Homo sapiens

286 known processes

NOTCH1

notch 1

(Aliases: hN1,TAN1)

NOTCH1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
notch signaling involved in heart development GO:0061314 2 1.000
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 1.000
cell fate commitment involved in pattern specification GO:0060581 1 1.000
Fly
neuron fate commitment GO:0048663 2 1.000
Mouse
i kappab phosphorylation GO:0007252 7 1.000
Fly
cardiac right ventricle morphogenesis GO:0003215 3 1.000
Mouse
neuronal stem cell maintenance GO:0097150 5 1.000
aortic valve development GO:0003176 3 1.000
glial cell migration GO:0008347 4 1.000
Fly
negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 6 1.000
cardiac cell fate specification GO:0060912 1 1.000
Fly
regulation of cell migration involved in sprouting angiogenesis GO:0090049 9 1.000
organ formation GO:0048645 3 1.000
Rat Fly
spinal cord development GO:0021510 4 1.000
Zebrafish Rat
spinal cord dorsal ventral patterning GO:0021513 2 1.000
cell differentiation in spinal cord GO:0021515 1 1.000
Zebrafish Rat
endocardial cushion development GO:0003197 3 1.000
Mouse
muscle cell fate commitment GO:0042693 4 1.000
Fly
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 3 1.000
Mouse
pulmonary valve morphogenesis GO:0003184 5 1.000
loop of henle development GO:0072070 2 1.000
mesenchymal cell development GO:0014031 50 0.999
ventral spinal cord interneuron differentiation GO:0021514 1 0.999
nephron epithelium development GO:0072009 23 0.999
Mouse
pulmonary artery morphogenesis GO:0061156 3 0.999
sprouting angiogenesis GO:0002040 29 0.999
somatic stem cell maintenance GO:0035019 4 0.999
urogenital system development GO:0001655 65 0.999
Mouse Fly
cell fate determination GO:0001709 3 0.999
Fly
cell migration involved in sprouting angiogenesis GO:0002042 19 0.999
negative regulation of interleukin 10 production GO:0032693 7 0.999
hair cell differentiation GO:0035315 2 0.998
Mouse
pulmonary valve development GO:0003177 5 0.998
kidney epithelium development GO:0072073 25 0.998
Mouse
kidney development GO:0001822 53 0.998
Mouse
mitral valve morphogenesis GO:0003183 2 0.998
cell surface receptor signaling pathway involved in heart development GO:0061311 8 0.998
ventral spinal cord development GO:0021517 1 0.997
Zebrafish
circulatory system development GO:0072359 262 0.997
cardiocyte differentiation GO:0035051 23 0.997
Mouse Fly
cardiac atrium morphogenesis GO:0003209 7 0.997
Human Mouse
aorta morphogenesis GO:0035909 1 0.996
secondary heart field specification GO:0003139 2 0.995
pronephros development GO:0048793 2 0.995
cardioblast cell fate commitment GO:0042684 1 0.995
Fly
glomerulus development GO:0032835 15 0.993
Mouse
regulation of muscle organ development GO:0048634 27 0.993
cardioblast cell fate specification GO:0042685 1 0.992
Fly
mesenchyme development GO:0060485 59 0.991
regulation of epithelial cell migration GO:0010632 93 0.991
neural crest cell development GO:0014032 3 0.991
regulation of striated muscle cell differentiation GO:0051153 25 0.991
notch signaling pathway GO:0007219 31 0.990
stem cell development GO:0048864 69 0.990
ventricular trabecula myocardium morphogenesis GO:0003222 1 0.990
Mouse
regulation of cardiac cell fate specification GO:2000043 1 0.990
Fly
nephric duct development GO:0072176 4 0.990
blood vessel remodeling GO:0001974 2 0.989
mesenchymal cell differentiation GO:0048762 52 0.989
cardiac muscle tissue development GO:0048738 39 0.989
Mouse
cardiac atrium development GO:0003230 10 0.989
Human Mouse
