induction GO:0002664 4 0.915
Human
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.913
negative regulation of natural killer cell mediated immunity GO:0002716 5 0.902
positive regulation of tolerance induction GO:0002645 2 0.893
Human
antigen processing and presentation GO:0019882 33 0.889
defense response GO:0006952 315 0.881
negative regulation of cell proliferation GO:0008285 228 0.878
Human
negative regulation of leukocyte activation GO:0002695 26 0.875
Human
positive regulation of adaptive immune response GO:0002821 21 0.875
detection of bacterium GO:0016045 13 0.868
regulation of innate immune response GO:0045088 97 0.865
regulation of t cell activation GO:0050863 77 0.864
positive regulation of memory t cell activation GO:2000568 1 0.863
regulation of leukocyte proliferation GO:0070663 67 0.861
Human
cell adhesion GO:0007155 325 0.835
Human
positive regulation of cytokine production GO:0001819 167 0.829
anatomical structure homeostasis GO:0060249 100 0.828
Human
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.824
Human
leukocyte mediated cytotoxicity GO:0001909 27 0.824
negative regulation of immune response GO:0050777 40 0.821
innate immune response GO:0045087 178 0.809
negative regulation of defense response GO:0031348 47 0.806
regulation of tolerance induction GO:0002643 4 0.804
Human
negative regulation of multicellular organismal process GO:0051241 317 0.799
Human
t cell mediated immunity GO:0002456 25 0.791
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.786
interleukin 12 production GO:0032615 15 0.780
Human
antigen processing and presentation of endogenous peptide antigen GO:0002483 6 0.777
immune effector process GO:0002252 159 0.775
positive regulation of interferon gamma production GO:0032729 26 0.771
positive regulation of t cell mediated cytotoxicity GO:0001916 7 0.766
positive regulation of developmental process GO:0051094 314 0.758
Human
t cell activation GO:0042110 99 0.754
regulation of immune effector process GO:0002697 91 0.749
regulation of defense response GO:0031347 154 0.745
negative regulation of innate immune response GO:0045824 18 0.736
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.716
system process GO:0003008 349 0.712
Human
immune response regulating signaling pathway GO:0002764 97 0.711
Human
positive regulation of cell differentiation GO:0045597 211 0.705
Human
positive regulation of leukocyte differentiation GO:1902107 37 0.697
Human
lymphocyte proliferation GO:0046651 70 0.693
Human
positive regulation of leukocyte activation GO:0002696 80 0.678
positive regulation of innate immune response GO:0045089 79 0.670
Human
regulation of cell differentiation GO:0045595 393 0.669
Human
immune response GO:0006955 307 0.662
hematopoietic or lymphoid organ development GO:0048534 186 0.627
Human
response to bacterium GO:0009617 144 0.627
regulation of lymphocyte activation GO:0051249 103 0.626
cd8 positive alpha beta t cell activation GO:0036037 3 0.618
leukocyte proliferation GO:0070661 74 0.608
Human
neurological system process GO:0050877 163 0.600
Human
regulation of cell activation GO:0050865 125 0.595
mononuclear cell proliferation GO:0032943 71 0.588
Human
biological adhesion GO:0022610 331 0.575
Human
detection of stimulus involved in sensory perception GO:0050906 43 0.574
Human
sensory perception GO:0007600 103 0.558
Human
positive regulation of immune response GO:0050778 159 0.557
regulation of t cell differentiation GO:0045580 19 0.552
Human
negative regulation of immune effector process GO:0002698 38 0.532
regulation of interferon gamma production GO:0032649 36 0.524
positive regulation of defense response GO:0031349 87 0.521
Human
negative regulation of immune system process GO:0002683 136 0.519
positive regulation of immune system process GO:0002684 283 0.511
regulation of immune response GO:0050776 201 0.497
regulation of leukocyte differentiation GO:1902105 61 0.495
Human
negative regulation of cell killing GO:0031342 5 0.488
negative regulation of developmental process GO:0051093 247 0.487
