Homo sapiens

215 known processes

IRS1

insulin receptor substrate 1

(Aliases: HIRS-1)

IRS1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.999
enzyme linked receptor protein signaling pathway GO:0007167 303 0.996
regulation of glycogen metabolic process GO:0070873 15 0.996
cellular lipid metabolic process GO:0044255 303 0.996
lipid metabolic process GO:0006629 381 0.993
asymmetric stem cell division GO:0098722 1 0.992
Fly
regulation of glycogen biosynthetic process GO:0005979 14 0.989
positive regulation of steroid hormone biosynthetic process GO:0090031 2 0.986
cellular response to ph GO:0071467 9 0.984
single organism carbohydrate metabolic process GO:0044723 193 0.978
carbohydrate metabolic process GO:0005975 207 0.976
positive regulation of glycogen biosynthetic process GO:0045725 10 0.973
phosphatidylinositol mediated signaling GO:0048015 55 0.967
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 3 0.964
cellular glucan metabolic process GO:0006073 22 0.963
cellular polysaccharide biosynthetic process GO:0033692 21 0.960
stem cell division GO:0017145 2 0.956
Fly
positive regulation of glucose import in response to insulin stimulus GO:2001275 3 0.953
regulation of cellular ketone metabolic process GO:0010565 50 0.951
positive regulation of lipid metabolic process GO:0045834 50 0.951
activation of mapk activity GO:0000187 45 0.948
associative learning GO:0008306 1 0.943
Fly
positive regulation of map kinase activity GO:0043406 80 0.937
cellular response to endogenous stimulus GO:0071495 336 0.934
energy reserve metabolic process GO:0006112 22 0.923
regulation of cell migration GO:0030334 289 0.922
Mouse
positive regulation of glucose metabolic process GO:0010907 12 0.920
monosaccharide metabolic process GO:0005996 74 0.918
glucan biosynthetic process GO:0009250 16 0.911
carbohydrate transport GO:0008643 37 0.904
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.885
multicellular organismal aging GO:0010259 3 0.882
Fly
monocarboxylic acid metabolic process GO:0032787 185 0.881
glucan metabolic process GO:0044042 22 0.875
lipid biosynthetic process GO:0008610 177 0.855
negative regulation of programmed cell death GO:0043069 321 0.852
regulation of locomotion GO:0040012 329 0.850
Mouse
cellular amino acid metabolic process GO:0006520 116 0.847
circadian sleep wake cycle GO:0042745 2 0.847
positive regulation of locomotion GO:0040017 186 0.844
Mouse
fibroblast apoptotic process GO:0044346 8 0.840
female gamete generation GO:0007292 2 0.835
Fly
glucose metabolic process GO:0006006 45 0.833
polysaccharide biosynthetic process GO:0000271 27 0.823
positive regulation of cell proliferation GO:0008284 301 0.822
Mouse
cellular response to alkaline ph GO:0071469 1 0.819
inositol lipid mediated signaling GO:0048017 55 0.819
regulation of glucose metabolic process GO:0010906 28 0.819
glycerolipid biosynthetic process GO:0045017 51 0.817
mitotic cell cycle GO:0000278 326 0.812
negative regulation of cell death GO:0060548 345 0.812
positive regulation of secretion by cell GO:1903532 108 0.804
Rat
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.803
response to peptide GO:1901652 65 0.802
regulation of cellular amine metabolic process GO:0033238 11 0.799
cellular polysaccharide metabolic process GO:0044264 27 0.782
positive regulation of kinase activity GO:0033674 204 0.780
Mouse Rat
cellular amine metabolic process GO:0044106 41 0.778
post embryonic development GO:0009791 2 0.777
regulation of cellular component movement GO:0051270 334 0.774
Mouse
insulin like growth factor receptor signaling pathway GO:0048009 13 0.773
circulatory system development GO:0072359 262 0.773
positive regulation of cellular response to insulin stimulus GO:1900078 6 0.769
positive regulation of transport GO:0051050 336 0.760
growth GO:0040007 202 0.754
Fly
cellular response to insulin stimulus GO:0032869 41 0.752
regulation of glucan biosynthetic process GO:0010962 14 0.742
