Homo sapiens

524 known processes

SIRT1

sirtuin 1

(Aliases: SIR2L1)

SIRT1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 1.000
covalent chromatin modification GO:0016569 254 1.000
chromatin organization GO:0006325 351 1.000
histone modification GO:0016570 251 0.999
histone acetylation GO:0016573 93 0.997
Worm Fly
cellular response to endogenous stimulus GO:0071495 336 0.996
cellular response to external stimulus GO:0071496 111 0.994
chromatin modification GO:0016568 298 0.990
negative regulation of cell death GO:0060548 345 0.987
cellular response to growth factor stimulus GO:0071363 197 0.986
Mouse
internal peptidyl lysine acetylation GO:0018393 97 0.975
Worm Fly
negative regulation of cell cycle GO:0045786 193 0.975
intracellular receptor signaling pathway GO:0030522 104 0.971
regulation of cellular ketone metabolic process GO:0010565 50 0.968
Mouse
response to starvation GO:0042594 59 0.965
negative regulation of cell proliferation GO:0008285 228 0.963
peptidyl lysine acetylation GO:0018394 101 0.962
cellular response to dna damage stimulus GO:0006974 379 0.961
regulation of gene expression epigenetic GO:0040029 73 0.957
protein acetylation GO:0006473 116 0.955
response to abiotic stimulus GO:0009628 336 0.951
muscle tissue development GO:0060537 62 0.948
protein acylation GO:0043543 138 0.943
lipid metabolic process GO:0006629 381 0.943
Mouse
positive regulation of programmed cell death GO:0043068 249 0.942
gene silencing GO:0016458 49 0.941
enzyme linked receptor protein signaling pathway GO:0007167 303 0.940
regulation of cell cycle GO:0051726 393 0.940
response to radiation GO:0009314 151 0.926
Mouse
multicellular organismal aging GO:0010259 3 0.924
Worm Fly
cellular ketone metabolic process GO:0042180 80 0.921
Mouse
amine metabolic process GO:0009308 44 0.919
cell development GO:0048468 328 0.908
vasculature development GO:0001944 181 0.907
response to transforming growth factor beta GO:0071559 94 0.900
Mouse
mesenchymal cell differentiation GO:0048762 52 0.898
cellular component morphogenesis GO:0032989 314 0.893
regulation of cellular ketone metabolic process by positive regulation of transcription from rna polymerase ii promoter GO:0072366 1 0.888
regulation of cell cycle process GO:0010564 266 0.887
muscle structure development GO:0061061 98 0.884
macromolecule methylation GO:0043414 97 0.880
histone h4 acetylation GO:0043967 47 0.879
determination of adult lifespan GO:0008340 2 0.869
Worm Fly
female gamete generation GO:0007292 2 0.853
Mouse
regulation of cellular response to stress GO:0080135 244 0.845
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.837
Mouse
circulatory system development GO:0072359 262 0.834
peptidyl lysine modification GO:0018205 144 0.832
cellular response to starvation GO:0009267 58 0.822
positive regulation of cell differentiation GO:0045597 211 0.811
mapk cascade GO:0000165 288 0.810
dna templated transcription initiation GO:0006352 35 0.798
growth GO:0040007 202 0.796
n terminal protein amino acid modification GO:0031365 13 0.791
circadian rhythm GO:0007623 21 0.787
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.782
Mouse
cellular response to insulin stimulus GO:0032869 41 0.769
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.768
Mouse
epithelium development GO:0060429 227 0.765
response to organonitrogen compound GO:0010243 156 0.763
cellular response to hormone stimulus GO:0032870 125 0.753
carbohydrate metabolic process GO:0005975 207 0.749
Mouse
cytoplasmic transport GO:0016482 379 0.741
cellular response to organonitrogen compound GO:0071417 124 0.740
response to extracellular stimulus GO:0009991 85 0.740
internal protein amino acid acetylation GO:0006475 101 0.734
Worm Fly
cellular response to cytokine stimulus GO:0071345 181 0.732