positive regulation of cell differentiation GO:0045597 211 0.988
blood vessel development GO:0001568 172 0.988
heart valve formation GO:0003188 2 0.988
cardiovascular system development GO:0072358 262 0.987
peripheral nervous system development GO:0007422 2 0.987
Zebrafish Fly
cardiac septum morphogenesis GO:0060411 9 0.987
negative regulation of multicellular organismal process GO:0051241 317 0.986
artery morphogenesis GO:0048844 7 0.986
Mouse
regulation of muscle tissue development GO:1901861 26 0.985
heart valve development GO:0003170 8 0.985
atrioventricular valve formation GO:0003190 1 0.985
angiogenesis GO:0001525 147 0.984
epithelial cell differentiation GO:0030855 141 0.983
Mouse Rat Fly
regulation of myotube differentiation GO:0010830 18 0.982
renal system development GO:0072001 63 0.982
Mouse Fly
nephron development GO:0072006 30 0.982
Mouse
heart valve morphogenesis GO:0003179 8 0.982
aortic valve morphogenesis GO:0003180 3 0.981
memory GO:0007613 3 0.980
Fly
regulation of striated muscle tissue development GO:0016202 26 0.979
vasculature development GO:0001944 181 0.977
heart development GO:0007507 95 0.976
morphogenesis of an epithelium GO:0002009 60 0.975
Mouse Fly
hematopoietic or lymphoid organ development GO:0048534 186 0.975
Mouse Fly
spinal cord patterning GO:0021511 2 0.975
muscle tissue development GO:0060537 62 0.974
regulation of cell differentiation GO:0045595 393 0.973
negative regulation of stem cell differentiation GO:2000737 22 0.972
cellular response to gonadotropin stimulus GO:0071371 4 0.972
organ morphogenesis GO:0009887 147 0.971
atrioventricular valve development GO:0003171 3 0.970
myoblast differentiation GO:0045445 21 0.970
blood vessel morphogenesis GO:0048514 162 0.969
regulation of epithelial to mesenchymal transition GO:0010717 37 0.967
distal tubule development GO:0072017 4 0.967
Mouse
positive regulation of bmp signaling pathway GO:0030513 9 0.966
Mouse
cardiac chamber development GO:0003205 30 0.964
t cell selection GO:0045058 4 0.963
epidermal cell differentiation GO:0009913 45 0.963
Mouse
positive regulation of mitotic cell cycle GO:0045931 60 0.961
Fly
g1 s transition of mitotic cell cycle GO:0000082 78 0.960
Fly
positive regulation of cell proliferation GO:0008284 301 0.960
cytokine production GO:0001816 247 0.960
Mouse
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.960
tube morphogenesis GO:0035239 95 0.960
oogenesis GO:0048477 2 0.959
Fly
heart morphogenesis GO:0003007 48 0.958
regulation of wnt signaling pathway involved in heart development GO:0003307 3 0.957
cell cell signaling involved in cell fate commitment GO:0045168 5 0.956
Worm Fly
epithelium development GO:0060429 227 0.956
Zebrafish Mouse Rat Fly
myeloid dendritic cell differentiation GO:0043011 3 0.955
regulation of cell cycle phase transition GO:1901987 126 0.954
Fly
regulation of myoblast differentiation GO:0045661 12 0.953
leukocyte differentiation GO:0002521 98 0.950
negative regulation of developmental process GO:0051093 247 0.949
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.949
Fly
cardiac muscle cell fate commitment GO:0060923 4 0.946
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.945
Mouse
regulation of stem cell differentiation GO:2000736 56 0.945
regulation of cardiac muscle cell differentiation GO:2000725 7 0.945
cardioblast differentiation GO:0010002 8 0.939
Mouse Fly
renal tubule development GO:0061326 19 0.935
Mouse Fly
myeloid cell differentiation GO:0030099 117 0.934
cartilage development involved in endochondral bone morphogenesis GO:0060351 2 0.933