Human
regulation of leukocyte activation GO:0002694 115 0.484
negative regulation of cell differentiation GO:0045596 171 0.473
Human
regulation of cytokine production GO:0001817 232 0.466
cell activation GO:0001775 213 0.453
positive regulation of immune effector process GO:0002699 40 0.448
negative regulation of leukocyte proliferation GO:0070664 16 0.427
Human
inorganic ion import into cell GO:0099587 2 0.425
Human
negative regulation of lymphocyte proliferation GO:0050672 15 0.417
Human
leukocyte differentiation GO:0002521 98 0.410
Human
immune system development GO:0002520 195 0.409
Human
regulation of t cell proliferation GO:0042129 42 0.404
Human
lymphocyte differentiation GO:0030098 35 0.395
Human
regulation of interleukin 12 production GO:0032655 15 0.385
Human
regulation of mononuclear cell proliferation GO:0032944 65 0.374
Human
lymphocyte activation GO:0046649 133 0.353
memory t cell activation GO:0035709 1 0.348
leukocyte mediated immunity GO:0002443 59 0.339
hemopoiesis GO:0030097 180 0.332
Human
positive regulation of t cell differentiation GO:0045582 11 0.308
Human
metal ion transport GO:0030001 272 0.299
Human
negative regulation of cell activation GO:0050866 33 0.286
Human
cytokine production GO:0001816 247 0.276
leukocyte activation GO:0045321 164 0.252
t cell differentiation GO:0030217 29 0.239
Human
interleukin 6 production GO:0032635 37 0.220
post embryonic development GO:0009791 2 0.218
positive regulation of t cell activation GO:0050870 54 0.212
regulation of memory t cell activation GO:2000567 1 0.209
positive regulation of cell activation GO:0050867 81 0.204
cytoplasmic transport GO:0016482 379 0.180
protection from natural killer cell mediated cytotoxicity GO:0042270 3 0.174
negative regulation of lymphocyte activation GO:0051250 24 0.150
Human
t cell differentiation in thymus GO:0033077 4 0.149
viral gene expression GO:0019080 35 0.124
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 28 0.115
Human
regulation of lymphocyte proliferation GO:0050670 64 0.110
Human
response to interferon gamma GO:0034341 39 0.102
iron ion transport GO:0006826 12 0.099
Human
nucleotide catabolic process GO:0009166 408 0.096
intracellular protein transport GO:0006886 270 0.092
response to type i interferon GO:0034340 14 0.091
regulatory t cell differentiation GO:0045066 5 0.090
Human
interaction with host GO:0051701 42 0.090
regulation of lymphocyte differentiation GO:0045619 22 0.081
Human
chemical homeostasis GO:0048878 306 0.078
cellular response to oxidative stress GO:0034599 85 0.076
negative regulation of cellular protein metabolic process GO:0032269 353 0.073
cation homeostasis GO:0055080 189 0.072
purine containing compound catabolic process GO:0072523 411 0.072
negative regulation of mononuclear cell proliferation GO:0032945 15 0.070
Human
ribonucleoside monophosphate catabolic process GO:0009158 158 0.070
nucleoside monophosphate metabolic process GO:0009123 191 0.066
mapk cascade GO:0000165 288 0.064
response to muramyl dipeptide GO:0032495 4 0.063
ion homeostasis GO:0050801 230 0.061
response to inorganic substance GO:0010035 127 0.056
purine ribonucleoside metabolic process GO:0046128 437 0.051
ribonucleoside monophosphate metabolic process GO:0009161 187 0.050
detection of muramyl dipeptide GO:0032498 1 0.047
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.046
purine nucleoside catabolic process GO:0006152 398 0.046
cell projection organization GO:0030030 252 0.046
nucleoside catabolic process GO:0009164 408 0.045
negative regulation of t cell activation GO:0050868 18 0.040
Human
regulation of cell migration GO:0030334 289 0.039
cytokine production involved in immune response GO:0002367 27 0.038
ribonucleoside triphosphate metabolic process GO:0009199 412 0.037
cellular amine metabolic process GO:0044106 41 0.036
multicellular organismal aging GO:0010259 3 0.036
positive regulation of cellular amine metabolic process GO:0033240 7 0.035
t cell proliferation GO:0042098 45 0.033
Human
