Homo sapiens

56 known processes

DOT1L

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

(Aliases: KMT4,DOT1,KIAA1814,DKFZp586P1823)

DOT1L biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
covalent chromatin modification GO:0016569 254 0.976
histone modification GO:0016570 251 0.928
protein acylation GO:0043543 138 0.905
histone acetylation GO:0016573 93 0.861
internal peptidyl lysine acetylation GO:0018393 97 0.779
peptidyl lysine modification GO:0018205 144 0.771
histone h4 k12 acetylation GO:0043983 6 0.751
histone h3 acetylation GO:0043966 45 0.698
regulation of cell cycle process GO:0010564 266 0.692
negative regulation of cell cycle process GO:0010948 121 0.567
protein acetylation GO:0006473 116 0.564
mitotic cell cycle GO:0000278 326 0.542
histone h4 acetylation GO:0043967 47 0.530
histone h4 k8 acetylation GO:0043982 15 0.505
internal protein amino acid acetylation GO:0006475 101 0.501
regulation of mitotic cell cycle GO:0007346 189 0.483
mitotic cell cycle phase transition GO:0044772 162 0.469
negative regulation of cell cycle GO:0045786 193 0.462
chromatin modification GO:0016568 298 0.434
regulation of wnt signaling pathway planar cell polarity pathway GO:2000095 2 0.427
regulation of cell cycle GO:0051726 393 0.402
morphogenesis of a polarized epithelium GO:0001738 3 0.358
negative regulation of mitotic cell cycle GO:0045930 102 0.308
cellular macromolecule catabolic process GO:0044265 380 0.285
chromatin organization GO:0006325 351 0.275
mitotic cell cycle process GO:1903047 286 0.271
nucleotide excision repair GO:0006289 31 0.251
post embryonic development GO:0009791 2 0.247
regulation of cell cycle phase transition GO:1901987 126 0.243
negative regulation of cell cycle phase transition GO:1901988 89 0.240
regulation of mitotic cell cycle phase transition GO:1901990 118 0.236
regulation of cellular amine metabolic process GO:0033238 11 0.234
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.228
regulation of proteasomal protein catabolic process GO:0061136 87 0.224
cell cycle phase transition GO:0044770 173 0.212
chromosome separation GO:0051304 23 0.210
histone h4 k5 acetylation GO:0043981 15 0.197
ubiquitin dependent protein catabolic process GO:0006511 206 0.195
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.193
cellular amine metabolic process GO:0044106 41 0.188
cellular response to dna damage stimulus GO:0006974 379 0.183
chromatin assembly GO:0031497 61 0.178
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.178
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.177
amine metabolic process GO:0009308 44 0.172
negative regulation of cellular catabolic process GO:0031330 83 0.171
chromatin assembly or disassembly GO:0006333 78 0.171
dna replication independent nucleosome organization GO:0034724 27 0.166
nucleosome assembly GO:0006334 50 0.159
negative regulation of cell death GO:0060548 345 0.157
posttranscriptional regulation of gene expression GO:0010608 213 0.157
nucleosome organization GO:0034728 66 0.156
mitotic sister chromatid segregation GO:0000070 53 0.152
cellular ketone metabolic process GO:0042180 80 0.151
cellular macromolecular complex assembly GO:0034622 324 0.151
regulation of mitosis GO:0007088 63 0.144
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.143
negative regulation of catabolic process GO:0009895 104 0.142
negative regulation of protein processing GO:0010955 142 0.138
regulation of cellular protein catabolic process GO:1903362 96 0.125
protein maturation GO:0051604 233 0.122
regulation of chromosome segregation GO:0051983 44 0.122
dna conformation change GO:0071103 113 0.121
sister chromatid segregation GO:0000819 54 0.119
determination of adult lifespan GO:0008340 2 0.118
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.112
dna replication dependent nucleosome assembly GO:0006335 32 0.112
anatomical structure formation involved in morphogenesis GO:0048646 284 0.112
gene silencing GO:0016458 49 0.112
epithelium development GO:0060429 227 0.111
mitotic sister chromatid separation GO:0051306 18 0.111
negative regulation of wnt signaling pathway GO:0030178 69 0.111
cell division GO:0051301 168 0.109
rna interference GO:0016246 4 0.107
cellular amino acid metabolic process GO:0006520 116 0.106
negative regulation of chromosome organization GO:2001251 48 0.104
