|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
2 |
1.000
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.999
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.999
|
|
|
|
positive regulation of protein linear polyubiquitination
|
GO:1902530 |
2 |
0.999
|
Human |
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.999
|
|
|
|
cellular response to muramyl dipeptide
|
GO:0071225 |
3 |
0.998
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.997
|
Human |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.996
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
24 |
0.995
|
|
|
|
positive regulation of canonical wnt signaling pathway
|
GO:0090263 |
33 |
0.994
|
Human |
|
|
regulation of protein linear polyubiquitination
|
GO:1902528 |
2 |
0.994
|
Human |
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.994
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.990
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.989
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.989
|
|
|
|
regulation of necroptotic process
|
GO:0060544 |
7 |
0.987
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.987
|
|
|
|
positive regulation of protein monoubiquitination
|
GO:1902527 |
1 |
0.986
|
|
|
|
positive regulation of protein k48 linked ubiquitination
|
GO:1902524 |
1 |
0.986
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.984
|
|
|
|
regulation of natural killer cell apoptotic process
|
GO:0070247 |
1 |
0.982
|
Human |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.981
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.981
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.980
|
|
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.979
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.979
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.978
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.978
|
Human |
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
4 |
0.977
|
|
|
|
regulation of macrophage differentiation
|
GO:0045649 |
9 |
0.977
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.976
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
0.974
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.973
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.970
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.968
|
|
|
|
positive regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903557 |
22 |
0.966
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.963
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.961
|
|
|
|
regulation of protein monoubiquitination
|
GO:1902525 |
1 |
0.955
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.955
|
Human |
|
|
positive regulation of macrophage differentiation
|
GO:0045651 |
7 |
0.955
|
|
|
|
positive regulation of protein k63 linked ubiquitination
|
GO:1902523 |
1 |
0.953
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.946
|
|
|
|
positive regulation of protein polyubiquitination
|
GO:1902916 |
3 |
0.944
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.939
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.935
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.933
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.932
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.928
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.924
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.924
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.914
|
Human |
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.908
|
Human |
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.907
|
Human |
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.900
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.893
|
|
|
|
carbohydrate derivative transport
|
GO:1901264 |
20 |
0.890
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.888
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.884
|
Human |
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
15 |
0.875
|
Human |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.870
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.868
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.867
|
|
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
4 |
0.864
|
|
|
|
positive regulation of tumor necrosis factor production
|
GO:0032760 |
21 |
0.862
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.855
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.854
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.851
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.842
|
Human |
|
|
necroptotic process
|
GO:0070266 |
16 |
0.841
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.834
|
Human |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.830
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.828
|
|
|
|
protein linear polyubiquitination
|
GO:0097039 |
5 |
0.823
|
Human |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.810
|
|
|
|
regulation of necrotic cell death
|
GO:0010939 |
9 |
0.805
|
|
|
|
trail activated apoptotic signaling pathway
|
GO:0036462 |
4 |
0.796
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.794
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.785
|
Human |
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.774
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.763
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.741
|
Human |
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.729
|
|
|
|
regulation of nucleoside transport
|
GO:0032242 |
1 |
0.723
|
|
|
|
ripoptosome assembly
|
GO:0097343 |
1 |
0.723
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.716
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.713
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.713
|
Human |
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.703
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.699
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.698
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.691
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.686
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.686
|
Human |
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.683
|
Human |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.681
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.674
|
Human |
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.671
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
6 |
0.670
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.669
|
|
|
|
nucleoside transport
|
GO:0015858 |
8 |
0.663
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.662
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.660
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.657
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.653
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.647
|
Human |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.647
|
Human |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.637
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.637
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.608
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.608
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.605
|
|
|
|
regulation of protein k63 linked ubiquitination
|
GO:1900044 |
6 |
0.604
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.589
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.576
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.574
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.562
|
|
|
|
negative regulation of i kappab kinase nf kappab signaling
|
GO:0043124 |
32 |
0.556
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.555
