Mus musculus

191 known processes

Foxo3

forkhead box O3

(Aliases: FKHRL1,2010203A17Rik,Fkhr2,1110048B16Rik,C76856,Foxo3a)

Foxo3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.773
dna metabolic process GO:0006259 303 0.673
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.651
Fly
dna repair GO:0006281 107 0.642
cellular response to starvation GO:0009267 57 0.632
Fly
carbohydrate derivative biosynthetic process GO:1901137 183 0.591
Fly
male gamete generation GO:0048232 285 0.501
germ cell development GO:0007281 185 0.440
embryonic organ morphogenesis GO:0048562 276 0.401
regionalization GO:0003002 337 0.371
cyclic nucleotide metabolic process GO:0009187 59 0.352
Fly
apoptotic signaling pathway GO:0097190 306 0.330
spermatid development GO:0007286 108 0.329
regulation of cellular response to stress GO:0080135 159 0.328
Fly
generation of precursor metabolites and energy GO:0006091 103 0.324
Fly
negative regulation of cell cycle GO:0045786 123 0.318
Mouse
negative regulation of mitotic cell cycle GO:0045930 58 0.310
Mouse
negative regulation of cell proliferation GO:0008285 296 0.292
Mouse Fly
regulation of histone methylation GO:0031060 30 0.289
rhythmic process GO:0048511 174 0.289
purine ribonucleotide metabolic process GO:0009150 290 0.283
Fly
mitotic cell cycle GO:0000278 195 0.283
Mouse
intrinsic apoptotic signaling pathway GO:0097193 132 0.267
cohesin localization to chromatin GO:0071921 1 0.266
female gonad development GO:0008585 71 0.264
cell cycle arrest GO:0007050 37 0.251
purine containing compound biosynthetic process GO:0072522 70 0.245
Fly
cellular amino acid metabolic process GO:0006520 103 0.232
limb morphogenesis GO:0035108 149 0.227
nucleotide biosynthetic process GO:0009165 78 0.224
Fly
regulation of mitotic cell cycle GO:0007346 126 0.212
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.199
muscle tissue development GO:0060537 308 0.198
Worm
response to nutrient levels GO:0031667 109 0.197
Fly
protein targeting GO:0006605 143 0.196
stem cell development GO:0048864 219 0.193
mitotic cell cycle process GO:1903047 159 0.191
Mouse
antral ovarian follicle growth GO:0001547 5 0.186
cellular homeostasis GO:0019725 240 0.184
stem cell maintenance GO:0019827 130 0.182
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.174
reactive oxygen species metabolic process GO:0072593 84 0.173
canonical wnt signaling pathway GO:0060070 130 0.173
regulation of cell cycle phase transition GO:1901987 77 0.168
Mouse
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.165
positive regulation of apoptotic process GO:0043065 217 0.165
Human Worm
cellular response to oxidative stress GO:0034599 76 0.164
regulation of feeding behavior GO:0060259 3 0.163
Fly
skeletal system development GO:0001501 356 0.160
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.159
oocyte differentiation GO:0009994 35 0.156
cellular response to nutrient levels GO:0031669 64 0.150
Fly
extrinsic apoptotic signaling pathway GO:0097191 126 0.150
regulation of cell cycle GO:0051726 281 0.150
Mouse Worm
sperm individualization GO:0007291 1 0.149
response to uv GO:0009411 44 0.147
Worm
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.147
Fly
negative regulation of cell cycle phase transition GO:1901988 48 0.144
Mouse
cellular response to external stimulus GO:0071496 88 0.144
Fly
regulation of reactive oxygen species metabolic process GO:2000377 40 0.141
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.139
macroautophagy GO:0016236 21 0.136
Fly
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.136
intra s dna damage checkpoint GO:0031573 4 0.135
ovarian follicle development GO:0001541 40 0.129
positive regulation of cell death GO:0010942 224 0.129
