IMP

Process View

Homo sapiens

41 genes annotated in human

positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway

Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD7	SMAD family member 7	1.000	Human
SMAD3	SMAD family member 3	1.000	Human
SMAD2	SMAD family member 2	0.995
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.976	Human
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.963
BMPR1A	bone morphogenetic protein receptor, type IA	0.927
SP1	Sp1 transcription factor	0.883
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.845
NRP1	neuropilin 1	0.830
TGFB1	transforming growth factor, beta 1	0.787
NOTCH1	notch 1	0.784	Mouse
JAG1	jagged 1	0.668
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.648
EP300	E1A binding protein p300	0.615
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.596
FN1	fibronectin 1	0.590
CTGF	connective tissue growth factor	0.572	Human
BMP2	bone morphogenetic protein 2	0.513
FSTL1	follistatin-like 1	0.499
SNIP1	Smad nuclear interacting protein 1	0.490
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.414
BCAR1	breast cancer anti-estrogen resistance 1	0.360
PTK2	PTK2 protein tyrosine kinase 2	0.323
ACVR1	activin A receptor, type I	0.301
FKBP1A	FK506 binding protein 1A, 12kDa	0.298
TGFB3	transforming growth factor, beta 3	0.275	Mouse
BMPR1B	bone morphogenetic protein receptor, type IB	0.265	Human
FBXL12	F-box and leucine-rich repeat protein 12	0.255
NCK2	NCK adaptor protein 2	0.244
CYR61	cysteine-rich, angiogenic inducer, 61	0.241
FOXD3	forkhead box D3	0.227
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.222
TPBG	trophoblast glycoprotein	0.191
GDF5	growth differentiation factor 5	0.182	Human
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.175	Mouse
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.168
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.163
DLG1	discs, large homolog 1 (Drosophila)	0.151
RNF5	ring finger protein 5	0.145
PIAS4	protein inhibitor of activated STAT, 4	0.132
NOG	noggin	0.129
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.125
PARVA	parvin, alpha	0.124
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.116
STRADA	STE20-related kinase adaptor alpha	0.111
PHC2	polyhomeotic homolog 2 (Drosophila)	0.111
HCFC1	host cell factor C1 (VP16-accessory protein)	0.108
SIAH1	seven in absentia homolog 1 (Drosophila)	0.099
SMAD1	SMAD family member 1	0.097	Human
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.096
BBS10	Bardet-Biedl syndrome 10	0.086
CDH5	cadherin 5, type 2 (vascular endothelium)	0.084
TGFBR1	transforming growth factor, beta receptor 1	0.082
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.082
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.079
SKIL	SKI-like oncogene	0.071
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.069
HOXA1	homeobox A1	0.066
TADA3	transcriptional adaptor 3	0.066
NCOR2	nuclear receptor corepressor 2	0.062
LIMS1	LIM and senescent cell antigen-like domains 1	0.060	Human
LPXN	leupaxin	0.060	Human
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.059
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.059
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.059
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.057
SIRT1	sirtuin 1	0.057
MAML1	mastermind-like 1 (Drosophila)	0.056
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.051
TP53BP2	tumor protein p53 binding protein, 2	0.051
ZEB2	zinc finger E-box binding homeobox 2	0.050
SMAD6	SMAD family member 6	0.048	Human
QKI	quaking homolog, KH domain RNA binding (mouse)	0.047
BGN	biglycan	0.047
VCL	vinculin	0.047
LIMD1	LIM domains containing 1	0.046
FBLN1	fibulin 1	0.045
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.045
FILIP1L	filamin A interacting protein 1-like	0.045
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.045
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.045
ING2	inhibitor of growth family, member 2	0.044
THBS1	thrombospondin 1	0.044
PIAS1	protein inhibitor of activated STAT, 1	0.044
TGFB2	transforming growth factor, beta 2	0.044	Human Fly
FBXL15	F-box and leucine-rich repeat protein 15	0.044
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.042