regulation of mitotic sister chromatid separation GO:0010965 27 0.101
establishment of tissue polarity GO:0007164 3 0.097
segmentation GO:0035282 4 0.095
regulation of cell cycle g1 s phase transition GO:1902806 42 0.094
protein dna complex assembly GO:0065004 64 0.093
negative regulation of protein maturation GO:1903318 142 0.093
dna packaging GO:0006323 77 0.090
establishment of planar polarity GO:0001736 3 0.090
regulation of cell growth GO:0001558 135 0.090
cell cycle checkpoint GO:0000075 117 0.088
regulation of cellular amino acid metabolic process GO:0006521 6 0.088
cellular protein catabolic process GO:0044257 261 0.088
dna repair GO:0006281 198 0.086
mitotic nuclear division GO:0007067 119 0.086
negative regulation of protein metabolic process GO:0051248 391 0.083
regulation of protein maturation GO:1903317 150 0.082
spindle assembly checkpoint GO:0071173 17 0.081
regulation of protein processing GO:0070613 150 0.080
regulation of sister chromatid segregation GO:0033045 27 0.079
negative regulation of cellular component organization GO:0051129 235 0.076
negative regulation of chromosome segregation GO:0051985 18 0.075
modification dependent macromolecule catabolic process GO:0043632 212 0.075
regulation of cell division GO:0051302 116 0.075
regulation of gene expression epigenetic GO:0040029 73 0.074
positive regulation of mapk cascade GO:0043410 190 0.074
negative regulation of programmed cell death GO:0043069 321 0.072
mitotic spindle checkpoint GO:0071174 18 0.071
reproductive process GO:0022414 106 0.071
carbohydrate metabolic process GO:0005975 207 0.071
single organism reproductive process GO:0044702 98 0.071
regulation of canonical wnt signaling pathway GO:0060828 88 0.071
multicellular organismal aging GO:0010259 3 0.070
protein dna complex subunit organization GO:0071824 80 0.069
dna replication independent nucleosome assembly GO:0006336 27 0.068
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.068
organelle fission GO:0048285 149 0.065
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.065
negative regulation of cellular protein metabolic process GO:0032269 353 0.064
modification dependent protein catabolic process GO:0019941 209 0.064
regulation of mitotic sister chromatid segregation GO:0033047 27 0.062
locomotory behavior GO:0007626 1 0.062
regulation of protein catabolic process GO:0042176 155 0.062
proteasomal protein catabolic process GO:0010498 176 0.061
protein processing GO:0016485 226 0.061
protein catabolic process GO:0030163 325 0.061
chromosome segregation GO:0007059 114 0.061
positive regulation of non canonical wnt signaling pathway GO:2000052 3 0.060
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.060
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.060
positive regulation of phosphorylation GO:0042327 394 0.060
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.059
negative regulation of protein catabolic process GO:0042177 59 0.059
dna replication dependent nucleosome organization GO:0034723 32 0.059
organophosphate catabolic process GO:0046434 430 0.059
wnt signaling pathway planar cell polarity pathway GO:0060071 5 0.059
purine ribonucleoside catabolic process GO:0046130 398 0.058
growth GO:0040007 202 0.058
nuclear division GO:0000280 128 0.058
mapk cascade GO:0000165 288 0.058
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.056
cell cycle g1 s phase transition GO:0044843 80 0.055
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.055
regulation of wnt signaling pathway GO:0030111 123 0.054
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.054
membrane organization GO:0061024 292 0.053
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.051
regulation of protein serine threonine kinase activity GO:0071900 179 0.050
oogenesis GO:0048477 2 0.050
regulation of proteolysis GO:0030162 293 0.049
nucleoside phosphate catabolic process GO:1901292 412 0.049
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.049
embryo development GO:0009790 123 0.049
ribonucleotide catabolic process GO:0009261 405 0.048
peptidyl lysine acetylation GO:0018394 101 0.048
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.048
wnt signaling pathway GO:0016055 156 0.047
small gtpase mediated signal transduction GO:0007264 78 0.047
positive regulation of cellular amine metabolic process GO:0033240 7 0.046
positive regulation of cell proliferation GO:0008284 301 0.046