protein refolding GO:0042026 14 0.032
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.032
regulation of cellular ketone metabolic process GO:0010565 50 0.031
interleukin 13 biosynthetic process GO:0042231 1 0.031
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.031
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.030
entry into host cell GO:0030260 25 0.029
purine ribonucleotide catabolic process GO:0009154 404 0.028
cellular response to oxygen containing compound GO:1901701 276 0.028
response to drug GO:0042493 81 0.027
peptide transport GO:0015833 74 0.027
purine nucleotide catabolic process GO:0006195 405 0.027
positive regulation of cell death GO:0010942 263 0.027
multi organism cellular process GO:0044764 156 0.027
detection of peptidoglycan GO:0032499 1 0.027
ribonucleoside triphosphate catabolic process GO:0009203 391 0.026
negative regulation of protein activation cascade GO:2000258 7 0.025
purine nucleoside monophosphate metabolic process GO:0009126 186 0.025
ossification GO:0001503 121 0.025
secretion GO:0046903 254 0.025
regulation of cellular amino acid metabolic process GO:0006521 6 0.025
ribonucleotide catabolic process GO:0009261 405 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
metal ion homeostasis GO:0055065 169 0.025
response to molecule of bacterial origin GO:0002237 82 0.024
cellular response to interferon gamma GO:0071346 24 0.024
nucleoside phosphate catabolic process GO:1901292 412 0.024
regulation of secretion by cell GO:1903530 177 0.024
protein maturation GO:0051604 233 0.023
atp metabolic process GO:0046034 176 0.023
protein folding GO:0006457 38 0.023
response to oxygen containing compound GO:1901700 369 0.022
cellular response to type i interferon GO:0071357 12 0.022
dna catabolic process exonucleolytic GO:0000738 17 0.022
purine nucleoside triphosphate metabolic process GO:0009144 412 0.021
purine nucleoside triphosphate catabolic process GO:0009146 392 0.021
regulation of purine nucleotide metabolic process GO:1900542 264 0.021
regulation of kinase activity GO:0043549 314 0.021
transmission of nerve impulse GO:0019226 11 0.021
amide transport GO:0042886 76 0.020
negative regulation of cell death GO:0060548 345 0.020
carbohydrate homeostasis GO:0033500 31 0.020
nucleoside monophosphate catabolic process GO:0009125 159 0.020
cellular response to lipid GO:0071396 127 0.020
organophosphate catabolic process GO:0046434 430 0.020
protein localization to organelle GO:0033365 280 0.019
regulation of ossification GO:0030278 58 0.019
atp catabolic process GO:0006200 157 0.019
nucleoside triphosphate metabolic process GO:0009141 422 0.019
purine nucleoside monophosphate catabolic process GO:0009128 158 0.019
lipid metabolic process GO:0006629 381 0.019
regulation of cell cycle GO:0051726 393 0.018
regulation of cellular amine metabolic process GO:0033238 11 0.018
maintenance of location in cell GO:0051651 62 0.018
collagen catabolic process GO:0030574 10 0.018
negative regulation of protein metabolic process GO:0051248 391 0.018
mitotic spindle organization GO:0007052 27 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.017
cellular response to nutrient levels GO:0031669 69 0.017
regulation of branching involved in ureteric bud morphogenesis GO:0090189 3 0.017
determination of adult lifespan GO:0008340 2 0.017
regulation of protein localization GO:0032880 296 0.016
negative regulation of multi organism process GO:0043901 92 0.016
sensory perception of sweet taste GO:0050916 2 0.016
blastoderm segmentation GO:0007350 2 0.016
regulation of ion homeostasis GO:2000021 73 0.015
negative regulation of protein modification process GO:0031400 200 0.015
response to nitrogen compound GO:1901698 184 0.015
maintenance of location GO:0051235 112 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
secretion by cell GO:0032940 226 0.015
negative regulation of type i interferon mediated signaling pathway GO:0060339 4 0.014
regulation of ion transport GO:0043269 189 0.014
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