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.552
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.550
|
Human |
|
|
necrotic cell death
|
GO:0070265 |
21 |
0.544
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.540
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.540
|
Human |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.529
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.517
|
|
|
|
response to lipoteichoic acid
|
GO:0070391 |
3 |
0.514
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.509
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.499
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.496
|
|
|
|
amyloid fibril formation
|
GO:1990000 |
3 |
0.485
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.472
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.472
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.470
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.456
|
|
|
|
positive regulation of interleukin 8 production
|
GO:0032757 |
36 |
0.453
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.452
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.447
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.442
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.434
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.430
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.427
|
|
|
|
er associated ubiquitin dependent protein catabolic process
|
GO:0030433 |
31 |
0.426
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.425
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.414
|
|
|
|
positive regulation of necroptotic process
|
GO:0060545 |
2 |
0.402
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.399
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.394
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.391
|
Human |
|
|
regulation of phosphatase activity
|
GO:0010921 |
81 |
0.389
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.388
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.388
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.380
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.368
|
Human |
|
|
response to lipid
|
GO:0033993 |
206 |
0.368
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.359
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.357
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.357
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.350
|
Human |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.348
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.328
|
Human |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.317
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.316
|
|
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.312
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.311
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.305
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.295
|
Human |
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.288
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.284
|
Human |
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.283
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.281
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.281
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.281
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.269
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.264
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.252
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.247
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.247
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.246
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.245
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.240
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.238
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.237
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.229
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.225
|
|
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
61 |
0.224
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.221
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.220
|
Human |
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.218
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.216
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.215
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.215
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.208
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.208
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.207
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.207
|
|
|
|
response to peptidoglycan
|
GO:0032494 |
3 |
0.201
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
22 |
0.201
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.195
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.194
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
50 |
0.194
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.184
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.183
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.180
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.175
|
|
|
|
negative regulation of g1 s transition of mitotic cell cycle
|
GO:2000134 |
29 |
0.174
|
|
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.167
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.166
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.159
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.157
|
|
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.156
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.156
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.155
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.154
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.154
|
|
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.153
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.153
|
|
|
|
fibril organization
|
GO:0097435 |
10 |
0.151
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.149
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.148
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.146
|
Human |
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.146
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.145
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.142
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.142
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.141
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.138
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.137
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.136
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.132
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.130
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.127
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.125
|
|
|
|
macrophage differentiation
|
GO:0030225 |
11 |
0.124
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.123
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.120
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.119
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.118
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
35 |
0.117
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.116
|
|
|
|
positive regulation of dna binding
|
GO:0043388 |
17 |
0.116
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.115
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.114
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.112
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.108
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.108
