IMP

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Homo sapiens

21 genes annotated in human

early endosome to late endosome transport

The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "early endosome to late endosome transport"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "early endosome to late endosome transport" (in gray)

Name	Description	Probability	Func Analog Organism
FYN	FYN oncogene related to SRC, FGR, YES	1.000	Human
PDCD6IP	programmed cell death 6 interacting protein	0.992
VTI1B	vesicle transport through interaction with t-SNAREs homolog 1B (yeast)	0.903
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.776
SH3KBP1	SH3-domain kinase binding protein 1	0.737
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.612
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.554
CLASP1	cytoplasmic linker associated protein 1	0.540
WIPF1	WAS/WASL interacting protein family, member 1	0.500
PDCD6	programmed cell death 6	0.498
AKTIP	AKT interacting protein	0.455
HCK	hemopoietic cell kinase	0.444	Human
CHMP4B	chromatin modifying protein 4B	0.425
FLNB	filamin B, beta	0.412
FN1	fibronectin 1	0.395
LCK	lymphocyte-specific protein tyrosine kinase	0.392	Human
BECN1	beclin 1, autophagy related	0.384
VAMP7	vesicle-associated membrane protein 7	0.310
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.280
TSG101	tumor susceptibility gene 101	0.277	Worm
BLNK	B-cell linker	0.263
HOOK3	hook homolog 3 (Drosophila)	0.244
SH3GL2	SH3-domain GRB2-like 2	0.244
QKI	quaking homolog, KH domain RNA binding (mouse)	0.230
CD2AP	CD2-associated protein	0.191
CEP55	centrosomal protein 55kDa	0.140
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.132
STX7	syntaxin 7	0.118
CHMP1A	chromatin modifying protein 1A	0.117
GAS7	growth arrest-specific 7	0.101
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.098	Human
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.091
NCK1	NCK adaptor protein 1	0.089
GRB2	growth factor receptor-bound protein 2	0.088
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.086
ARL8B	ADP-ribosylation factor-like 8B	0.085
EEA1	early endosome antigen 1	0.081
SYK	spleen tyrosine kinase	0.079
EIF1B	eukaryotic translation initiation factor 1B	0.072
PTK2	PTK2 protein tyrosine kinase 2	0.070
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.069
MYO6	myosin VI	0.064
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.052
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.050
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.049
UVRAG	UV radiation resistance associated gene	0.048
GOLGA7	golgin A7	0.047
LRP6	low density lipoprotein receptor-related protein 6	0.047
RASAL2	RAS protein activator like 2	0.042
CREB3	cAMP responsive element binding protein 3	0.040
RNF111	ring finger protein 111	0.038
SNX33	sorting nexin 33	0.036
SPRR2A	small proline-rich protein 2A	0.035
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.034
ITK	IL2-inducible T-cell kinase	0.033
PRKCQ	protein kinase C, theta	0.033
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.032
BTK	Bruton agammaglobulinemia tyrosine kinase	0.031	Human
PIK3R4	phosphoinositide-3-kinase, regulatory subunit 4	0.030
ATG14	ATG14 autophagy related 14 homolog (S. cerevisiae)	0.029
VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)	0.029
ZNF295	zinc finger protein 295	0.029
REEP6	receptor accessory protein 6	0.028
LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	0.027
HOOK1	hook homolog 1 (Drosophila)	0.026
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.026
ZNF654	zinc finger protein 654	0.025
KIF1B	kinesin family member 1B	0.025	Human
CCDC33	coiled-coil domain containing 33	0.024
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.024	Human
CAB39	calcium binding protein 39	0.024
DLG1	discs, large homolog 1 (Drosophila)	0.024
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	0.024
RTN1	reticulon 1	0.023
UBE2W	ubiquitin-conjugating enzyme E2W (putative)	0.023
ARRB2	arrestin, beta 2	0.023
ACTN1	actinin, alpha 1	0.022
TGFBR1	transforming growth factor, beta receptor 1	0.021
RGS14	regulator of G-protein signaling 14	0.021
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.021
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.021
ALOX5	arachidonate 5-lipoxygenase	0.021
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.020
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.020
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.020
HOOK2	hook homolog 2 (Drosophila)	0.020
SH3BP4	SH3-domain binding protein 4	0.020
CDK17	cyclin-dependent kinase 17	0.020
RAP1B	RAP1B, member of RAS oncogene family	0.020
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.020
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.020
C11orf66	chromosome 11 open reading frame 66	0.020
MUC1	mucin 1, cell surface associated	0.020
RB1CC1	RB1-inducible coiled-coil 1	0.019
ACTR10	actin-related protein 10 homolog (S. cerevisiae)	0.019
