Mus musculus

75 known processes

Fbn1

fibrillin 1

(Aliases: Fib-1,AI536462,B430209H23,Tsk)

Fbn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extracellular matrix organization GO:0030198 147 0.997
elastic fiber assembly GO:0048251 4 0.995
bone development GO:0060348 120 0.993
extracellular structure organization GO:0043062 148 0.991
collagen fibril organization GO:0030199 32 0.989
skeletal system development GO:0001501 356 0.989
Human Mouse
cellular response to oxygen radical GO:0071450 14 0.985
cartilage condensation GO:0001502 18 0.984
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.984
growth plate cartilage development GO:0003417 14 0.983
regulation of removal of superoxide radicals GO:2000121 4 0.982
connective tissue development GO:0061448 179 0.980
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.975
skeletal system morphogenesis GO:0048705 203 0.974
Mouse
negative regulation of cell motility GO:2000146 61 0.964
appendage morphogenesis GO:0035107 149 0.963
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.953
face morphogenesis GO:0060325 29 0.950
cell aggregation GO:0098743 18 0.944
cellular amine metabolic process GO:0044106 44 0.944
limb development GO:0060173 166 0.943
Mouse
blood circulation GO:0008015 195 0.940
embryonic skeletal system development GO:0048706 120 0.939
chondrocyte differentiation GO:0002062 72 0.935
bone morphogenesis GO:0060349 78 0.933
positive regulation of protein phosphorylation GO:0001934 242 0.933
cellular response to superoxide GO:0071451 14 0.923
endochondral bone morphogenesis GO:0060350 50 0.920
negative regulation of cell migration GO:0030336 59 0.915
chondrocyte development GO:0002063 24 0.907
extrinsic apoptotic signaling pathway GO:0097191 126 0.901
head morphogenesis GO:0060323 34 0.892
response to oxidative stress GO:0006979 123 0.886
respiratory system development GO:0060541 190 0.882
extracellular matrix assembly GO:0085029 12 0.882
positive regulation of axon extension GO:0045773 20 0.871
cartilage development GO:0051216 140 0.871
peptidyl amino acid modification GO:0018193 336 0.837
negative regulation of blood circulation GO:1903523 15 0.837
retinal ganglion cell axon guidance GO:0031290 18 0.833
reactive oxygen species metabolic process GO:0072593 84 0.828
glycoprotein metabolic process GO:0009100 116 0.828
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.826
positive regulation of interferon gamma secretion GO:1902715 3 0.822
cellular response to fluid shear stress GO:0071498 4 0.816
positive regulation of transferase activity GO:0051347 167 0.815
respiratory tube development GO:0030323 167 0.801
regulation of cellular response to growth factor stimulus GO:0090287 82 0.798
lung alveolus development GO:0048286 45 0.796
aorta smooth muscle tissue morphogenesis GO:0060414 2 0.786
skin development GO:0043588 220 0.776
regulation of anatomical structure size GO:0090066 178 0.770
antibacterial peptide secretion GO:0002779 1 0.767
small gtpase mediated signal transduction GO:0007264 97 0.763
lung development GO:0030324 164 0.756
response to oxygen levels GO:0070482 62 0.752
response to decreased oxygen levels GO:0036293 59 0.752
regulation of protein kinase activity GO:0045859 232 0.752
embryonic skeletal system morphogenesis GO:0048704 91 0.749
signal transduction in absence of ligand GO:0038034 55 0.741
removal of superoxide radicals GO:0019430 12 0.731
response to organic cyclic compound GO:0014070 198 0.730
response to growth factor GO:0070848 198 0.723
muscle tissue development GO:0060537 308 0.722
cellular response to growth factor stimulus GO:0071363 197 0.720
protein catabolic process GO:0030163 221 0.719
regulation of cartilage development GO:0061035 44 0.708
development of primary female sexual characteristics GO:0046545 73 0.704
macromolecule catabolic process GO:0009057 281 0.704
