|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.960
|
Human Mouse |
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.949
|
Human |
|
|
mast cell degranulation
|
GO:0043303 |
4 |
0.946
|
Mouse |
|
|
immune system development
|
GO:0002520 |
195 |
0.939
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.890
|
Human Mouse |
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.872
|
Human Mouse |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.867
|
Human |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.866
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.813
|
Human |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.796
|
Human |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.779
|
Human |
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.759
|
Human Mouse |
|
|
serotonin transport
|
GO:0006837 |
3 |
0.751
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.714
|
Human |
|
|
serotonin secretion
|
GO:0001820 |
1 |
0.710
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.700
|
Human Mouse |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.694
|
Human Mouse |
|
|
cell activation
|
GO:0001775 |
213 |
0.684
|
Human Mouse |
|
|
granulocyte migration
|
GO:0097530 |
40 |
0.680
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.661
|
Human |
|
|
gamma delta t cell activation
|
GO:0046629 |
3 |
0.657
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.648
|
Mouse |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.646
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.636
|
|
|
|
exocytosis
|
GO:0006887 |
71 |
0.634
|
Mouse |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.634
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.627
|
Human Mouse |
|
|
response to other organism
|
GO:0051707 |
261 |
0.613
|
Mouse |
|
|
regulation of mast cell degranulation
|
GO:0043304 |
3 |
0.608
|
Mouse |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.590
|
Human Mouse |
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
28 |
0.570
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.570
|
Human Fly |
|
|
leukotriene metabolic process
|
GO:0006691 |
10 |
0.569
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.569
|
Mouse |
|
|
positive regulation of granulocyte macrophage colony stimulating factor production
|
GO:0032725 |
4 |
0.567
|
|
|
|
positive regulation of myeloid leukocyte mediated immunity
|
GO:0002888 |
1 |
0.558
|
Mouse |
|
|
positive regulation of mast cell activation
|
GO:0033005 |
2 |
0.548
|
Mouse |
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.544
|
Human Mouse |
|
|
regulation of mast cell activation
|
GO:0033003 |
5 |
0.543
|
Mouse |
|
|
mast cell activation involved in immune response
|
GO:0002279 |
4 |
0.529
|
Mouse |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.527
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.524
|
Human |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.514
|
Human |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.511
|
Human Fly |
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.502
|
Human Fly |
|
|
phagocytosis recognition
|
GO:0006910 |
3 |
0.493
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.492
|
Human Fly |
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.486
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.477
|
Human |
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.476
|
Human |
|
|
macrophage activation involved in immune response
|
GO:0002281 |
1 |
0.471
|
|
|
|
myeloid leukocyte migration
|
GO:0097529 |
62 |
0.463
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.456
|
Fly |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.452
|
Human Mouse |
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.446
|
Mouse |
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.439
|
Human |
|
|
granulocyte chemotaxis
|
GO:0071621 |
37 |
0.434
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.430
|
Human Mouse |
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.428
|
Human Mouse |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.428
|
|
|
|
leukotriene biosynthetic process
|
GO:0019370 |
6 |
0.427
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
34 |
0.414
|
Mouse |
|
|
positive regulation of cytoskeleton organization
|
GO:0051495 |
83 |
0.414
|
Human |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.410
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.407
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.404
|
Human Mouse |
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.399
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.398
|
Human |
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.396
|
Human Mouse |
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.388
|
|
|
|
menstrual cycle phase
|
GO:0022601 |
2 |
0.388
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.383
|
Human |
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.383
|
Mouse |
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.379
|
Human |
|
|
innate immune response
|
GO:0045087 |
178 |
0.354
|
Human Mouse |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.351
|
Human Fly |
|
|
t cell activation
|
GO:0042110 |
99 |
0.346
|
Human |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.345
|
Human Mouse |
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.340
|
Fly |
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.337
|
Human |
|
|
cell development
|
GO:0048468 |
328 |
0.335
|
Human Fly |
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.333
|
Mouse |
|
|
cation transport
|
GO:0006812 |
331 |
0.329
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.324
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.323
|
Human Fly |
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.321
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.321
|
Human |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.319
|
Human |
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.316
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.313
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
56 |
0.310
|
Fly |
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.307
|
Mouse |
|
|
immune effector process
|
GO:0002252 |
159 |
0.307
|
Mouse |
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.307
|
Human Mouse |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.297
|
Fly |
|
|
regulation of blood coagulation
|
GO:0030193 |
42 |
0.295
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.282