epithelial cell fate commitment GO:0072148 3 0.933
Mouse
cell activation GO:0001775 213 0.928
positive regulation of cardiac muscle cell differentiation GO:2000727 4 0.927
epithelium migration GO:0090132 119 0.925
cell proliferation in forebrain GO:0021846 1 0.924
endothelial cell migration GO:0043542 86 0.924
epithelial tube morphogenesis GO:0060562 38 0.923
Mouse Fly
striated muscle cell differentiation GO:0051146 43 0.920
specification of organ identity GO:0010092 3 0.920
positive regulation of notch signaling pathway GO:0045747 6 0.918
Fly
positive regulation of striated muscle cell differentiation GO:0051155 9 0.915
epithelial to mesenchymal transition GO:0001837 48 0.915
blood vessel endothelial cell migration GO:0043534 42 0.915
immune system development GO:0002520 195 0.914
Mouse Fly
thymic t cell selection GO:0045061 2 0.913
cellular response to vascular endothelial growth factor stimulus GO:0035924 26 0.912
stem cell maintenance GO:0019827 19 0.911
positive regulation of osteoblast differentiation GO:0045669 23 0.910
cardiac septum development GO:0003279 13 0.910
skin development GO:0043588 76 0.909
Mouse
positive regulation of stem cell differentiation GO:2000738 29 0.908
muscle cell development GO:0055001 29 0.907
regulation of vasculature development GO:1901342 97 0.897
cell development GO:0048468 328 0.897
atrioventricular valve morphogenesis GO:0003181 2 0.897
compound eye development GO:0048749 1 0.895
Fly
regulation of myeloid cell differentiation GO:0045637 81 0.894
cardiac ventricle development GO:0003231 23 0.887
skeletal muscle fiber development GO:0048741 12 0.886
negative regulation of angiogenesis GO:0016525 39 0.879
semicircular canal morphogenesis GO:0048752 1 0.879
i kappab kinase nf kappab signaling GO:0007249 166 0.871
Fly
nephron tubule development GO:0072080 17 0.869
Mouse
cardiac conduction system development GO:0003161 2 0.868
Mouse
cardiac cell fate commitment GO:0060911 7 0.867
Fly
oligodendrocyte development GO:0014003 6 0.865
cardiac ventricle morphogenesis GO:0003208 20 0.860
Mouse
ventral spinal cord interneuron fate commitment GO:0060579 1 0.859
hemopoiesis GO:0030097 180 0.856
Mouse Fly
regulation of endothelial cell migration GO:0010594 67 0.855
atrial septum morphogenesis GO:0060413 5 0.853
Human
negative regulation of cellular component movement GO:0051271 106 0.852
mitotic cell cycle phase transition GO:0044772 162 0.850
Fly
positive regulation of epithelial to mesenchymal transition GO:0010718 22 0.849
regulation of cardioblast cell fate specification GO:0042686 1 0.844
Fly
positive regulation of myeloid cell differentiation GO:0045639 39 0.841
negative regulation of myoblast differentiation GO:0045662 7 0.840
epidermis development GO:0008544 59 0.837
Mouse
proximal tubule development GO:0072014 1 0.836
negative regulation of blood vessel endothelial cell migration GO:0043537 16 0.835
regulation of blood vessel endothelial cell migration GO:0043535 30 0.834
cardiac epithelial to mesenchymal transition GO:0060317 3 0.833
Mouse
salivary gland morphogenesis GO:0007435 4 0.833
negative regulation of cell development GO:0010721 48 0.832
Zebrafish Mouse Rat Fly
stem cell differentiation GO:0048863 93 0.832
regulation of blood vessel size GO:0050880 18 0.831
female gamete generation GO:0007292 2 0.830
Fly
pattern specification process GO:0007389 43 0.827
Zebrafish Mouse Worm Fly
regulation of cell migration GO:0030334 289 0.826
regulation of skeletal muscle fiber development GO:0048742 12 0.825
regulation of muscle cell differentiation GO:0051147 31 0.823