cellular response to hormone stimulus GO:0032870 125 0.740
regulation of glucose import GO:0046324 21 0.736
positive regulation of phosphorylation GO:0042327 394 0.734
Mouse Rat
regulation of growth GO:0040008 165 0.730
Fly
positive regulation of glycogen metabolic process GO:0070875 10 0.727
blastoderm segmentation GO:0007350 2 0.726
cellular carbohydrate biosynthetic process GO:0034637 21 0.717
regulation of lipid metabolic process GO:0019216 96 0.708
regulation of cell motility GO:2000145 299 0.705
Mouse
regulation of kinase activity GO:0043549 314 0.701
Mouse Rat
chemical homeostasis GO:0048878 306 0.690
positive regulation of organelle organization GO:0010638 195 0.690
g protein coupled receptor signaling pathway GO:0007186 207 0.682
response to cocaine GO:0042220 1 0.681
negative regulation of apoptotic process GO:0043066 316 0.679
determination of adult lifespan GO:0008340 2 0.677
Fly
behavior GO:0007610 112 0.668
Fly
glycerolipid metabolic process GO:0046486 107 0.664
Mouse Rat
ion transmembrane transport GO:0034220 338 0.652
Human
regulation of glucose import in response to insulin stimulus GO:2001273 4 0.647
positive regulation of protein phosphorylation GO:0001934 313 0.645
circadian sleep wake cycle process GO:0022410 2 0.643
glycogen metabolic process GO:0005977 22 0.639
cellular response to organonitrogen compound GO:0071417 124 0.637
phosphatidylinositol metabolic process GO:0046488 53 0.633
Mouse Rat
monosaccharide transport GO:0015749 32 0.626
regulation of protein localization GO:0032880 296 0.617
positive regulation of protein kinase activity GO:0045860 190 0.617
negative regulation of transport GO:0051051 176 0.616
cellular response to nitrogen compound GO:1901699 144 0.612
glycogen biosynthetic process GO:0005978 16 0.609
cell development GO:0048468 328 0.602
Fly
regulation of protein kinase activity GO:0045859 289 0.596
regulation of transferase activity GO:0051338 355 0.592
Mouse Rat
positive regulation of muscle cell apoptotic process GO:0010661 4 0.592
regulation of ion transmembrane transport GO:0034765 132 0.582
Human
cellular response to oxygen containing compound GO:1901701 276 0.581
inactivation of mapkk activity GO:0051389 1 0.576
response to organonitrogen compound GO:0010243 156 0.571
mating GO:0007618 1 0.552
hexose metabolic process GO:0019318 55 0.549
positive regulation of mapk cascade GO:0043410 190 0.548
oxidation reduction process GO:0055114 396 0.548
cellular carbohydrate metabolic process GO:0044262 84 0.539
regulation of cellular amino acid metabolic process GO:0006521 6 0.534
photoreceptor cell differentiation GO:0046530 2 0.517
cellular ketone metabolic process GO:0042180 80 0.515
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.507
organophosphate biosynthetic process GO:0090407 163 0.503
immune response GO:0006955 307 0.492
Fly
regulation of feeding behavior GO:0060259 3 0.491
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.490
positive regulation of cell division GO:0051781 59 0.490
response to oxygen containing compound GO:1901700 369 0.487
regulation of cell differentiation GO:0045595 393 0.486
regulation of carbohydrate metabolic process GO:0006109 54 0.475
positive regulation of cell migration GO:0030335 172 0.473
Mouse
cortisol secretion GO:0043400 4 0.471
phospholipid metabolic process GO:0006644 99 0.467
Mouse Rat
cell activation GO:0001775 213 0.463
response to hormone GO:0009725 175 0.459
response to insulin GO:0032868 45 0.457
lipid localization GO:0010876 106 0.453
Human
regulation of jnk cascade GO:0046328 73 0.450
smooth muscle cell proliferation GO:0048659 28 0.442
regulation of tor signaling GO:0032006 30 0.436
ribonucleotide catabolic process GO:0009261 405 0.433
regulation of mitosis GO:0007088 63 0.432
regulation of cell development GO:0060284 161 0.428
regulation of erk1 and erk2 cascade GO:0070372 99 0.427
positive regulation of protein kinase b signaling GO:0051897 42 0.425
cell morphogenesis GO:0000902 296 0.423
