IMP

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Homo sapiens

21 genes annotated in human

Multi-species View

positive regulation of adaptive immune response

GO:0002821

Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of adaptive immune response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of adaptive immune response" (in gray)

Name	Description	Probability	Func Analog Organism
B2M	beta-2-microglobulin	0.921	Mouse
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.881
HLA-A	major histocompatibility complex, class I, A	0.875
HLA-B	major histocompatibility complex, class I, B	0.845
TRAF1	TNF receptor-associated factor 1	0.838	Human
TRAF3	TNF receptor-associated factor 3	0.798	Human
TRAF6	TNF receptor-associated factor 6	0.748
SYK	spleen tyrosine kinase	0.745
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.740
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.697
HLA-G	major histocompatibility complex, class I, G	0.689	Human
BIRC3	baculoviral IAP repeat containing 3	0.663
HLA-F	major histocompatibility complex, class I, F	0.607	Human
HLA-C	major histocompatibility complex, class I, C	0.595	Human
HLA-E	major histocompatibility complex, class I, E	0.568	Human
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.549
CXCL9	chemokine (C-X-C motif) ligand 9	0.548
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.538
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.534
IL4R	interleukin 4 receptor	0.531
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.519
TAPBP	TAP binding protein (tapasin)	0.457
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.395
CD40	CD40 molecule, TNF receptor superfamily member 5	0.372	Mouse Rat
CCL4	chemokine (C-C motif) ligand 4	0.332	Human
CCR5	chemokine (C-C motif) receptor 5	0.309
CCL5	chemokine (C-C motif) ligand 5	0.262	Human
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.260
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.225
HLA-DMB	major histocompatibility complex, class II, DM beta	0.163
TRAF2	TNF receptor-associated factor 2	0.149
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.146
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.127
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.125
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.120
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.106
GRAP2	GRB2-related adaptor protein 2	0.105
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.102
TNF	tumor necrosis factor	0.099
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.093
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.093
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.091
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.090
FAS	Fas (TNF receptor superfamily, member 6)	0.088
CXCL10	chemokine (C-X-C motif) ligand 10	0.086
CCR7	chemokine (C-C motif) receptor 7	0.084
IL23A	interleukin 23, alpha subunit p19	0.083
LCK	lymphocyte-specific protein tyrosine kinase	0.073
FASLG	Fas ligand (TNF superfamily, member 6)	0.073
CREBBP	CREB binding protein	0.069
RIPK2	receptor-interacting serine-threonine kinase 2	0.068	Mouse
TRADD	TNFRSF1A-associated via death domain	0.067
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.061
IDE	insulin-degrading enzyme	0.055
CCL2	chemokine (C-C motif) ligand 2	0.054	Human
CSF1R	colony stimulating factor 1 receptor	0.054
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.053
NLRC4	NLR family, CARD domain containing 4	0.053
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.052
NCOA6	nuclear receptor coactivator 6	0.051
CD80	CD80 molecule	0.051
CFH	complement factor H	0.049
IL10RA	interleukin 10 receptor, alpha	0.048
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.046
CXCL11	chemokine (C-X-C motif) ligand 11	0.046
HSPH1	heat shock 105kDa/110kDa protein 1	0.044
BIRC2	baculoviral IAP repeat containing 2	0.044
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.044
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.044
CCL8	chemokine (C-C motif) ligand 8	0.041	Human
CCL22	chemokine (C-C motif) ligand 22	0.041	Human
CD86	CD86 molecule	0.040
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.040
IFNG	interferon, gamma	0.040
ZMYND11	zinc finger, MYND-type containing 11	0.039
H2AFX	H2A histone family, member X	0.037
TANK	TRAF family member-associated NFKB activator	0.037
IL2RB	interleukin 2 receptor, beta	0.036
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.036
AR	androgen receptor	0.035
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.035
PVRL4	poliovirus receptor-related 4	0.032