ventricular septum development GO:0003281 5 0.823
negative regulation of cell migration GO:0030336 102 0.822
leukocyte activation GO:0045321 164 0.820
ras protein signal transduction GO:0007265 73 0.819
Human
positive regulation of muscle cell differentiation GO:0051149 15 0.818
tissue morphogenesis GO:0048729 96 0.817
Zebrafish Mouse Fly
mitotic cell cycle GO:0000278 326 0.815
Fly
negative regulation of endothelial cell migration GO:0010596 29 0.805
regulation of ossification GO:0030278 58 0.805
Mouse
muscle fiber development GO:0048747 16 0.804
regeneration GO:0031099 4 0.800
Rat
negative regulation of programmed cell death GO:0043069 321 0.800
negative regulation of vasculature development GO:1901343 43 0.800
regulation of heart morphogenesis GO:2000826 4 0.799
Mouse Rat
negative regulation of cell proliferation GO:0008285 228 0.797
t cell activation GO:0042110 99 0.795
determination of adult lifespan GO:0008340 2 0.792
Worm Fly
negative regulation of neuron differentiation GO:0045665 21 0.790
Mouse Rat Fly
cardiac muscle cell myoblast differentiation GO:0060379 5 0.787
Mouse
regulation of anatomical structure morphogenesis GO:0022603 286 0.787
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 41 0.784
Mouse
negative regulation of locomotion GO:0040013 118 0.782
gliogenesis GO:0042063 21 0.780
Zebrafish Mouse Rat Fly
negative regulation of cytokine production GO:0001818 82 0.779
positive regulation of developmental process GO:0051094 314 0.777
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.773
regulation of chemotaxis GO:0050920 74 0.770
negative regulation of epithelial cell migration GO:0010633 38 0.770
myeloid dendritic cell activation GO:0001773 4 0.768
endocardial cushion cell differentiation GO:0061443 1 0.762
regulation of cell motility GO:2000145 299 0.755
regulation of locomotion GO:0040012 329 0.755
endothelial cell chemotaxis GO:0035767 13 0.752
response to biotic stimulus GO:0009607 276 0.752
Rat Fly
lymphocyte mediated immunity GO:0002449 48 0.750
embryonic hemopoiesis GO:0035162 4 0.749
Fly
anatomical structure formation involved in morphogenesis GO:0048646 284 0.748
lymphocyte activation GO:0046649 133 0.744
actin cytoskeleton organization GO:0030036 207 0.738
Fly
negative regulation of cell differentiation GO:0045596 171 0.733
muscle cell differentiation GO:0042692 63 0.730
immune response GO:0006955 307 0.729
Mouse
ameboidal type cell migration GO:0001667 135 0.729
oligodendrocyte differentiation GO:0048709 7 0.725
Mouse Rat
multicellular organismal aging GO:0010259 3 0.724
Worm Fly
head development GO:0060322 108 0.723
Zebrafish Mouse Rat
regulation of heart growth GO:0060420 4 0.723
Mouse
tissue remodeling GO:0048771 16 0.719
Human
regulation of behavior GO:0050795 82 0.713
cuticle development GO:0042335 1 0.701
regulation of cellular component movement GO:0051270 334 0.695
cell fate commitment GO:0045165 27 0.690
Zebrafish Mouse Worm Fly
atrial septum development GO:0003283 8 0.685
Human
negative regulation of neurogenesis GO:0050768 26 0.683
Zebrafish Mouse Rat Fly
skeletal system development GO:0001501 79 0.681
cellular response to growth factor stimulus GO:0071363 197 0.681
keratinocyte differentiation GO:0030216 36 0.672
Mouse
embryonic heart tube morphogenesis GO:0003143 8 0.669
Mouse
embryonic organ development GO:0048568 36 0.669
Zebrafish Mouse Fly
cell chemotaxis GO:0060326 112 0.660
gland development GO:0048732 48 0.660
Human Mouse Fly
cellular response to endogenous stimulus GO:0071495 336 0.654
nervous system development GO:0007399 293 0.651