Fly
regulation of cellular response to insulin stimulus GO:1900076 17 0.417
epithelium development GO:0060429 227 0.417
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 2 0.413
negative regulation of phosphate metabolic process GO:0045936 267 0.411
embryonic viscerocranium morphogenesis GO:0048703 1 0.410
cell differentiation in spinal cord GO:0021515 1 0.409
fatty acid metabolic process GO:0006631 115 0.409
peptidyl tyrosine phosphorylation GO:0018108 170 0.409
cell type specific apoptotic process GO:0097285 125 0.409
positive regulation of endothelial cell migration GO:0010595 39 0.405
regeneration GO:0031099 4 0.402
cellular component morphogenesis GO:0032989 314 0.401
Fly
positive regulation of transferase activity GO:0051347 227 0.401
Mouse Rat
positive regulation of mitotic cell cycle GO:0045931 60 0.399
response to abiotic stimulus GO:0009628 336 0.396
Fly
response to growth factor GO:0070848 205 0.395
protein autophosphorylation GO:0046777 123 0.386
positive regulation of cellular amine metabolic process GO:0033240 7 0.385
oogenesis GO:0048477 2 0.385
Fly
negative regulation of circadian sleep wake cycle sleep GO:0042321 1 0.384
cellular response to abiotic stimulus GO:0071214 117 0.376
positive regulation of cellular component movement GO:0051272 181 0.376
Mouse
cell division GO:0051301 168 0.372
Fly
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.367
nuclear transport GO:0051169 179 0.366
sulfur compound metabolic process GO:0006790 101 0.365
response to testosterone GO:0033574 1 0.362
syncytium formation by plasma membrane fusion GO:0000768 2 0.360
response to interleukin 15 GO:0070672 6 0.357
generation of neurons GO:0048699 152 0.355
positive regulation of respiratory burst GO:0060267 5 0.355
negative regulation of glycogen biosynthetic process GO:0045719 3 0.355
neuron remodeling GO:0016322 2 0.353
cellular response to peptide GO:1901653 59 0.352
protein heterotetramerization GO:0051290 3 0.348
cellular response to peptide hormone stimulus GO:0071375 56 0.348
regulation of protein serine threonine kinase activity GO:0071900 179 0.346
response to ph GO:0009268 12 0.345
striated muscle cell apoptotic process GO:0010658 3 0.343
energy derivation by oxidation of organic compounds GO:0015980 43 0.341
polysaccharide metabolic process GO:0005976 33 0.331
digestive system development GO:0055123 75 0.328
positive regulation of catabolic process GO:0009896 310 0.322
neuron differentiation GO:0030182 138 0.321
response to alkaline ph GO:0010446 2 0.321
regulation of response to external stimulus GO:0032101 222 0.320
glycerophospholipid metabolic process GO:0006650 84 0.319
Mouse Rat
response to nitrogen compound GO:1901698 184 0.316
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.315
rho protein signal transduction GO:0007266 26 0.313
regulation of cellular component biogenesis GO:0044087 281 0.311
regulation of polysaccharide metabolic process GO:0032881 21 0.309
regulation of glucose transport GO:0010827 23 0.309
carbohydrate biosynthetic process GO:0016051 42 0.308
embryonic camera type eye development GO:0031076 2 0.307
positive regulation of cell motility GO:2000147 177 0.304
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.302
activation of protein kinase activity GO:0032147 90 0.297
modulation by virus of host morphology or physiology GO:0019048 10 0.297
regulation of establishment of protein localization GO:0070201 242 0.293
regulation of reactive oxygen species metabolic process GO:2000377 41 0.291
female gonad development GO:0008585 10 0.289
regulation of map kinase activity GO:0043405 108 0.289
response to manganese ion GO:0010042 2 0.287
response to peptide hormone GO:0043434 61 0.285
response to metal ion GO:0010038 84 0.283
regulation of natural killer cell differentiation GO:0032823 2 0.282
somatic stem cell division GO:0048103 1 0.280
protein localization to organelle GO:0033365 280 0.278
Mouse