oxidation reduction process GO:0055114 342 0.693
endochondral bone growth GO:0003416 19 0.693
vascular process in circulatory system GO:0003018 62 0.691
female gonad development GO:0008585 71 0.680
replacement ossification GO:0036075 26 0.677
positive regulation of kinase activity GO:0033674 155 0.676
regulation of cellular ketone metabolic process GO:0010565 66 0.672
response to superoxide GO:0000303 16 0.669
regulation of apoptotic signaling pathway GO:2001233 197 0.664
amine metabolic process GO:0009308 45 0.653
protein heterotrimerization GO:0070208 8 0.644
renal system development GO:0072001 225 0.644
ovarian follicle development GO:0001541 40 0.635
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.624
response to hypoxia GO:0001666 58 0.619
regulation of cell migration GO:0030334 219 0.619
cellular response to amino acid stimulus GO:0071230 29 0.606
response to steroid hormone GO:0048545 56 0.602
cellular amino acid metabolic process GO:0006520 103 0.602
regulation of proteolysis GO:0030162 164 0.600
positive regulation of cytokine production GO:0001819 174 0.580
positive regulation of metanephros development GO:0072216 9 0.577
anatomical structure homeostasis GO:0060249 145 0.574
bone mineralization GO:0030282 54 0.571
Mouse
regulation of chondrocyte differentiation GO:0032330 33 0.567
regulation of blood pressure GO:0008217 93 0.556
phospholipase c activating angiotensin activated signaling pathway GO:0086097 1 0.545
limb morphogenesis GO:0035108 149 0.544
Mouse
negative regulation of smooth muscle cell apoptotic process GO:0034392 1 0.540
regulation of monooxygenase activity GO:0032768 7 0.540
cell type specific apoptotic process GO:0097285 268 0.535
negative regulation of cell substrate adhesion GO:0010812 16 0.534
response to amino acid GO:0043200 37 0.531
lymph vessel morphogenesis GO:0036303 11 0.525
circulatory system process GO:0003013 197 0.524
molting cycle GO:0042303 90 0.519
Worm
response to oxygen radical GO:0000305 16 0.516
regulation of cell aging GO:0090342 9 0.511
positive regulation of cell projection organization GO:0031346 95 0.509
negative regulation of cartilage development GO:0061037 17 0.504
positive regulation of protein modification process GO:0031401 299 0.495
inflammatory response GO:0006954 244 0.484
positive regulation of hydrolase activity GO:0051345 148 0.481
multicellular organismal homeostasis GO:0048871 164 0.471
appendage development GO:0048736 166 0.470
Mouse
multicellular organismal catabolic process GO:0044243 7 0.468
bronchus morphogenesis GO:0060434 2 0.468
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.465
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.461
response to activity GO:0014823 13 0.458
negative regulation of apoptotic signaling pathway GO:2001234 104 0.458
bone resorption GO:0045453 38 0.452
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway GO:0051482 4 0.445
response to light stimulus GO:0009416 135 0.438
regulation of cell cycle GO:0051726 281 0.435
response to organonitrogen compound GO:0010243 246 0.435
regulation of protein transport GO:0051223 163 0.435
negative regulation of molecular function GO:0044092 258 0.433
organonitrogen compound biosynthetic process GO:1901566 192 0.433
cell matrix adhesion GO:0007160 68 0.433
cellular response to acid chemical GO:0071229 68 0.430
striated muscle tissue development GO:0014706 293 0.429
positive regulation of angiogenesis GO:0045766 46 0.429
regulation of cell motility GO:2000145 236 0.426
positive regulation of protein kinase activity GO:0045860 144 0.420
response to hyperoxia GO:0055093 2 0.417
forebrain development GO:0030900 302 0.410
regulation of system process GO:0044057 200 0.410
negative regulation of cell proliferation GO:0008285 296 0.408
proteoglycan metabolic process GO:0006029 38 0.406