negative regulation of apoptotic process GO:0043066 316 0.044
system process GO:0003008 349 0.044
cellular lipid metabolic process GO:0044255 303 0.044
cell growth GO:0016049 160 0.043
female gamete generation GO:0007292 2 0.043
spindle checkpoint GO:0031577 26 0.043
negative regulation of proteolysis GO:0045861 132 0.042
regulation of protein kinase activity GO:0045859 289 0.042
nucleotide catabolic process GO:0009166 408 0.042
negative regulation of cellular protein catabolic process GO:1903363 38 0.041
tissue morphogenesis GO:0048729 96 0.041
vesicle mediated transport GO:0016192 371 0.041
regulation of establishment of planar polarity GO:0090175 5 0.041
ribonucleoside triphosphate metabolic process GO:0009199 412 0.041
regulation of cell differentiation GO:0045595 393 0.041
signal transduction by phosphorylation GO:0023014 297 0.040
ribonucleoside catabolic process GO:0042454 406 0.039
nucleoside triphosphate metabolic process GO:0009141 422 0.039
defense response GO:0006952 315 0.039
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.039
regulation of locomotion GO:0040012 329 0.039
regulation of purine nucleotide metabolic process GO:1900542 264 0.038
purine containing compound catabolic process GO:0072523 411 0.038
canonical wnt signaling pathway GO:0060070 116 0.037
purine nucleoside triphosphate metabolic process GO:0009144 412 0.037
posttranscriptional gene silencing by rna GO:0035194 25 0.037
glycosyl compound catabolic process GO:1901658 413 0.037
organ morphogenesis GO:0009887 147 0.037
carbohydrate derivative biosynthetic process GO:1901137 207 0.036
regulation of growth GO:0040008 165 0.036
positive regulation of transferase activity GO:0051347 227 0.035
neuromuscular junction development GO:0007528 3 0.035
rho protein signal transduction GO:0007266 26 0.035
developmental process involved in reproduction GO:0003006 66 0.034
peptidyl serine phosphorylation GO:0018105 101 0.034
cell development GO:0048468 328 0.034
regulation of chromosome organization GO:0033044 103 0.034
peptidyl serine modification GO:0018209 106 0.034
regulation of nuclear division GO:0051783 65 0.034
negative regulation of cell proliferation GO:0008285 228 0.033
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.033
regulation of cell motility GO:2000145 299 0.033
positive regulation of developmental process GO:0051094 314 0.033
lipid metabolic process GO:0006629 381 0.032
posttranscriptional gene silencing GO:0016441 25 0.032
cytoplasmic transport GO:0016482 379 0.032
positive regulation of protein kinase activity GO:0045860 190 0.031
single organism cellular localization GO:1902580 332 0.031
protein localization to organelle GO:0033365 280 0.031
single organism carbohydrate metabolic process GO:0044723 193 0.031
histone methylation GO:0016571 60 0.031
regulation of gene silencing GO:0060968 24 0.031
organelle assembly GO:0070925 176 0.030
purine nucleotide catabolic process GO:0006195 405 0.030
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.030
mitotic cell cycle checkpoint GO:0007093 68 0.030
purine nucleoside triphosphate catabolic process GO:0009146 392 0.030
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.030
microtubule based process GO:0007017 210 0.029
positive regulation of wnt signaling pathway GO:0030177 54 0.029
nervous system development GO:0007399 293 0.029
immune response GO:0006955 307 0.029
ras protein signal transduction GO:0007265 73 0.029
blastoderm segmentation GO:0007350 2 0.028
negative regulation of sister chromatid segregation GO:0033046 17 0.028
response to abiotic stimulus GO:0009628 336 0.028
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.028
regulation of kinase activity GO:0043549 314 0.028
response to radiation GO:0009314 151 0.027
reproductive structure development GO:0048608 55 0.027
cardiovascular system development GO:0072358 262 0.027
positive regulation of catabolic process GO:0009896 310 0.027
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.026
regulation of ras protein signal transduction GO:0046578 155 0.026
regulation of mapk cascade GO:0043408 262 0.026
macromolecule methylation GO:0043414 97 0.026
chemical homeostasis GO:0048878 306 0.026
regulation of non canonical wnt signaling pathway GO:2000050 4 0.025
reproduction GO:0000003 63 0.025
positive regulation of protein phosphorylation GO:0001934 313 0.025