generation of precursor metabolites and energy GO:0006091 68 0.275
reactive oxygen species biosynthetic process GO:1903409 4 0.273
lymphocyte activation GO:0046649 133 0.272
maintenance of location GO:0051235 112 0.272
regulation of mitotic cell cycle GO:0007346 189 0.270
regulation of secretion by cell GO:1903530 177 0.266
negative regulation of cellular carbohydrate metabolic process GO:0010677 14 0.265
regulation of mapk cascade GO:0043408 262 0.260
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.259
regulation of generation of precursor metabolites and energy GO:0043467 27 0.259
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.257
neurotrophin trk receptor signaling pathway GO:0048011 4 0.257
circadian sleep wake cycle sleep GO:0050802 2 0.254
transformation of host cell by virus GO:0019087 2 0.252
regulation of activin receptor signaling pathway GO:0032925 14 0.250
Fly
regulation of multicellular organism growth GO:0040014 8 0.248
Fly
regulation of circadian sleep wake cycle sleep GO:0045187 2 0.247
negative regulation of protein modification process GO:0031400 200 0.247
nuclear division GO:0000280 128 0.245
regulation of lymphocyte proliferation GO:0050670 64 0.244
tyrosine phosphorylation of stat protein GO:0007260 33 0.244
amine metabolic process GO:0009308 44 0.241
cytokine mediated signaling pathway GO:0019221 109 0.241
regulation of behavior GO:0050795 82 0.240
mammary gland development GO:0030879 17 0.238
Mouse
neuron projection regeneration GO:0031102 1 0.237
response to oxidative stress GO:0006979 121 0.236
axon regeneration GO:0031103 1 0.234
positive regulation of cell activation GO:0050867 81 0.234
sex determination GO:0007530 3 0.233
negative regulation of protein phosphorylation GO:0001933 140 0.233
interleukin 6 mediated signaling pathway GO:0070102 7 0.232
regulation of nucleocytoplasmic transport GO:0046822 98 0.231
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.230
circadian behavior GO:0048512 2 0.230
regulation of glucocorticoid secretion GO:2000849 4 0.225
stress activated mapk cascade GO:0051403 93 0.225
myoblast fusion GO:0007520 1 0.225
pyruvate metabolic process GO:0006090 26 0.224
glucose transport GO:0015758 30 0.223
positive regulation of hormone biosynthetic process GO:0046886 4 0.222
prostate gland morphogenesis GO:0060512 1 0.222
tyrosine phosphorylation of stat5 protein GO:0042506 13 0.221
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.219
negative regulation of circadian rhythm GO:0042754 1 0.218
regulation of autophagy GO:0010506 52 0.216
carbohydrate catabolic process GO:0016052 36 0.216
cardiovascular system development GO:0072358 262 0.216
steroid metabolic process GO:0008202 94 0.215
positive regulation of cell cycle GO:0045787 140 0.214
glycerophospholipid biosynthetic process GO:0046474 40 0.213
regulation of intracellular protein transport GO:0033157 123 0.213
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.212
positive regulation of organ growth GO:0046622 2 0.210
regulation of cardiac muscle cell apoptotic process GO:0010665 3 0.210
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.208
vascular endothelial growth factor receptor signaling pathway GO:0048010 19 0.207
glucocorticoid secretion GO:0035933 4 0.207
single organism reproductive process GO:0044702 98 0.206
Fly
tyrosine phosphorylation of stat3 protein GO:0042503 20 0.205
glucose import GO:0046323 24 0.202
spinal cord development GO:0021510 4 0.201
negative regulation of protein metabolic process GO:0051248 391 0.201
ventral spinal cord development GO:0021517 1 0.199
positive regulation of insulin secretion GO:0032024 10 0.199
negative regulation of feeding behavior GO:2000252 1 0.197
cellular response to starvation GO:0009267 58 0.196
leukocyte activation GO:0045321 164 0.195
reactive nitrogen species metabolic process GO:2001057 3 0.195
regulation of peptide hormone secretion GO:0090276 41 0.194
negative regulation of catalytic activity GO:0043086 335 0.193