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.404
striated muscle cell development GO:0055002 125 0.402
face development GO:0060324 38 0.400
smooth muscle contraction GO:0006939 44 0.398
stem cell development GO:0048864 219 0.397
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.395
regulation of blood vessel size GO:0050880 56 0.394
negative regulation of fat cell differentiation GO:0045599 36 0.392
digestive tract development GO:0048565 190 0.388
response to inorganic substance GO:0010035 96 0.383
regulation of establishment of protein localization GO:0070201 181 0.382
cell chemotaxis GO:0060326 81 0.375
development of primary sexual characteristics GO:0045137 143 0.369
response to reactive oxygen species GO:0000302 56 0.367
regulation of transferase activity GO:0051338 263 0.360
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.357
superoxide metabolic process GO:0006801 27 0.357
positive regulation of proteolysis GO:0045862 85 0.345
blood vessel morphogenesis GO:0048514 285 0.344
regulation of lung blood pressure GO:0014916 2 0.339
developmental growth involved in morphogenesis GO:0060560 138 0.338
negative regulation of cell adhesion GO:0007162 45 0.338
regulation of anti mullerian hormone signaling pathway GO:1902612 1 0.337
response to radiation GO:0009314 165 0.337
positive regulation of programmed cell death GO:0043068 218 0.333
superoxide anion generation GO:0042554 11 0.333
digestive tract morphogenesis GO:0048546 147 0.332
intrinsic apoptotic signaling pathway in response to osmotic stress GO:0008627 2 0.326
regulation of protein localization GO:0032880 231 0.324
regulation of cellular response to oxidative stress GO:1900407 19 0.322
cardiac muscle tissue development GO:0048738 130 0.321
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.320
regulation of kinase activity GO:0043549 249 0.319
apoptotic signaling pathway GO:0097190 306 0.314
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.308
regulation of angiogenesis GO:0045765 81 0.307
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902218 1 0.305
body morphogenesis GO:0010171 45 0.302
release of cytochrome c from mitochondria GO:0001836 23 0.301
regulation of fat cell differentiation GO:0045598 81 0.301
regulation of neuron apoptotic process GO:0043523 122 0.300
regulation of endothelial cell proliferation GO:0001936 23 0.296
cellular ketone metabolic process GO:0042180 84 0.295
regulation of reactive oxygen species metabolic process GO:2000377 40 0.294
hair follicle development GO:0001942 85 0.290
response to transforming growth factor beta GO:0071559 88 0.289
digestive system development GO:0055123 200 0.289
endothelial cell proliferation GO:0001935 27 0.289
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.288
axonogenesis GO:0007409 274 0.284
regulation of response to oxidative stress GO:1902882 19 0.283
peripheral nervous system axon regeneration GO:0014012 2 0.280
smoothened signaling pathway GO:0007224 105 0.279
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.275
positive regulation of nitric oxide synthase activity GO:0051000 2 0.274
nephron development GO:0072006 109 0.274
regulation of cellular component biogenesis GO:0044087 181 0.270
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.269
negative regulation of cellular amine metabolic process GO:0033239 1 0.267
negative regulation of epithelial cell proliferation GO:0050680 64 0.264
female sex differentiation GO:0046660 84 0.264
tissue homeostasis GO:0001894 115 0.263
regulation of tube size GO:0035150 57 0.259
regulation of tolerance induction to self antigen GO:0002649 1 0.256
regulation of secretion by cell GO:1903530 249 0.255
regulation of actin filament based process GO:0032970 99 0.251
stem cell differentiation GO:0048863 268 0.251
positive regulation of dendritic spine development GO:0060999 12 0.249