activin receptor signaling pathway GO:0032924 24 0.732
positive regulation of catabolic process GO:0009896 310 0.718
cell cycle arrest GO:0007050 71 0.710
maintenance of location GO:0051235 112 0.693
positive regulation of cell proliferation GO:0008284 301 0.693
negative regulation of phosphorylation GO:0042326 174 0.690
chromatin silencing at rdna GO:0000183 5 0.687
outflow tract morphogenesis GO:0003151 10 0.679
regulation of cellular component size GO:0032535 82 0.669
negative regulation of programmed cell death GO:0043069 321 0.661
regulation of growth GO:0040008 165 0.659
digestive tract development GO:0048565 75 0.655
stem cell differentiation GO:0048863 93 0.638
positive regulation of developmental process GO:0051094 314 0.627
cellular response to nutrient levels GO:0031669 69 0.625
chemical homeostasis GO:0048878 306 0.622
Mouse
neuron differentiation GO:0030182 138 0.619
nervous system development GO:0007399 293 0.617
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.595
dna damage checkpoint GO:0000077 68 0.592
autophagy GO:0006914 88 0.585
regulation of muscle organ development GO:0048634 27 0.580
regulation of cellular amine metabolic process GO:0033238 11 0.578
embryo development GO:0009790 123 0.569
signal transduction by phosphorylation GO:0023014 297 0.568
regulation of response to external stimulus GO:0032101 222 0.568
positive regulation of apoptotic process GO:0043065 246 0.566
positive regulation of cell death GO:0010942 263 0.562
rhythmic process GO:0048511 31 0.561
negative regulation of apoptotic signaling pathway GO:2001234 97 0.557
circadian behavior GO:0048512 2 0.551
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.551
regulation of activin receptor signaling pathway GO:0032925 14 0.545
lymphocyte activation GO:0046649 133 0.534
cellular response to nitrogen compound GO:1901699 144 0.528
generation of neurons GO:0048699 152 0.524
cell morphogenesis involved in differentiation GO:0000904 144 0.510
response to nutrient levels GO:0031667 81 0.506
cell morphogenesis GO:0000902 296 0.504
histone h3 acetylation GO:0043966 45 0.502
Worm
histone h3 k9 modification GO:0061647 11 0.500
peptidyl serine phosphorylation GO:0018105 101 0.498
monosaccharide metabolic process GO:0005996 74 0.496
Mouse
signal transduction in response to dna damage GO:0042770 57 0.496
cellular response to extracellular stimulus GO:0031668 72 0.495
regulation of reactive oxygen species metabolic process GO:2000377 41 0.492
muscle organ development GO:0007517 56 0.489
regulation of protein complex assembly GO:0043254 147 0.488
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.485
negative regulation of transferase activity GO:0051348 124 0.474
macroautophagy GO:0016236 39 0.464
hexose metabolic process GO:0019318 55 0.463
Mouse
protein ubiquitination GO:0016567 314 0.461
cellular amine metabolic process GO:0044106 41 0.458
response to light stimulus GO:0009416 87 0.455
single organism carbohydrate metabolic process GO:0044723 193 0.454
Mouse
mitotic cell cycle phase transition GO:0044772 162 0.453
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.452
hindbrain development GO:0030902 3 0.450
posttranscriptional regulation of gene expression GO:0010608 213 0.437
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.434
apoptotic signaling pathway GO:0097190 268 0.433
rostrocaudal neural tube patterning GO:0021903 1 0.430
negative regulation of cellular protein metabolic process GO:0032269 353 0.413
chromatin silencing GO:0006342 12 0.408
nitrogen compound transport GO:0071705 191 0.406
regulation of anatomical structure morphogenesis GO:0022603 286 0.405
signal transduction by p53 class mediator GO:0072331 72 0.403
positive regulation of cell size GO:0045793 3 0.400
neurogenesis GO:0022008 169 0.399