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 9 0.193
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 11 0.192
reactive oxygen species metabolic process GO:0072593 75 0.192
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.192
negative regulation of phosphorylation GO:0042326 174 0.192
mitotic nuclear division GO:0007067 119 0.191
regulation of insulin receptor signaling pathway GO:0046626 13 0.191
Rat
somatic muscle development GO:0007525 1 0.189
viral process GO:0016032 146 0.189
cellular response to growth factor stimulus GO:0071363 197 0.189
phosphatidylinositol biosynthetic process GO:0006661 25 0.187
rhythmic behavior GO:0007622 2 0.185
response to oxygen levels GO:0070482 100 0.185
Fly
protein localization to nucleus GO:0034504 136 0.184
Mouse
inner ear morphogenesis GO:0042472 4 0.183
regulation of nuclear division GO:0051783 65 0.182
phospholipid biosynthetic process GO:0008654 44 0.181
tube development GO:0035295 125 0.180
insulin receptor signaling pathway GO:0008286 23 0.179
regulation of circadian sleep wake cycle GO:0042749 2 0.179
negative regulation of wnt signaling pathway GO:0030178 69 0.178
cell cell signaling GO:0007267 155 0.178
regulation of leukocyte proliferation GO:0070663 67 0.178
positive regulation of mitosis GO:0045840 25 0.177
intracellular protein transport GO:0006886 270 0.177
regulation of protein targeting GO:1903533 91 0.175
negative regulation of secretion GO:0051048 58 0.174
cardiac muscle cell apoptotic process GO:0010659 3 0.173
b cell activation GO:0042113 33 0.171
mononuclear cell proliferation GO:0032943 71 0.171
regulation of response to reactive oxygen species GO:1901031 12 0.171
positive regulation of jnk cascade GO:0046330 52 0.171
cellular response to external stimulus GO:0071496 111 0.170
peptide secretion GO:0002790 51 0.169
mitotic cell cycle process GO:1903047 286 0.169
vesicle mediated transport GO:0016192 371 0.169
semicircular canal morphogenesis GO:0048752 1 0.168
regulation of polysaccharide biosynthetic process GO:0032885 20 0.167
negative regulation of cell differentiation GO:0045596 171 0.167
protein kinase b signaling GO:0043491 69 0.164
Mouse
sleep GO:0030431 2 0.164
immune effector process GO:0002252 159 0.163
neurogenesis GO:0022008 169 0.163
locomotory behavior GO:0007626 1 0.162
regulation of cell cycle GO:0051726 393 0.162
biological adhesion GO:0022610 331 0.162
activation of protein kinase b activity GO:0032148 14 0.160
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 16 0.159
male sex differentiation GO:0046661 25 0.159
response to cytokine GO:0034097 232 0.158
regulation of neuron differentiation GO:0045664 70 0.158
positive regulation of leukocyte activation GO:0002696 80 0.157
regulation of stress activated mapk cascade GO:0032872 84 0.155
regulation of cell cycle process GO:0010564 266 0.155
taxis GO:0042330 157 0.154
developmental growth GO:0048589 48 0.152
Fly
cellular response to dna damage stimulus GO:0006974 379 0.152
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.152
Fly
positive regulation of apoptotic process GO:0043065 246 0.150
intracellular receptor signaling pathway GO:0030522 104 0.150
activin receptor signaling pathway GO:0032924 24 0.150
Fly
tor signaling GO:0031929 39 0.149
positive regulation of cell cycle process GO:0090068 106 0.148
reproductive process GO:0022414 106 0.148
Fly
regulation of smooth muscle cell proliferation GO:0048660 28 0.147
negative regulation of carbohydrate metabolic process GO:0045912 20 0.147
positive regulation of glucose transport GO:0010828 17 0.146
organelle fission GO:0048285 149 0.145
cell growth GO:0016049 160 0.145
Fly
digestive tract development GO:0048565 75 0.144
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 20 0.144
cellular response to nutrient levels GO:0031669 69 0.143
regulation of protein transport GO:0051223 213 0.143
osteoblast differentiation GO:0001649 92 0.143
response to decreased oxygen levels GO:0036293 96 0.143
