Homo sapiens

178 known processes

TBX5

T-box 5

(Aliases: HOS)

TBX5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cardioblast differentiation GO:0051891 2 1.000
right ventricular cardiac muscle tissue morphogenesis GO:0003221 2 1.000
globus pallidus development GO:0021759 1 1.000
cardiac right ventricle morphogenesis GO:0003215 3 1.000
outflow tract septum morphogenesis GO:0003148 4 1.000
Human
cardiac ventricle formation GO:0003211 2 1.000
Mouse
regulation of cardioblast differentiation GO:0051890 4 0.999
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.999
regulation of cardiac muscle tissue development GO:0055024 13 0.999
septum secundum development GO:0003285 2 0.999
cardiac atrium morphogenesis GO:0003209 7 0.999
Human Mouse
atrial septum morphogenesis GO:0060413 5 0.998
Human Mouse
cardiac conduction system development GO:0003161 2 0.997
Mouse
cardiac chamber formation GO:0003207 2 0.997
Mouse
regulation of heart growth GO:0060420 4 0.997
cardiac atrium development GO:0003230 10 0.993
Human Mouse
cardiac muscle cell proliferation GO:0060038 6 0.989
regulation of thyroid hormone generation GO:2000609 2 0.988
muscle cell fate commitment GO:0042693 4 0.987
negative regulation of cardiac muscle cell apoptotic process GO:0010667 2 0.981
muscle cell proliferation GO:0033002 35 0.974
atrial septum development GO:0003283 8 0.965
Human Mouse
venous blood vessel development GO:0060841 2 0.963
Human
cardiac muscle cell fate commitment GO:0060923 4 0.956
cd8 positive alpha beta t cell differentiation involved in immune response GO:0002302 1 0.953
Human
regulation of cardiac muscle contraction GO:0055117 33 0.946
lung morphogenesis GO:0060425 6 0.944
muscle system process GO:0003012 81 0.942
regulation of cardiac muscle cell apoptotic process GO:0010665 3 0.935
positive regulation of stem cell differentiation GO:2000738 29 0.924
striated muscle cell apoptotic process GO:0010658 3 0.918
cation transmembrane transport GO:0098655 238 0.917
pharynx development GO:0060465 1 0.917
cardiac cell fate determination GO:0060913 3 0.916
regulation of transmembrane transporter activity GO:0022898 74 0.911
positive regulation of ion transmembrane transporter activity GO:0032414 29 0.909
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.907
organ formation GO:0048645 3 0.904
Mouse
regulation of striated muscle tissue development GO:0016202 26 0.902
regulation of muscle tissue development GO:1901861 26 0.890
pharyngeal system development GO:0060037 2 0.889
Human
negative regulation of myotube differentiation GO:0010832 4 0.888
embryonic heart tube morphogenesis GO:0003143 8 0.874
Zebrafish
regulation of muscle system process GO:0090257 53 0.872
cardiac septum morphogenesis GO:0060411 9 0.866
Human Mouse
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.864
regulation of calcium ion transmembrane transporter activity GO:1901019 28 0.863
heart contraction GO:0060047 62 0.859
positive regulation of calcium ion transport GO:0051928 51 0.858
cardiac muscle tissue development GO:0048738 39 0.852
regulation of ion transport GO:0043269 189 0.850
cardiac muscle tissue growth GO:0055017 6 0.835
ion transmembrane transport GO:0034220 338 0.833
regulation of stem cell differentiation GO:2000736 56 0.831
regulation of calcium ion transmembrane transport GO:1903169 28 0.824
regulation of muscle contraction GO:0006937 45 0.821
regulation of blood circulation GO:1903522 59 0.818
pulmonary vein morphogenesis GO:0060577 1 0.815
Human
regulation of ion transmembrane transporter activity GO:0032412 72 0.812
divalent metal ion transport GO:0070838 152 0.807
positive regulation of transcription via serum response element binding GO:0010735 3 0.799
cardiac ventricle morphogenesis GO:0003208 20 0.796
Mouse
regulation of heart contraction GO:0008016 50 0.794
ventricular septum morphogenesis GO:0060412 3 0.786
sodium ion transport GO:0006814 61 0.784
regulation of ion transmembrane transport GO:0034765 132 0.783