Zebrafish Mouse Rat Fly
positive regulation of cardiac muscle tissue growth GO:0055023 2 0.651
Mouse
cardiac muscle cell differentiation GO:0055007 15 0.644
system process GO:0003008 349 0.638
Fly
endochondral bone morphogenesis GO:0060350 3 0.635
leukocyte mediated immunity GO:0002443 59 0.632
inner ear morphogenesis GO:0042472 4 0.615
tube development GO:0035295 125 0.610
negative regulation of cell substrate adhesion GO:0010812 24 0.610
renal filtration cell differentiation GO:0061318 4 0.609
defense response GO:0006952 315 0.606
Mouse
hair cycle GO:0042633 28 0.605
Mouse
neuron differentiation GO:0030182 138 0.603
Zebrafish Mouse Rat Fly
cardiac chamber morphogenesis GO:0003206 26 0.597
regulation of mitotic cell cycle GO:0007346 189 0.593
Fly
regulation of neurogenesis GO:0050767 82 0.593
Zebrafish Mouse Rat Fly
positive regulation of ossification GO:0045778 32 0.592
positive regulation of cell cycle GO:0045787 140 0.588
Fly
glial cell differentiation GO:0010001 11 0.585
Zebrafish Mouse Rat Fly
regulation of cell fate commitment GO:0010453 7 0.583
Zebrafish Fly
negative regulation of cell cycle GO:0045786 193 0.581
Human
kidney vasculature development GO:0061440 7 0.578
Mouse
regulation of angiogenesis GO:0045765 92 0.578
negative regulation of notch signaling pathway GO:0045746 10 0.568
epithelial cell migration GO:0010631 119 0.567
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.566
developmental programmed cell death GO:0010623 3 0.555
Mouse
lateral mesoderm development GO:0048368 1 0.554
regulation of cardiac muscle tissue development GO:0055024 13 0.553
Mouse
myotube differentiation GO:0014902 22 0.551
regulation of ras protein signal transduction GO:0046578 155 0.548
Human
lymphocyte differentiation GO:0030098 35 0.547
regulation of cell proliferation involved in heart morphogenesis GO:2000136 1 0.546
Mouse Rat
actin filament organization GO:0007015 128 0.538
Fly
response to growth factor GO:0070848 205 0.537
muscle structure development GO:0061061 98 0.536
negative regulation of muscle cell differentiation GO:0051148 17 0.536
regulation of neuron differentiation GO:0045664 70 0.531
Mouse Rat Fly
pituitary gland development GO:0021983 2 0.531
generation of neurons GO:0048699 152 0.525
Zebrafish Mouse Rat Fly
muscle organ development GO:0007517 56 0.522
cell cycle phase transition GO:0044770 173 0.512
Fly
negative regulation of blood vessel morphogenesis GO:2000181 41 0.511
outflow tract morphogenesis GO:0003151 10 0.509
negative regulation of cell motility GO:2000146 104 0.505
positive regulation of cell development GO:0010720 92 0.505
regulation of cardiac muscle cell proliferation GO:0060043 4 0.503
Mouse
lung cell differentiation GO:0060479 1 0.502
adaptive immune response GO:0002250 49 0.498
cell projection organization GO:0030030 252 0.498
Zebrafish Mouse Fly
heart field specification GO:0003128 2 0.498
cell substrate adhesion GO:0031589 132 0.497
post embryonic development GO:0009791 2 0.497
Worm Fly
wnt signaling pathway involved in heart development GO:0003306 5 0.496
determination of left right asymmetry in lateral mesoderm GO:0003140 1 0.487
regulation of smooth muscle cell proliferation GO:0048660 28 0.482
positive regulation of cardiac muscle tissue development GO:0055025 6 0.475
Mouse
regulation of cell cycle GO:0051726 393 0.473
Human Worm Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.467
Mouse
mitral valve development GO:0003174 3 0.462
tissue migration GO:0090130 119 0.460
trabecula morphogenesis GO:0061383 2 0.459
Mouse