TOX4	TOX high mobility group box family member 4	0.042
CXXC5	CXXC finger protein 5	0.041
ACVR1B	activin A receptor, type IB	0.041
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.041
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.040
CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	0.039
SCARB2	scavenger receptor class B, member 2	0.039
MEST	mesoderm specific transcript homolog (mouse)	0.038
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.038
SFRP4	secreted frizzled-related protein 4	0.038
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.037
ACVR2B	activin A receptor, type IIB	0.037
EGR1	early growth response 1	0.037
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.036
CALD1	caldesmon 1	0.036
NOTCH3	notch 3	0.035
HIPK3	homeodomain interacting protein kinase 3	0.035	Human
MXRA5	matrix-remodelling associated 5	0.035
ATXN1L	ataxin 1-like	0.035
ENG	endoglin	0.034
AMOTL2	angiomotin like 2	0.034
XIAP	X-linked inhibitor of apoptosis	0.034
TP53	tumor protein p53	0.033
MSX2	msh homeobox 2	0.033	Mouse
TYRP1	tyrosinase-related protein 1	0.033
NQO1	NAD(P)H dehydrogenase, quinone 1	0.033
DLL1	delta-like 1 (Drosophila)	0.033
RUNX1	runt-related transcription factor 1	0.033
SOX21	SRY (sex determining region Y)-box 21	0.032
SMAD4	SMAD family member 4	0.032
TIMP3	TIMP metallopeptidase inhibitor 3	0.031
IP6K2	inositol hexakisphosphate kinase 2	0.030
MSX1	msh homeobox 1	0.029	Mouse
PXN	paxillin	0.029	Human
PRKG1	protein kinase, cGMP-dependent, type I	0.029
INHBB	inhibin, beta B	0.029	Human
TBX5	T-box 5	0.029
SLIT3	slit homolog 3 (Drosophila)	0.028
CDC42EP1	CDC42 effector protein (Rho GTPase binding) 1	0.028
ATXN1	ataxin 1	0.027
YY1	YY1 transcription factor	0.027
EDN1	endothelin 1	0.027
STRADB	STE20-related kinase adaptor beta	0.027
MYO1C	myosin IC	0.027
COL8A1	collagen, type VIII, alpha 1	0.027
SOX11	SRY (sex determining region Y)-box 11	0.027	Mouse
CSNK1E	casein kinase 1, epsilon	0.026
IGF2R	insulin-like growth factor 2 receptor	0.026
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.026
CDK6	cyclin-dependent kinase 6	0.026
GSK3B	glycogen synthase kinase 3 beta	0.025
HIPK2	homeodomain interacting protein kinase 2	0.024
FERMT2	fermitin family member 2	0.024
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.024
CNOT4	CCR4-NOT transcription complex, subunit 4	0.024
TRAF4	TNF receptor-associated factor 4	0.024
RUNX2	runt-related transcription factor 2	0.023
ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	0.023
TNS1	tensin 1	0.022
PHF21A	PHD finger protein 21A	0.022
INHBA	inhibin, beta A	0.022
COL11A1	collagen, type XI, alpha 1	0.022
WT1	Wilms tumor 1	0.022
RNF11	ring finger protein 11	0.021
SOX7	SRY (sex determining region Y)-box 7	0.021
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.021
VEGFC	vascular endothelial growth factor C	0.021
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.021
CXXC1	CXXC finger protein 1	0.021
NOTCH2NL	notch 2 N-terminal like	0.021
USF2	upstream transcription factor 2, c-fos interacting	0.021
DLC1	deleted in liver cancer 1	0.021
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.020
GREM1	gremlin 1	0.020
TBX2	T-box 2	0.020
COL2A1	collagen, type II, alpha 1	0.020
POU3F2	POU class 3 homeobox 2	0.020	Human
CLU	clusterin	0.020
ADARB1	adenosine deaminase, RNA-specific, B1	0.020
BMP4	bone morphogenetic protein 4	0.020
EVC2	Ellis van Creveld syndrome 2	0.020
IGFBP5	insulin-like growth factor binding protein 5	0.020
NOTCH2	notch 2	0.019	Mouse
LIMK2	LIM domain kinase 2	0.019
SOX10	SRY (sex determining region Y)-box 10	0.019
ZNF331	zinc finger protein 331	0.019
IGFBP3	insulin-like growth factor binding protein 3	0.019
LIMS2	LIM and senescent cell antigen-like domains 2	0.019	Human
FZD7	frizzled homolog 7 (Drosophila)	0.019
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.019
OLIG2	oligodendrocyte lineage transcription factor 2	0.019
CNN1	calponin 1, basic, smooth muscle	0.019
PML	promyelocytic leukemia	0.019
TGFBR3	transforming growth factor, beta receptor III	0.018	Human Rat
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.018
GAS1	growth arrest-specific 1	0.018
ITGA8	integrin, alpha 8	0.018
FANCE	Fanconi anemia, complementation group E	0.018