VPS37A	vacuolar protein sorting 37 homolog A (S. cerevisiae)	0.019
ACTN4	actinin, alpha 4	0.019
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.019
TIAM1	T-cell lymphoma invasion and metastasis 1	0.018
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.018
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.018
SH3BP2	SH3-domain binding protein 2	0.017
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.017
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.017
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.017
THRAP3	thyroid hormone receptor associated protein 3	0.017
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.017
ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A	0.017
ATG5	ATG5 autophagy related 5 homolog (S. cerevisiae)	0.017
RAP2C	RAP2C, member of RAS oncogene family	0.017
GRAP2	GRB2-related adaptor protein 2	0.016
SERINC1	serine incorporator 1	0.016
ABI3	ABI family, member 3	0.016
ARID3A	AT rich interactive domain 3A (BRIGHT-like)	0.016
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.016
WDR47	WD repeat domain 47	0.015
OCRL	oculocerebrorenal syndrome of Lowe	0.015
VAMP8	vesicle-associated membrane protein 8 (endobrevin)	0.015
ERC1	ELKS/RAB6-interacting/CAST family member 1	0.015
RAB18	RAB18, member RAS oncogene family	0.015
HSPG2	heparan sulfate proteoglycan 2	0.015
SUN2	Sad1 and UNC84 domain containing 2	0.015
C7orf60	chromosome 7 open reading frame 60	0.015
GDI1	GDP dissociation inhibitor 1	0.014
RAB7A	RAB7A, member RAS oncogene family	0.014
EPC2	enhancer of polycomb homolog 2 (Drosophila)	0.014
CCNY	cyclin Y	0.014
SAMD4A	sterile alpha motif domain containing 4A	0.014
RAB6A	RAB6A, member RAS oncogene family	0.014
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.014
LRRK2	leucine-rich repeat kinase 2	0.014
ZNF250	zinc finger protein 250	0.014
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.014
ZBTB16	zinc finger and BTB domain containing 16	0.014
KIF1C	kinesin family member 1C	0.014	Human
PICALM	phosphatidylinositol binding clathrin assembly protein	0.014
RNF146	ring finger protein 146	0.013
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.013
VAV3	vav 3 guanine nucleotide exchange factor	0.013
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.013
DAPK1	death-associated protein kinase 1	0.013
PPP1R13B	protein phosphatase 1, regulatory (inhibitor) subunit 13B	0.013
SHOC2	soc-2 suppressor of clear homolog (C. elegans)	0.013
SBF2	SET binding factor 2	0.013
CTBP2	C-terminal binding protein 2	0.013
LAMP2	lysosomal-associated membrane protein 2	0.013
KPNA4	karyopherin alpha 4 (importin alpha 3)	0.013
WDR26	WD repeat domain 26	0.012
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.012
MAP2K4	mitogen-activated protein kinase kinase 4	0.012
OR5AR1	olfactory receptor, family 5, subfamily AR, member 1	0.012
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	0.012
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.012
VPS41	vacuolar protein sorting 41 homolog (S. cerevisiae)	0.012
RTN3	reticulon 3	0.012
CNST	consortin, connexin sorting protein	0.012
TNS3	tensin 3	0.012
ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D	0.012
RAB5A	RAB5A, member RAS oncogene family	0.012
RABAC1	Rab acceptor 1 (prenylated)	0.012
KIAA0232	KIAA0232	0.012
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.012
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.011
DYNLT3	dynein, light chain, Tctex-type 3	0.011
FAM82A2	family with sequence similarity 82, member A2	0.011
JAK3	Janus kinase 3	0.011
IGF2R	insulin-like growth factor 2 receptor	0.011
FBLIM1	filamin binding LIM protein 1	0.011
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.011
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.011
SPRY4	sprouty homolog 4 (Drosophila)	0.011
ATG9A	ATG9 autophagy related 9 homolog A (S. cerevisiae)	0.011
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.011
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.011
PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.011
ABLIM1	actin binding LIM protein 1	0.011
ADIPOR1	adiponectin receptor 1	0.011
VPS37C	vacuolar protein sorting 37 homolog C (S. cerevisiae)	0.010
FEM1C	fem-1 homolog c (C. elegans)	0.010
RAB9A	RAB9A, member RAS oncogene family	0.010
SH3PXD2A	SH3 and PX domains 2A	0.010
KIAA1468	KIAA1468	0.010
DZIP3	DAZ interacting protein 3, zinc finger	0.010
STX4	syntaxin 4	0.010
SOCS6	suppressor of cytokine signaling 6	0.010
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.010
GPSM2	G-protein signaling modulator 2	0.010
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.010
STAP2	signal transducing adaptor family member 2	0.010
CENPJ	centromere protein J	0.010
ENG	endoglin	0.010
FAM134C	family with sequence similarity 134, member C	0.010
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.010
EPS8	epidermal growth factor receptor pathway substrate 8	0.010
CDC37L1	cell division cycle 37 homolog (S. cerevisiae)-like 1	0.010