response to organonitrogen compound GO:0010243 156 0.458
Mouse
regulation of notch signaling pathway GO:0008593 18 0.449
Fly
glomerulus vasculature development GO:0072012 6 0.448
Mouse
positive regulation of cell cycle process GO:0090068 106 0.443
Fly
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.439
regulation of cardioblast differentiation GO:0051890 4 0.438
Fly
lung epithelial cell differentiation GO:0060487 1 0.438
negative regulation of cell death GO:0060548 345 0.436
regulation of cell morphogenesis GO:0022604 153 0.428
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.425
central nervous system development GO:0007417 123 0.418
Zebrafish Mouse Rat
glomerular visceral epithelial cell differentiation GO:0072112 4 0.415
t cell differentiation in thymus GO:0033077 4 0.411
cell morphogenesis involved in differentiation GO:0000904 144 0.410
segmentation GO:0035282 4 0.408
Zebrafish Mouse Fly
ear development GO:0043583 14 0.402
Mouse
myeloid leukocyte differentiation GO:0002573 60 0.399
positive regulation of small gtpase mediated signal transduction GO:0051057 12 0.398
Human
defense response to bacterium GO:0042742 63 0.395
motor neuron axon guidance GO:0008045 2 0.394
Fly
glomerular epithelial cell differentiation GO:0072311 5 0.393
ossification GO:0001503 121 0.391
Mouse
pronephric nephron development GO:0039019 1 0.382
regionalization GO:0003002 29 0.377
Zebrafish Mouse Fly
regulation of cellular component biogenesis GO:0044087 281 0.376
Mouse Fly
determination of bilateral symmetry GO:0009855 15 0.375
Zebrafish Mouse
regulation of cell development GO:0060284 161 0.372
sensory organ development GO:0007423 52 0.367
Mouse Fly
ventricular cardiac muscle tissue development GO:0003229 14 0.367
Mouse
behavior GO:0007610 112 0.366
canonical wnt signaling pathway GO:0060070 116 0.366
Mouse
humoral immune response GO:0006959 49 0.364
Mouse
regulation of osteoblast differentiation GO:0045667 38 0.363
Mouse
positive regulation of immune system process GO:0002684 283 0.360
liver development GO:0001889 9 0.359
Mouse
osteoblast differentiation GO:0001649 92 0.357
Mouse
hepaticobiliary system development GO:0061008 10 0.356
Mouse
cell cycle g1 s phase transition GO:0044843 80 0.350
Fly
response to nitrogen compound GO:1901698 184 0.344
Mouse
response to muramyl dipeptide GO:0032495 4 0.343
Mouse
chordate embryonic development GO:0043009 34 0.337
Zebrafish Mouse
aorta development GO:0035904 2 0.337
defense response to other organism GO:0098542 129 0.336
response to peptide GO:1901652 65 0.333
Mouse
cardiac muscle tissue morphogenesis GO:0055008 18 0.333
Mouse
neurogenesis GO:0022008 169 0.328
Zebrafish Mouse Rat Fly
blastoderm segmentation GO:0007350 2 0.327
response to cytokine GO:0034097 232 0.327
epithelial cell differentiation involved in kidney development GO:0035850 9 0.324
Mouse
gland morphogenesis GO:0022612 8 0.323
Mouse
cell cell signaling GO:0007267 155 0.315
Worm Fly
response to fibroblast growth factor GO:0071774 39 0.314
dendritic cell differentiation GO:0097028 13 0.308
regulation of organ morphogenesis GO:2000027 24 0.305
Zebrafish Mouse Rat Fly
cardiac left ventricle morphogenesis GO:0003214 6 0.300
Mouse
filopodium assembly GO:0046847 18 0.293
Fly
cell proliferation involved in heart morphogenesis GO:0061323 1 0.291
Rat
semicircular canal development GO:0060872 1 0.287
regulation of cell adhesion GO:0030155 166 0.283
respiratory system development GO:0060541 22 0.272
Mouse Fly
regulation of skeletal muscle tissue development GO:0048641 15 0.271
epithelial cell proliferation GO:0050673 128 0.271