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.107
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
49 |
0.107
|
|
|
|
limbic system development
|
GO:0021761 |
3 |
0.107
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.107
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.105
|
|
|
|
response to cobalt ion
|
GO:0032025 |
1 |
0.105
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.105
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.105
|
|
|
|
nucleobase containing compound transport
|
GO:0015931 |
51 |
0.105
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.102
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.100
|
|
|
|
regulation of atp adp antiporter activity
|
GO:0070926 |
1 |
0.096
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.093
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
4 |
0.093
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.091
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.090
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.090
|
|
|
|
mrna metabolic process
|
GO:0016071 |
175 |
0.089
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.089
|
|
|
|
positive regulation of cell cycle arrest
|
GO:0071158 |
23 |
0.088
|
|
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.088
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.087
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.087
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.086
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.086
|
|
|
|
protein deubiquitination
|
GO:0016579 |
79 |
0.081
|
|
|
|
execution phase of apoptosis
|
GO:0097194 |
32 |
0.081
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
19 |
0.080
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.080
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.080
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.079
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.079
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.079
|
|
|
|
regulation of cell cycle arrest
|
GO:0071156 |
36 |
0.078
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.078
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.078
|
|
|
|
mitotic dna damage checkpoint
|
GO:0044773 |
28 |
0.076
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.076
|
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.076
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.075
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.075
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.074
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.072
|
|
|
|
signal transduction involved in dna damage checkpoint
|
GO:0072422 |
15 |
0.072
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.071
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.070
|
Human |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.069
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.069
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.069
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
4 |
0.069
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.068
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.068
|
|
|
|
immature t cell proliferation
|
GO:0033079 |
1 |
0.068
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.067
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.067
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.064
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.063
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.063
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.063
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.063
|
|
|
|
positive regulation of t helper 1 type immune response
|
GO:0002827 |
4 |
0.062
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.062
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.061
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.061
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.061
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
4 |
0.059
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.059
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.058
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.057
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.057
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.056
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.056
|
|
|
|
activated t cell proliferation
|
GO:0050798 |
13 |
0.056
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.055
|
Human |
|
|
positive regulation of peptidyl threonine phosphorylation
|
GO:0010800 |
9 |
0.055
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.054
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
37 |
0.053
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.053
|
|
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.053
|
|
|
|
signal transduction involved in mitotic cell cycle checkpoint
|
GO:0072413 |
13 |
0.053
|
|
|
|
regulation of g1 s transition of mitotic cell cycle
|
GO:2000045 |
40 |
0.053
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.052
|
|
|
|
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest
|
GO:0006977 |
9 |
0.051
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.051
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.051
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.051
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.050
|
|
|
|
mitotic g1 dna damage checkpoint
|
GO:0031571 |
17 |
0.050
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.049
|
|
|
|
positive regulation of phosphatase activity
|
GO:0010922 |
14 |
0.049
|
|
|
|
mitotic dna integrity checkpoint
|
GO:0044774 |
30 |
0.049
|
|
|
|
primary neural tube formation
|
GO:0014020 |
3 |
0.049
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.048
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.048
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.047
|
|
|
|
spliceosomal snrnp assembly
|
GO:0000387 |
28 |
0.047
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.046
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.046
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.046
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.046
|
|
|
|
positive regulation of neuron apoptotic process
|
GO:0043525 |
8 |
0.046
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.045
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.045
|
|
|
|
cellular response to uv
|
GO:0034644 |
32 |
0.045
|
|
|
|
regulation of protein polyubiquitination
|
GO:1902914 |
8 |
0.044
|
|
|
|
negative regulation of protein polyubiquitination
|
GO:1902915 |
4 |
0.044
|
|
|
|
negative regulation of necroptotic process
|
GO:0060546 |
2 |
0.044
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.044
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
21 |
0.044
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.043
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.043
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.042
|
|
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.042
|
|
|
|
nucleotide binding domain leucine rich repeat containing receptor signaling pathway
|
GO:0035872 |
5 |
0.042
|
|
|
|
protein heterooligomerization
|
GO:0051291 |
16 |
0.041
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.041
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.040
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.040
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.040
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.040
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.039
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.039
|
|
|
|
positive regulation of dephosphorylation