response to cytokine GO:0034097 232 0.025
atp metabolic process GO:0046034 176 0.025
cellular chemical homeostasis GO:0055082 180 0.025
protein ubiquitination GO:0016567 314 0.025
intrinsic apoptotic signaling pathway GO:0097193 127 0.024
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.024
purine ribonucleoside metabolic process GO:0046128 437 0.024
positive regulation of gtpase activity GO:0043547 166 0.024
negative regulation of organelle organization GO:0010639 126 0.024
apoptotic signaling pathway GO:0097190 268 0.024
glycosylation GO:0070085 71 0.024
establishment of protein localization to organelle GO:0072594 172 0.024
positive regulation of synaptic transmission GO:0050806 4 0.024
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.024
nucleoside triphosphate catabolic process GO:0009143 394 0.024
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.024
positive regulation of cell growth GO:0030307 48 0.024
positive regulation of map kinase activity GO:0043406 80 0.023
cell fate determination GO:0001709 3 0.023
memory GO:0007613 3 0.023
nucleoside catabolic process GO:0009164 408 0.023
positive regulation of wnt signaling pathway planar cell polarity pathway GO:2000096 2 0.023
negative regulation of mitosis GO:0045839 24 0.022
glycoprotein metabolic process GO:0009100 110 0.022
purine nucleoside monophosphate metabolic process GO:0009126 186 0.022
ribonucleoside monophosphate metabolic process GO:0009161 187 0.022
regulation of organ morphogenesis GO:2000027 24 0.022
regulation of nucleotide metabolic process GO:0006140 269 0.022
negative regulation of phosphate metabolic process GO:0045936 267 0.022
positive regulation of hydrolase activity GO:0051345 331 0.022
mitotic spindle assembly checkpoint GO:0007094 14 0.022
regulation of cellular response to stress GO:0080135 244 0.022
positive regulation of immune system process GO:0002684 283 0.022
negative regulation of cellular amine metabolic process GO:0033239 3 0.021
striated muscle myosin thick filament assembly GO:0071688 2 0.021
immune system development GO:0002520 195 0.021
organonitrogen compound biosynthetic process GO:1901566 200 0.021
morphogenesis of an epithelium GO:0002009 60 0.021
positive regulation of cell migration GO:0030335 172 0.021
methylation GO:0032259 106 0.021
regulation of response to dna damage stimulus GO:2001020 94 0.021
regulation of transferase activity GO:0051338 355 0.021
compound eye development GO:0048749 1 0.020
guanosine containing compound metabolic process GO:1901068 244 0.020
oxidation reduction process GO:0055114 396 0.020
negative regulation of cell division GO:0051782 31 0.020
g1 s transition of mitotic cell cycle GO:0000082 78 0.020
glycoprotein biosynthetic process GO:0009101 91 0.020
extrinsic apoptotic signaling pathway GO:0097191 119 0.020
cell cycle arrest GO:0007050 71 0.020
positive regulation of nucleotide metabolic process GO:0045981 230 0.020
positive regulation of kinase activity GO:0033674 204 0.020
mrna metabolic process GO:0016071 175 0.020
nitrogen compound transport GO:0071705 191 0.020
regulation of cellular component biogenesis GO:0044087 281 0.020
ameboidal type cell migration GO:0001667 135 0.020
tissue migration GO:0090130 119 0.020
regulation of immune response GO:0050776 201 0.020
spermatid development GO:0007286 4 0.019
circulatory system development GO:0072359 262 0.019
regulation of dna metabolic process GO:0051052 153 0.019
peripheral nervous system development GO:0007422 2 0.019
anterior posterior axis specification GO:0009948 2 0.019
oocyte development GO:0048599 1 0.019
spermatid differentiation GO:0048515 4 0.019
gtp catabolic process GO:0006184 237 0.019
cell type specific apoptotic process GO:0097285 125 0.019
peptidyl tyrosine phosphorylation GO:0018108 170 0.019
regulation of chromatin organization GO:1902275 56 0.019
protein methylation GO:0006479 74 0.019
hematopoietic or lymphoid organ development GO:0048534 186 0.019
ribonucleoside triphosphate catabolic process GO:0009203 391 0.019
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.018
tube development GO:0035295 125 0.018
cellular homeostasis GO:0019725 196 0.018
regulation of cell activation GO:0050865 125 0.018
regulation of cell migration GO:0030334 289 0.018
peptidyl tyrosine modification GO:0018212 170 0.018
leukocyte activation GO:0045321 164 0.018
