IMP

Process View

Homo sapiens

16 genes annotated in human

Multi-species View

negative regulation of leukocyte proliferation

GO:0070664

Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of leukocyte proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of leukocyte proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
HLA-B	major histocompatibility complex, class I, B	0.677
B2M	beta-2-microglobulin	0.638
HLA-C	major histocompatibility complex, class I, C	0.553	Human
CD80	CD80 molecule	0.525
HLA-G	major histocompatibility complex, class I, G	0.439
HLA-A	major histocompatibility complex, class I, A	0.427	Human
HLA-F	major histocompatibility complex, class I, F	0.348	Human
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.301
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.271
CD86	CD86 molecule	0.184
PILRA	paired immunoglobin-like type 2 receptor alpha	0.178
HLA-E	major histocompatibility complex, class I, E	0.176	Human
TRAF1	TNF receptor-associated factor 1	0.157
FSTL1	follistatin-like 1	0.139
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.128	Mouse
CCL4	chemokine (C-C motif) ligand 4	0.092	Human
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.072
TFF1	trefoil factor 1	0.071
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.070
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.053	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.053
POU3F2	POU class 3 homeobox 2	0.052
BMPR1A	bone morphogenetic protein receptor, type IA	0.049
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.048	Mouse
CCR5	chemokine (C-C motif) receptor 5	0.047
DPP4	dipeptidyl-peptidase 4	0.045
IL22RA1	interleukin 22 receptor, alpha 1	0.044
CCR1	chemokine (C-C motif) receptor 1	0.041
IDE	insulin-degrading enzyme	0.041
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.041
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.040
APP	amyloid beta (A4) precursor protein	0.040
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.038
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.038
SLAMF1	signaling lymphocytic activation molecule family member 1	0.034
CCL2	chemokine (C-C motif) ligand 2	0.033	Human
CD33	CD33 molecule	0.030
IL10RA	interleukin 10 receptor, alpha	0.030
CCL5	chemokine (C-C motif) ligand 5	0.029	Human
CCL8	chemokine (C-C motif) ligand 8	0.029	Human
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.029
BTN3A2	butyrophilin, subfamily 3, member A2	0.029
IL10	interleukin 10	0.028
ADAM17	ADAM metallopeptidase domain 17	0.027
HK3	hexokinase 3 (white cell)	0.027
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.026	Human
GRAP2	GRB2-related adaptor protein 2	0.026
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.025
SYK	spleen tyrosine kinase	0.023
FPR3	formyl peptide receptor 3	0.023
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.023
CXCL10	chemokine (C-X-C motif) ligand 10	0.023
IFNG	interferon, gamma	0.022
ICAM1	intercellular adhesion molecule 1	0.022
MARCO	macrophage receptor with collagenous structure	0.022
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.022
CD40	CD40 molecule, TNF receptor superfamily member 5	0.022
IL1B	interleukin 1, beta	0.021
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.020	Human
TRAF5	TNF receptor-associated factor 5	0.020
CCL13	chemokine (C-C motif) ligand 13	0.019	Human
CCL7	chemokine (C-C motif) ligand 7	0.017	Human
CCR7	chemokine (C-C motif) receptor 7	0.017
CXCL3	chemokine (C-X-C motif) ligand 3	0.017
AIF1	allograft inflammatory factor 1	0.017
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.016
RIPK2	receptor-interacting serine-threonine kinase 2	0.015
CDK6	cyclin-dependent kinase 6	0.015
EPOR	erythropoietin receptor	0.015
NLRP3	NLR family, pyrin domain containing 3	0.015
XIAP	X-linked inhibitor of apoptosis	0.014
IL22RA2	interleukin 22 receptor, alpha 2	0.014
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.014
CCR4	chemokine (C-C motif) receptor 4	0.014
IL6	interleukin 6 (interferon, beta 2)	0.014
CMKLR1	chemokine-like receptor 1	0.013
CD163	CD163 molecule	0.013
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.013
IL8	interleukin 8	0.013
ENG	endoglin	0.013
CYTH4	cytohesin 4	0.012
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.012
SIGLEC7	sialic acid binding Ig-like lectin 7	0.012
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.012
PAX3	paired box 3	0.012
HCK	hemopoietic cell kinase	0.012
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.012
RNF111	ring finger protein 111	0.012
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.012
IL2RA	interleukin 2 receptor, alpha	0.012	Mouse
TNF	tumor necrosis factor	0.012
PLK3	polo-like kinase 3	0.012
CCDC85B	coiled-coil domain containing 85B	0.011
CLEC10A	C-type lectin domain family 10, member A	0.011
ZFYVE9	zinc finger, FYVE domain containing 9	0.011
IDO1	indoleamine 2,3-dioxygenase 1	0.011
SLAMF7	SLAM family member 7	0.011
SMAD7	SMAD family member 7	0.011
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.011	Mouse
SLAMF8	SLAM family member 8	0.011
C3	complement component 3	0.011
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.011
C1QB	complement component 1, q subcomponent, B chain	0.011
CH25H	cholesterol 25-hydroxylase	0.011
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.011
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.011
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.011
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.011
IL2RB	interleukin 2 receptor, beta	0.011
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.011
CD14	CD14 molecule	0.011
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.010
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.010
CXCL5	chemokine (C-X-C motif) ligand 5	0.010
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.010
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.010