muscle cell proliferation GO:0033002 35 0.389
stress activated protein kinase signaling cascade GO:0031098 94 0.376
response to hormone GO:0009725 175 0.373
regulation of dna templated transcription elongation GO:0032784 23 0.373
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.370
Mouse
protein localization to nucleus GO:0034504 136 0.369
glucose homeostasis GO:0042593 31 0.362
Mouse
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.361
Mouse
epithelial cell differentiation GO:0030855 141 0.359
cell cycle phase transition GO:0044770 173 0.356
cellular response to peptide hormone stimulus GO:0071375 56 0.356
regulation of cell differentiation GO:0045595 393 0.354
Mouse
heart development GO:0007507 95 0.351
protein deacylation GO:0035601 39 0.346
response to growth factor GO:0070848 205 0.345
Mouse
lipid storage GO:0019915 28 0.344
response to cytokine GO:0034097 232 0.343
regulation of stress activated mapk cascade GO:0032872 84 0.343
rhythmic behavior GO:0007622 2 0.342
cellular macromolecular complex assembly GO:0034622 324 0.342
aging GO:0007568 66 0.342
regulation of protein stability GO:0031647 87 0.336
Mouse
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.334
negative regulation of cell cycle phase transition GO:1901988 89 0.333
peptidyl serine modification GO:0018209 106 0.329
regulation of cellular amino acid metabolic process GO:0006521 6 0.327
positive regulation of cellular amine metabolic process GO:0033240 7 0.321
lipid localization GO:0010876 106 0.320
Mouse
angiogenesis GO:0001525 147 0.316
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 3 0.314
cellular response to abiotic stimulus GO:0071214 117 0.313
Mouse
regulation of kinase activity GO:0043549 314 0.312
dna integrity checkpoint GO:0031570 71 0.311
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.307
single organism reproductive process GO:0044702 98 0.303
Mouse
peptidyl tyrosine phosphorylation GO:0018108 170 0.303
locomotory behavior GO:0007626 1 0.301
cellular response to oxygen containing compound GO:1901701 276 0.299
regulation of carbohydrate biosynthetic process GO:0043255 27 0.295
morphogenesis of an epithelium GO:0002009 60 0.292
negative regulation of phosphorus metabolic process GO:0010563 267 0.291
cellular amino acid metabolic process GO:0006520 116 0.284
positive regulation of protein phosphorylation GO:0001934 313 0.282
protein modification by small protein conjugation GO:0032446 342 0.281
response to nitrogen compound GO:1901698 184 0.280
cell activation GO:0001775 213 0.278
response to organic cyclic compound GO:0014070 204 0.277
response to uv GO:0009411 73 0.275
negative regulation of catalytic activity GO:0043086 335 0.270
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.269
Mouse
regulation of cellular component biogenesis GO:0044087 281 0.269
system process GO:0003008 349 0.265
cell cycle checkpoint GO:0000075 117 0.263
carbohydrate biosynthetic process GO:0016051 42 0.256
regulation of carbohydrate metabolic process GO:0006109 54 0.254
Mouse
reproductive process GO:0022414 106 0.253
Mouse
stem cell development GO:0048864 69 0.242
peptidyl tyrosine modification GO:0018212 170 0.242
response to peptide hormone GO:0043434 61 0.241
regulation of transferase activity GO:0051338 355 0.240
positive regulation of gluconeogenesis GO:0045722 1 0.238
cytokine mediated signaling pathway GO:0019221 109 0.237
homeostasis of number of cells GO:0048872 40 0.233
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.230
extrinsic apoptotic signaling pathway GO:0097191 119 0.227
neuron development GO:0048666 113 0.220
post embryonic development GO:0009791 2 0.220
Worm
wnt signaling pathway GO:0016055 156 0.218
cardiac chamber development GO:0003205 30 0.213
regulation of circadian rhythm GO:0042752 11 0.212
