IMP

Process View

Homo sapiens

24 genes annotated in human

negative regulation of mitosis

Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of mitosis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of mitosis" (in gray)

Name	Description	Probability	Func Analog Organism
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.767	Fly
CDK2	cyclin-dependent kinase 2	0.695
TOLLIP	toll interacting protein	0.632
ANAPC7	anaphase promoting complex subunit 7	0.528
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.474
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.463	Yeast
CCNA2	cyclin A2	0.281
CCNB1	cyclin B1	0.224
FGF1	fibroblast growth factor 1 (acidic)	0.166
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.166
BMPR1A	bone morphogenetic protein receptor, type IA	0.162
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.126	Yeast
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.122	Yeast
BCL2L1	BCL2-like 1	0.095
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.089	Worm Fly
SKA1	spindle and kinetochore associated complex subunit 1	0.076
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.073
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.067
BRCA2	breast cancer 2, early onset	0.061
AURKB	aurora kinase B	0.059
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.057
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.054
ANAPC4	anaphase promoting complex subunit 4	0.048
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.048
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.047	Yeast
BMPR1B	bone morphogenetic protein receptor, type IB	0.046
MDC1	mediator of DNA-damage checkpoint 1	0.043
ORC2	origin recognition complex, subunit 2	0.042
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.041
SKA3	spindle and kinetochore associated complex subunit 3	0.039
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.039
HUWE1	HECT, UBA and WWE domain containing 1	0.037
SKP2	S-phase kinase-associated protein 2 (p45)	0.036
SMC3	structural maintenance of chromosomes 3	0.036
ANAPC11	anaphase promoting complex subunit 11	0.036
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.034
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.034
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.034
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.033
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.031
H2AFX	H2A histone family, member X	0.031
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.030
SKA2	spindle and kinetochore associated complex subunit 2	0.030
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.028
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.028
ORC1	origin recognition complex, subunit 1	0.027
CLSPN	claspin	0.027
ZWINT	ZW10 interactor	0.026
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.026
NOG	noggin	0.025
ATAD2	ATPase family, AAA domain containing 2	0.023
RFWD2	ring finger and WD repeat domain 2	0.023
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.023
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.023
FGF10	fibroblast growth factor 10	0.023
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.023
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.022
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.022
KAT5	K(lysine) acetyltransferase 5	0.022
FSTL1	follistatin-like 1	0.022
CREBBP	CREB binding protein	0.022
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.021
FANCD2	Fanconi anemia, complementation group D2	0.021
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.021
CDT1	chromatin licensing and DNA replication factor 1	0.021
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.021
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.021
FBXO5	F-box protein 5	0.020
BTRC	beta-transducin repeat containing	0.019
HERC2	hect domain and RLD 2	0.019
TP53BP1	tumor protein p53 binding protein 1	0.018
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.018
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.017
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.017
CCNB2	cyclin B2	0.017
RAD52	RAD52 homolog (S. cerevisiae)	0.017
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.017
FXR2	fragile X mental retardation, autosomal homolog 2	0.017
ATF5	activating transcription factor 5	0.017
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.017
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.016
CCND3	cyclin D3	0.016
TOP3A	topoisomerase (DNA) III alpha	0.016
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.016
ZFYVE9	zinc finger, FYVE domain containing 9	0.016
PPME1	protein phosphatase methylesterase 1	0.015
KIF18A	kinesin family member 18A	0.015
PRNP	prion protein	0.015
PLK1	polo-like kinase 1	0.015
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.015
CCND1	cyclin D1	0.015
SGOL2	shugoshin-like 2 (S. pombe)	0.014
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.014
PPP5C	protein phosphatase 5, catalytic subunit	0.014
C13orf34	chromosome 13 open reading frame 34	0.014
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.014
MYST1	MYST histone acetyltransferase 1	0.014
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.013
FGFR2	fibroblast growth factor receptor 2	0.013	Mouse
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.013
HIST1H4A	histone cluster 1, H4a	0.013
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.013
RAD51AP1	RAD51 associated protein 1	0.012
KDM4A	lysine (K)-specific demethylase 4A	0.012
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.012
KRT8	keratin 8	0.012
RBL1	retinoblastoma-like 1 (p107)	0.012
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.012
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.012
RAD21	RAD21 homolog (S. pombe)	0.012
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.012
BLM	Bloom syndrome, RecQ helicase-like	0.012
BMP2	bone morphogenetic protein 2	0.012	Human
FGFR1	fibroblast growth factor receptor 1	0.012
LMNA	lamin A/C	0.012
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.012
DBF4	DBF4 homolog (S. cerevisiae)	0.012
ATMIN	ATM interactor	0.011
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.011
STAG1	stromal antigen 1	0.011
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.011
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.011
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.011	Yeast
NOMO1	NODAL modulator 1	0.011
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.011	Fly
L3MBTL1	l(3)mbt-like 1 (Drosophila)	0.011
TACC2	transforming, acidic coiled-coil containing protein 2	0.010
ATM	ataxia telangiectasia mutated	0.010
KIF5B	kinesin family member 5B	0.010
TCF4	transcription factor 4	0.010
CKS2	CDC28 protein kinase regulatory subunit 2	0.010
HIST1H1E	histone cluster 1, H1e	0.010
CDKN3	cyclin-dependent kinase inhibitor 3	0.010
BCL2	B-cell CLL/lymphoma 2	0.010
COL2A1	collagen, type II, alpha 1	0.010
CASC5	cancer susceptibility candidate 5	0.010
SRRM2	serine/arginine repetitive matrix 2	0.010