response to virus GO:0009615 126 0.014
amine metabolic process GO:0009308 44 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.014
negative regulation of hydrolase activity GO:0051346 182 0.013
negative regulation of cytoplasmic transport GO:1903650 46 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
regulation of complement activation lectin pathway GO:0001868 2 0.013
regulation of hormone levels GO:0010817 125 0.013
regulation of cytoplasmic transport GO:1903649 149 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
regulation of cellular component movement GO:0051270 334 0.013
muscle structure development GO:0061061 98 0.012
multi organism metabolic process GO:0044033 41 0.012
antigen processing and presentation of exogenous peptide antigen GO:0002478 4 0.012
viral transcription GO:0019083 35 0.012
regulation of calcium ion transport GO:0051924 79 0.012
negative regulation of catalytic activity GO:0043086 335 0.012
osteoblast differentiation GO:0001649 92 0.012
regulation of secretion GO:0051046 194 0.012
positive regulation of secretion GO:0051047 116 0.012
cellular ketone metabolic process GO:0042180 80 0.012
response to thyroid hormone GO:0097066 9 0.012
negative regulation of viral process GO:0048525 66 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
defense response to other organism GO:0098542 129 0.011
regulation of cellular response to stress GO:0080135 244 0.011
regulation of cell motility GO:2000145 299 0.011
single organism membrane organization GO:0044802 268 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
negative regulation of protein transport GO:0051224 75 0.011
positive regulation of hydrolase activity GO:0051345 331 0.011
cellular amino acid metabolic process GO:0006520 116 0.011
actin filament based movement GO:0030048 17 0.011
carbohydrate derivative biosynthetic process GO:1901137 207 0.011
oocyte development GO:0048599 1 0.011
entry into host GO:0044409 25 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
regulation of viral genome replication GO:0045069 48 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
regulation of cell development GO:0060284 161 0.010
apoptotic signaling pathway GO:0097190 268 0.010
anterior posterior axis specification embryo GO:0008595 2 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010
regulation of purine nucleotide catabolic process GO:0033121 205 0.010
nitrogen compound transport GO:0071705 191 0.010
regulation of elastin catabolic process GO:0060310 1 0.010
regulation of osteoblast differentiation GO:0045667 38 0.010
transition metal ion homeostasis GO:0055076 31 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.010
regulation of cell projection organization GO:0031344 107 0.010

HLA-A disease predictions

Disease DO term ID Size Probability Func Analog Org
acquired immunodeficiency syndrome DOID:635 13 0.869
Human
disease by infectious agent DOID:0050117 34 0.869
Human
viral infectious disease DOID:934 13 0.869
Human
human immunodeficiency virus infectious disease DOID:526 13 0.869
Human
musculoskeletal system disease DOID:17 223 0.809
primary immunodeficiency disease DOID:612 36 0.184
severe combined immunodeficiency DOID:627 10 0.184
combined t cell and b cell immunodeficiency DOID:628 12 0.184
immune system disease DOID:2914 155 0.184
bone disease DOID:0080001 88 0.107
connective tissue disease DOID:65 109 0.107
disease of metabolism DOID:0014667 295 0.033
Human
cancer DOID:162 167 0.025
disease of cellular proliferation DOID:14566 174 0.025
organ system cancer DOID:0050686 164 0.025
inherited metabolic disorder DOID:655 242 0.020
Human
integumentary system disease DOID:16 43 0.015
Human
vascular disease DOID:178 25 0.012
cardiovascular system disease DOID:1287 106 0.012
sensory system disease DOID:0050155 203 0.011
nervous system disease DOID:863 431 0.011
Human
cerebral degeneration DOID:1443 16 0.010
central nervous system disease DOID:331 186 0.010
Human
brain disease DOID:936 73 0.010
leukodystrophy DOID:10579 8 0.010