prostate gland morphogenesis GO:0060512 32 0.248
aorta morphogenesis GO:0035909 22 0.248
positive regulation of cell substrate adhesion GO:0010811 47 0.246
regulation of response to osmotic stress GO:0047484 3 0.244
rhythmic process GO:0048511 174 0.243
heart process GO:0003015 94 0.243
direct ossification GO:0036072 5 0.241
urogenital system development GO:0001655 261 0.239
regulation of secretion GO:0051046 274 0.239
axon guidance GO:0007411 141 0.237
endoderm formation GO:0001706 20 0.237
negative regulation of insulin secretion GO:0046676 14 0.236
dopamine metabolic process GO:0042417 23 0.236
angiogenesis GO:0001525 201 0.236
ras protein signal transduction GO:0007265 77 0.235
glycoprotein biosynthetic process GO:0009101 89 0.235
endoderm development GO:0007492 45 0.235
phospholipid metabolic process GO:0006644 87 0.232
nephron epithelium morphogenesis GO:0072088 68 0.231
embryonic organ morphogenesis GO:0048562 276 0.229
antibacterial peptide biosynthetic process GO:0002780 2 0.222
cardiac ventricle development GO:0003231 83 0.222
positive regulation of bone remodeling GO:0046852 13 0.222
multi multicellular organism process GO:0044706 109 0.220
hair follicle morphogenesis GO:0031069 29 0.218
cellular response to organonitrogen compound GO:0071417 145 0.218
regulation of biomineral tissue development GO:0070167 33 0.215
Mouse
positive regulation of cellular component biogenesis GO:0044089 94 0.214
single organismal cell cell adhesion GO:0016337 131 0.213
negative regulation of vasoconstriction GO:0045906 2 0.210
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure GO:0002033 2 0.210
positive regulation of cellular amine metabolic process GO:0033240 5 0.209
response to monosaccharide GO:0034284 67 0.208
positive regulation of secretion by cell GO:1903532 114 0.207
cardiocyte differentiation GO:0035051 87 0.206
mesenchymal cell proliferation GO:0010463 44 0.206
regulation of protein catabolic process GO:0042176 108 0.205
peptide hormone secretion GO:0030072 109 0.201
growth plate cartilage chondrocyte development GO:0003431 3 0.201
regulation of neuron differentiation GO:0045664 281 0.200
dendrite development GO:0016358 115 0.198
positive regulation of ras protein signal transduction GO:0046579 13 0.198
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.197
ovulation cycle GO:0042698 59 0.197
male gamete generation GO:0048232 285 0.196
indolalkylamine metabolic process GO:0006586 4 0.195
transmembrane transport GO:0055085 412 0.195
negative regulation of macrophage chemotaxis GO:0010760 1 0.195
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.192
negative regulation of cardiac muscle tissue development GO:0055026 8 0.192
anatomical structure maturation GO:0071695 49 0.192
muscle contraction GO:0006936 101 0.190
renal system process GO:0003014 48 0.189
purine containing compound metabolic process GO:0072521 311 0.186
basement membrane organization GO:0071711 8 0.184
cellular response to hormone stimulus GO:0032870 150 0.184
negative regulation of nervous system development GO:0051961 156 0.183
artery development GO:0060840 53 0.182
cholesterol import GO:0070508 2 0.182
cellular response to oxidative stress GO:0034599 76 0.182
peptide metabolic process GO:0006518 46 0.181
peptide transport GO:0015833 133 0.178
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.177
regulation of homeostatic process GO:0032844 182 0.176
insulin secretion GO:0030073 89 0.176
odontogenesis of dentin containing tooth GO:0042475 66 0.174
tissue remodeling GO:0048771 102 0.174
positive regulation of nervous system development GO:0051962 221 0.174
maintenance of protein location in nucleus GO:0051457 2 0.173
regulation of cytokine production GO:0001817 266 0.172
cellular response to abiotic stimulus GO:0071214 56 0.172