inorganic cation transmembrane transport GO:0098662 194 0.782
endocrine system development GO:0035270 26 0.771
Human
negative regulation of cell migration GO:0030336 102 0.768
negative regulation of striated muscle cell apoptotic process GO:0010664 2 0.768
regulation of cellular component movement GO:0051270 334 0.766
metal ion transport GO:0030001 272 0.751
regulation of calcium ion transport GO:0051924 79 0.750
regulation of striated muscle contraction GO:0006942 37 0.736
cation transport GO:0006812 331 0.733
blood circulation GO:0008015 113 0.731
heart growth GO:0060419 6 0.729
ventricular cardiac muscle cell differentiation GO:0055012 1 0.726
canonical wnt signaling pathway GO:0060070 116 0.722
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.711
divalent inorganic cation transport GO:0072511 158 0.708
blood vessel development GO:0001568 172 0.705
Human
apoptotic process involved in morphogenesis GO:0060561 3 0.705
inorganic ion transmembrane transport GO:0098660 231 0.703
negative regulation of multicellular organismal process GO:0051241 317 0.702
regulation of system process GO:0044057 101 0.701
cardiac chamber morphogenesis GO:0003206 26 0.700
Human Mouse
regulation of metal ion transport GO:0010959 120 0.690
positive regulation of ion transport GO:0043270 87 0.690
ventricular cardiac muscle tissue development GO:0003229 14 0.685
Mouse
calcium ion transport GO:0006816 147 0.680
cardiac muscle cell apoptotic process GO:0010659 3 0.680
positive regulation of cell proliferation GO:0008284 301 0.676
Human Mouse
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.667
regulation of muscle cell differentiation GO:0051147 31 0.667
Human
regulation of cell migration GO:0030334 289 0.658
heart formation GO:0060914 2 0.652
Mouse
interleukin 13 secretion GO:0072611 2 0.651
organ morphogenesis GO:0009887 147 0.646
Human Zebrafish Mouse
actin filament based process GO:0030029 224 0.642
negative regulation of cell motility GO:2000146 104 0.633
positive regulation of developmental process GO:0051094 314 0.628
regulation of cell motility GO:2000145 299 0.628
positive regulation of transporter activity GO:0032411 32 0.626
luteinizing hormone secretion GO:0032275 1 0.621
Human
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.616
branching morphogenesis of an epithelial tube GO:0048754 19 0.616
adult heart development GO:0007512 6 0.614
monovalent inorganic cation transport GO:0015672 128 0.612
amine metabolic process GO:0009308 44 0.608
dna templated transcription initiation GO:0006352 35 0.606
negative regulation of cellular component movement GO:0051271 106 0.605
cellular amine metabolic process GO:0044106 41 0.600
circulatory system process GO:0003013 113 0.596
positive regulation of transmembrane transport GO:0034764 41 0.594
foramen ovale closure GO:0035922 1 0.594
Human
negative regulation of stem cell differentiation GO:2000737 22 0.589
regulation of canonical wnt signaling pathway GO:0060828 88 0.587
developmental programmed cell death GO:0010623 3 0.586
regulation of cell differentiation GO:0045595 393 0.586
regulation of striated muscle cell differentiation GO:0051153 25 0.581
Human
regulation of transmembrane transport GO:0034762 139 0.578
regulation of cellular amino acid metabolic process GO:0006521 6 0.570
cardiac chamber development GO:0003205 30 0.569
Human Mouse
regulation of cation channel activity GO:2001257 33 0.569
trabecula morphogenesis GO:0061383 2 0.565
muscle contraction GO:0006936 73 0.564
cardiac ventricle development GO:0003231 23 0.563
Mouse
negative regulation of striated muscle cell differentiation GO:0051154 8 0.561
cardiac muscle cell differentiation GO:0055007 15 0.561
Zebrafish Mouse
system process GO:0003008 349 0.561
Human
lung development GO:0030324 20 0.559
Mouse
transmembrane transport GO:0055085 399 0.556
response to growth factor GO:0070848 205 0.553
circulatory system development GO:0072359 262 0.550