small molecule biosynthetic process GO:0044283 157 0.209
Mouse
response to alcohol GO:0097305 64 0.208
fatty acid metabolic process GO:0006631 115 0.207
Mouse
mesenchymal cell development GO:0014031 50 0.207
blood vessel development GO:0001568 172 0.207
regulation of cell development GO:0060284 161 0.202
rho protein signal transduction GO:0007266 26 0.202
regulation of neural precursor cell proliferation GO:2000177 4 0.201
skin development GO:0043588 76 0.200
negative regulation of stress activated protein kinase signaling cascade GO:0070303 19 0.198
modification dependent macromolecule catabolic process GO:0043632 212 0.198
response to peptide GO:1901652 65 0.197
regulation of anatomical structure size GO:0090066 101 0.197
morphogenesis of a branching structure GO:0001763 21 0.196
response to hypoxia GO:0001666 96 0.196
single organism nuclear import GO:1902593 104 0.196
cardiovascular system development GO:0072358 262 0.195
neuron projection development GO:0031175 106 0.192
response to insulin GO:0032868 45 0.192
negative regulation of protein metabolic process GO:0051248 391 0.192
regulation of nervous system development GO:0051960 88 0.187
neuron projection morphogenesis GO:0048812 50 0.187
embryonic morphogenesis GO:0048598 85 0.186
neural tube patterning GO:0021532 2 0.184
embryonic organ morphogenesis GO:0048562 24 0.184
negative regulation of kinase activity GO:0033673 106 0.179
positive regulation of erythrocyte differentiation GO:0045648 11 0.177
canonical wnt signaling pathway GO:0060070 116 0.176
regulation of mitotic cell cycle GO:0007346 189 0.174
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.174
rna processing GO:0006396 255 0.174
regionalization GO:0003002 29 0.171
anatomical structure homeostasis GO:0060249 100 0.170
protein modification by small protein removal GO:0070646 92 0.170
response to glucagon GO:0033762 1 0.169
regulation of response to dna damage stimulus GO:2001020 94 0.168
response to gamma radiation GO:0010332 14 0.168
oogenesis GO:0048477 2 0.167
regulation of cell activation GO:0050865 125 0.167
regulation of cellular response to growth factor stimulus GO:0090287 76 0.166
Mouse
dna templated transcription elongation GO:0006354 25 0.164
regulation of smooth muscle cell proliferation GO:0048660 28 0.163
anatomical structure formation involved in morphogenesis GO:0048646 284 0.163
neural tube formation GO:0001841 3 0.163
regulation of heart growth GO:0060420 4 0.163
somitogenesis GO:0001756 2 0.162
regulation of neurogenesis GO:0050767 82 0.161
regulation of mapk cascade GO:0043408 262 0.160
cardiac chamber morphogenesis GO:0003206 26 0.159
dna conformation change GO:0071103 113 0.158
leukocyte activation GO:0045321 164 0.158
regulation of apoptotic signaling pathway GO:2001233 175 0.157
heart morphogenesis GO:0003007 48 0.156
regulation of locomotion GO:0040012 329 0.152
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 13 0.152
neurological system process GO:0050877 163 0.151
response to acid chemical GO:0001101 66 0.150
regulation of lymphocyte activation GO:0051249 103 0.150
negative regulation of cell cycle process GO:0010948 121 0.149
positive regulation of phosphorylation GO:0042327 394 0.147
syncytium formation by plasma membrane fusion GO:0000768 2 0.144
negative regulation of mitotic cell cycle GO:0045930 102 0.144
stress activated mapk cascade GO:0051403 93 0.143
androgen receptor signaling pathway GO:0030521 34 0.143
skeletal system development GO:0001501 79 0.141
monocarboxylic acid metabolic process GO:0032787 185 0.140
Mouse
digestive system development GO:0055123 75 0.140
protein import into nucleus GO:0006606 104 0.140
negative regulation of protein modification process GO:0031400 200 0.140
organ morphogenesis GO:0009887 147 0.139
