IMP

Process View

Homo sapiens

18 genes annotated in human

filopodium assembly

The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "filopodium assembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "filopodium assembly" (in gray)

Name	Description	Probability	Func Analog Organism
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.999
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.967	Human Fly
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.767
RHOA	ras homolog gene family, member A	0.710	Fly
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.658
JAG1	jagged 1	0.644
DAAM1	dishevelled associated activator of morphogenesis 1	0.419	Fly
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.400	Rat Fly
IQGAP1	IQ motif containing GTPase activating protein 1	0.360
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.331
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.310	Fly
NOTCH1	notch 1	0.293	Fly
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.275
NCF1	neutrophil cytosolic factor 1	0.260
PRKCZ	protein kinase C, zeta	0.211
YAP1	Yes-associated protein 1	0.169
ARHGAP1	Rho GTPase activating protein 1	0.152
FASLG	Fas ligand (TNF superfamily, member 6)	0.145
LRRK2	leucine-rich repeat kinase 2	0.141
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.141	Fly
ARFIP2	ADP-ribosylation factor interacting protein 2	0.139
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.135
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.111
RAB1A	RAB1A, member RAS oncogene family	0.102
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.096
TGFB1	transforming growth factor, beta 1	0.094
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.093
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.091	Fly
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.087	Fly
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.085	Fly
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.083
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.081
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.079	Fly
FGF1	fibroblast growth factor 1 (acidic)	0.069
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.067
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.066
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.064
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.055
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.054	Fly
PICALM	phosphatidylinositol binding clathrin assembly protein	0.050
HTT	huntingtin	0.048
RHOC	ras homolog gene family, member C	0.048	Fly
BAIAP2	BAI1-associated protein 2	0.046
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.044
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.042
LDOC1	leucine zipper, down-regulated in cancer 1	0.042
DNM2	dynamin 2	0.040
FNBP1L	formin binding protein 1-like	0.040
JUP	junction plakoglobin	0.040
CLASP1	cytoplasmic linker associated protein 1	0.036
JAG2	jagged 2	0.035
FKBP1A	FK506 binding protein 1A, 12kDa	0.034
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.033
TRPC4	transient receptor potential cation channel, subfamily C, member 4	0.032
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.031
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.030
ACTB	actin, beta	0.030
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.029
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.028
NCF2	neutrophil cytosolic factor 2	0.028
FMNL1	formin-like 1	0.028
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.028
ITSN1	intersectin 1 (SH3 domain protein)	0.027
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.024
F11R	F11 receptor	0.024
TRIP10	thyroid hormone receptor interactor 10	0.024	Human
HIPK1	homeodomain interacting protein kinase 1	0.024
PRKCI	protein kinase C, iota	0.024
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.024
APC	adenomatous polyposis coli	0.023
CD2AP	CD2-associated protein	0.022
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.022
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.022
LAT	linker for activation of T cells	0.021
FAT1	FAT tumor suppressor homolog 1 (Drosophila)	0.021
MSN	moesin	0.020
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.020
SH3GL3	SH3-domain GRB2-like 3	0.019
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.019	Fly
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.019
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.019
SPAG9	sperm associated antigen 9	0.019
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.019
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.018
FGFR2	fibroblast growth factor receptor 2	0.018	Fly
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.018
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.017	Fly
WIPF1	WAS/WASL interacting protein family, member 1	0.017
SFN	stratifin	0.017
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.016
TNIK	TRAF2 and NCK interacting kinase	0.016
RAB10	RAB10, member RAS oncogene family	0.016
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.015
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.015
FGF10	fibroblast growth factor 10	0.015
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.015
RALGDS	ral guanine nucleotide dissociation stimulator	0.015
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.015
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.014
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.014
CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	0.014
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.014
NCKIPSD	NCK interacting protein with SH3 domain	0.014
DLL1	delta-like 1 (Drosophila)	0.013
SORBS3	sorbin and SH3 domain containing 3	0.013
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.013
RIN1	Ras and Rab interactor 1	0.013
RAP1B	RAP1B, member of RAS oncogene family	0.013
CAPZA1	capping protein (actin filament) muscle Z-line, alpha 1	0.013	Fly
ENG	endoglin	0.013
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.012
ADAM9	ADAM metallopeptidase domain 9	0.012
TP53BP2	tumor protein p53 binding protein, 2	0.012
ITGB5	integrin, beta 5	0.012
DNM1	dynamin 1	0.012
COL17A1	collagen, type XVII, alpha 1	0.012
CLTB	clathrin, light chain B	0.012
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.012
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.011
MYOCD	myocardin	0.011
TBC1D10A	TBC1 domain family, member 10A	0.011
MACF1	microtubule-actin crosslinking factor 1	0.011	Fly
HMGA1	high mobility group AT-hook 1	0.011
MPDZ	multiple PDZ domain protein	0.011
HOOK2	hook homolog 2 (Drosophila)	0.011
RAP1A	RAP1A, member of RAS oncogene family	0.011
NOTCH2NL	notch 2 N-terminal like	0.011
GNG10	guanine nucleotide binding protein (G protein), gamma 10	0.011
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.011
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.011
AXIN1	axin 1	0.010
WASL	Wiskott-Aldrich syndrome-like	0.010	Rat
DRD2	dopamine receptor D2	0.010
RALBP1	ralA binding protein 1	0.010
CORO1C	coronin, actin binding protein, 1C	0.010
ATN1	atrophin 1	0.010
WDR1	WD repeat domain 1	0.010
CYTH2	cytohesin 2	0.010
GFI1B	growth factor independent 1B transcription repressor	0.010
ZNF71	zinc finger protein 71	0.010