Fly
cell migration involved in gastrulation GO:0042074 1 0.141
positive regulation of fatty acid beta oxidation GO:0032000 5 0.141
regulation of autophagic vacuole assembly GO:2000785 6 0.140
positive regulation of cardiac muscle cell apoptotic process GO:0010666 1 0.140
regulation of cell division GO:0051302 116 0.140
response to lipid GO:0033993 206 0.139
inorganic ion transmembrane transport GO:0098660 231 0.139
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.139
negative regulation of cell proliferation GO:0008285 228 0.139
regulation of striated muscle cell apoptotic process GO:0010662 3 0.137
regulation of response to oxidative stress GO:1902882 26 0.137
interspecies interaction between organisms GO:0044419 156 0.137
leukocyte differentiation GO:0002521 98 0.134
cell projection morphogenesis GO:0048858 129 0.133
regulation of lipid catabolic process GO:0050994 23 0.132
regulation of wnt signaling pathway GO:0030111 123 0.131
epidermis development GO:0008544 59 0.130
response to uv GO:0009411 73 0.130
anatomical structure formation involved in morphogenesis GO:0048646 284 0.129
regulation of hormone secretion GO:0046883 57 0.129
regulation of chemotaxis GO:0050920 74 0.128
regulation of carbohydrate biosynthetic process GO:0043255 27 0.127
positive regulation of glycolytic process GO:0045821 4 0.126
glycosyl compound catabolic process GO:1901658 413 0.126
small molecule catabolic process GO:0044282 92 0.126
positive regulation of cell differentiation GO:0045597 211 0.125
regulation of respiratory burst GO:0060263 8 0.125
positive regulation of lymphocyte activation GO:0051251 73 0.125
gland development GO:0048732 48 0.125
Mouse
regulation of cellular response to stress GO:0080135 244 0.123
monocarboxylic acid catabolic process GO:0072329 37 0.122
modification of morphology or physiology of other organism GO:0035821 43 0.122
wnt signaling pathway GO:0016055 156 0.121
nervous system development GO:0007399 293 0.121
regulation of hydrogen peroxide metabolic process GO:0010310 6 0.121
negative regulation of type i interferon mediated signaling pathway GO:0060339 4 0.120
single organism behavior GO:0044708 28 0.120
Fly
nucleocytoplasmic transport GO:0006913 176 0.119
respiratory burst GO:0045730 12 0.118
negative regulation of cellular protein metabolic process GO:0032269 353 0.118
myeloid cell differentiation GO:0030099 117 0.115
hexose transport GO:0008645 30 0.115
positive regulation of striated muscle cell apoptotic process GO:0010663 1 0.115
regulation of dna metabolic process GO:0051052 153 0.114
organic anion transport GO:0015711 103 0.114
Human
neuron development GO:0048666 113 0.114
jnk cascade GO:0007254 80 0.113
regulation of cytokinesis GO:0032465 45 0.112
cellular ion homeostasis GO:0006873 168 0.112
hormone secretion GO:0046879 65 0.112
multi organism cellular process GO:0044764 156 0.112
anion transport GO:0006820 161 0.112
Human
positive regulation of epithelial cell proliferation GO:0050679 65 0.110
chemotaxis GO:0006935 157 0.109
response to axon injury GO:0048678 1 0.109
regulation of system process GO:0044057 101 0.107
muscle cell apoptotic process GO:0010657 11 0.105
glucose import in response to insulin stimulus GO:0044381 4 0.105
positive regulation of immune response GO:0050778 159 0.104
Fly
positive regulation of multicellular organism growth GO:0040018 6 0.104
Fly
protein oligomerization GO:0051259 173 0.103
Rat
regulation of vacuole organization GO:0044088 8 0.103
epithelial cell differentiation GO:0030855 141 0.103
ameboidal type cell migration GO:0001667 135 0.102
cellular lipid catabolic process GO:0044242 65 0.102
response to organic cyclic compound GO:0014070 204 0.102
Rat
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 12 0.102
regulation of neuron projection development GO:0010975 57 0.101
negative regulation of secretion by cell GO:1903531 52 0.101
regulation of interleukin 6 mediated signaling pathway GO:0070103 3 0.101
