Homo sapiens

87 known processes

MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

(Aliases: HPK1)

MAP4K1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mapk cascade GO:0000165 288 0.868
regulation of cellular amine metabolic process GO:0033238 11 0.819
ras protein signal transduction GO:0007265 73 0.800
regulation of mapk cascade GO:0043408 262 0.783
small gtpase mediated signal transduction GO:0007264 78 0.779
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.770
Fly
positive regulation of stress activated mapk cascade GO:0032874 60 0.763
Human Fly
positive regulation of map kinase activity GO:0043406 80 0.759
Human
positive regulation of phosphorylation GO:0042327 394 0.749
regulation of map kinase activity GO:0043405 108 0.656
Human
regulation of jun kinase activity GO:0043506 27 0.646
Human
leukocyte activation GO:0045321 164 0.584
jnk cascade GO:0007254 80 0.529
Human Fly
positive regulation of mapk cascade GO:0043410 190 0.522
positive regulation of gtp catabolic process GO:0033126 166 0.494
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.474
Human Fly
ribonucleoside triphosphate catabolic process GO:0009203 391 0.439
regulation of jnk cascade GO:0046328 73 0.419
Human Fly
ribonucleoside triphosphate metabolic process GO:0009199 412 0.410
positive regulation of jun kinase activity GO:0043507 23 0.396
Human
purine nucleoside triphosphate catabolic process GO:0009146 392 0.389
regulation of cell migration GO:0030334 289 0.380
regulation of small gtpase mediated signal transduction GO:0051056 156 0.380
response to oxygen containing compound GO:1901700 369 0.378
Fly
positive regulation of transport GO:0051050 336 0.377
response to other organism GO:0051707 261 0.365
positive regulation of gtpase activity GO:0043547 166 0.364
rap protein signal transduction GO:0032486 7 0.350
cellular amine metabolic process GO:0044106 41 0.344
activation of protein kinase activity GO:0032147 90 0.343
regulation of cellular component movement GO:0051270 334 0.338
regulation of cellular amino acid metabolic process GO:0006521 6 0.335
activation of jnkk activity GO:0007256 1 0.333
regulation of ras protein signal transduction GO:0046578 155 0.326
cellular response to nitrogen compound GO:1901699 144 0.324
Fly
regulation of cell activation GO:0050865 125 0.318
positive regulation of kinase activity GO:0033674 204 0.305
purine nucleoside catabolic process GO:0006152 398 0.295
mononuclear cell proliferation GO:0032943 71 0.294
signal transduction by phosphorylation GO:0023014 297 0.293
nucleoside triphosphate metabolic process GO:0009141 422 0.288
t cell activation GO:0042110 99 0.286
cellular response to endogenous stimulus GO:0071495 336 0.283
Fly
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.276
Human Fly
purine ribonucleoside catabolic process GO:0046130 398 0.276
regulation of cell motility GO:2000145 299 0.275
positive regulation of rap gtpase activity GO:0032854 8 0.274
regulation of cell differentiation GO:0045595 393 0.269
regulation of nucleoside metabolic process GO:0009118 209 0.269
nucleoside phosphate catabolic process GO:1901292 412 0.269
peptidyl tyrosine modification GO:0018212 170 0.260
leukocyte migration GO:0050900 107 0.249
gtp metabolic process GO:0046039 239 0.248
cell activation GO:0001775 213 0.246
regulation of t cell activation GO:0050863 77 0.245
regulation of locomotion GO:0040012 329 0.243
regulation of lymphocyte proliferation GO:0050670 64 0.240
regulation of leukocyte activation GO:0002694 115 0.238
immune system development GO:0002520 195 0.237
stress activated protein kinase signaling cascade GO:0031098 94 0.233
Human Fly
second messenger mediated signaling GO:0019932 78 0.231
regulation of immune response GO:0050776 201 0.228
immune response GO:0006955 307 0.225
organophosphate catabolic process GO:0046434 430 0.220
epithelial cell migration GO:0010631 119 0.218
