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Process View

Homo sapiens

26 genes annotated in human

endothelial cell differentiation

The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endothelial cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endothelial cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
CAV1	caveolin 1, caveolae protein, 22kDa	0.773
SMAD3	SMAD family member 3	0.754
RARA	retinoic acid receptor, alpha	0.659
TGFB1	transforming growth factor, beta 1	0.387
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.386
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.317	Mouse
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.255
CD44	CD44 molecule (Indian blood group)	0.211
CAB39	calcium binding protein 39	0.200
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.187
GAB1	GRB2-associated binding protein 1	0.180
NCOA1	nuclear receptor coactivator 1	0.166
SMAD2	SMAD family member 2	0.159
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.153
SMAD7	SMAD family member 7	0.149
NRP1	neuropilin 1	0.145
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.143
FKBP1A	FK506 binding protein 1A, 12kDa	0.142
EZR	ezrin	0.142
DTNA	dystrobrevin, alpha	0.139
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.133
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.114
NOTCH1	notch 1	0.114	Mouse Rat
CNOT8	CCR4-NOT transcription complex, subunit 8	0.110
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.104
PBX1	pre-B-cell leukemia homeobox 1	0.099
PAX3	paired box 3	0.097
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.092	Mouse
JAG1	jagged 1	0.090
FLNA	filamin A, alpha	0.088
EGFR	epidermal growth factor receptor	0.086
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.085
MED25	mediator complex subunit 25	0.084
GAS6	growth arrest-specific 6	0.078
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.078
POU3F2	POU class 3 homeobox 2	0.073
CDH5	cadherin 5, type 2 (vascular endothelium)	0.072
TECPR1	tectonin beta-propeller repeat containing 1	0.071
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.071
PTCH1	patched 1	0.071
SPOP	speckle-type POZ protein	0.066
HNF4A	hepatocyte nuclear factor 4, alpha	0.060	Human
BMP2	bone morphogenetic protein 2	0.058
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.058
ENG	endoglin	0.054
POU5F1	POU class 5 homeobox 1	0.053
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.047
BCR	breakpoint cluster region	0.047
TJP1	tight junction protein 1 (zona occludens 1)	0.046
PLCG1	phospholipase C, gamma 1	0.043
LAT	linker for activation of T cells	0.042
ERBB2IP	erbb2 interacting protein	0.042
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.041
RXRA	retinoid X receptor, alpha	0.041	Human
FGFR1	fibroblast growth factor receptor 1	0.040
GATA2	GATA binding protein 2	0.039
PROX1	prospero homeobox 1	0.039
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.038
ABI1	abl-interactor 1	0.036
CTNND1	catenin (cadherin-associated protein), delta 1	0.034
PDCD10	programmed cell death 10	0.033
CXCR5	chemokine (C-X-C motif) receptor 5	0.031
ACVR1B	activin A receptor, type IB	0.030	Human
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.030
RANBP9	RAN binding protein 9	0.030
RAP1A	RAP1A, member of RAS oncogene family	0.029
TGFB3	transforming growth factor, beta 3	0.029
TBC1D10A	TBC1 domain family, member 10A	0.029
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.029
EPS8	epidermal growth factor receptor pathway substrate 8	0.028
GDF5	growth differentiation factor 5	0.028
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.028
FOXD3	forkhead box D3	0.028
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.027
NOTCH3	notch 3	0.026
PTEN	phosphatase and tensin homolog	0.026
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.025
MEIS2	Meis homeobox 2	0.023
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.022
GJA1	gap junction protein, alpha 1, 43kDa	0.022
DTNB	dystrobrevin, beta	0.022
THBS1	thrombospondin 1	0.022
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.021
ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	0.021
PTPRB	protein tyrosine phosphatase, receptor type, B	0.021
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.021
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.021
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.021
BMPR1A	bone morphogenetic protein receptor, type IA	0.020	Human
KRT5	keratin 5	0.020
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.020
PECAM1	platelet/endothelial cell adhesion molecule	0.020
MAML1	mastermind-like 1 (Drosophila)	0.019
IRAK2	interleukin-1 receptor-associated kinase 2	0.019
CAV2	caveolin 2	0.019
PICALM	phosphatidylinositol binding clathrin assembly protein	0.019
FAM46A	family with sequence similarity 46, member A	0.018
FYN	FYN oncogene related to SRC, FGR, YES	0.018
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.018
ACTN4	actinin, alpha 4	0.018
FN1	fibronectin 1	0.017	Zebrafish
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.017
HOXA9	homeobox A9	0.017
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.017
SREBF2	sterol regulatory element binding transcription factor 2	0.017
WNK4	WNK lysine deficient protein kinase 4	0.017