Mouse Fly
ventricular septum morphogenesis GO:0060412 3 0.270
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 6 0.268
Mouse
striated muscle cell development GO:0055002 27 0.267
determination of left right symmetry GO:0007368 11 0.265
Zebrafish Mouse
growth GO:0040007 202 0.264
Human Mouse Rat Fly
regulation of tube size GO:0035150 18 0.263
ear morphogenesis GO:0042471 7 0.261
immune effector process GO:0002252 159 0.259
specification of symmetry GO:0009799 16 0.257
Zebrafish Mouse
muscle tissue morphogenesis GO:0060415 19 0.253
Mouse
wnt signaling pathway GO:0016055 156 0.249
Mouse
regulation of leukocyte differentiation GO:1902105 61 0.248
appendage morphogenesis GO:0035107 16 0.248
Mouse Fly
response to oxygen containing compound GO:1901700 369 0.247
Mouse Rat
forebrain development GO:0030900 26 0.246
Zebrafish Mouse
t cell differentiation GO:0030217 29 0.245
cellular amino acid metabolic process GO:0006520 116 0.244
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.243
Mouse
neurological system process GO:0050877 163 0.243
Fly
chemotaxis GO:0006935 157 0.242
embryonic placenta development GO:0001892 1 0.241
glomerular epithelium development GO:0072010 7 0.235
glial cell proliferation GO:0014009 6 0.234
Mouse
bone development GO:0060348 26 0.231
negative regulation of response to external stimulus GO:0032102 83 0.227
sebaceous gland development GO:0048733 1 0.220
interleukin 10 production GO:0032613 17 0.220
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.219
Mouse
vascular process in circulatory system GO:0003018 29 0.215
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 19 0.213
Fly
skeletal system morphogenesis GO:0048705 24 0.213
regulation of filopodium assembly GO:0051489 13 0.211
Fly
t cell mediated immunity GO:0002456 25 0.210
negative regulation of cell adhesion GO:0007162 64 0.208
glial cell development GO:0021782 7 0.207
negative regulation of nervous system development GO:0051961 28 0.206
Zebrafish Mouse Rat Fly
cell projection assembly GO:0030031 126 0.203
Fly
secretion GO:0046903 254 0.202
Mouse
negative regulation of endothelial cell chemotaxis GO:2001027 4 0.202
regulation of vesicle mediated transport GO:0060627 130 0.200
Zebrafish Mouse
positive regulation of cellular component organization GO:0051130 376 0.200
cellular response to organic cyclic compound GO:0071407 127 0.199
inner ear development GO:0048839 8 0.195
Mouse
regulation of nervous system development GO:0051960 88 0.193
Zebrafish Mouse Rat Fly
myotube cell development GO:0014904 14 0.187
regulation of growth GO:0040008 165 0.184
Mouse Fly
inflammatory response to antigenic stimulus GO:0002437 4 0.184
Mouse
positive regulation of leukocyte differentiation GO:1902107 37 0.184
positive regulation of apoptotic signaling pathway GO:2001235 70 0.183
endothelial cell fate commitment GO:0060839 3 0.183
sensory organ morphogenesis GO:0090596 21 0.181
Fly
myeloid leukocyte activation GO:0002274 34 0.179
response to hormone GO:0009725 175 0.178
regulation of mitotic cell cycle phase transition GO:1901990 118 0.178
Fly
renal system vasculature morphogenesis GO:0061438 1 0.176
digestive system development GO:0055123 75 0.176
Zebrafish Mouse Worm Fly
intrinsic apoptotic signaling pathway GO:0097193 127 0.176
secretion by cell GO:0032940 226 0.175
Mouse
taxis GO:0042330 157 0.174
cellular response to external stimulus GO:0071496 111 0.171
neuron projection development GO:0031175 106 0.170
Zebrafish Mouse Fly
hematopoietic stem cell differentiation GO:0060218 4 0.167