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.218
lymphocyte activation GO:0046649 133 0.214
positive regulation of immune system process GO:0002684 283 0.209
positive regulation of jnk cascade GO:0046330 52 0.201
Human Fly
regulation of nucleotide catabolic process GO:0030811 205 0.200
regulation of erk1 and erk2 cascade GO:0070372 99 0.194
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.191
purine nucleotide catabolic process GO:0006195 405 0.191
hematopoietic or lymphoid organ development GO:0048534 186 0.187
positive regulation of lymphocyte proliferation GO:0050671 46 0.186
enzyme linked receptor protein signaling pathway GO:0007167 303 0.186
Fly
regulation of protein serine threonine kinase activity GO:0071900 179 0.184
leukocyte proliferation GO:0070661 74 0.181
divalent metal ion transport GO:0070838 152 0.180
hemopoiesis GO:0030097 180 0.179
negative regulation of programmed cell death GO:0043069 321 0.177
regulation of cellular component biogenesis GO:0044087 281 0.176
purine nucleoside triphosphate metabolic process GO:0009144 412 0.175
cellular ketone metabolic process GO:0042180 80 0.172
positive regulation of leukocyte proliferation GO:0070665 48 0.168
stress activated mapk cascade GO:0051403 93 0.156
Human Fly
regulation of epithelial cell migration GO:0010632 93 0.156
positive regulation of t cell activation GO:0050870 54 0.152
actin cytoskeleton organization GO:0030036 207 0.144
positive regulation of cell motility GO:2000147 177 0.144
cell development GO:0048468 328 0.143
erk1 and erk2 cascade GO:0070371 104 0.143
lymphocyte proliferation GO:0046651 70 0.141
regulation of stress activated mapk cascade GO:0032872 84 0.137
Human Fly
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.136
positive regulation of nucleotide metabolic process GO:0045981 230 0.135
positive regulation of rac gtpase activity GO:0032855 31 0.134
regulation of gtpase activity GO:0043087 180 0.134
regulation of t cell proliferation GO:0042129 42 0.133
regulation of lymphocyte activation GO:0051249 103 0.133
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.128
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.128
positive regulation of cell proliferation GO:0008284 301 0.128
regulation of nucleotide metabolic process GO:0006140 269 0.127
response to cytokine GO:0034097 232 0.126
Human
positive regulation of immune response GO:0050778 159 0.126
cell type specific apoptotic process GO:0097285 125 0.124
nucleoside catabolic process GO:0009164 408 0.120
t cell differentiation in thymus GO:0033077 4 0.118
guanosine containing compound catabolic process GO:1901069 239 0.117
amine metabolic process GO:0009308 44 0.117
regulation of rap protein signal transduction GO:0032487 9 0.116
regulation of cell development GO:0060284 161 0.115
negative regulation of cell proliferation GO:0008285 228 0.114
positive regulation of nucleotide catabolic process GO:0030813 185 0.112
regulation of mononuclear cell proliferation GO:0032944 65 0.112
regulation of protein kinase activity GO:0045859 289 0.111
calcium mediated signaling GO:0019722 44 0.107
purine ribonucleotide catabolic process GO:0009154 404 0.106
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.105
positive regulation of leukocyte activation GO:0002696 80 0.104
response to organonitrogen compound GO:0010243 156 0.104
Fly
cellular protein complex assembly GO:0043623 188 0.102
positive regulation of mononuclear cell proliferation GO:0032946 47 0.101
cytokine production GO:0001816 247 0.101
negative regulation of cell death GO:0060548 345 0.100
response to nitrogen compound GO:1901698 184 0.100
Fly
cellular response to growth factor stimulus GO:0071363 197 0.099
positive regulation of cell adhesion GO:0045785 84 0.099
defense response GO:0006952 315 0.099
positive regulation of cell activation GO:0050867 81 0.096
regulation of gtp catabolic process GO:0033124 180 0.096
regulation of kinase activity GO:0043549 314 0.095