response to osmotic stress GO:0006970 21 0.171
positive regulation of protein secretion GO:0050714 52 0.171
negative regulation of heart rate GO:0010459 4 0.170
nitrogen compound transport GO:0071705 271 0.170
fused antrum stage GO:0048165 1 0.170
smooth muscle tissue development GO:0048745 22 0.169
response to acid chemical GO:0001101 111 0.168
regulation of response to reactive oxygen species GO:1901031 9 0.166
gastrulation GO:0007369 116 0.165
bone trabecula formation GO:0060346 9 0.163
Mouse
positive regulation of macrophage derived foam cell differentiation GO:0010744 4 0.160
ureteric bud morphogenesis GO:0060675 62 0.160
cell adhesion GO:0007155 329 0.160
positive regulation of map kinase activity GO:0043406 84 0.159
metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 3 0.159
inorganic cation transmembrane transport GO:0098662 207 0.156
regulation of neurotrophin trk receptor signaling pathway GO:0051386 4 0.156
peptidyl tyrosine phosphorylation GO:0018108 143 0.154
regulation of peptidase activity GO:0052547 96 0.154
vasodilation GO:0042311 28 0.154
synaptic transmission GO:0007268 329 0.154
calcium ion homeostasis GO:0055074 127 0.154
regulation of protein binding GO:0043393 60 0.153
positive regulation of tolerance induction to self antigen GO:0002651 1 0.153
neuron apoptotic process GO:0051402 142 0.152
leukocyte chemotaxis GO:0030595 69 0.151
antimicrobial peptide secretion GO:0002776 1 0.151
peptidyl serine modification GO:0018209 83 0.151
positive regulation of response to oxidative stress GO:1902884 6 0.151
negative regulation of proteolysis GO:0045861 74 0.150
regulation of mapk cascade GO:0043408 248 0.150
neuron death GO:0070997 154 0.150
antibacterial humoral response GO:0019731 8 0.149
regulation of axon extension GO:0030516 43 0.148
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.147
cardiac muscle tissue morphogenesis GO:0055008 44 0.146
hormone secretion GO:0046879 128 0.146
regeneration GO:0031099 38 0.145
protein processing GO:0016485 163 0.145
peptide secretion GO:0002790 114 0.144
cellular response to lipid GO:0071396 145 0.141
response to fluid shear stress GO:0034405 7 0.141
nitric oxide mediated signal transduction GO:0007263 4 0.139
regionalization GO:0003002 337 0.139
neural plate mediolateral regionalization GO:0021998 1 0.138
regulation of cellular component size GO:0032535 121 0.138
hindbrain morphogenesis GO:0021575 46 0.138
regulation of cellular amino acid metabolic process GO:0006521 5 0.137
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1902238 1 0.136
metanephric glomerulus development GO:0072224 13 0.136
positive regulation of monooxygenase activity GO:0032770 2 0.135
response to estrogen GO:0043627 24 0.135
collagen metabolic process GO:0032963 17 0.135
kidney epithelium development GO:0072073 121 0.133
tendon development GO:0035989 6 0.130
negative regulation of cellular protein metabolic process GO:0032269 247 0.130
regulation of chemotaxis GO:0050920 53 0.129
regulation of cholesterol esterification GO:0010872 2 0.129
cellular response to sterol depletion GO:0071501 4 0.126
regulation of phosphatidylcholine catabolic process GO:0010899 2 0.126
cellular response to organic cyclic compound GO:0071407 87 0.124
regulation of cell adhesion GO:0030155 154 0.122
vasoconstriction GO:0042310 27 0.121
negative regulation of neuron migration GO:2001223 6 0.121
regulation of endodermal cell differentiation GO:1903224 2 0.121
cellular response to steroid hormone stimulus GO:0071383 33 0.120
hair cycle GO:0042633 90 0.120
positive regulation of rho protein signal transduction GO:0035025 7 0.120
skeletal muscle organ development GO:0060538 163 0.119
metanephric nephron epithelium development GO:0072243 19 0.118
sequestering of calcium ion GO:0051208 18 0.118
kidney development GO:0001822 213 0.118