|
Human Mouse |
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.281
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.281
|
Mouse |
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.280
|
Human |
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.279
|
Human Mouse |
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.279
|
Human |
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.276
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.271
|
Human |
|
|
secretion
|
GO:0046903 |
254 |
0.270
|
Human Mouse |
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.267
|
Mouse |
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.267
|
Human Mouse |
|
|
regulation of actin filament length
|
GO:0030832 |
56 |
0.260
|
Fly |
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.259
|
Human |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.257
|
Worm Fly |
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.253
|
Human |
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.252
|
Human |
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.248
|
Human Fly |
|
|
positive regulation of immunoglobulin mediated immune response
|
GO:0002891 |
4 |
0.246
|
|
|
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.245
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
24 |
0.245
|
Mouse |
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.245
|
Human |
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.244
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.243
|
Human |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.242
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.242
|
Human |
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.242
|
Human |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.241
|
|
|
|
neutrophil migration
|
GO:1990266 |
25 |
0.239
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.235
|
Human |
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.234
|
Human |
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.230
|
Mouse |
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.229
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.228
|
Human |
|
|
cellular transition metal ion homeostasis
|
GO:0046916 |
21 |
0.224
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.224
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.218
|
Human Fly |
|
|
regulation of myeloid leukocyte mediated immunity
|
GO:0002886 |
4 |
0.217
|
Mouse |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.216
|
Human |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.214
|
Human |
|
|
actin filament polymerization
|
GO:0030041 |
45 |
0.214
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.212
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.211
|
Human |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.210
|
Human |
|
|
positive regulation of acute inflammatory response
|
GO:0002675 |
2 |
0.209
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.206
|
Human |
|
|
long term memory
|
GO:0007616 |
2 |
0.205
|
Fly |
|
|
oogenesis
|
GO:0048477 |
2 |
0.203
|
Fly |
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.201
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.196
|
Human |
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.194
|
Human |
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.194
|
Fly |
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.190
|
|
|
|
platelet degranulation
|
GO:0002576 |
2 |
0.189
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.188
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.185
|
Human |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.184
|
Human |
|
|
memory
|
GO:0007613 |
3 |
0.184
|
Fly |
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
56 |
0.181
|
Fly |
|
|
actin filament organization
|
GO:0007015 |
128 |
0.180
|
Human Fly |
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.180
|
Human |
|
|
inflammatory response
|
GO:0006954 |
79 |
0.180
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.180
|
Fly |
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.180
|
Human |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.178
|
Mouse |
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.172
|
Human Mouse |
|
|
tyrosine phosphorylation of stat3 protein
|
GO:0042503 |
20 |
0.170
|
Human |
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.168
|
Mouse |
|
|
regulation of leukocyte migration
|
GO:0002685 |
63 |
0.168
|
|
|
|
regulation of platelet aggregation
|
GO:0090330 |
4 |
0.168
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
59 |
0.167
|
|
|
|
interferon gamma mediated signaling pathway
|
GO:0060333 |
7 |
0.167
|
Human |
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.167
|
|
|
|
regulation of gamma delta t cell activation
|
GO:0046643 |
1 |
0.166
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.165
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.165
|
Human |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.165
|
Human |
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.163
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.162
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.161
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.161
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.161
|
Fly |
|
|
platelet activation
|
GO:0030168 |
44 |
0.161
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.159
|
Human |
|
|
regulation of acute inflammatory response to antigenic stimulus
|
GO:0002864 |
1 |
0.159
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.159
|
|
|
|
unsaturated fatty acid metabolic process
|
GO:0033559 |
37 |
0.159
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.158
|
Human |
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.158
|
|
|
|
fc receptor signaling pathway
|
GO:0038093 |
2 |
0.158
|
|
|
|
neutrophil activation involved in immune response
|
GO:0002283 |
3 |
0.156
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.156
|
Human |
|
|
maintenance of location
|
GO:0051235 |
112 |
0.154
|
|
|
|
regulation of mast cell activation involved in immune response
|
GO:0033006 |
3 |
0.154
|
Mouse |
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.154
|
Mouse |
|
|
zymogen activation
|
GO:0031638 |
70 |
0.154
|
Human |
|
|
caveolin mediated endocytosis
|
GO:0072584 |
4 |
0.153
|
Human |
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.152
|
Human Mouse Fly |
|
|
regulation of humoral immune response mediated by circulating immunoglobulin