neuron death GO:0070997 65 0.094
ameboidal type cell migration GO:0001667 135 0.094
guanosine containing compound metabolic process GO:1901068 244 0.093
activation of jun kinase activity GO:0007257 7 0.093
Human
regulation of anatomical structure morphogenesis GO:0022603 286 0.093
endosomal transport GO:0016197 129 0.090
purine containing compound catabolic process GO:0072523 411 0.088
rho protein signal transduction GO:0007266 26 0.087
chemical homeostasis GO:0048878 306 0.086
Fly
positive regulation of cellular catabolic process GO:0031331 284 0.085
immune response regulating signaling pathway GO:0002764 97 0.083
azole transport GO:0045117 4 0.083
cell chemotaxis GO:0060326 112 0.083
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.082
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.081
negative regulation of immune system process GO:0002683 136 0.081
innate immune response GO:0045087 178 0.079
regulation of protein polymerization GO:0032271 63 0.076
myeloid cell differentiation GO:0030099 117 0.075
cellular macromolecular complex assembly GO:0034622 324 0.075
regulation of neuron apoptotic process GO:0043523 35 0.075
system process GO:0003008 349 0.075
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.075
gtp catabolic process GO:0006184 237 0.074
peptidyl tyrosine phosphorylation GO:0018108 170 0.074
epithelium development GO:0060429 227 0.073
cellular ion homeostasis GO:0006873 168 0.073
cellular response to oxygen containing compound GO:1901701 276 0.071
Fly
ribonucleotide catabolic process GO:0009261 405 0.071
response to abiotic stimulus GO:0009628 336 0.071
Human
regulation of leukocyte proliferation GO:0070663 67 0.071
negative regulation of apoptotic process GO:0043066 316 0.070
antigen receptor mediated signaling pathway GO:0050851 38 0.070
regulation of metal ion transport GO:0010959 120 0.068
positive regulation of rho gtpase activity GO:0032321 56 0.068
exocytosis GO:0006887 71 0.068
determination of adult lifespan GO:0008340 2 0.068
positive regulation of cell death GO:0010942 263 0.067
Fly
regulation of purine nucleotide catabolic process GO:0033121 205 0.067
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.067
negative regulation of intracellular signal transduction GO:1902532 183 0.067
regulation of cellular response to stress GO:0080135 244 0.065
Human Fly
regulation of ion transport GO:0043269 189 0.065
positive regulation of locomotion GO:0040017 186 0.065
purine ribonucleoside metabolic process GO:0046128 437 0.065
positive regulation of cell migration GO:0030335 172 0.063
t cell proliferation GO:0042098 45 0.063
positive regulation of cellular amine metabolic process GO:0033240 7 0.062
metal ion transport GO:0030001 272 0.062
post embryonic development GO:0009791 2 0.061
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.061
negative regulation of phosphate metabolic process GO:0045936 267 0.059
t cell selection GO:0045058 4 0.059
metal ion homeostasis GO:0055065 169 0.058
negative regulation of cell migration GO:0030336 102 0.058
neurogenesis GO:0022008 169 0.058
positive regulation of transferase activity GO:0051347 227 0.058
circulatory system development GO:0072359 262 0.057
regulation of rho protein signal transduction GO:0035023 79 0.057
positive regulation of t cell proliferation GO:0042102 33 0.057
cation homeostasis GO:0055080 189 0.057
positive regulation of lymphocyte activation GO:0051251 73 0.056
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.055
negative regulation of binding GO:0051100 57 0.055
regulation of cytokine production GO:0001817 232 0.055
microtubule based process GO:0007017 210 0.055
positive regulation of ras gtpase activity GO:0032320 117 0.055
actin polymerization or depolymerization GO:0008154 56 0.054
single organism cell adhesion GO:0098602 179 0.053
axonogenesis GO:0007409 31 0.053
cellular metal ion homeostasis GO:0006875 146 0.053