muscle tissue development GO:0060537 62 0.018
purine nucleoside catabolic process GO:0006152 398 0.018
activation of protein kinase activity GO:0032147 90 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
single organism membrane organization GO:0044802 268 0.017
protein localization to membrane GO:0072657 160 0.017
regeneration GO:0031099 4 0.017
development of primary sexual characteristics GO:0045137 35 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.017
cell projection organization GO:0030030 252 0.017
nucleocytoplasmic transport GO:0006913 176 0.017
negative regulation of catalytic activity GO:0043086 335 0.017
apoptotic mitochondrial changes GO:0008637 57 0.017
histone h3 k9 modification GO:0061647 11 0.017
cellular protein complex assembly GO:0043623 188 0.016
regulation of apoptotic signaling pathway GO:2001233 175 0.016
cell activation GO:0001775 213 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
positive regulation of dna metabolic process GO:0051054 73 0.016
regulation of cellular component movement GO:0051270 334 0.016
endomembrane system organization GO:0010256 196 0.016
alcohol metabolic process GO:0006066 114 0.016
reactive nitrogen species metabolic process GO:2001057 3 0.016
tripartite regional subdivision GO:0007351 2 0.016
receptor mediated endocytosis GO:0006898 84 0.016
protein modification by small protein conjugation GO:0032446 342 0.016
epithelial cell migration GO:0010631 119 0.016
regulation of synaptic plasticity GO:0048167 3 0.016
positive regulation of cell death GO:0010942 263 0.016
purine ribonucleotide catabolic process GO:0009154 404 0.016
intracellular protein transport GO:0006886 270 0.016
nucleoside monophosphate catabolic process GO:0009125 159 0.016
myosin filament organization GO:0031033 2 0.016
heart contraction GO:0060047 62 0.015
epithelium migration GO:0090132 119 0.015
gonad development GO:0008406 34 0.015
regulation of gtpase activity GO:0043087 180 0.015
nuclear transport GO:0051169 179 0.015
establishment of protein localization to membrane GO:0090150 121 0.015
regulation of microtubule cytoskeleton organization GO:0070507 61 0.015
protein alkylation GO:0008213 74 0.015
organophosphate biosynthetic process GO:0090407 163 0.015
salivary gland morphogenesis GO:0007435 4 0.015
nucleus localization GO:0051647 1 0.015
regulation of response to external stimulus GO:0032101 222 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
cytokine production GO:0001816 247 0.014
regulation of secretion by cell GO:1903530 177 0.014
associative learning GO:0008306 1 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
regulation of mitochondrion organization GO:0010821 54 0.014
atp catabolic process GO:0006200 157 0.014
metal ion homeostasis GO:0055065 169 0.014
regulation of small gtpase mediated signal transduction GO:0051056 156 0.014
regulation of secretion GO:0051046 194 0.014
regulation of cell adhesion GO:0030155 166 0.014
endocytosis GO:0006897 159 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
regulation of map kinase activity GO:0043405 108 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
myosin filament assembly GO:0031034 2 0.014
anterior posterior axis specification embryo GO:0008595 2 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
protein autophosphorylation GO:0046777 123 0.014
positive regulation of ras gtpase activity GO:0032320 117 0.014
positive regulation of cellular catabolic process GO:0031331 284 0.014
somitogenesis GO:0001756 2 0.014
t cell differentiation in thymus GO:0033077 4 0.014
circadian behavior GO:0048512 2 0.014
dephosphorylation GO:0016311 209 0.014
negative regulation of hydrolase activity GO:0051346 182 0.013
oocyte differentiation GO:0009994 2 0.013
establishment of nucleus localization GO:0040023 1 0.013
response to nitrogen compound GO:1901698 184 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
cell cell signaling GO:0007267 155 0.013
spinal cord development GO:0021510 4 0.013
cellular cation homeostasis GO:0030003 163 0.013
reproductive system development GO:0061458 56 0.013
negative regulation of transferase activity GO:0051348 124 0.013
response to oxygen containing compound GO:1901700 369 0.013
anion transport GO:0006820 161 0.013
sex differentiation GO:0007548 45 0.013
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.013
