IMP

Process View

Homo sapiens

12 genes annotated in human

axon guidance

The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "axon guidance"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "axon guidance" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.952	Fly
EGFR	epidermal growth factor receptor	0.861
FYN	FYN oncogene related to SRC, FGR, YES	0.843	Fly
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.741	Fly
PLCG1	phospholipase C, gamma 1	0.674
ATXN1	ataxin 1	0.575
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.473	Fly
ATF2	activating transcription factor 2	0.440
FN1	fibronectin 1	0.439
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.356
QKI	quaking homolog, KH domain RNA binding (mouse)	0.263	Worm
TAL1	T-cell acute lymphocytic leukemia 1	0.232
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.230	Mouse
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.218
APP	amyloid beta (A4) precursor protein	0.196	Mouse
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.193
GSK3B	glycogen synthase kinase 3 beta	0.170
IGF1R	insulin-like growth factor 1 receptor	0.154	Fly
NRP1	neuropilin 1	0.133	Zebrafish Mouse Rat
JAG1	jagged 1	0.131
FLNA	filamin A, alpha	0.127	Fly
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.124
ZNF512B	zinc finger protein 512B	0.124
NOTCH1	notch 1	0.122	Fly
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.114	Fly
ITGB4	integrin, beta 4	0.110	Fly
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.110
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.101
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.091
TUBB3	tubulin, beta 3	0.090
MAPK8	mitogen-activated protein kinase 8	0.087	Fly
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.082
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.081
MSN	moesin	0.080	Fly
APC	adenomatous polyposis coli	0.074	Fly
ATN1	atrophin 1	0.069
SOS1	son of sevenless homolog 1 (Drosophila)	0.066	Fly
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.065	Fly
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.058
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.058
FKBP1A	FK506 binding protein 1A, 12kDa	0.057
PTPRC	protein tyrosine phosphatase, receptor type, C	0.057	Fly
HSPA1B	heat shock 70kDa protein 1B	0.056	Fly
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.055
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.053
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.049
FGFR2	fibroblast growth factor receptor 2	0.049	Worm
ABI1	abl-interactor 1	0.049	Fly
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.047	Mouse Worm Fly
TRIO	triple functional domain (PTPRF interacting)	0.046	Worm Fly
ZNF746	zinc finger protein 746	0.046
FGFR1	fibroblast growth factor receptor 1	0.045	Worm
SMAD2	SMAD family member 2	0.044
TCF4	transcription factor 4	0.043
SMO	smoothened homolog (Drosophila)	0.042	Zebrafish Rat
DST	dystonin	0.042	Fly
TCF12	transcription factor 12	0.039
JAG2	jagged 2	0.038
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.036	Fly
BMP7	bone morphogenetic protein 7	0.036	Mouse
MYO10	myosin X	0.033
RBPMS	RNA binding protein with multiple splicing	0.033
TUBB	tubulin, beta	0.033	Human
PLEC	plectin	0.033	Fly
CSNK2B	casein kinase 2, beta polypeptide	0.032
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.032
BCAR1	breast cancer anti-estrogen resistance 1	0.032
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.032
WDR5	WD repeat domain 5	0.031
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.031	Fly
LMO4	LIM domain only 4	0.031
SOX11	SRY (sex determining region Y)-box 11	0.031
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.031	Zebrafish
RHOXF2	Rhox homeobox family, member 2	0.030
WIPF1	WAS/WASL interacting protein family, member 1	0.030
SMAD3	SMAD family member 3	0.030
CBX8	chromobox homolog 8	0.029
PCGF2	polycomb group ring finger 2	0.028	Fly
IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	0.028
NOTCH3	notch 3	0.028	Fly
NCKAP1	NCK-associated protein 1	0.027
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.027
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.026
CSNK2A2	casein kinase 2, alpha prime polypeptide	0.026	Fly
PDIA3	protein disulfide isomerase family A, member 3	0.026
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.025
CEP170	centrosomal protein 170kDa	0.025
VHL	von Hippel-Lindau tumor suppressor	0.025	Worm
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.025
THBS1	thrombospondin 1	0.025
FGF1	fibroblast growth factor 1 (acidic)	0.024	Worm
LAMB1	laminin, beta 1	0.024
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.024
ZFYVE9	zinc finger, FYVE domain containing 9	0.024
SPTBN1	spectrin, beta, non-erythrocytic 1	0.024	Worm
C2orf65	chromosome 2 open reading frame 65	0.023
TUBB2C	tubulin, beta 2C	0.023	Human
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.023
CTCF	CCCTC-binding factor (zinc finger protein)	0.023
LAT	linker for activation of T cells	0.023
RUNX1	runt-related transcription factor 1	0.022	Fly
CHRD	chordin	0.022
NAV1	neuron navigator 1	0.022	Worm
PTCH1	patched 1	0.022	Fly