positive regulation of programmed cell death GO:0043068 249 0.053
Fly
positive regulation of developmental process GO:0051094 314 0.052
negative regulation of catalytic activity GO:0043086 335 0.052
post embryonic organ development GO:0048569 1 0.051
cytoplasmic transport GO:0016482 379 0.051
nucleoside triphosphate catabolic process GO:0009143 394 0.049
immune response activating signal transduction GO:0002757 90 0.049
multicellular organismal aging GO:0010259 3 0.049
positive regulation of intracellular transport GO:0032388 104 0.049
regulation of transferase activity GO:0051338 355 0.048
positive regulation of protein phosphorylation GO:0001934 313 0.048
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.048
negative regulation of phosphorus metabolic process GO:0010563 267 0.047
cellular calcium ion homeostasis GO:0006874 117 0.047
cell projection organization GO:0030030 252 0.047
leukocyte differentiation GO:0002521 98 0.047
regulation of cell shape GO:0008360 48 0.047
ribonucleoside catabolic process GO:0042454 406 0.047
response to hormone GO:0009725 175 0.046
Fly
regulation of actin polymerization or depolymerization GO:0008064 56 0.046
neuron development GO:0048666 113 0.045
regulation of actin cytoskeleton organization GO:0032956 116 0.044
biological adhesion GO:0022610 331 0.043
regulation of protein complex assembly GO:0043254 147 0.042
negative regulation of locomotion GO:0040013 118 0.042
regulation of protein localization GO:0032880 296 0.042
peptidyl threonine phosphorylation GO:0018107 41 0.042
cell division GO:0051301 168 0.042
lymphocyte homeostasis GO:0002260 4 0.041
activation of immune response GO:0002253 114 0.041
negative regulation of cellular component movement GO:0051271 106 0.041
nervous system development GO:0007399 293 0.041
regulation of cell cycle GO:0051726 393 0.041
negative regulation of multicellular organismal process GO:0051241 317 0.041
regulation of anatomical structure size GO:0090066 101 0.041
Fly
regulation of growth GO:0040008 165 0.040
Fly
hair follicle morphogenesis GO:0031069 2 0.040
phosphatidylinositol mediated signaling GO:0048015 55 0.040
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.040
regeneration GO:0031099 4 0.040
epithelial cell differentiation GO:0030855 141 0.040
generation of neurons GO:0048699 152 0.039
regulation of intracellular transport GO:0032386 195 0.039
negative regulation of phosphorylation GO:0042326 174 0.039
neuron differentiation GO:0030182 138 0.039
negative regulation of cell motility GO:2000146 104 0.039
secretion GO:0046903 254 0.038
peptidyl threonine modification GO:0018210 45 0.038
positive regulation of arp2 3 complex mediated actin nucleation GO:2000601 5 0.038
regulation of cell adhesion GO:0030155 166 0.038
smoothened signaling pathway GO:0007224 14 0.037
response to alcohol GO:0097305 64 0.037
Fly
regulation of cellular ketone metabolic process GO:0010565 50 0.037
single organism cellular localization GO:1902580 332 0.036
regulation of actin filament length GO:0030832 56 0.036
regulation of cytoplasmic transport GO:1903649 149 0.036
actin filament polymerization GO:0030041 45 0.035
nucleotide catabolic process GO:0009166 408 0.035
t cell migration GO:0072678 16 0.035
cell morphogenesis involved in differentiation GO:0000904 144 0.035
regulation of ras gtpase activity GO:0032318 128 0.034
response to temperature stimulus GO:0009266 22 0.034
substrate adhesion dependent cell spreading GO:0034446 41 0.034
neurological system process GO:0050877 163 0.034
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.034
cellular divalent inorganic cation homeostasis GO:0072503 128 0.034
cellular response to cytokine stimulus GO:0071345 181 0.033
apoptotic signaling pathway GO:0097190 268 0.033
cellular homeostasis GO:0019725 196 0.033
memory GO:0007613 3 0.033
glycosyl compound catabolic process GO:1901658 413 0.032
behavior GO:0007610 112 0.032
Fly