|
GO:0002923 |
3 |
0.151
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.150
|
Human |
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.149
|
Human Mouse |
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.147
|
|
|
|
negative regulation of mitochondrial depolarization
|
GO:0051902 |
2 |
0.146
|
Human |
|
|
arachidonic acid secretion
|
GO:0050482 |
7 |
0.146
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.146
|
Human |
|
|
organic hydroxy compound transport
|
GO:0015850 |
63 |
0.146
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.144
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.142
|
|
|
|
regulation of protein oligomerization
|
GO:0032459 |
26 |
0.141
|
Human |
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.139
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.136
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.135
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.134
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.134
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.134
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.133
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.132
|
|
|
|
regulation of coagulation
|
GO:0050818 |
44 |
0.131
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.131
|
Human |
|
|
system process
|
GO:0003008 |
349 |
0.131
|
Fly |
|
|
positive regulation of b cell differentiation
|
GO:0045579 |
1 |
0.131
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.129
|
Human |
|
|
acute inflammatory response to antigenic stimulus
|
GO:0002438 |
1 |
0.129
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.128
|
Human Mouse |
|
|
secretion by cell
|
GO:0032940 |
226 |
0.125
|
Human Mouse |
|
|
regulation of sequestering of calcium ion
|
GO:0051282 |
41 |
0.125
|
|
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.125
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
44 |
0.125
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.124
|
Human |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.123
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.122
|
Human |
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.122
|
|
|
|
positive regulation of actin filament polymerization
|
GO:0030838 |
38 |
0.122
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.121
|
Human Mouse Fly |
|
|
regulation of calcium mediated signaling
|
GO:0050848 |
17 |
0.121
|
|
|
|
positive regulation of exocytosis
|
GO:0045921 |
35 |
0.118
|
Mouse |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.118
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.118
|
Human |
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.117
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.117
|
Human |
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.116
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.115
|
Human |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.115
|
Human |
|
|
nerve development
|
GO:0021675 |
4 |
0.114
|
|
|
|
stress fiber assembly
|
GO:0043149 |
40 |
0.114
|
Human |
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
33 |
0.113
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.113
|
Human |
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.112
|
Human Mouse |
|
|
positive regulation of leukocyte chemotaxis
|
GO:0002690 |
38 |
0.111
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
30 |
0.110
|
Mouse |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.110
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
41 |
0.110
|
Human |
|
|
lipoxygenase pathway
|
GO:0019372 |
4 |
0.109
|
|
|
|
coagulation
|
GO:0050817 |
78 |
0.109
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.107
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.107
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.106
|
Fly |
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
33 |
0.106
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.105
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.105
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.104
|
Human Mouse |
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.104
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.103
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.103
|
|
|
|
leukocyte chemotaxis
|
GO:0030595 |
76 |
0.101
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.101
|
|
|
|
hemostasis
|
GO:0007599 |
76 |
0.100
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.100
|
Human |
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.099
|
|
|
|
regulation of regulated secretory pathway
|
GO:1903305 |
10 |
0.099
|
Mouse |
|
|
early endosome to late endosome transport
|
GO:0045022 |
21 |
0.098
|
Human |
|
|
regulation of interferon gamma production
|
GO:0032649 |
36 |
0.098
|
Human |
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.098
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.097
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.097
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.097
|
Human |
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.097
|
Mouse |
|
|
interferon gamma production
|
GO:0032609 |
39 |
0.096
|
Human |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.095
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.094
|
Human Mouse |
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.093
|
Human Fly |
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.092
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.092
|
Human |
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.090
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.089
|
Human |
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.089
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.089
|
Mouse |
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.089
|
Human |
|
|
response to hormone
|
GO:0009725 |
175 |
0.088
|
|
|
|
neutrophil chemotaxis
|
GO:0030593 |
24 |
0.088
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.088
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.087
|
Human |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.087
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.087
|
Human Mouse |
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.087
|
Human |
|
|
homotypic cell cell adhesion
|
GO:0034109 |
47 |
0.086
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.085
|
Human |
|
|
regulation of response to interferon gamma
|
GO:0060330 |
7 |
0.085
|
Human |
|
|
