IMP

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Homo sapiens

7 genes annotated in human

rap protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "rap protein signal transduction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "rap protein signal transduction" (in gray)

Name	Description	Probability	Func Analog Organism
ABI1	abl-interactor 1	0.989
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.989
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.988
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.950
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.944
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.927
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.897
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.862
EGFR	epidermal growth factor receptor	0.858
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.805
RALGDS	ral guanine nucleotide dissociation stimulator	0.654
CLASP1	cytoplasmic linker associated protein 1	0.646
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.623
LAT	linker for activation of T cells	0.576
FGFR1	fibroblast growth factor receptor 1	0.488
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.462
WASL	Wiskott-Aldrich syndrome-like	0.457
GRB2	growth factor receptor-bound protein 2	0.432
DNM1	dynamin 1	0.390
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.359
PLCG1	phospholipase C, gamma 1	0.358
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.356
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.350
RAP1A	RAP1A, member of RAS oncogene family	0.337
GAB1	GRB2-associated binding protein 1	0.302
SOS1	son of sevenless homolog 1 (Drosophila)	0.296	Human
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.283
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.267
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.246
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.227
CSNK1G2	casein kinase 1, gamma 2	0.222
RIN1	Ras and Rab interactor 1	0.200
STK4	serine/threonine kinase 4	0.191
GAB2	GRB2-associated binding protein 2	0.183
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.175
BCAR1	breast cancer anti-estrogen resistance 1	0.172
NCK1	NCK adaptor protein 1	0.171
MEOX2	mesenchyme homeobox 2	0.168
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.153
EPS8	epidermal growth factor receptor pathway substrate 8	0.152
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.146
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.127
PTCHD2	patched domain containing 2	0.125
RUNDC3A	RUN domain containing 3A	0.102
DYNC1I1	dynein, cytoplasmic 1, intermediate chain 1	0.098
PKN2	protein kinase N2	0.092
BCR	breakpoint cluster region	0.091
CDK17	cyclin-dependent kinase 17	0.091
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.087
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.087
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.083
ATP8	ATP synthase F0 subunit 8	0.074
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.072
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.058
GABARAPL1	GABA(A) receptor-associated protein like 1	0.055
STK3	serine/threonine kinase 3	0.054
CORO1C	coronin, actin binding protein, 1C	0.054
BAG1	BCL2-associated athanogene	0.053
SH3PXD2A	SH3 and PX domains 2A	0.050
PXN	paxillin	0.045
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.043
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.043
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.041
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	0.040
DNM2	dynamin 2	0.040
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.040
RAP1B	RAP1B, member of RAS oncogene family	0.036
ITSN1	intersectin 1 (SH3 domain protein)	0.036
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.035
SNAP25	synaptosomal-associated protein, 25kDa	0.035
AXL	AXL receptor tyrosine kinase	0.033
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.033
DGKZ	diacylglycerol kinase, zeta	0.032
PEBP1	phosphatidylethanolamine binding protein 1	0.031
REPS2	RALBP1 associated Eps domain containing 2	0.031
PTPRA	protein tyrosine phosphatase, receptor type, A	0.030
KRT8	keratin 8	0.029
RHOU	ras homolog gene family, member U	0.029
SHCBP1	SHC SH2-domain binding protein 1	0.028
PTK2	PTK2 protein tyrosine kinase 2	0.028
MAPK8	mitogen-activated protein kinase 8	0.027
BLNK	B-cell linker	0.027
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.027
HIPK1	homeodomain interacting protein kinase 1	0.026
CENPE	centromere protein E, 312kDa	0.026
VAV3	vav 3 guanine nucleotide exchange factor	0.026
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.026
RHEB	Ras homolog enriched in brain	0.026
CLTB	clathrin, light chain B	0.025
ADRBK1	adrenergic, beta, receptor kinase 1	0.024
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.024
SPRR2A	small proline-rich protein 2A	0.024
RAP2C	RAP2C, member of RAS oncogene family	0.023	Human Mouse
MAP2	microtubule-associated protein 2	0.023
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.022
NCKAP1	NCK-associated protein 1	0.022
NEB	nebulin	0.022
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.022