regulation of t cell differentiation GO:0045580 19 0.032
associative learning GO:0008306 1 0.032
leukocyte chemotaxis GO:0030595 76 0.032
thymic t cell selection GO:0045061 2 0.032
positive regulation of apoptotic process GO:0043065 246 0.032
Fly
cell activation involved in immune response GO:0002263 30 0.032
cytosolic calcium ion homeostasis GO:0051480 89 0.032
multicellular organismal homeostasis GO:0048871 67 0.032
positive regulation of jak stat cascade GO:0046427 35 0.031
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.031
negative regulation of protein modification process GO:0031400 200 0.031
response to peptide GO:1901652 65 0.031
Fly
negative regulation of developmental process GO:0051093 247 0.031
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.031
cell matrix adhesion GO:0007160 85 0.031
neutrophil chemotaxis GO:0030593 24 0.030
cell growth GO:0016049 160 0.030
growth GO:0040007 202 0.030
Fly
regulation of rho gtpase activity GO:0032319 66 0.030
regulation of apoptotic signaling pathway GO:2001233 175 0.030
stress fiber assembly GO:0043149 40 0.030
response to fungus GO:0009620 4 0.030
regulation of actin filament based process GO:0032970 141 0.029
negative regulation of cell cycle GO:0045786 193 0.029
regulation of cell growth GO:0001558 135 0.029
nucleocytoplasmic transport GO:0006913 176 0.029
cellular cation homeostasis GO:0030003 163 0.029
negative regulation of hydrolase activity GO:0051346 182 0.029
female gamete generation GO:0007292 2 0.028
negative regulation of transferase activity GO:0051348 124 0.028
positive regulation of cytoskeleton organization GO:0051495 83 0.028
activation of mapkk activity GO:0000186 18 0.028
negative regulation of t cell receptor signaling pathway GO:0050860 4 0.028
protein autophosphorylation GO:0046777 123 0.028
signal release GO:0023061 70 0.028
cellular amino acid metabolic process GO:0006520 116 0.028
cellular response to dna damage stimulus GO:0006974 379 0.028
cell junction assembly GO:0034329 67 0.027
negative regulation of protein metabolic process GO:0051248 391 0.027
extrinsic apoptotic signaling pathway GO:0097191 119 0.027
cellular response to peptide GO:1901653 59 0.027
Fly
positive regulation of cellular component organization GO:0051130 376 0.027
negative regulation of cellular component organization GO:0051129 235 0.027
jak stat cascade GO:0007259 46 0.027
positive regulation of cellular component movement GO:0051272 181 0.026
peptidyl serine phosphorylation GO:0018105 101 0.026
negative regulation of cell differentiation GO:0045596 171 0.026
negative regulation of transport GO:0051051 176 0.026
neuromuscular junction development GO:0007528 3 0.026
regulation of system process GO:0044057 101 0.025
regulation of cell projection organization GO:0031344 107 0.025
regulation of epithelial cell proliferation GO:0050678 113 0.025
oogenesis GO:0048477 2 0.025
secretion by cell GO:0032940 226 0.025
cell morphogenesis GO:0000902 296 0.025
endothelial cell differentiation GO:0045446 26 0.025
endothelial cell migration GO:0043542 86 0.025
positive regulation of rab gtpase activity GO:0032851 39 0.025
epithelium migration GO:0090132 119 0.025
positive regulation of cytokine production GO:0001819 167 0.025
erbb signaling pathway GO:0038127 44 0.024
Fly
positive regulation of leukocyte chemotaxis GO:0002690 38 0.024
establishment of endothelial barrier GO:0061028 16 0.024
calcium ion transport into cytosol GO:0060402 48 0.024
regulation of neuron death GO:1901214 56 0.024
cellular response to organic cyclic compound GO:0071407 127 0.024
response to biotic stimulus GO:0009607 276 0.024
divalent inorganic cation transport GO:0072511 158 0.024
negative regulation of protein phosphorylation GO:0001933 140 0.024
spermatid development GO:0007286 4 0.024
tissue migration GO:0090130 119 0.024
actin filament bundle organization GO:0061572 54 0.024