collagen catabolic process GO:0030574 6 0.118
spinal cord development GO:0021510 81 0.118
ear morphogenesis GO:0042471 118 0.117
negative regulation of endodermal cell differentiation GO:1903225 1 0.116
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1902239 1 0.115
regulation of protein secretion GO:0050708 82 0.115
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.114
negative regulation of immune system process GO:0002683 209 0.114
response to dexamethasone GO:0071548 8 0.113
actin filament polymerization GO:0030041 44 0.113
positive regulation of cytokine secretion GO:0050715 41 0.112
cellular modified amino acid metabolic process GO:0006575 63 0.112
oocyte axis specification GO:0007309 2 0.112
response to glucocorticoid GO:0051384 20 0.112
positive regulation of filopodium assembly GO:0051491 10 0.111
negative regulation of intracellular signal transduction GO:1902532 167 0.111
cellular response to bmp stimulus GO:0071773 14 0.111
organ growth GO:0035265 117 0.110
positive regulation of apoptotic process GO:0043065 217 0.110
fat cell differentiation GO:0045444 160 0.110
mesonephric epithelium development GO:0072163 94 0.109
epithelial cell migration GO:0010631 63 0.108
metal ion homeostasis GO:0055065 189 0.108
sulfur compound metabolic process GO:0006790 100 0.107
positive regulation of cell death GO:0010942 224 0.107
rho protein signal transduction GO:0007266 32 0.105
lateral mesoderm morphogenesis GO:0048369 3 0.105
nephron tubule morphogenesis GO:0072078 68 0.105
cellular response to glucocorticoid stimulus GO:0071385 13 0.105
negative regulation of cell cycle GO:0045786 123 0.104
regulation of cellular response to stress GO:0080135 159 0.104
metanephric glomerular mesangium development GO:0072223 3 0.103
protein hydroxylation GO:0018126 4 0.103
multicellular organismal macromolecule metabolic process GO:0044259 19 0.103
erythrocyte differentiation GO:0030218 88 0.103
positive regulation of mapk cascade GO:0043410 170 0.103
detection of chemical stimulus involved in sensory perception of taste GO:0050912 3 0.102
negative regulation of chondrocyte differentiation GO:0032331 13 0.101
protein polymerization GO:0051258 57 0.100
negative regulation of anti mullerian hormone signaling pathway GO:1902613 1 0.099
g protein coupled receptor signaling pathway coupled to cgmp nucleotide second messenger GO:0007199 1 0.098
response to nutrient levels GO:0031667 109 0.098
renin secretion into blood stream GO:0002001 5 0.097
response to fibroblast growth factor GO:0071774 47 0.096
aorta development GO:0035904 23 0.095
regulation of cell cycle process GO:0010564 160 0.095
negative regulation of heart growth GO:0061117 7 0.095
developmental maturation GO:0021700 193 0.095
nucleobase containing small molecule metabolic process GO:0055086 352 0.094
positive regulation of neuron projection development GO:0010976 79 0.094
protein trimerization GO:0070206 13 0.094
cardiac ventricle morphogenesis GO:0003208 50 0.093
cell differentiation in hindbrain GO:0021533 24 0.093
negative regulation of protein modification process GO:0031400 163 0.091
regulation of hormone secretion GO:0046883 88 0.091
cellular response to dexamethasone stimulus GO:0071549 8 0.091
regulation of cell substrate adhesion GO:0010810 73 0.091
astrocyte cell migration GO:0043615 3 0.090
endothelial cell migration GO:0043542 44 0.090
nuclear import GO:0051170 95 0.089
regulation of blood circulation GO:1903522 93 0.089
homeostasis of number of cells GO:0048872 210 0.089
cellular response to corticosteroid stimulus GO:0071384 13 0.087
cardiac muscle cell development GO:0055013 39 0.087
muscle tissue morphogenesis GO:0060415 53 0.087
biomineral tissue development GO:0031214 64 0.087
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.087
response to corticosteroid GO:0031960 20 0.086
myeloid leukocyte migration GO:0097529 57 0.086