establishment of protein localization to organelle GO:0072594 172 0.138
regulation of protein ubiquitination GO:0031396 95 0.138
negative regulation of growth GO:0045926 97 0.137
positive regulation of cell cycle GO:0045787 140 0.137
response to oxygen containing compound GO:1901700 369 0.136
regulation of secretion GO:0051046 194 0.135
regulation of dna templated transcription in response to stress GO:0043620 18 0.135
response to decreased oxygen levels GO:0036293 96 0.135
response to ionizing radiation GO:0010212 65 0.135
Mouse
cell projection organization GO:0030030 252 0.133
gland development GO:0048732 48 0.132
regulation of muscle tissue development GO:1901861 26 0.132
positive regulation of heart growth GO:0060421 2 0.131
positive regulation of wnt signaling pathway GO:0030177 54 0.130
myoblast fusion GO:0007520 1 0.130
cellular carbohydrate metabolic process GO:0044262 84 0.129
Mouse
peptide secretion GO:0002790 51 0.129
positive regulation of immune response GO:0050778 159 0.128
regulation of macroautophagy GO:0016241 19 0.127
epithelial to mesenchymal transition GO:0001837 48 0.127
protein dna complex assembly GO:0065004 64 0.126
regulation of cellular response to insulin stimulus GO:1900076 17 0.126
chemotaxis GO:0006935 157 0.125
cell projection morphogenesis GO:0048858 129 0.125
immune system development GO:0002520 195 0.124
positive regulation of dna templated transcription elongation GO:0032786 18 0.123
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 9 0.123
methylation GO:0032259 106 0.122
circadian regulation of gene expression GO:0032922 8 0.121
regulation of hormone secretion GO:0046883 57 0.121
tissue morphogenesis GO:0048729 96 0.120
regulation of protein kinase activity GO:0045859 289 0.120
cellular response to peptide GO:1901653 59 0.117
regulation of striated muscle tissue development GO:0016202 26 0.116
erythrocyte homeostasis GO:0034101 31 0.115
protein autophosphorylation GO:0046777 123 0.114
cell fate commitment GO:0045165 27 0.113
ubiquitin dependent protein catabolic process GO:0006511 206 0.112
cellular response to radiation GO:0071478 65 0.111
Mouse
protein deubiquitination GO:0016579 79 0.110
viral transcription GO:0019083 35 0.109
response to oxidative stress GO:0006979 121 0.107
regulation of glial cell differentiation GO:0045685 3 0.107
negative regulation of apoptotic process GO:0043066 316 0.106
developmental process involved in reproduction GO:0003006 66 0.106
Mouse
cellular macromolecule catabolic process GO:0044265 380 0.106
axonogenesis GO:0007409 31 0.106
tube morphogenesis GO:0035239 95 0.105
hormone secretion GO:0046879 65 0.105
regulation of developmental growth GO:0048638 30 0.105
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.104
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.104
positive regulation of mapk cascade GO:0043410 190 0.103
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.101
cardiac muscle tissue development GO:0048738 39 0.099
regulation of viral process GO:0050792 103 0.099
negative regulation of hormone secretion GO:0046888 15 0.099
insulin receptor signaling pathway GO:0008286 23 0.098
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.098
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.098
multicellular organism reproduction GO:0032504 42 0.098
Mouse
behavior GO:0007610 112 0.096
Fly
neural crest cell development GO:0014032 3 0.096
developmental growth GO:0048589 48 0.095
embryonic skeletal system development GO:0048706 13 0.095
regulation of feeding behavior GO:0060259 3 0.094
Fly
myeloid cell differentiation GO:0030099 117 0.094
lipid biosynthetic process GO:0008610 177 0.094
Mouse
regulation of mitotic cell cycle phase transition GO:1901990 118 0.093
positive regulation of cellular catabolic process GO:0031331 284 0.091