long term memory GO:0007616 2 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
divalent metal ion transport GO:0070838 152 0.013
meiotic chromosome segregation GO:0045132 4 0.013
response to axon injury GO:0048678 1 0.013
protein localization to chromosome GO:0034502 30 0.013
response to lipid GO:0033993 206 0.013
regulation of lymphocyte activation GO:0051249 103 0.013
regulation of neurotransmitter secretion GO:0046928 3 0.013
cell part morphogenesis GO:0032990 137 0.013
response to other organism GO:0051707 261 0.013
lipid localization GO:0010876 106 0.013
protein targeting GO:0006605 187 0.013
regulation of microtubule based process GO:0032886 74 0.013
rna processing GO:0006396 255 0.013
positive regulation of programmed cell death GO:0043068 249 0.013
positive regulation of cellular component movement GO:0051272 181 0.013
small molecule biosynthetic process GO:0044283 157 0.013
cell differentiation in spinal cord GO:0021515 1 0.013
cellular component morphogenesis GO:0032989 314 0.013
mitochondrion organization GO:0007005 156 0.013
secretion by cell GO:0032940 226 0.013
blood circulation GO:0008015 113 0.013
stem cell division GO:0017145 2 0.012
positive regulation of cell cycle GO:0045787 140 0.012
peptidyl lysine methylation GO:0018022 37 0.012
neuron fate commitment GO:0048663 2 0.012
dna replication GO:0006260 116 0.012
positive regulation of locomotion GO:0040017 186 0.012
endosomal transport GO:0016197 129 0.012
negative regulation of phosphorus metabolic process GO:0010563 267 0.012
regulation of epithelial cell migration GO:0010632 93 0.012
phototransduction GO:0007602 3 0.012
actin cytoskeleton organization GO:0030036 207 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
engulfment of apoptotic cell GO:0043652 2 0.012
positive regulation of secretion by cell GO:1903532 108 0.012
sex determination GO:0007530 3 0.012
regulation of cell development GO:0060284 161 0.012
myoblast fusion GO:0007520 1 0.012
motor neuron axon guidance GO:0008045 2 0.012
immune response regulating signaling pathway GO:0002764 97 0.012
circulatory system process GO:0003013 113 0.012
rna splicing GO:0008380 131 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.012
negative regulation of apoptotic signaling pathway GO:2001234 97 0.012
cdc42 protein signal transduction GO:0032488 4 0.012
neurotransmitter secretion GO:0007269 4 0.012
multi organism reproductive process GO:0044703 54 0.012
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.012
positive regulation of proteolysis GO:0045862 142 0.012
neuron projection regeneration GO:0031102 1 0.012
tube morphogenesis GO:0035239 95 0.012
innate immune response GO:0045087 178 0.012
telomere maintenance GO:0000723 32 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
rrna transcription GO:0009303 9 0.012
endothelial cell migration GO:0043542 86 0.012
activation of mapk activity GO:0000187 45 0.011
vasculature development GO:0001944 181 0.011
actin mediated cell contraction GO:0070252 12 0.011
syncytium formation by plasma membrane fusion GO:0000768 2 0.011
sequestering of metal ion GO:0051238 24 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
synaptic transmission GO:0007268 61 0.011
neural tube formation GO:0001841 3 0.011
regulation of protein complex assembly GO:0043254 147 0.011
regulation of endopeptidase activity GO:0052548 170 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
response to inorganic substance GO:0010035 127 0.011

DOT1L disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.034
cancer DOID:162 167 0.027
immune system disease DOID:2914 155 0.027
organ system cancer DOID:0050686 164 0.024
myopathy DOID:423 104 0.022
muscular disease DOID:0080000 114 0.022
musculoskeletal system disease DOID:17 223 0.022
muscle tissue disease DOID:66 113 0.022
disease of metabolism DOID:0014667 295 0.022
sensory system disease DOID:0050155 203 0.018
nervous system disease DOID:863 431 0.018
neuropathy DOID:870 52 0.017
central nervous system disease DOID:331 186 0.015
heart disease DOID:114 68 0.015
cardiovascular system disease DOID:1287 106 0.015
neuromuscular disease DOID:440 38 0.013
eye and adnexa disease DOID:1492 150 0.012
eye disease DOID:5614 149 0.012
brain disease DOID:936 73 0.012
retinal disease DOID:5679 118 0.012
integumentary system disease DOID:16 43 0.012
neurodegenerative disease DOID:1289 102 0.011