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.018
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.018
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.018
MAPK8	mitogen-activated protein kinase 8	0.017
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.017
MTMR4	myotubularin related protein 4	0.017
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.017
FNDC3B	fibronectin type III domain containing 3B	0.017
SOX1	SRY (sex determining region Y)-box 1	0.017
DSE	dermatan sulfate epimerase	0.017
TIMP2	TIMP metallopeptidase inhibitor 2	0.017
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.017
MYST1	MYST histone acetyltransferase 1	0.017
EBF1	early B-cell factor 1	0.016
ANGPTL2	angiopoietin-like 2	0.016
ACAN	aggrecan	0.016
RHOB	ras homolog gene family, member B	0.016
TAGLN	transgelin	0.016
LTBP2	latent transforming growth factor beta binding protein 2	0.016
PDLIM4	PDZ and LIM domain 4	0.016
GLUL	glutamate-ammonia ligase	0.016
GCSH	glycine cleavage system protein H (aminomethyl carrier)	0.016
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.016
SDC4	syndecan 4	0.016
TEK	TEK tyrosine kinase, endothelial	0.015
PLD3	phospholipase D family, member 3	0.015
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.015
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.015
COL10A1	collagen, type X, alpha 1	0.015
BBC3	BCL2 binding component 3	0.015
TFPI2	tissue factor pathway inhibitor 2	0.015
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.015
DLX5	distal-less homeobox 5	0.015
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.015
NUAK1	NUAK family, SNF1-like kinase, 1	0.015
HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	0.015
EYA2	eyes absent homolog 2 (Drosophila)	0.015
RSU1	Ras suppressor protein 1	0.014
SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	0.014
CCND3	cyclin D3	0.014
UNC5B	unc-5 homolog B (C. elegans)	0.014
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.014
KLF2	Kruppel-like factor 2 (lung)	0.014
PARVB	parvin, beta	0.014
SFRP2	secreted frizzled-related protein 2	0.014
TPM1	tropomyosin 1 (alpha)	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.014
MYOD1	myogenic differentiation 1	0.014
ATP13A2	ATPase type 13A2	0.014
BIK	BCL2-interacting killer (apoptosis-inducing)	0.014
CNN3	calponin 3, acidic	0.014
ARRDC3	arrestin domain containing 3	0.014
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.014
HOXA9	homeobox A9	0.014
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.014
CRLF1	cytokine receptor-like factor 1	0.014
MARK4	MAP/microtubule affinity-regulating kinase 4	0.013
HEG1	HEG homolog 1 (zebrafish)	0.013
HAS2	hyaluronan synthase 2	0.013
PNPLA2	patatin-like phospholipase domain containing 2	0.013
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.013
RXRA	retinoid X receptor, alpha	0.013
COL18A1	collagen, type XVIII, alpha 1	0.013
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.013
PDGFC	platelet derived growth factor C	0.013
EFNB3	ephrin-B3	0.013
KLF7	Kruppel-like factor 7 (ubiquitous)	0.013
DCN	decorin	0.013
USP42	ubiquitin specific peptidase 42	0.013
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.013
OGFR	opioid growth factor receptor	0.013
SLIT2	slit homolog 2 (Drosophila)	0.013
PITX2	paired-like homeodomain 2	0.013
LRP6	low density lipoprotein receptor-related protein 6	0.013
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.013
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	0.013
FGF2	fibroblast growth factor 2 (basic)	0.013
TLE2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	0.013
MEF2A	myocyte enhancer factor 2A	0.013
SOX9	SRY (sex determining region Y)-box 9	0.013
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.013
PIAS2	protein inhibitor of activated STAT, 2	0.013
WISP1	WNT1 inducible signaling pathway protein 1	0.013	Human
TPP1	tripeptidyl peptidase I	0.012
COMP	cartilage oligomeric matrix protein	0.012	Human
MCAM	melanoma cell adhesion molecule	0.012
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.012
POU3F3	POU class 3 homeobox 3	0.012	Human
SAP30	Sin3A-associated protein, 30kDa	0.012
SOX17	SRY (sex determining region Y)-box 17	0.012
DLX2	distal-less homeobox 2	0.012
OCLN	occludin	0.012