inflammatory response to antigenic stimulus
|
GO:0002437 |
4 |
0.085
|
|
|
|
actin filament bundle organization
|
GO:0061572 |
54 |
0.085
|
Human Fly |
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.084
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.084
|
Mouse |
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.084
|
|
|
|
regulation of hemostasis
|
GO:1900046 |
42 |
0.084
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.083
|
Human Mouse |
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.082
|
Human |
|
|
positive regulation of gamma delta t cell activation
|
GO:0046645 |
1 |
0.082
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.081
|
Human |
|
|
neurological system process
|
GO:0050877 |
163 |
0.080
|
Fly |
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.080
|
Human |
|
|
salivary gland morphogenesis
|
GO:0007435 |
4 |
0.080
|
Fly |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.080
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.079
|
Human Fly |
|
|
positive regulation of cytokine mediated signaling pathway
|
GO:0001961 |
12 |
0.078
|
Human |
|
|
icosanoid metabolic process
|
GO:0006690 |
35 |
0.078
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.078
|
|
|
|
negative regulation of myeloid cell apoptotic process
|
GO:0033033 |
4 |
0.078
|
|
|
|
mast cell activation
|
GO:0045576 |
6 |
0.077
|
Mouse |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.077
|
Human |
|
|
positive regulation of response to interferon gamma
|
GO:0060332 |
2 |
0.077
|
Human |
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.076
|
Human |
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.076
|
|
|
|
myeloid cell activation involved in immune response
|
GO:0002275 |
10 |
0.074
|
Mouse |
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.073
|
Human |
|
|
cell projection organization
|
GO:0030030 |
252 |
0.072
|
Human Fly |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.071
|
Human |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.070
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.070
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.070
|
Human Mouse |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.070
|
Human |
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.069
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.069
|
Human |
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.068
|
|
|
|
positive regulation of interferon gamma production
|
GO:0032729 |
26 |
0.068
|
Human |
|
|
organic acid biosynthetic process
|
GO:0016053 |
97 |
0.068
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.067
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.067
|
Human |
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.067
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.067
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.067
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.065
|
Mouse Worm |
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.065
|
Human |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.065
|
Human |
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.064
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.064
|
Human |
|
|
amide transport
|
GO:0042886 |
76 |
0.064
|
Human |
|
|
endosomal transport
|
GO:0016197 |
129 |
0.063
|
Human |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.063
|
Fly |
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.063
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.062
|
Human Fly |
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.062
|
Human |
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.062
|
Human |
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.062
|
Human |
|
|
positive regulation of leukocyte degranulation
|
GO:0043302 |
3 |
0.062
|
Mouse |
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.061
|
Human |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.061
|
Fly |
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.061
|
Mouse |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.060
|
Human |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.060
|
Human |
|
|
oocyte development
|
GO:0048599 |
1 |
0.060
|
|
|
|
myeloid leukocyte mediated immunity
|
GO:0002444 |
10 |
0.060
|
Mouse |
|
|
monoamine transport
|
GO:0015844 |
10 |
0.060
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.060
|
Human |
|
|
epithelium development
|
GO:0060429 |
227 |
0.059
|
Fly |
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.059
|
Human |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.058
|
Human Mouse |
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
19 |
0.058
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.057
|
|
|
|
hepoxilin metabolic process
|
GO:0051121 |
1 |
0.057
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.057
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.056
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.056
|
Fly |
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.055
|
Human |
|
|
circulatory system process
|
GO:0003013 |
113 |
0.055
|
|
|
|
leukocyte degranulation
|
GO:0043299 |
11 |
0.055
|
Mouse |
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.055
|
Human |
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.055
|
Mouse |
|
|
myeloid cell homeostasis
|
GO:0002262 |
34 |
0.055
|
|
|
|
phospholipase c activating g protein coupled receptor signaling pathway
|
GO:0007200 |
15 |
0.054
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.054
|
Human |
|
|
negative regulation of interleukin 10 production
|
GO:0032693 |
7 |
0.054
|
|
|
|
t cell selection
|
GO:0045058 |
4 |
0.054
|
|
|
|
regulation of acute inflammatory response
|
GO:0002673 |
13 |
0.054
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.054
|
Human |
|
|
carboxylic acid biosynthetic process
|
GO:0046394 |
97 |
0.054
|
|
|
|
regulation of leukocyte degranulation
|
GO:0043300 |
6 |
0.054
|
Mouse |
|
|
azole transport
|
GO:0045117 |
4 |
0.054
|
|
|
|
lipid localization
|
GO:0010876 |
106 |
0.053
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.053
|
Human |
|
|
regulation of neutrophil activation
|
GO:1902563 |
1 |
0.053
|
|
|
|
negative regulation of activation of jak2 kinase activity
|
GO:1902569 |
1 |
0.053
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.051
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.051
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
23 |
0.051
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.051