anatomical structure formation involved in morphogenesis GO:0048646 284 0.548
Zebrafish Mouse
secretion GO:0046903 254 0.546
Human
negative regulation of epithelial to mesenchymal transition GO:0010719 14 0.537
regulation of cellular amine metabolic process GO:0033238 11 0.537
cardiovascular system development GO:0072358 262 0.535
blood vessel morphogenesis GO:0048514 162 0.532
Human
mesenchymal cell development GO:0014031 50 0.529
regulation of interleukin 5 secretion GO:2000662 2 0.527
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.526
Human
thyroid gland development GO:0030878 5 0.525
enzyme linked receptor protein signaling pathway GO:0007167 303 0.524
cellular response to endogenous stimulus GO:0071495 336 0.522
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.521
positive regulation of cell differentiation GO:0045597 211 0.517
mesenchyme development GO:0060485 59 0.514
Zebrafish Mouse
heart morphogenesis GO:0003007 48 0.510
Human Zebrafish Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.506
vasculature development GO:0001944 181 0.506
Human
cardiac muscle tissue morphogenesis GO:0055008 18 0.506
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.505
muscle organ morphogenesis GO:0048644 19 0.504
regulation of locomotion GO:0040012 329 0.498
stem cell differentiation GO:0048863 93 0.493
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.486
positive regulation of ion transmembrane transport GO:0034767 40 0.475
mesenchymal cell differentiation GO:0048762 52 0.473
bmp signaling pathway GO:0030509 49 0.466
striated muscle tissue development GO:0014706 59 0.465
positive regulation of interleukin 5 production GO:0032754 3 0.462
regulation of epithelial to mesenchymal transition GO:0010717 37 0.462
response to hormone GO:0009725 175 0.458
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.455
Human
skeletal system development GO:0001501 79 0.452
Human
negative regulation of developmental process GO:0051093 247 0.449
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.448
hematopoietic or lymphoid organ development GO:0048534 186 0.448
Human
response to estrogen GO:0043627 47 0.447
regulation of myotube differentiation GO:0010830 18 0.447
Human
positive regulation of blood circulation GO:1903524 12 0.445
organ growth GO:0035265 12 0.441
regulation of transporter activity GO:0032409 82 0.437
response to organic cyclic compound GO:0014070 204 0.435
cellular response to growth factor stimulus GO:0071363 197 0.434
nervous system development GO:0007399 293 0.434
Human Zebrafish
regulation of striated muscle cell apoptotic process GO:0010662 3 0.431
positive regulation of transport GO:0051050 336 0.425
cell type specific apoptotic process GO:0097285 125 0.420
regulation of cellular response to growth factor stimulus GO:0090287 76 0.418
regulation of cardiac muscle tissue growth GO:0055021 4 0.417
cardioblast differentiation GO:0010002 8 0.414
regulation of hormone levels GO:0010817 125 0.413
Human
determination of bilateral symmetry GO:0009855 15 0.406
Zebrafish
ventricular trabecula myocardium morphogenesis GO:0003222 1 0.402
positive regulation of sodium ion transport GO:0010765 14 0.401
negative regulation of cell death GO:0060548 345 0.393
Human
ventricular cardiac muscle tissue morphogenesis GO:0055010 14 0.392
response to oxygen containing compound GO:1901700 369 0.390
cardiac septum development GO:0003279 13 0.387
Human Mouse
hemopoiesis GO:0030097 180 0.383
Human
ventricular septum development GO:0003281 5 0.380
Mouse
positive regulation of protein phosphorylation GO:0001934 313 0.375
actin cytoskeleton organization GO:0030036 207 0.371
negative regulation of locomotion GO:0040013 118 0.370
heart looping GO:0001947 7 0.370
Zebrafish
outflow tract morphogenesis GO:0003151 10 0.370
Human
wnt signaling pathway GO:0016055 156 0.362
positive regulation of phosphorylation GO:0042327 394 0.358