protein targeting to nucleus GO:0044744 104 0.091
negative regulation of cell differentiation GO:0045596 171 0.090
Mouse
cell cycle g1 s phase transition GO:0044843 80 0.090
protein processing GO:0016485 226 0.090
regulation of gene silencing GO:0060968 24 0.089
defense response GO:0006952 315 0.089
regulation of peptidase activity GO:0052547 180 0.088
cellular response to lipid GO:0071396 127 0.088
regulation of binding GO:0051098 111 0.087
jnk cascade GO:0007254 80 0.087
actin filament based process GO:0030029 224 0.087
nuclear transport GO:0051169 179 0.085
nucleocytoplasmic transport GO:0006913 176 0.085
negative regulation of protein phosphorylation GO:0001933 140 0.084
embryonic camera type eye morphogenesis GO:0048596 2 0.084
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 3 0.083
rna interference GO:0016246 4 0.083
reproduction GO:0000003 63 0.083
Mouse
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.083
regulation of viral transcription GO:0046782 34 0.082
regulation of neuron differentiation GO:0045664 70 0.082
regulation of autophagy GO:0010506 52 0.082
regulation of meiotic cell cycle GO:0051445 4 0.081
organ formation GO:0048645 3 0.080
positive regulation of cellular component organization GO:0051130 376 0.080
mating GO:0007618 1 0.079
embryonic camera type eye development GO:0031076 2 0.079
response to other organism GO:0051707 261 0.079
regulation of secretion by cell GO:1903530 177 0.078
hepaticobiliary system development GO:0061008 10 0.078
protein alkylation GO:0008213 74 0.077
molting cycle GO:0042303 28 0.077
b cell activation GO:0042113 33 0.077
cardiac ventricle development GO:0003231 23 0.077
intrinsic apoptotic signaling pathway GO:0097193 127 0.076
myeloid cell homeostasis GO:0002262 34 0.075
somatic muscle development GO:0007525 1 0.075
glycoprotein metabolic process GO:0009100 110 0.074
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.074
mitotic cell cycle GO:0000278 326 0.073
peptide transport GO:0015833 74 0.073
dendrite development GO:0016358 24 0.073
blastocyst development GO:0001824 3 0.072
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.072
Mouse
response to hyperoxia GO:0055093 4 0.071
striated muscle tissue development GO:0014706 59 0.070
oxidation reduction process GO:0055114 396 0.070
viral process GO:0016032 146 0.070
negative regulation of mapk cascade GO:0043409 56 0.070
modification dependent protein catabolic process GO:0019941 209 0.070
response to estradiol GO:0032355 23 0.069
neuron apoptotic process GO:0051402 39 0.069
cell aging GO:0007569 52 0.068
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.067
leukocyte proliferation GO:0070661 74 0.067
mitotic cell cycle process GO:1903047 286 0.066
g protein coupled receptor signaling pathway GO:0007186 207 0.066
regulation of glucose metabolic process GO:0010906 28 0.065
Mouse
negative regulation of cellular amine metabolic process GO:0033239 3 0.065
positive regulation of cell development GO:0010720 92 0.065
ventricular septum morphogenesis GO:0060412 3 0.064
cytokine production GO:0001816 247 0.064
negative regulation of stress activated mapk cascade GO:0032873 19 0.064
embryonic placenta development GO:0001892 1 0.064
microtubule cytoskeleton organization GO:0000226 176 0.064
negative regulation of intracellular signal transduction GO:1902532 183 0.064
cell growth GO:0016049 160 0.064
response to nutrient GO:0007584 20 0.063
Fly
negative regulation of phosphate metabolic process GO:0045936 267 0.063
determination of bilateral symmetry GO:0009855 15 0.062
bmp signaling pathway GO:0030509 49 0.062
embryonic organ development GO:0048568 36 0.062
smooth muscle cell differentiation GO:0051145 8 0.062
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.062
polysaccharide metabolic process GO:0005976 33 0.062