mesoderm development GO:0007498 14 0.165
Zebrafish Fly
actin filament based process GO:0030029 224 0.164
Fly
cellular component morphogenesis GO:0032989 314 0.162
regulation of cytokine production GO:0001817 232 0.159
amine metabolic process GO:0009308 44 0.158
kidney vasculature morphogenesis GO:0061439 1 0.155
regulation of cellular amino acid metabolic process GO:0006521 6 0.155
positive regulation of programmed cell death GO:0043068 249 0.153
Mouse
digestive tract development GO:0048565 75 0.150
Zebrafish Mouse Worm Fly
neuron development GO:0048666 113 0.146
Zebrafish Mouse Fly
branching morphogenesis of an epithelial tube GO:0048754 19 0.146
Mouse
regulation of myeloid leukocyte differentiation GO:0002761 39 0.146
morphogenesis of an epithelial sheet GO:0002011 12 0.145
Mouse
long term memory GO:0007616 2 0.141
Fly
thyroid gland development GO:0030878 5 0.138
reproductive structure development GO:0048608 55 0.137
Mouse Worm Fly
reproductive system development GO:0061458 56 0.137
Mouse Worm Fly
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.136
hair follicle maturation GO:0048820 3 0.136
Mouse
axonogenesis GO:0007409 31 0.136
Zebrafish Mouse Fly
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.134
cell fate specification GO:0001708 8 0.133
Zebrafish Mouse Worm Fly
cell projection morphogenesis GO:0048858 129 0.132
Zebrafish Mouse Fly
ventricular cardiac muscle tissue morphogenesis GO:0055010 14 0.131
Mouse
positive regulation of protein phosphorylation GO:0001934 313 0.131
negative regulation of epidermal cell differentiation GO:0045605 4 0.128
regulation of response to external stimulus GO:0032101 222 0.126
organophosphate catabolic process GO:0046434 430 0.126
blood circulation GO:0008015 113 0.125
response to organic cyclic compound GO:0014070 204 0.124
Rat
cardiac muscle cell proliferation GO:0060038 6 0.123
Mouse
epithelial cell development GO:0002064 34 0.123
Mouse Fly
axon guidance GO:0007411 12 0.122
Fly
ephrin receptor signaling pathway GO:0048013 15 0.119
embryo development GO:0009790 123 0.117
Zebrafish Mouse Worm Fly
regulation of kinase activity GO:0043549 314 0.117
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.115
endothelial cell differentiation GO:0045446 26 0.114
Mouse Rat
enzyme linked receptor protein signaling pathway GO:0007167 303 0.113
Mouse
regulation of peptidase activity GO:0052547 180 0.112
cell adhesion GO:0007155 325 0.112
eye development GO:0001654 42 0.111
Fly
connective tissue development GO:0061448 39 0.111
Mouse
cell growth GO:0016049 160 0.111
Human
embryonic morphogenesis GO:0048598 85 0.111
Zebrafish Mouse Fly
positive regulation of myotube differentiation GO:0010831 3 0.108
fat soluble vitamin metabolic process GO:0006775 19 0.108
regulation of cysteine type endopeptidase activity GO:2000116 127 0.106
regulation of small gtpase mediated signal transduction GO:0051056 156 0.105
Human
positive regulation of cell cycle phase transition GO:1901989 22 0.104
Fly
negative regulation of fat cell differentiation GO:0045599 9 0.104
mitotic cell cycle process GO:1903047 286 0.104
Fly
cellular response to abiotic stimulus GO:0071214 117 0.103
regulation of endopeptidase activity GO:0052548 170 0.103

NOTCH1 disease predictions

Disease DO term ID Size Probability Func Analog Org
hepatobiliary disease DOID:3118 7 1.000
Human
gastrointestinal system disease DOID:77 36 1.000
Human
liver disease DOID:409 7 1.000
Human
cardiovascular system disease DOID:1287 106 0.986
heart disease DOID:114 68 0.970
congenital heart disease DOID:1682 16 0.774