positive regulation of cellular component organization GO:0051130 376 0.357
response to lipid GO:0033993 206 0.354
positive regulation of protein complex assembly GO:0031334 86 0.351
secretion by cell GO:0032940 226 0.351
Human
tube morphogenesis GO:0035239 95 0.349
Zebrafish
embryonic morphogenesis GO:0048598 85 0.348
respiratory system development GO:0060541 22 0.348
Mouse
follicle stimulating hormone secretion GO:0046884 3 0.347
Human
epithelial tube morphogenesis GO:0060562 38 0.343
Zebrafish
response to estradiol GO:0032355 23 0.333
cell fate determination GO:0001709 3 0.331
positive regulation of cell development GO:0010720 92 0.331
regulation of growth GO:0040008 165 0.329
muscle cell apoptotic process GO:0010657 11 0.326
regulation of voltage gated calcium channel activity GO:1901385 7 0.324
cardiac cell fate commitment GO:0060911 7 0.321
regulation of wnt signaling pathway GO:0030111 123 0.321
segmentation GO:0035282 4 0.320
Human
heart development GO:0007507 95 0.320
response to abiotic stimulus GO:0009628 336 0.318
regulation of interleukin 13 secretion GO:2000665 2 0.314
response to transforming growth factor beta GO:0071559 94 0.314
positive regulation of calcium ion transmembrane transporter activity GO:1901021 13 0.309
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.309
immune system development GO:0002520 195 0.298
Human
muscle tissue morphogenesis GO:0060415 19 0.296
morphogenesis of a branching epithelium GO:0061138 20 0.293
peptidyl tyrosine modification GO:0018212 170 0.293
regulation of cellular component biogenesis GO:0044087 281 0.289
specification of organ identity GO:0010092 3 0.286
cardiocyte differentiation GO:0035051 23 0.285
positive regulation of immune system process GO:0002684 283 0.283
regulation of muscle organ development GO:0048634 27 0.283
growth GO:0040007 202 0.277
negative regulation of wnt signaling pathway GO:0030178 69 0.275
embryonic forelimb morphogenesis GO:0035115 4 0.264
regulation of anatomical structure morphogenesis GO:0022603 286 0.258
Mouse
epithelial to mesenchymal transition GO:0001837 48 0.257
muscle organ development GO:0007517 56 0.254
positive regulation of cell motility GO:2000147 177 0.248
regulation of neuron differentiation GO:0045664 70 0.246
cell development GO:0048468 328 0.246
Human
negative regulation of cell morphogenesis involved in differentiation GO:0010771 24 0.245
regulation of cell development GO:0060284 161 0.245
Human
muscle cell development GO:0055001 29 0.244
Human
kidney development GO:0001822 53 0.243
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.243
vesicle mediated transport GO:0016192 371 0.242
muscle structure development GO:0061061 98 0.241
cardiac muscle adaptation GO:0014887 4 0.239
cardiac myofibril assembly GO:0055003 3 0.235
neural nucleus development GO:0048857 47 0.233
cardiac muscle cell development GO:0055013 5 0.230
striated muscle cell differentiation GO:0051146 43 0.229
Human Zebrafish Mouse
positive regulation of cellular component biogenesis GO:0044089 158 0.228
negative regulation of cell differentiation GO:0045596 171 0.226
Human
forelimb morphogenesis GO:0035136 4 0.224
regulation of sodium ion transport GO:0002028 24 0.222
negative regulation of apoptotic process GO:0043066 316 0.219
Human
brain development GO:0007420 97 0.219
Human
regulation of cell cycle GO:0051726 393 0.216
Human
response to external biotic stimulus GO:0043207 261 0.213
Human
renal system development GO:0072001 63 0.202
endothelial cell migration GO:0043542 86 0.200
epithelium development GO:0060429 227 0.197
gland development GO:0048732 48 0.197
Human
negative regulation of cellular component organization GO:0051129 235 0.192
tube development GO:0035295 125 0.190
Zebrafish Mouse
soft palate development GO:0060023 3 0.190
Human
forebrain development GO:0030900 26 0.189
cranial nerve development GO:0021545 4 0.188
Zebrafish
digestive tract development GO:0048565 75 0.187
cellular component morphogenesis GO:0032989 314 0.187