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.032
ICAM1	intercellular adhesion molecule 1	0.031
CCR1	chemokine (C-C motif) receptor 1	0.031
CXCL13	chemokine (C-X-C motif) ligand 13	0.031
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.030
IL7R	interleukin 7 receptor	0.028
IRF4	interferon regulatory factor 4	0.027
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.026
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.026
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.026
SQSTM1	sequestosome 1	0.026
IL10	interleukin 10	0.023
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.023
CCR4	chemokine (C-C motif) receptor 4	0.023
CCL13	chemokine (C-C motif) ligand 13	0.023	Human
ENG	endoglin	0.023
BCL10	B-cell CLL/lymphoma 10	0.023
IL4	interleukin 4	0.022	Mouse
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.022	Mouse
CD2	CD2 molecule	0.022
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.022
CXCR6	chemokine (C-X-C motif) receptor 6	0.021
CCL19	chemokine (C-C motif) ligand 19	0.021	Human Mouse
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.020
MDC1	mediator of DNA-damage checkpoint 1	0.020
CD48	CD48 molecule	0.020
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.020
CCL3	chemokine (C-C motif) ligand 3	0.019	Human
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.019
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.019
IFITM2	interferon induced transmembrane protein 2 (1-8D)	0.019
MEFV	Mediterranean fever	0.019
RNASE6	ribonuclease, RNase A family, k6	0.019
CFLAR	CASP8 and FADD-like apoptosis regulator	0.019
MAVS	mitochondrial antiviral signaling protein	0.019
CCL7	chemokine (C-C motif) ligand 7	0.018	Human
PLEK	pleckstrin	0.018
UBASH3B	ubiquitin associated and SH3 domain containing B	0.018
CTSS	cathepsin S	0.018
DPP4	dipeptidyl-peptidase 4	0.018
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.018
SMAD2	SMAD family member 2	0.017
FSTL1	follistatin-like 1	0.017
NUMBL	numb homolog (Drosophila)-like	0.017
FHL2	four and a half LIM domains 2	0.017
SH2D1A	SH2 domain containing 1A	0.017
STX6	syntaxin 6	0.017
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.017
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.016
TYROBP	TYRO protein tyrosine kinase binding protein	0.016
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.016
UBD	ubiquitin D	0.016
CARD11	caspase recruitment domain family, member 11	0.016
CD1C	CD1c molecule	0.016
IL21R	interleukin 21 receptor	0.015
CLEC10A	C-type lectin domain family 10, member A	0.015
CD163	CD163 molecule	0.015
ITK	IL2-inducible T-cell kinase	0.015
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.014	Human
IFITM1	interferon induced transmembrane protein 1 (9-27)	0.014
IL2RG	interleukin 2 receptor, gamma	0.014
BLNK	B-cell linker	0.014
CCL17	chemokine (C-C motif) ligand 17	0.013	Human
KAT2B	K(lysine) acetyltransferase 2B	0.013
SNX3	sorting nexin 3	0.013
PPID	peptidylprolyl isomerase D	0.013
FOXO3	forkhead box O3	0.013
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.012
NSF	N-ethylmaleimide-sensitive factor	0.012
VCAM1	vascular cell adhesion molecule 1	0.012
TGFBR1	transforming growth factor, beta receptor 1	0.012
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.012
TRAF5	TNF receptor-associated factor 5	0.012	Human
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.012
FGL2	fibrinogen-like 2	0.012
HCP5	HLA complex P5	0.012
CD83	CD83 molecule	0.012
TP53BP1	tumor protein p53 binding protein 1	0.012
BTK	Bruton agammaglobulinemia tyrosine kinase	0.012
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.012
TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	0.012	Human
SH2D2A	SH2 domain containing 2A	0.012
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.011
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.011
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.011
SMAD7	SMAD family member 7	0.011
CCL11	chemokine (C-C motif) ligand 11	0.011	Human
SELL	selectin L	0.011
IRF1	interferon regulatory factor 1	0.011
IFITM3	interferon induced transmembrane protein 3 (1-8U)	0.011
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.011
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.011	Mouse
CD84	CD84 molecule	0.011
CD40LG	CD40 ligand	0.011
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.011
CFI	complement factor I	0.011
IL8	interleukin 8	0.010
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.010
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.010
CXCL3	chemokine (C-X-C motif) ligand 3	0.010