protein modification by small protein conjugation GO:0032446 342 0.023
vesicle mediated transport GO:0016192 371 0.023
response to insulin GO:0032868 45 0.023
Fly
ion homeostasis GO:0050801 230 0.023
protein kinase b signaling GO:0043491 69 0.023
positive regulation of protein kinase b signaling GO:0051897 42 0.023
neuron projection morphogenesis GO:0048812 50 0.023
mast cell activation involved in immune response GO:0002279 4 0.023
divalent inorganic cation homeostasis GO:0072507 136 0.023
neuron projection development GO:0031175 106 0.022
pericardium development GO:0060039 2 0.022
calcium ion homeostasis GO:0055074 122 0.022
regulation of cellular component size GO:0032535 82 0.022
Fly
regulation of actin nucleation GO:0051125 10 0.022
behavioral response to ethanol GO:0048149 2 0.022
Fly
maintenance of location GO:0051235 112 0.022
monovalent inorganic cation transport GO:0015672 128 0.022
dephosphorylation GO:0016311 209 0.022
regulation of cell morphogenesis GO:0022604 153 0.022
mitotic cell cycle process GO:1903047 286 0.022
positive regulation of actin filament polymerization GO:0030838 38 0.022
cation transport GO:0006812 331 0.021
negative regulation of cell adhesion GO:0007162 64 0.021
cellular response to camp GO:0071320 21 0.021
intracellular protein transport GO:0006886 270 0.021
t cell receptor signaling pathway GO:0050852 21 0.021
endothelial cell development GO:0001885 18 0.021
positive regulation of secretion GO:0051047 116 0.020
lipid metabolic process GO:0006629 381 0.020
blood vessel morphogenesis GO:0048514 162 0.020
rac protein signal transduction GO:0016601 12 0.020
oocyte development GO:0048599 1 0.020
single organismal cell cell adhesion GO:0016337 148 0.020
negative regulation of cellular amine metabolic process GO:0033239 3 0.020
response to lipid GO:0033993 206 0.020
actin filament bundle assembly GO:0051017 54 0.020
protein import into nucleus GO:0006606 104 0.020
positive regulation of secretion by cell GO:1903532 108 0.020
positive regulation of hydrolase activity GO:0051345 331 0.020
regulation of cytokinesis GO:0032465 45 0.020
myeloid leukocyte differentiation GO:0002573 60 0.020
regulation of response to external stimulus GO:0032101 222 0.019
mitotic cell cycle phase transition GO:0044772 162 0.019
cellular response to insulin stimulus GO:0032869 41 0.019
Fly
positive regulation of cellular component biogenesis GO:0044089 158 0.019
regulation of establishment of protein localization GO:0070201 242 0.019
positive regulation of cytoplasmic transport GO:1903651 82 0.019
positive regulation of catabolic process GO:0009896 310 0.019
chemotaxis GO:0006935 157 0.019
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.019
reproductive process GO:0022414 106 0.019
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.018
developmental growth GO:0048589 48 0.018
mitotic cell cycle GO:0000278 326 0.018
regulation of growth rate GO:0040009 1 0.018
Fly
blood circulation GO:0008015 113 0.018
taxis GO:0042330 157 0.018
negative regulation of homeostatic process GO:0032845 59 0.018
cell cycle phase transition GO:0044770 173 0.018
regulation of protein kinase b signaling GO:0051896 61 0.018
cytosolic calcium ion transport GO:0060401 48 0.018
sequestering of calcium ion GO:0051208 17 0.018
microtubule cytoskeleton organization GO:0000226 176 0.018
regulation of purine nucleotide metabolic process GO:1900542 264 0.018
sequestering of metal ion GO:0051238 24 0.018
epidermal growth factor receptor signaling pathway GO:0007173 39 0.017
Fly
cellular lipid metabolic process GO:0044255 303 0.017
negative regulation of growth GO:0045926 97 0.017
protein localization to nucleus GO:0034504 136 0.017
regulation of protein transport GO:0051223 213 0.017
regulation of endothelial cell migration GO:0010594 67 0.017
regulation of receptor mediated endocytosis GO:0048259 32 0.017
engulfment of apoptotic cell GO:0043652 2 0.017
homeostasis of number of cells GO:0048872 40 0.017