|
GO:0035306 |
26 |
0.039
|
|
|
|
histone ubiquitination
|
GO:0016574 |
31 |
0.039
|
|
|
|
male gamete generation
|
GO:0048232 |
22 |
0.038
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.038
|
|
|
|
signal transduction involved in dna integrity checkpoint
|
GO:0072401 |
15 |
0.038
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.038
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.038
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.038
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.038
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.037
|
|
|
|
defense response to gram positive bacterium
|
GO:0050830 |
29 |
0.037
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.037
|
|
|
|
cellular response to glucocorticoid stimulus
|
GO:0071385 |
4 |
0.037
|
|
|
|
substantia nigra development
|
GO:0021762 |
45 |
0.037
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.037
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.037
|
|
|
|
interleukin 2 secretion
|
GO:0070970 |
3 |
0.036
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.036
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.036
|
|
|
|
hippocampus development
|
GO:0021766 |
1 |
0.036
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.036
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.036
|
|
|
|
positive regulation of interleukin 6 production
|
GO:0032755 |
21 |
0.036
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.035
|
|
|
|
interleukin 8 production
|
GO:0032637 |
51 |
0.035
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.035
|
|
|
|
mrna splicing via spliceosome
|
GO:0000398 |
89 |
0.035
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.034
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.034
|
|
|
|
interferon gamma production
|
GO:0032609 |
39 |
0.034
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.034
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.034
|
|
|
|
mitotic g1 s transition checkpoint
|
GO:0044819 |
17 |
0.034
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.034
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.033
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
11 |
0.033
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.033
|
|
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.032
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.032
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.032
|
|
|
|
cerebellum development
|
GO:0021549 |
2 |
0.032
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.031
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.031
|
|
|
|
entry into other organism involved in symbiotic interaction
|
GO:0051828 |
25 |
0.031
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.031
|
|
|
|
positive regulation of protein homodimerization activity
|
GO:0090073 |
5 |
0.031
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.031
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.030
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.030
|
|
|
|
signal transduction in absence of ligand
|
GO:0038034 |
22 |
0.030
|
|
|
|
negative regulation of phosphatase activity
|
GO:0010923 |
61 |
0.030
|
|
|
|
rna splicing
|
GO:0008380 |
131 |
0.029
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.029
|
|
|
|
g1 dna damage checkpoint
|
GO:0044783 |
18 |
0.029
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
26 |
0.029
|
|
|
|
protein stabilization
|
GO:0050821 |
64 |
0.029
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.028
|
|
|
|
rna splicing via transesterification reactions with bulged adenosine as nucleophile
|
GO:0000377 |
89 |
0.028
|
|
|
|
inner ear morphogenesis
|
GO:0042472 |
4 |
0.028
|
|
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.028
|
|
|
|
intracellular mrna localization
|
GO:0008298 |
1 |
0.028
|
|
|
|
regulation of t helper 1 type immune response
|
GO:0002825 |
5 |
0.028
|
|
|
|
intracellular signal transduction involved in g1 dna damage checkpoint
|
GO:1902400 |
10 |
0.028
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.028
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.027
|
|
|
|
protein k48 linked deubiquitination
|
GO:0071108 |
19 |
0.027
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.027
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.027
|
|
|
|
positive regulation of interleukin 1 beta secretion
|
GO:0050718 |
11 |
0.027
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
18 |
0.027
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.027
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.026
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.026
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.026
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.026
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.026
|
|
|
|
negative regulation of dna metabolic process
|
GO:0051053 |
57 |
0.026
|
|
|
|
ribonucleoprotein complex subunit organization
|
GO:0071826 |
81 |
0.026
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.026
|
|
|
|
regulation of t helper 1 cell differentiation
|
GO:0045625 |
1 |
0.026
|
|
|
|
mrna processing
|
GO:0006397 |
133 |
0.026
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.026
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.025
|
|
|
|
head development
|
GO:0060322 |
108 |
0.025
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.025
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.025
|
|
|
|
response to oxygen levels
|
GO:0070482 |
100 |
0.024
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.024
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.024
|
|
|
|
forebrain neuron development
|
GO:0021884 |
2 |
0.024
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.024
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.024
|
|
|
|
fibroblast proliferation
|
GO:0048144 |
33 |
0.024
|
|
|
|
negative regulation of protein k63 linked ubiquitination
|
GO:1900045 |
4 |
0.023
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.023
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.023
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.023
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.023
|
|
|
|
cellular response to toxic substance
|
GO:0097237 |
4 |
0.023
|
|
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.023
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.022
|
|
|
|
coenzyme metabolic process
|
GO:0006732 |
65 |
0.022
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
49 |
0.022
|
|
|
|
release of cytoplasmic sequestered nf kappab
|
GO:0008588 |
4 |
0.022
|
|
|
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
GO:0008631 |
21 |
0.022
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.022
|
|
|
|
skin development
|
GO:0043588 |
76 |
0.021
|
|
|
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.021
|
|
|
|
t cell cytokine production
|
GO:0002369 |
12 |
0.021
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.021
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.021
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.021
|
|
|
|
entry into host
|
GO:0044409 |
25 |
0.021
|
|
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.021
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.021
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.020
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.020
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.020
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.020
|
|
|
|
aging
|
GO:0007568 |
66 |
0.020
|
|
|
|
positive regulation of peptidyl serine phosphorylation
|
GO:0033138 |
42 |
0.020
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
38 |
0.020
|
|