positive regulation of neurogenesis GO:0050769 49 0.187
cardiac muscle contraction GO:0060048 34 0.185
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.184
positive regulation of interleukin 13 production GO:0032736 4 0.182
endocardial cushion development GO:0003197 3 0.175
Mouse
positive regulation of cytokine production GO:0001819 167 0.175
determination of heart left right asymmetry GO:0061371 8 0.173
Zebrafish
stem cell development GO:0048864 69 0.173
neuron differentiation GO:0030182 138 0.172
head development GO:0060322 108 0.172
Human
specification of symmetry GO:0009799 16 0.171
Zebrafish
muscle tissue development GO:0060537 62 0.169
cell morphogenesis GO:0000902 296 0.168
actin filament based movement GO:0030048 17 0.167
negative regulation of cell development GO:0010721 48 0.166
response to alcohol GO:0097305 64 0.165
spleen development GO:0048536 1 0.165
regulation of response to external stimulus GO:0032101 222 0.161
generation of neurons GO:0048699 152 0.161
angiogenesis GO:0001525 147 0.161
lymphocyte migration GO:0072676 28 0.158
Human
organelle assembly GO:0070925 176 0.158
digestive system development GO:0055123 75 0.157
left right pattern formation GO:0060972 2 0.156
spinal cord development GO:0021510 4 0.154
leukocyte differentiation GO:0002521 98 0.154
Human
striated muscle contraction GO:0006941 52 0.152
negative regulation of programmed cell death GO:0043069 321 0.150
Human
vasculogenesis GO:0001570 8 0.146
positive regulation of neuron differentiation GO:0045666 40 0.145
positive regulation of cation channel activity GO:2001259 16 0.143
epithelial cell proliferation GO:0050673 128 0.143
epithelial cell fate commitment GO:0072148 3 0.142
central nervous system development GO:0007417 123 0.141
Human
positive regulation of secretion by cell GO:1903532 108 0.140
regulation of cardiac muscle cell proliferation GO:0060043 4 0.140
regulation of neurogenesis GO:0050767 82 0.139
developmental growth GO:0048589 48 0.138
cardioblast cell fate commitment GO:0042684 1 0.136
regulation of cell morphogenesis GO:0022604 153 0.135
response to cytokine GO:0034097 232 0.135
atrioventricular valve development GO:0003171 3 0.131
Zebrafish Mouse
nerve development GO:0021675 4 0.129
Zebrafish
embryonic organ development GO:0048568 36 0.129
Human Zebrafish
muscle hypertrophy in response to stress GO:0003299 4 0.128
cell cell signaling GO:0007267 155 0.128
cell adhesion GO:0007155 325 0.127
positive regulation of endothelial cell migration GO:0010595 39 0.126
regulation of endothelial cell migration GO:0010594 67 0.125
organic hydroxy compound metabolic process GO:1901615 147 0.123
determination of left right symmetry GO:0007368 11 0.123
Zebrafish
tissue morphogenesis GO:0048729 96 0.123
Human Zebrafish Mouse
regulation of nervous system development GO:0051960 88 0.123
regulation of immune response GO:0050776 201 0.122
heart process GO:0003015 62 0.122
hormone secretion GO:0046879 65 0.122
Human
regulation of establishment of protein localization GO:0070201 242 0.122
regulation of epithelial cell proliferation GO:0050678 113 0.121
basophil differentiation GO:0030221 2 0.120
forebrain regionalization GO:0021871 3 0.120
cytokine production GO:0001816 247 0.119
myotube differentiation GO:0014902 22 0.117
Human
tissue migration GO:0090130 119 0.117
sarcomere organization GO:0045214 8 0.116
regulation of response to wounding GO:1903034 101 0.115
cellular chemical homeostasis GO:0055082 180 0.113
neurogenesis GO:0022008 169 0.113
striated muscle cell proliferation GO:0014855 7 0.113
positive regulation of cellular component movement GO:0051272 181 0.111
formation of primary germ layer GO:0001704 42 0.111
striated muscle adaptation GO:0014888 4 0.111
hormone metabolic process GO:0042445 61 0.111
actomyosin structure organization GO:0031032 59 0.110
thyroid hormone generation GO:0006590 2 0.109
epithelial cell differentiation GO:0030855 141 0.108