regulation of calcium ion transport GO:0051924 79 0.017
positive regulation of endothelial cell migration GO:0010595 39 0.017
single organism membrane organization GO:0044802 268 0.017
positive regulation of cell substrate adhesion GO:0010811 37 0.017
t cell differentiation GO:0030217 29 0.017
positive regulation of protein polymerization GO:0032273 45 0.017
regulation of protein binding GO:0043393 66 0.016
inositol lipid mediated signaling GO:0048017 55 0.016
protein targeting GO:0006605 187 0.016
cell projection assembly GO:0030031 126 0.016
g1 s transition of mitotic cell cycle GO:0000082 78 0.016
regulation of binding GO:0051098 111 0.016
regulation of immune effector process GO:0002697 91 0.016
regulation of mitotic cell cycle GO:0007346 189 0.016
transmembrane transport GO:0055085 399 0.016
regulation of cell cycle process GO:0010564 266 0.016
regulation of cell substrate adhesion GO:0010810 68 0.016
protein localization to organelle GO:0033365 280 0.016
negative regulation of protein maturation GO:1903318 142 0.016
regulation of reactive oxygen species metabolic process GO:2000377 41 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
cytokine mediated signaling pathway GO:0019221 109 0.015
positive regulation of small gtpase mediated signal transduction GO:0051057 12 0.015
cell junction organization GO:0034330 79 0.015
myeloid leukocyte activation GO:0002274 34 0.015
regulation of protein processing GO:0070613 150 0.015
cellular response to ethanol GO:0071361 1 0.015
positive regulation of protein transport GO:0051222 135 0.015
regulation of pro b cell differentiation GO:2000973 1 0.015
regulation of defense response GO:0031347 154 0.015
immune effector process GO:0002252 159 0.015
central nervous system development GO:0007417 123 0.015
response to organophosphorus GO:0046683 41 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
cell cycle g1 s phase transition GO:0044843 80 0.015
actin mediated cell contraction GO:0070252 12 0.015
response to bacterium GO:0009617 144 0.015
nuclear transport GO:0051169 179 0.014
negative regulation of protein kinase activity GO:0006469 98 0.014
positive regulation of phagocytosis engulfment GO:0060100 1 0.014
negative regulation of mapk cascade GO:0043409 56 0.014
regulation of blood coagulation GO:0030193 42 0.014
syncytium formation by plasma membrane fusion GO:0000768 2 0.014
leukocyte mediated immunity GO:0002443 59 0.014
regulation of secretion by cell GO:1903530 177 0.014
regulation of body fluid levels GO:0050878 99 0.014
actin filament based process GO:0030029 224 0.014
cellular chemical homeostasis GO:0055082 180 0.014
positive regulation of synapse structural plasticity GO:0051835 2 0.014
cytokine biosynthetic process GO:0042089 37 0.014
regulation of response to biotic stimulus GO:0002831 55 0.014
inflammatory response GO:0006954 79 0.014
defense response to other organism GO:0098542 129 0.014
motor neuron axon guidance GO:0008045 2 0.014
regulation of rap gtpase activity GO:0032317 8 0.014
positive regulation of calcium ion transport GO:0051928 51 0.014
regulation of phagocytosis engulfment GO:0060099 2 0.014
cellular component morphogenesis GO:0032989 314 0.014
response to growth factor GO:0070848 205 0.013
positive regulation of proteolysis GO:0045862 142 0.013
positive regulation of neuron death GO:1901216 14 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
protein secretion GO:0009306 98 0.013
cellular response to lipid GO:0071396 127 0.013
stem cell differentiation GO:0048863 93 0.013

MAP4K1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.267
hematopoietic system disease DOID:74 100 0.051
blood protein disease DOID:620 16 0.023
disease of cellular proliferation DOID:14566 174 0.023
primary immunodeficiency disease DOID:612 36 0.023
agammaglobulinemia DOID:2583 16 0.023
b cell deficiency DOID:2115 17 0.023
disease of metabolism DOID:0014667 295 0.016