POU4F1	POU class 4 homeobox 1	0.012	Human
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.012
DCAF7	DDB1 and CUL4 associated factor 7	0.012
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.012
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.012
APP	amyloid beta (A4) precursor protein	0.012
HES1	hairy and enhancer of split 1, (Drosophila)	0.012	Mouse
ELN	elastin	0.012
COL5A1	collagen, type V, alpha 1	0.012
TWIST1	twist homolog 1 (Drosophila)	0.012
THBS2	thrombospondin 2	0.012	Human
LHX1	LIM homeobox 1	0.012
OTP	orthopedia homeobox	0.012
THBS4	thrombospondin 4	0.012	Human
NRP2	neuropilin 2	0.012
ACVR2A	activin A receptor, type IIA	0.012
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.012
FNDC1	fibronectin type III domain containing 1	0.012
FOXS1	forkhead box S1	0.012
OTX2	orthodenticle homeobox 2	0.012
CYBRD1	cytochrome b reductase 1	0.012
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.012
CEP290	centrosomal protein 290kDa	0.012
SPRED1	sprouty-related, EVH1 domain containing 1	0.012
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.012
PITX1	paired-like homeodomain 1	0.012
FOXC1	forkhead box C1	0.012
ARHGAP29	Rho GTPase activating protein 29	0.012
FZD1	frizzled homolog 1 (Drosophila)	0.012
LAMP1	lysosomal-associated membrane protein 1	0.011
KLF13	Kruppel-like factor 13	0.011
HAND2	heart and neural crest derivatives expressed 2	0.011
BCL2L1	BCL2-like 1	0.011
CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	0.011
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.011
F3	coagulation factor III (thromboplastin, tissue factor)	0.011
MN1	meningioma (disrupted in balanced translocation) 1	0.011
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.011
SIAH2	seven in absentia homolog 2 (Drosophila)	0.011
FLT4	fms-related tyrosine kinase 4	0.011
WRN	Werner syndrome, RecQ helicase-like	0.011
ZNF426	zinc finger protein 426	0.011
SDC2	syndecan 2	0.011
C1orf94	chromosome 1 open reading frame 94	0.011
TMEM127	transmembrane protein 127	0.011
SNRK	SNF related kinase	0.011
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.011
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.011	Mouse
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.011
UBE2Q2	ubiquitin-conjugating enzyme E2Q family member 2	0.011
VASN	vasorin	0.011
COL12A1	collagen, type XII, alpha 1	0.011
TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	0.011
CIR1	corepressor interacting with RBPJ, 1	0.011
VASP	vasodilator-stimulated phosphoprotein	0.011
RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.011
IQGAP1	IQ motif containing GTPase activating protein 1	0.011
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.011
MKRN1	makorin ring finger protein 1	0.011
LRRC15	leucine rich repeat containing 15	0.011
RND3	Rho family GTPase 3	0.011
STC1	stanniocalcin 1	0.011
FST	follistatin	0.010
LHX2	LIM homeobox 2	0.010
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.010
HDAC1	histone deacetylase 1	0.010
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.010
NOX4	NADPH oxidase 4	0.010
WNT2	wingless-type MMTV integration site family member 2	0.010
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	0.010
LENG1	leukocyte receptor cluster (LRC) member 1	0.010
ITGB5	integrin, beta 5	0.010
CREB1	cAMP responsive element binding protein 1	0.010
FBXW8	F-box and WD repeat domain containing 8	0.010
EGR2	early growth response 2	0.010
AMBRA1	autophagy/beclin-1 regulator 1	0.010
DLX4	distal-less homeobox 4	0.010
PTCH1	patched 1	0.010
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.010
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.010
FZD10	frizzled homolog 10 (Drosophila)	0.010
MKL2	MKL/myocardin-like 2	0.010
NAV2	neuron navigator 2	0.010
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.010
PRRX2	paired related homeobox 2	0.010
PPP1R13L	protein phosphatase 1, regulatory (inhibitor) subunit 13 like	0.010
CRTAP	cartilage associated protein	0.010
PLK2	polo-like kinase 2	0.010
LRP2	low density lipoprotein receptor-related protein 2	0.010
HEXB	hexosaminidase B (beta polypeptide)	0.010
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.010
EBF2	early B-cell factor 2	0.010
FBP1	fructose-1,6-bisphosphatase 1	0.010