IMP

Process View

Homo sapiens

2 genes annotated in human

negative regulation of necroptotic process

Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of necroptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of necroptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.419
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.280
TRAF1	TNF receptor-associated factor 1	0.246
FAS	Fas (TNF receptor superfamily, member 6)	0.190
CFLAR	CASP8 and FADD-like apoptosis regulator	0.116	Mouse
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.112
TRAF6	TNF receptor-associated factor 6	0.059
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.049	Mouse
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.047
BIRC2	baculoviral IAP repeat containing 2	0.044
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.043
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.039
RNF31	ring finger protein 31	0.026
RIPK2	receptor-interacting serine-threonine kinase 2	0.023
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.019
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.018
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.018
TRAF3	TNF receptor-associated factor 3	0.016
EIF4A1	eukaryotic translation initiation factor 4A1	0.016
RIPK3	receptor-interacting serine-threonine kinase 3	0.015
MAPK1	mitogen-activated protein kinase 1	0.013
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.011