|
Human Mouse Fly |
|
|
metal ion transport
|
GO:0030001 |
272 |
0.051
|
|
|
|
blood coagulation
|
GO:0007596 |
76 |
0.051
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.050
|
Human |
|
|
response to drug
|
GO:0042493 |
81 |
0.050
|
Human |
|
|
complement receptor mediated signaling pathway
|
GO:0002430 |
3 |
0.050
|
|
|
|
acute inflammatory response
|
GO:0002526 |
21 |
0.050
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.050
|
Human |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.049
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.049
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
4 |
0.049
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.049
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.048
|
|
|
|
mast cell mediated immunity
|
GO:0002448 |
5 |
0.048
|
Mouse |
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.048
|
Human |
|
|
regulation of membrane depolarization
|
GO:0003254 |
19 |
0.048
|
Human |
|
|
immunoglobulin transcytosis in epithelial cells
|
GO:0002414 |
1 |
0.048
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.048
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.048
|
|
|
|
positive regulation of mononuclear cell proliferation
|
GO:0032946 |
47 |
0.048
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.048
|
Human |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.047
|
|
|
|
regulation of lipid kinase activity
|
GO:0043550 |
19 |
0.047
|
|
|
|
positive regulation of regulated secretory pathway
|
GO:1903307 |
8 |
0.046
|
Mouse |
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.046
|
|
|
|
cellular response to interferon gamma
|
GO:0071346 |
24 |
0.046
|
Human |
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.046
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.046
|
|
|
|
icosanoid transport
|
GO:0071715 |
11 |
0.045
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.045
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.045
|
Mouse |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.045
|
Human |
|
|
endoderm development
|
GO:0007492 |
33 |
0.045
|
Worm |
|
|
platelet aggregation
|
GO:0070527 |
32 |
0.044
|
|
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.044
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.044
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.044
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.044
|
Human |
|
|
regulation of hormone secretion
|
GO:0046883 |
57 |
0.044
|
Human |
|
|
transition metal ion homeostasis
|
GO:0055076 |
31 |
0.044
|
Human |
|
|
positive regulation of lipid kinase activity
|
GO:0090218 |
13 |
0.044
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.044
|
|
|
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
41 |
0.043
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.043
|
Human |
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.043
|
|
|
|
negative regulation of sequestering of calcium ion
|
GO:0051283 |
41 |
0.043
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.043
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.043
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.043
|
|
|
|
positive regulation of tyrosine phosphorylation of stat protein
|
GO:0042531 |
28 |
0.043
|
|
|
|
regulation of cell shape
|
GO:0008360 |
48 |
0.043
|
Human Mouse |
|
|
epithelial cell cell adhesion
|
GO:0090136 |
7 |
0.042
|
Fly |
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.042
|
Human |
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.042
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.042
|
Human |
|
|
unsaturated fatty acid biosynthetic process
|
GO:0006636 |
21 |
0.041
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.041
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.041
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.041
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.041
|
Worm |
|
|
hormone transport
|
GO:0009914 |
68 |
0.041
|
Human |
|
|
segmentation
|
GO:0035282 |
4 |
0.040
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.040
|
|
|
|
zinc ion homeostasis
|
GO:0055069 |
12 |
0.040
|
Human |
|
|
negative regulation of platelet aggregation
|
GO:0090331 |
3 |
0.040
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.039
|
Human |
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.039
|
Human |
|
|
sensory perception of smell
|
GO:0007608 |
2 |
0.039
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.039
|
Human |
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.038
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.038
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.038
|
|
|
|
regulation of mitochondrial membrane potential
|
GO:0051881 |
23 |
0.038
|
Human |
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.038
|
Human |
|
|
protein processing
|
GO:0016485 |
226 |
0.038
|
Human |
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.038
|
Human |
|
|
growth
|
GO:0040007 |
202 |
0.038
|
Fly |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.038
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
54 |
0.037
|
Human Fly |
|
|
negative regulation of leukocyte apoptotic process
|
GO:2000107 |
16 |
0.037
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.037
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.037
|
Human |
|
|
microtubule based process
|
GO:0007017 |
210 |
0.037
|
Worm |
|
|
sensory perception
|
GO:0007600 |
103 |
0.036
|
|
|
|
b cell activation
|
GO:0042113 |
33 |
0.036
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.036
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.036
|
Human Fly |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.036
|
|
|
|
regulation of cytokinesis
|
GO:0032465 |
45 |
0.036
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.036
|
|
|
|
fatty acid derivative transport
|
GO:1901571 |
11 |
0.036
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.036
|
|
|
|
granulocyte activation
|
GO:0036230 |
10 |
0.036
|
|
|
|
regulation of podosome assembly
|
GO:0071801 |
5 |
0.036
|
Human |
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.035
|
|
|
|
positive regulation of endocytosis
|
GO:0045807 |
42 |
0.035
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.035
|
|
|
|
integrin mediated signaling pathway
|
GO:0007229 |
32 |
0.035
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.035
|
Fly |
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.035
|
|
|
|
regulation of insulin secretion
|
GO:0050796 |
33 |
0.035
|
Human |
