IMP

Process View

Mus musculus

10 genes annotated in mouse

Multi-species View

membrane protein proteolysis

GO:0033619

The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "membrane protein proteolysis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "membrane protein proteolysis" (in gray)

Name	Description	Probability	Func Analog Organism
Psen1	presenilin 1	0.987	Human
Notch2	Notch gene homolog 2 (Drosophila)	0.715
App	amyloid beta (A4) precursor protein	0.570
Lamp2	lysosomal-associated membrane protein 2	0.490
Ctsb	cathepsin B	0.428
Klf3	Kruppel-like factor 3 (basic)	0.401
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.361
Adam15	a disintegrin and metallopeptidase domain 15 (metargidin)	0.223	Mouse
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.182
Prnp	prion protein	0.170
Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	0.157	Mouse
Ncstn	nicastrin	0.152	Human Fly
Ctnnb1	catenin (cadherin associated protein), beta 1	0.121
Il1r1	interleukin 1 receptor, type I	0.112
Agtr1a	angiotensin II receptor, type 1a	0.093
Psap	prosaposin	0.091
Fbn1	fibrillin 1	0.080
Apoe	apolipoprotein E	0.080	Human
Psen2	presenilin 2	0.073	Human
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.072
Ldlr	low density lipoprotein receptor	0.071
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.064
Il6	interleukin 6	0.053
Asah1	N-acylsphingosine amidohydrolase 1	0.052
Hif1a	hypoxia inducible factor 1, alpha subunit	0.050
Ngp	neutrophilic granule protein	0.048
Vav2	vav 2 oncogene	0.047
Dmd	dystrophin, muscular dystrophy	0.047
Erlin2	ER lipid raft associated 2	0.045
Syvn1	synovial apoptosis inhibitor 1, synoviolin	0.042
Mmp2	matrix metallopeptidase 2	0.041
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.040
Aplp2	amyloid beta (A4) precursor-like protein 2	0.039
Thbs1	thrombospondin 1	0.039
Lgmn	legumain	0.037
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.036
Adam17	a disintegrin and metallopeptidase domain 17	0.034
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.034
Notch1	Notch gene homolog 1 (Drosophila)	0.033
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.033
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.032
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.032	Mouse
Il1rn	interleukin 1 receptor antagonist	0.031
Snap23	synaptosomal-associated protein 23	0.031
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.031
Efnb2	ephrin B2	0.028
Sirpa	signal-regulatory protein alpha	0.027
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.026
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.025
Mertk	c-mer proto-oncogene tyrosine kinase	0.025
Atp11c	ATPase, class VI, type 11C	0.025
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.025
Cx3cr1	chemokine (C-X3-C) receptor 1	0.025
Tnf	tumor necrosis factor	0.023
C3	complement component 3	0.023
Ltf	lactotransferrin	0.023
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.023
Axl	AXL receptor tyrosine kinase	0.022
Lox	lysyl oxidase	0.022
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.022
Idua	iduronidase, alpha-L-	0.021
Vhl	von Hippel-Lindau tumor suppressor	0.021
Dlg1	discs, large homolog 1 (Drosophila)	0.020
Eln	elastin	0.020
Npc2	Niemann Pick type C2	0.020
L1cam	L1 cell adhesion molecule	0.020
Ctsz	cathepsin Z	0.020
Plbd2	phospholipase B domain containing 2	0.019
Myo7a	myosin VIIA	0.019
Ctsl	cathepsin L	0.019
Klf15	Kruppel-like factor 15	0.019
Tgfbr1	transforming growth factor, beta receptor I	0.019
Stam2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.018
Cd14	CD14 antigen	0.018
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.018
Tgfb1	transforming growth factor, beta 1	0.018
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.017
Adam23	a disintegrin and metallopeptidase domain 23	0.017	Mouse
Ctsa	cathepsin A	0.016
Jup	junction plakoglobin	0.016
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.016
Il6st	interleukin 6 signal transducer	0.016
Pax1	paired box gene 1	0.016
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.016
Pold4	polymerase (DNA-directed), delta 4	0.015
Wt1	Wilms tumor 1 homolog	0.015
D19Wsu162e	DNA segment, Chr 19, Wayne State University 162, expressed	0.015
Camp	cathelicidin antimicrobial peptide	0.015
Lta	lymphotoxin A	0.015
Spp1	secreted phosphoprotein 1	0.014
Cd44	CD44 antigen	0.014
Hif3a	hypoxia inducible factor 3, alpha subunit	0.014
Bcl3	B-cell leukemia/lymphoma 3	0.014
Ptgs2	prostaglandin-endoperoxide synthase 2	0.014
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.014
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.014
Glis2	GLIS family zinc finger 2	0.013
Ggta1	glycoprotein galactosyltransferase alpha 1, 3	0.013
Lamp1	lysosomal-associated membrane protein 1	0.013
B3gnt1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1	0.013
Capn5	calpain 5	0.013	Worm
Anxa4	annexin A4	0.013
Zfp385a	zinc finger protein 385A	0.012
Soat1	sterol O-acyltransferase 1	0.012
Galnt2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2	0.012
Fas	Fas (TNF receptor superfamily member 6)	0.011
Glipr2	GLI pathogenesis-related 2	0.011
Il1a	interleukin 1 alpha	0.011
Plaur	plasminogen activator, urokinase receptor	0.011
Sec14l1	SEC14-like 1 (S. cerevisiae)	0.011
Gm2a	GM2 ganglioside activator protein	0.011
Cpd	carboxypeptidase D	0.011
C5ar1	complement component 5a receptor 1	0.011
Tmed8	transmembrane emp24 domain containing 8	0.011
Hexa	hexosaminidase A	0.011
Rxra	retinoid X receptor alpha	0.011
Gns	glucosamine (N-acetyl)-6-sulfatase	0.011
Lepr	leptin receptor	0.011
Ctnnd1	catenin (cadherin associated protein), delta 1	0.011
Qsox1	quiescin Q6 sulfhydryl oxidase 1	0.011
Akt1	thymoma viral proto-oncogene 1	0.011	Mouse
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.010
Trim46	tripartite motif-containing 46	0.010
Dpysl2	dihydropyrimidinase-like 2	0.010
Icam5	intercellular adhesion molecule 5, telencephalin	0.010
Col20a1	collagen, type XX, alpha 1	0.010
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.010
Ifngr1	interferon gamma receptor 1	0.010
Pnmt	phenylethanolamine-N-methyltransferase	0.010