SAMD4A	sterile alpha motif domain containing 4A	0.021
KIF5B	kinesin family member 5B	0.021
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.020
ADAM15	ADAM metallopeptidase domain 15	0.020
RASAL2	RAS protein activator like 2	0.019
ARHGAP29	Rho GTPase activating protein 29	0.019
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.019
MAGI1	membrane associated guanylate kinase, WW and PDZ domain containing 1	0.019
PAX3	paired box 3	0.019
GOLT1B	golgi transport 1B	0.019
ADRB1	adrenergic, beta-1-, receptor	0.018
MEX3B	mex-3 homolog B (C. elegans)	0.018
AP2S1	adaptor-related protein complex 2, sigma 1 subunit	0.018
PDE4DIP	phosphodiesterase 4D interacting protein	0.018
KCNE3	potassium voltage-gated channel, Isk-related family, member 3	0.018
RET	ret proto-oncogene	0.017
IGSF21	immunoglobin superfamily, member 21	0.017
NRBF2	nuclear receptor binding factor 2	0.017
TIAM1	T-cell lymphoma invasion and metastasis 1	0.017
KCTD9	potassium channel tetramerisation domain containing 9	0.017
WDR44	WD repeat domain 44	0.017
PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	0.017
SPAG9	sperm associated antigen 9	0.017
SPRY2	sprouty homolog 2 (Drosophila)	0.016
OSBPL3	oxysterol binding protein-like 3	0.016
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.016
IGF1R	insulin-like growth factor 1 receptor	0.016
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.016
UBASH3B	ubiquitin associated and SH3 domain containing B	0.016
WIPF2	WAS/WASL interacting protein family, member 2	0.016
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.015
SHANK3	SH3 and multiple ankyrin repeat domains 3	0.015
SECISBP2L	SECIS binding protein 2-like	0.015
SH3BP4	SH3-domain binding protein 4	0.015
MAP2K1	mitogen-activated protein kinase kinase 1	0.014
CD28	CD28 molecule	0.014
PTP4A2	protein tyrosine phosphatase type IVA, member 2	0.014
DPP4	dipeptidyl-peptidase 4	0.014
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.014
RAB21	RAB21, member RAS oncogene family	0.014
GNA13	guanine nucleotide binding protein (G protein), alpha 13	0.014
STBD1	starch binding domain 1	0.014
PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	0.014
ERRFI1	ERBB receptor feedback inhibitor 1	0.014
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.014
FAM82A2	family with sequence similarity 82, member A2	0.013
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.013
QKI	quaking homolog, KH domain RNA binding (mouse)	0.013
RP2	retinitis pigmentosa 2 (X-linked recessive)	0.013
CADM4	cell adhesion molecule 4	0.013
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.013
CCNY	cyclin Y	0.013
CKAP2L	cytoskeleton associated protein 2-like	0.013
MRAS	muscle RAS oncogene homolog	0.013
ARL8B	ADP-ribosylation factor-like 8B	0.013
CMIP	c-Maf-inducing protein	0.013
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.012
AKAP2	A kinase (PRKA) anchor protein 2	0.012
WDR1	WD repeat domain 1	0.012
PLCE1	phospholipase C, epsilon 1	0.012
CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.012
ZNF267	zinc finger protein 267	0.012
IRS2	insulin receptor substrate 2	0.012
ATF7IP	activating transcription factor 7 interacting protein	0.012
PICALM	phosphatidylinositol binding clathrin assembly protein	0.012
MSI2	musashi homolog 2 (Drosophila)	0.012
STAT5A	signal transducer and activator of transcription 5A	0.012
LOC100288675	hypothetical protein LOC100288675	0.012
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.012
RIT1	Ras-like without CAAX 1	0.012
VANGL1	vang-like 1 (van gogh, Drosophila)	0.012
RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	0.012
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.012
RAP1GAP	RAP1 GTPase activating protein	0.012
ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A	0.012
KIF23	kinesin family member 23	0.012
IER5	immediate early response 5	0.012
KIAA0930	KIAA0930	0.011
TFG	TRK-fused gene	0.011
CPEB2	cytoplasmic polyadenylation element binding protein 2	0.011
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.011
OR5AR1	olfactory receptor, family 5, subfamily AR, member 1	0.011
ATXN1	ataxin 1	0.011
RAP2A	RAP2A, member of RAS oncogene family	0.011	Human Mouse
PSTPIP2	proline-serine-threonine phosphatase interacting protein 2	0.011
SFN	stratifin	0.011
PDCD10	programmed cell death 10	0.011
AGFG1	ArfGAP with FG repeats 1	0.011
LBR	lamin B receptor	0.011
TMOD3	tropomodulin 3 (ubiquitous)	0.011
DOCK4	dedicator of cytokinesis 4	0.011
CLIC4	chloride intracellular channel 4	0.011
C14orf176	chromosome 14 open reading frame 176	0.011
EEA1	early endosome antigen 1	0.010
ZNF295	zinc finger protein 295	0.010
FAP	fibroblast activation protein, alpha	0.010
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.010
CADPS	Ca++-dependent secretion activator	0.010
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.010
BZW1	basic leucine zipper and W2 domains 1	0.010
TJP2	tight junction protein 2 (zona occludens 2)	0.010
WASF1	WAS protein family, member 1	0.010
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.010
CHMP1A	chromatin modifying protein 1A	0.010
JAK2	Janus kinase 2	0.010
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.010