cellular response to growth hormone stimulus GO:0071378 10 0.100
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.100
aging GO:0007568 66 0.100
Fly
endothelial cell migration GO:0043542 86 0.099
negative regulation of tyrosine phosphorylation of stat protein GO:0042532 2 0.098
negative regulation of protein transport GO:0051224 75 0.098
mapk cascade GO:0000165 288 0.097
regulation of ion transport GO:0043269 189 0.096
Human
epithelial cell proliferation GO:0050673 128 0.096
neutral lipid metabolic process GO:0006638 27 0.095
regulation of hormone levels GO:0010817 125 0.095
negative regulation of developmental process GO:0051093 247 0.094
regulation of dna replication GO:0006275 68 0.094
dna replication GO:0006260 116 0.094
negative regulation of lipid transport GO:0032369 18 0.094
Human
leukocyte proliferation GO:0070661 74 0.093
muscle cell migration GO:0014812 19 0.092
macromolecule methylation GO:0043414 97 0.092
memory GO:0007613 3 0.092
hematopoietic or lymphoid organ development GO:0048534 186 0.091
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.091
muscle cell differentiation GO:0042692 63 0.091
epithelial cell migration GO:0010631 119 0.091
skin development GO:0043588 76 0.091
cellular response to molecule of bacterial origin GO:0071219 62 0.090
regulation of protein kinase b signaling GO:0051896 61 0.090
regulation of endothelial cell migration GO:0010594 67 0.089
response to inorganic substance GO:0010035 127 0.089
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.088
embryonic morphogenesis GO:0048598 85 0.088
response to light stimulus GO:0009416 87 0.088
anatomical structure homeostasis GO:0060249 100 0.088
Fly
single organism carbohydrate catabolic process GO:0044724 33 0.087
erk1 and erk2 cascade GO:0070371 104 0.087
wound healing GO:0042060 115 0.087
response to nutrient levels GO:0031667 81 0.086
Fly
prostate gland development GO:0030850 3 0.086
negative regulation of transferase activity GO:0051348 124 0.085
ion homeostasis GO:0050801 230 0.085
acylglycerol metabolic process GO:0006639 27 0.085
hormone mediated signaling pathway GO:0009755 22 0.085
negative regulation of cell size GO:0045792 3 0.083
regulation of immune response GO:0050776 201 0.083
Fly
regulation of ossification GO:0030278 58 0.083
regulation of fatty acid beta oxidation GO:0031998 8 0.082
dephosphorylation GO:0016311 209 0.082
negative regulation of insulin secretion GO:0046676 9 0.082
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.082
actin filament based process GO:0030029 224 0.082
genetic imprinting GO:0071514 1 0.081
regulation of protein localization to nucleus GO:1900180 85 0.081
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 11 0.081
negative regulation of insulin receptor signaling pathway GO:0046627 8 0.081
Rat
ribonucleoside triphosphate catabolic process GO:0009203 391 0.080
protein targeting GO:0006605 187 0.080
inactivation of mapk activity GO:0000188 5 0.080
natural killer cell differentiation GO:0001779 2 0.079
muscle structure development GO:0061061 98 0.079
regulation of cytokine production GO:0001817 232 0.079
negative regulation of anoikis GO:2000811 15 0.079
positive regulation of nuclear division GO:0051785 27 0.078

IRS1 disease predictions

Disease DO term ID Size Probability Func Analog Org
hyperinsulinemic hypoglycemia DOID:13317 7 0.997
disease of metabolism DOID:0014667 295 0.997
carbohydrate metabolic disorder DOID:2978 55 0.997
inherited metabolic disorder DOID:655 242 0.997
diabetes mellitus DOID:9351 31 0.297
type 2 diabetes mellitus DOID:9352 28 0.297
carbohydrate metabolism disease DOID:0050013 32 0.297
glucose metabolism disease DOID:4194 32 0.297
acquired metabolic disease DOID:0060158 58 0.297
cancer DOID:162 167 0.241
disease of cellular proliferation DOID:14566 174 0.241
organ system cancer DOID:0050686 164 0.241
reproductive organ cancer DOID:193 23 0.213
gastrointestinal system cancer DOID:3119 52 0.164