morphogenesis of an epithelium GO:0002009 60 0.108
Zebrafish Mouse
immune response GO:0006955 307 0.107
Human
striated muscle cell development GO:0055002 27 0.105
Human
regulation of cytokine production GO:0001817 232 0.105
ameboidal type cell migration GO:0001667 135 0.105
cellular component assembly involved in morphogenesis GO:0010927 73 0.105
aortic valve development GO:0003176 3 0.104
Human
positive regulation of heart growth GO:0060421 2 0.104
Mouse
muscle cell differentiation GO:0042692 63 0.103
Human Zebrafish Mouse
positive regulation of nervous system development GO:0051962 54 0.103
embryonic heart tube development GO:0035050 9 0.102
Zebrafish
cell morphogenesis involved in differentiation GO:0000904 144 0.100
regulation of angiogenesis GO:0045765 92 0.099
cellular response to gonadotropin stimulus GO:0071371 4 0.098
regulation of transcription initiation from rna polymerase ii promoter GO:0060260 8 0.098
diencephalon development GO:0021536 6 0.095
regulation of vasculature development GO:1901342 97 0.095
signal release GO:0023061 70 0.094
Human
biological adhesion GO:0022610 331 0.094
embryonic viscerocranium morphogenesis GO:0048703 1 0.092
Human
small gtpase mediated signal transduction GO:0007264 78 0.090
positive regulation of mapk cascade GO:0043410 190 0.089
platelet formation GO:0030220 4 0.088
endoderm formation GO:0001706 33 0.088
neuron fate commitment GO:0048663 2 0.088
response to radiation GO:0009314 151 0.088
cd8 positive alpha beta t cell activation GO:0036037 3 0.088
Human
cellular ketone metabolic process GO:0042180 80 0.087
positive regulation of odontogenesis GO:0042482 3 0.086
positive regulation of angiogenesis GO:0045766 51 0.086
mapk cascade GO:0000165 288 0.086
atrioventricular valve morphogenesis GO:0003181 2 0.086
Zebrafish Mouse
regulation of hormone metabolic process GO:0032350 14 0.085
cellular response to hormone stimulus GO:0032870 125 0.084
positive regulation of protein kinase activity GO:0045860 190 0.084
regulation of dna templated transcription initiation GO:2000142 9 0.082
positive regulation of cell death GO:0010942 263 0.082
nucleoside phosphate catabolic process GO:1901292 412 0.081
hindbrain development GO:0030902 3 0.080
response to other organism GO:0051707 261 0.080
Human
apoptotic signaling pathway GO:0097190 268 0.080
cellular amino acid metabolic process GO:0006520 116 0.079
chordate embryonic development GO:0043009 34 0.079
Human
cellular response to cytokine stimulus GO:0071345 181 0.077
regionalization GO:0003002 29 0.077
Human
ribonucleotide catabolic process GO:0009261 405 0.077
myeloid cell differentiation GO:0030099 117 0.076
myeloid leukocyte differentiation GO:0002573 60 0.076
negative regulation of protein metabolic process GO:0051248 391 0.075
positive regulation of locomotion GO:0040017 186 0.075
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.074
Mouse
endocytosis GO:0006897 159 0.073
single organismal cell cell adhesion GO:0016337 148 0.073
cytoplasmic transport GO:0016482 379 0.073
regulation of protein localization GO:0032880 296 0.073
positive regulation of secretion GO:0051047 116 0.073
lipid metabolic process GO:0006629 381 0.073
signal transduction by phosphorylation GO:0023014 297 0.073
extrinsic apoptotic signaling pathway GO:0097191 119 0.073
mesonephric duct development GO:0072177 3 0.072
nucleoside catabolic process GO:0009164 408 0.072
regulation of mapk cascade GO:0043408 262 0.072
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.071
cell differentiation in spinal cord GO:0021515 1 0.071
positive regulation of protein transport GO:0051222 135 0.071
regulation of myeloid cell differentiation GO:0045637 81 0.071
organophosphate catabolic process GO:0046434 430 0.070
response to drug GO:0042493 81 0.070
receptor mediated endocytosis GO:0006898 84 0.070
locomotory behavior GO:0007626 1 0.070
positive regulation of hormone biosynthetic process GO:0046886 4 0.068