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.085
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.085
nuclear membrane organization GO:0071763 4 0.085
regulation of macrophage chemotaxis GO:0010758 8 0.085
mesenchyme development GO:0060485 152 0.085
telencephalon development GO:0021537 186 0.085
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.085
cerebellar cortex formation GO:0021697 22 0.084
catecholamine biosynthetic process GO:0042423 11 0.083
locomotory behavior GO:0007626 195 0.082
regulation of cell projection organization GO:0031344 206 0.082
mesoderm structural organization GO:0048338 1 0.081
membrane protein proteolysis GO:0033619 10 0.080
protein localization to nucleus GO:0034504 121 0.080
negative regulation of systemic arterial blood pressure GO:0003085 15 0.079
intestinal cholesterol absorption GO:0030299 5 0.079
negative regulation of endothelial cell migration GO:0010596 4 0.078
nuclear transport GO:0051169 139 0.077
myeloid cell differentiation GO:0030099 233 0.077
regulation of interferon gamma secretion GO:1902713 3 0.077
regulation of ossification GO:0030278 112 0.077
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.077
regulation of neuron migration GO:2001222 22 0.076
organelle assembly GO:0070925 177 0.076
regulation of extent of cell growth GO:0061387 52 0.076
blood vessel remodeling GO:0001974 33 0.076
regulation of nucleotide metabolic process GO:0006140 169 0.076
cellular amide metabolic process GO:0043603 58 0.076
positive regulation of protein kinase b signaling GO:0051897 32 0.075
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.075
neutral lipid metabolic process GO:0006638 57 0.074
regulation of hormone levels GO:0010817 211 0.073
negative regulation of protein maturation GO:1903318 79 0.073
steroid metabolic process GO:0008202 119 0.073
response to sterol GO:0036314 4 0.072
nucleotide metabolic process GO:0009117 332 0.071
ribose phosphate metabolic process GO:0019693 291 0.071
production of molecular mediator of immune response GO:0002440 103 0.071
response to retinoic acid GO:0032526 56 0.071
actin polymerization or depolymerization GO:0008154 54 0.070
response to increased oxygen levels GO:0036296 2 0.070
mullerian duct regression GO:0001880 1 0.070
fibril organization GO:0097435 2 0.069
negative regulation of protein metabolic process GO:0051248 282 0.069
ribonucleotide catabolic process GO:0009261 208 0.069
neuron migration GO:0001764 122 0.068
oocyte construction GO:0007308 2 0.068
myeloid dendritic cell differentiation GO:0043011 16 0.068
alpha amino acid metabolic process GO:1901605 59 0.068
regulation of hydrolase activity GO:0051336 246 0.068
trabecula morphogenesis GO:0061383 40 0.068
Mouse
positive regulation of skeletal muscle tissue regeneration GO:0043415 4 0.068
cellular metal ion homeostasis GO:0006875 151 0.067
response to drug GO:0042493 75 0.066

Fbn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 1.000
musculoskeletal system disease DOID:17 0 1.000
connective tissue disease DOID:65 0 1.000
cardiovascular system disease DOID:1287 0 0.891
bone development disease DOID:0080006 0 0.786
bone disease DOID:0080001 0 0.786
heart disease DOID:114 0 0.736
vascular disease DOID:178 0 0.348
disease of cellular proliferation DOID:14566 0 0.203
cancer DOID:162 0 0.198
organ system cancer DOID:0050686 0 0.198
gastrointestinal system cancer DOID:3119 0 0.132
myopathy DOID:423 0 0.119
congenital muscular dystrophy DOID:0050557 0 0.119
muscular disease DOID:0080000 0 0.119
muscular dystrophy DOID:9884 0 0.119
muscle tissue disease DOID:66 0 0.119
bone remodeling disease DOID:0080005 0 0.106
osteochondrodysplasia DOID:2256 0 0.106
osteogenesis imperfecta DOID:12347 0 0.106
disease of metabolism DOID:0014667 0 0.105
inherited metabolic disorder DOID:655 0 0.105