embryo development ending in birth or egg hatching GO:0009792 34 0.061
cell type specific apoptotic process GO:0097285 125 0.061
Mouse
protein deacetylation GO:0006476 38 0.061
muscle cell differentiation GO:0042692 63 0.060
embryonic digestive tract morphogenesis GO:0048557 2 0.060
protein dna complex subunit organization GO:0071824 80 0.060
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.060
response to external biotic stimulus GO:0043207 261 0.060
dendrite morphogenesis GO:0048813 14 0.060
positive regulation of gliogenesis GO:0014015 4 0.059
long term memory GO:0007616 2 0.059
regulation of multicellular organism growth GO:0040014 8 0.058
t cell differentiation GO:0030217 29 0.057
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 41 0.057
positive regulation of leukocyte activation GO:0002696 80 0.056
regulation of cell motility GO:2000145 299 0.056
regulation of smooth muscle cell differentiation GO:0051150 3 0.056
regulation of protein import into nucleus GO:0042306 78 0.056
gene silencing by rna GO:0031047 26 0.055
fibroblast proliferation GO:0048144 33 0.055
blood circulation GO:0008015 113 0.055
pattern specification process GO:0007389 43 0.055
central nervous system development GO:0007417 123 0.055
hemopoiesis GO:0030097 180 0.054
embryonic epithelial tube formation GO:0001838 4 0.054
regulation of cell migration GO:0030334 289 0.054
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.054
generation of precursor metabolites and energy GO:0006091 68 0.053
regulation of leukocyte activation GO:0002694 115 0.053
glucose metabolic process GO:0006006 45 0.053
Mouse
cell part morphogenesis GO:0032990 137 0.053
response to wounding GO:0009611 168 0.052
striated muscle cell differentiation GO:0051146 43 0.052
connective tissue development GO:0061448 39 0.052
positive regulation of stem cell proliferation GO:2000648 10 0.052
lipid oxidation GO:0034440 33 0.052
positive regulation of feeding behavior GO:2000253 1 0.052
Fly
modulation by host of viral transcription GO:0043921 20 0.051
stem cell division GO:0017145 2 0.051
respiratory tube development GO:0030323 20 0.051
regulation of cysteine type endopeptidase activity GO:2000116 127 0.051
sexual reproduction GO:0019953 37 0.051
Mouse
cellular response to oxygen levels GO:0071453 55 0.051
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.051
g1 s transition of mitotic cell cycle GO:0000082 78 0.051
negative regulation of cell growth GO:0030308 83 0.051
regulation of response to nutrient levels GO:0032107 22 0.051
cell cell signaling GO:0007267 155 0.050
memory GO:0007613 3 0.049
embryonic viscerocranium morphogenesis GO:0048703 1 0.049
response to drug GO:0042493 81 0.049
receptor biosynthetic process GO:0032800 18 0.049
neuroblast proliferation GO:0007405 4 0.049
muscle system process GO:0003012 81 0.049
cellular glucan metabolic process GO:0006073 22 0.049
mesenchyme development GO:0060485 59 0.049
lung development GO:0030324 20 0.048
regulation of cell cycle phase transition GO:1901987 126 0.048
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.047
positive regulation of autophagy GO:0010508 24 0.047
cellular lipid catabolic process GO:0044242 65 0.047
positive regulation of viral transcription GO:0050434 13 0.047
regulation of cell morphogenesis GO:0022604 153 0.047
head development GO:0060322 108 0.047
oocyte development GO:0048599 1 0.047
cellular response to oxidative stress GO:0034599 85 0.047
blood vessel morphogenesis GO:0048514 162 0.047
small gtpase mediated signal transduction GO:0007264 78 0.047
interspecies interaction between organisms GO:0044419 156 0.047

SIRT1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.561
cancer DOID:162 167 0.525
organ system cancer DOID:0050686 164 0.525
gastrointestinal system cancer DOID:3119 52 0.087