positive regulation of hormone metabolic process GO:0032352 6 0.067
nucleotide catabolic process GO:0009166 408 0.067
metencephalon development GO:0022037 2 0.066
coagulation GO:0050817 78 0.065
endoderm development GO:0007492 33 0.065
post embryonic development GO:0009791 2 0.065
purine nucleotide catabolic process GO:0006195 405 0.065
hormone transport GO:0009914 68 0.065
Human
heart valve formation GO:0003188 2 0.065
Zebrafish
heart trabecula morphogenesis GO:0061384 1 0.064
regulation of protein kinase activity GO:0045859 289 0.064
positive regulation of catabolic process GO:0009896 310 0.064
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.064
response to steroid hormone GO:0048545 80 0.063
ribonucleoside triphosphate catabolic process GO:0009203 391 0.063
g protein coupled receptor signaling pathway GO:0007186 207 0.063
eosinophil fate commitment GO:0035854 2 0.063
neuron development GO:0048666 113 0.062
single organism cell adhesion GO:0098602 179 0.062
pattern specification process GO:0007389 43 0.062
Human Zebrafish Mouse
response to thyroid hormone GO:0097066 9 0.061
nucleoside phosphate biosynthetic process GO:1901293 109 0.061
trabecula formation GO:0060343 1 0.060
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 3 0.060
Human
cellular modified amino acid metabolic process GO:0006575 64 0.060
purine ribonucleoside catabolic process GO:0046130 398 0.060
nucleoside triphosphate catabolic process GO:0009143 394 0.060
negative regulation of binding GO:0051100 57 0.059
ribonucleoside triphosphate metabolic process GO:0009199 412 0.059
cell growth GO:0016049 160 0.059
protein secretion GO:0009306 98 0.059
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.058
embryo development GO:0009790 123 0.058
male gonad development GO:0008584 23 0.058
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.058
neuron projection development GO:0031175 106 0.057
regulation of transferase activity GO:0051338 355 0.057
regulation of apoptotic signaling pathway GO:2001233 175 0.057
behavior GO:0007610 112 0.057
response to organonitrogen compound GO:0010243 156 0.056
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.056
signal transduction involved in regulation of gene expression GO:0023019 1 0.056
regulation of homeostatic process GO:0032844 121 0.055
thyroid hormone metabolic process GO:0042403 4 0.055
lung alveolus development GO:0048286 4 0.054
aortic valve morphogenesis GO:0003180 3 0.054
Human
epithelium migration GO:0090132 119 0.054
lymphocyte activation GO:0046649 133 0.053
Human
positive regulation of programmed cell death GO:0043068 249 0.053
multicellular organismal aging GO:0010259 3 0.052
purine containing compound catabolic process GO:0072523 411 0.052
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.051
skeletal system morphogenesis GO:0048705 24 0.051
Human
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.051
mitotic cell cycle GO:0000278 326 0.051
regulation of actin filament based process GO:0032970 141 0.051
somatic stem cell maintenance GO:0035019 4 0.051
regulation of developmental growth GO:0048638 30 0.051
negative regulation of cell cycle GO:0045786 193 0.050
heart valve morphogenesis GO:0003179 8 0.050
Human Zebrafish Mouse
forebrain generation of neurons GO:0021872 3 0.050

TBX5 disease predictions

Disease DO term ID Size Probability Func Analog Org
congenital heart disease DOID:1682 16 1.000
Human
heart septal defect DOID:1681 14 1.000
Human
heart disease DOID:114 68 1.000
Human
ventricular septal defect DOID:1657 8 1.000
Human
cardiovascular system disease DOID:1287 106 1.000
Human
atrial heart septal defect DOID:1882 8 1.000
Human
tetralogy of fallot DOID:6419 7 1.000
Human
thyroid gland disease DOID:50 11 0.745
hypothyroidism DOID:1459 10 0.745
congenital hypothyroidism DOID:0050328 8 0.745
endocrine system disease DOID:28 26 0.745
musculoskeletal system disease DOID:17 223 0.081
disease of metabolism DOID:0014667 295 0.051