IMP

Process View

Homo sapiens

8 genes annotated in human

Multi-species View

positive regulation of neuron apoptotic process

GO:0043525

Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of neuron apoptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of neuron apoptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	1.000	Human
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.980	Mouse Rat
BAX	BCL2-associated X protein	0.957
MAPK8	mitogen-activated protein kinase 8	0.951
CREBBP	CREB binding protein	0.945
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.923	Mouse
BCL2L1	BCL2-like 1	0.893	Human
TP53	tumor protein p53	0.891	Zebrafish Mouse
JUN	jun proto-oncogene	0.887	Rat
XIAP	X-linked inhibitor of apoptosis	0.880
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.746
AR	androgen receptor	0.698
BID	BH3 interacting domain death agonist	0.683
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.520
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.495	Rat
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.403	Mouse
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.350
APAF1	apoptotic peptidase activating factor 1	0.343
ATF3	activating transcription factor 3	0.258
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.241
BAD	BCL2-associated agonist of cell death	0.234
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.231
BAK1	BCL2-antagonist/killer 1	0.197	Human
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.135
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.110
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.106
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.103
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.091
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.080
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.080
IER2	immediate early response 2	0.074
LDLR	low density lipoprotein receptor	0.073
ZNF746	zinc finger protein 746	0.066
MEF2A	myocyte enhancer factor 2A	0.064
FAS	Fas (TNF receptor superfamily, member 6)	0.064
KAT2B	K(lysine) acetyltransferase 2B	0.062
NCOA1	nuclear receptor coactivator 1	0.061
TP53BP2	tumor protein p53 binding protein, 2	0.061
DAXX	death-domain associated protein	0.057
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.053
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.050
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.047
BIRC2	baculoviral IAP repeat containing 2	0.046
ESR1	estrogen receptor 1	0.042
ATF2	activating transcription factor 2	0.041
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.040
NCOA2	nuclear receptor coactivator 2	0.038
HUWE1	HECT, UBA and WWE domain containing 1	0.037
CFLAR	CASP8 and FADD-like apoptosis regulator	0.036
APP	amyloid beta (A4) precursor protein	0.034
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.034	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.032
ENG	endoglin	0.031
SMAD4	SMAD family member 4	0.030
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.028	Mouse
TCF4	transcription factor 4	0.027
SH3BP4	SH3-domain binding protein 4	0.027
WASL	Wiskott-Aldrich syndrome-like	0.027
IQGAP1	IQ motif containing GTPase activating protein 1	0.026
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.026	Mouse
IDE	insulin-degrading enzyme	0.026
GSK3B	glycogen synthase kinase 3 beta	0.025
CAV1	caveolin 1, caveolae protein, 22kDa	0.025
FOXO3	forkhead box O3	0.024
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.023
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.023
NBN	nibrin	0.022
MAPK9	mitogen-activated protein kinase 9	0.021
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.020
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.018
S100B	S100 calcium binding protein B	0.018
HSPA1B	heat shock 70kDa protein 1B	0.017
SKA3	spindle and kinetochore associated complex subunit 3	0.017
ATMIN	ATM interactor	0.017
HIPK2	homeodomain interacting protein kinase 2	0.017
KCTD1	potassium channel tetramerisation domain containing 1	0.016
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.016
DBP	D site of albumin promoter (albumin D-box) binding protein	0.016
FANCD2	Fanconi anemia, complementation group D2	0.016
TRIB3	tribbles homolog 3 (Drosophila)	0.015
BTRC	beta-transducin repeat containing	0.015
EP300	E1A binding protein p300	0.015
FADD	Fas (TNFRSF6)-associated via death domain	0.015
DDIT3	DNA-damage-inducible transcript 3	0.015	Mouse
SNAI1	snail homolog 1 (Drosophila)	0.015
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.015
NCOR1	nuclear receptor corepressor 1	0.014
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.014
DLG4	discs, large homolog 4 (Drosophila)	0.014
RHOG	ras homolog gene family, member G (rho G)	0.014
HSPA8	heat shock 70kDa protein 8	0.013
LRRK2	leucine-rich repeat kinase 2	0.013
SKP1	S-phase kinase-associated protein 1	0.013
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.013
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.013
DIABLO	diablo, IAP-binding mitochondrial protein	0.012
NCF4	neutrophil cytosolic factor 4, 40kDa	0.012
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.012
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.012
PPP5C	protein phosphatase 5, catalytic subunit	0.012
BRCA1	breast cancer 1, early onset	0.012
BBC3	BCL2 binding component 3	0.012
PSEN1	presenilin 1	0.011
C4orf14	chromosome 4 open reading frame 14	0.011
TRIP10	thyroid hormone receptor interactor 10	0.011
PML	promyelocytic leukemia	0.011
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.011
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.011
RIPK2	receptor-interacting serine-threonine kinase 2	0.011
RNF144B	ring finger protein 144B	0.011
BAG2	BCL2-associated athanogene 2	0.010
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.010
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.010
CHERP	calcium homeostasis endoplasmic reticulum protein	0.010
TNK2	tyrosine kinase, non-receptor, 2	0.010