PLXNB1	plexin B1	0.017
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.017
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.017
HOXB7	homeobox B7	0.017
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.017
PRKG1	protein kinase, cGMP-dependent, type I	0.016
EMP3	epithelial membrane protein 3	0.016
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.016
ATXN1L	ataxin 1-like	0.016
PCDH17	protocadherin 17	0.016
RUNDC3A	RUN domain containing 3A	0.016
RUNX1	runt-related transcription factor 1	0.016
CXXC5	CXXC finger protein 5	0.016
TLR4	toll-like receptor 4	0.016
MSN	moesin	0.016
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.015
TCF4	transcription factor 4	0.015
QKI	quaking homolog, KH domain RNA binding (mouse)	0.015
TGFBR1	transforming growth factor, beta receptor 1	0.015	Human Rat
RALGDS	ral guanine nucleotide dissociation stimulator	0.015
CDV3	CDV3 homolog (mouse)	0.015
RET	ret proto-oncogene	0.014
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	0.014
ATP8	ATP synthase F0 subunit 8	0.014
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.014
SIAH1	seven in absentia homolog 1 (Drosophila)	0.014
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.014
VEGFC	vascular endothelial growth factor C	0.014
TCF12	transcription factor 12	0.014
RXRB	retinoid X receptor, beta	0.014	Human
HOXB6	homeobox B6	0.014
ACTN1	actinin, alpha 1	0.014
SNW1	SNW domain containing 1	0.014
CORO1C	coronin, actin binding protein, 1C	0.014
DLL1	delta-like 1 (Drosophila)	0.013
SKIL	SKI-like oncogene	0.013
VWF	von Willebrand factor	0.013
OXSR1	oxidative-stress responsive 1	0.013	Fly
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.013
PGF	placental growth factor	0.013
HOXB9	homeobox B9	0.013
MCAM	melanoma cell adhesion molecule	0.013
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.013
ATXN1	ataxin 1	0.013
ADRB2	adrenergic, beta-2-, receptor, surface	0.013
PKN2	protein kinase N2	0.013
CNOT1	CCR4-NOT transcription complex, subunit 1	0.013
TJP2	tight junction protein 2 (zona occludens 2)	0.013
BZW1	basic leucine zipper and W2 domains 1	0.013
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.013
SALL2	sal-like 2 (Drosophila)	0.013
SMAD6	SMAD family member 6	0.013
INADL	InaD-like (Drosophila)	0.012
BCAR1	breast cancer anti-estrogen resistance 1	0.012
HNF1A	HNF1 homeobox A	0.012
CLDN5	claudin 5	0.012
CTGF	connective tissue growth factor	0.012
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.012
ADAM9	ADAM metallopeptidase domain 9	0.012
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.012
OSMR	oncostatin M receptor	0.012
NOTCH2	notch 2	0.012
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.012
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.012
USP15	ubiquitin specific peptidase 15	0.012
RBPMS	RNA binding protein with multiple splicing	0.012
MED28	mediator complex subunit 28	0.012
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.012
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.012
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.011
NCOR2	nuclear receptor corepressor 2	0.011
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.011
VIM	vimentin	0.011
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.011
SH3PXD2A	SH3 and PX domains 2A	0.011
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.011	Human
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.011
MYH9	myosin, heavy chain 9, non-muscle	0.011
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.011
PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	0.011
YAP1	Yes-associated protein 1	0.011
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
DDIT4	DNA-damage-inducible transcript 4	0.011
MEOX2	mesenchyme homeobox 2	0.011
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.011
PAX6	paired box 6	0.011
GJA4	gap junction protein, alpha 4, 37kDa	0.011
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.011
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.011
RAMP3	receptor (G protein-coupled) activity modifying protein 3	0.011
RHOG	ras homolog gene family, member G (rho G)	0.011
FSTL1	follistatin-like 1	0.011
FXYD5	FXYD domain containing ion transport regulator 5	0.010
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.010
HOXA10	homeobox A10	0.010
EGFL7	EGF-like-domain, multiple 7	0.010
LYL1	lymphoblastic leukemia derived sequence 1	0.010
TSC22D1	TSC22 domain family, member 1	0.010
ITGB4	integrin, beta 4	0.010
PLEC	plectin	0.010
VCAM1	vascular cell adhesion molecule 1	0.010
SMAD1	SMAD family member 1	0.010
RHOC	ras homolog gene family, member C	0.010
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.010
RHOA	ras homolog gene family, member A	0.010
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.010
BMP4	bone morphogenetic protein 4	0.010	Mouse
ARHGAP29	Rho GTPase activating protein 29	0.010
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.010
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.010
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.010
SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	0.010
KANK3	KN motif and ankyrin repeat domains 3	0.010
TBX2	T-box 2	0.010
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.010	Mouse