ENG	endoglin	0.022
ARRB1	arrestin, beta 1	0.021
SLIT2	slit homolog 2 (Drosophila)	0.021
RING1	ring finger protein 1	0.021
TUBB2A	tubulin, beta 2A	0.021	Human
SYK	spleen tyrosine kinase	0.021
LRP6	low density lipoprotein receptor-related protein 6	0.020
CD44	CD44 molecule (Indian blood group)	0.020
SEMA6D	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.020	Human Fly
MYH9	myosin, heavy chain 9, non-muscle	0.020
JUN	jun proto-oncogene	0.020
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.020	Fly
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.020
LDOC1	leucine zipper, down-regulated in cancer 1	0.020
DDR1	discoidin domain receptor tyrosine kinase 1	0.020
RNF2	ring finger protein 2	0.019
NCOR1	nuclear receptor corepressor 1	0.019
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.019	Fly
KIF1B	kinesin family member 1B	0.019	Fly
DOCK1	dedicator of cytokinesis 1	0.019
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.018
HSPA1A	heat shock 70kDa protein 1A	0.018	Fly
PFN1	profilin 1	0.018
POU5F1	POU class 5 homeobox 1	0.018
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.018
GHR	growth hormone receptor	0.017
USP11	ubiquitin specific peptidase 11	0.017
AGRN	agrin	0.017	Rat
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.017
GAS7	growth arrest-specific 7	0.017
HSPG2	heparan sulfate proteoglycan 2	0.016
CPE	carboxypeptidase E	0.016
SPRR2A	small proline-rich protein 2A	0.016
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.016
RANBP2	RAN binding protein 2	0.016
PBX1	pre-B-cell leukemia homeobox 1	0.016
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.016	Fly
CLASP1	cytoplasmic linker associated protein 1	0.016	Fly
TUBA1C	tubulin, alpha 1c	0.016
SPTA1	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	0.016
SIRT1	sirtuin 1	0.015
LRP1	low density lipoprotein receptor-related protein 1	0.015
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.015
ARHGAP1	Rho GTPase activating protein 1	0.015
NCOR2	nuclear receptor corepressor 2	0.015
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.015
CBX4	chromobox homolog 4	0.015
CCNK	cyclin K	0.015
FGFR3	fibroblast growth factor receptor 3	0.015	Worm
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.015
NRP2	neuropilin 2	0.015	Zebrafish Mouse Rat
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.015
EPS8	epidermal growth factor receptor pathway substrate 8	0.015
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.015
CBX6	chromobox homolog 6	0.015
AXIN1	axin 1	0.015
TUBA1A	tubulin, alpha 1a	0.014
TGFB2	transforming growth factor, beta 2	0.014	Mouse Fly
MAP2K4	mitogen-activated protein kinase kinase 4	0.014
BMP2	bone morphogenetic protein 2	0.014
COL2A1	collagen, type II, alpha 1	0.014
SORBS1	sorbin and SH3 domain containing 1	0.014
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.014
SFRP1	secreted frizzled-related protein 1	0.014
MYOD1	myogenic differentiation 1	0.014
VIM	vimentin	0.014
ACTB	actin, beta	0.014
CHD7	chromodomain helicase DNA binding protein 7	0.014	Fly
ZMYND11	zinc finger, MYND-type containing 11	0.014
DCC	deleted in colorectal carcinoma	0.014	Mouse Rat Fly
RANBP9	RAN binding protein 9	0.013
SOX21	SRY (sex determining region Y)-box 21	0.013
ITGA6	integrin, alpha 6	0.013	Fly
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.013
GRB2	growth factor receptor-bound protein 2	0.013
PPARA	peroxisome proliferator-activated receptor alpha	0.013
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.013
TUBA1B	tubulin, alpha 1b	0.012
EFNA5	ephrin-A5	0.012
CBX7	chromobox homolog 7	0.012
EPHB3	EPH receptor B3	0.012	Mouse Worm
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.012
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.012	Zebrafish
BMPR1A	bone morphogenetic protein receptor, type IA	0.012
LAMA5	laminin, alpha 5	0.012	Fly
GBP3	guanylate binding protein 3	0.012
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.011
PLXND1	plexin D1	0.011
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.011
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.011
TNRC6B	trinucleotide repeat containing 6B	0.011
FZD1	frizzled homolog 1 (Drosophila)	0.011
MEOX2	mesenchyme homeobox 2	0.011
UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	0.011
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.011
ADAM10	ADAM metallopeptidase domain 10	0.011
TUBB2B	tubulin, beta 2B	0.011	Human
MAPT	microtubule-associated protein tau	0.011
VAV1	vav 1 guanine nucleotide exchange factor	0.011	Fly
SMAD5	SMAD family member 5	0.011
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.011
ANK1	ankyrin 1, erythrocytic	0.011
PTPRD	protein tyrosine phosphatase, receptor type, D	0.010	Human Fly
EFNB2	ephrin-B2	0.010
FOXA2	forkhead box A2	0.010
CAPN1	calpain 1, (mu/I) large subunit	0.010
EGR3	early growth response 3	0.010
TJP1	tight junction protein 1 (zona occludens 1)	0.010
SIX3	SIX homeobox 3	0.010
KLHL3	kelch-like 3 (Drosophila)	0.010
PTN	pleiotrophin	0.010
TGFB3	transforming growth factor, beta 3	0.010
SOX9	SRY (sex determining region Y)-box 9	0.010
RABGAP1	RAB GTPase activating protein 1	0.010