Human Worm
cellular response to extracellular stimulus GO:0031668 81 0.127
Fly
histone lysine methylation GO:0034968 50 0.125
lung development GO:0030324 164 0.125
dna biosynthetic process GO:0071897 22 0.125
sulfur compound biosynthetic process GO:0044272 37 0.121
ribose phosphate metabolic process GO:0019693 291 0.121
Fly
protein methylation GO:0006479 81 0.120
embryonic skeletal system development GO:0048706 120 0.120
mitotic cell cycle arrest GO:0071850 4 0.119
morphogenesis of a branching structure GO:0001763 203 0.117
regulation of binding GO:0051098 111 0.116
embryonic limb morphogenesis GO:0030326 126 0.115
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.113
response to oxygen levels GO:0070482 62 0.110
cellular amine metabolic process GO:0044106 44 0.110
spermatogenesis GO:0007283 284 0.109
regulation of protein kinase activity GO:0045859 232 0.108
embryonic appendage morphogenesis GO:0035113 126 0.107
response to organonitrogen compound GO:0010243 246 0.105
Mouse Worm Fly
sulfur compound metabolic process GO:0006790 100 0.105
regulation of cohesin localization to chromatin GO:0071922 1 0.104
fat cell differentiation GO:0045444 160 0.102
Mouse
purine nucleotide biosynthetic process GO:0006164 65 0.101
Fly
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.101
regulation of autophagy GO:0010506 30 0.101
Fly
camp biosynthetic process GO:0006171 31 0.101
Fly
regulation of canonical wnt signaling pathway GO:0060828 82 0.100
macromolecule methylation GO:0043414 120 0.100
establishment of protein localization to organelle GO:0072594 118 0.100
response to extracellular stimulus GO:0009991 127 0.100
Fly
carbohydrate metabolic process GO:0005975 230 0.099
Mouse Fly
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.097
regulation of leukocyte differentiation GO:1902105 159 0.097
development of primary female sexual characteristics GO:0046545 73 0.097
regulation of cell size GO:0008361 72 0.096
Fly
regulation of protein serine threonine kinase activity GO:0071900 157 0.095
response to light stimulus GO:0009416 135 0.095
Worm
cellular macromolecule catabolic process GO:0044265 206 0.094
glycoprotein biosynthetic process GO:0009101 89 0.092
circulatory system process GO:0003013 197 0.092
locomotory behavior GO:0007626 195 0.092
Fly
negative regulation of growth GO:0045926 99 0.091
Worm Fly
g1 s transition of mitotic cell cycle GO:0000082 57 0.090
double strand break repair GO:0006302 48 0.090
spermatid differentiation GO:0048515 115 0.089
respiratory system development GO:0060541 190 0.085
oogenesis GO:0048477 56 0.085
cell type specific apoptotic process GO:0097285 268 0.085
Human Zebrafish
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.085
autophagy GO:0006914 45 0.085
Fly
carbohydrate homeostasis GO:0033500 128 0.084
skeletal muscle organ development GO:0060538 163 0.083
female sex differentiation GO:0046660 84 0.082
proteoglycan biosynthetic process GO:0030166 20 0.082
energy derivation by oxidation of organic compounds GO:0015980 77 0.082
Fly
regulation of macroautophagy GO:0016241 12 0.082
Fly
ribose phosphate biosynthetic process GO:0046390 59 0.082
Fly
embryonic viscerocranium morphogenesis GO:0048703 8 0.082
regulation of organelle organization GO:0033043 289 0.080
amine metabolic process GO:0009308 45 0.080
negative regulation of protein metabolic process GO:0051248 282 0.080
negative regulation of protein phosphorylation GO:0001933 126 0.080
nucleotide excision repair GO:0006289 13 0.080
sensory perception of sound GO:0007605 97 0.079
blood circulation GO:0008015 195 0.079
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.078
negative regulation of leukocyte differentiation GO:1902106 51 0.078
cell cycle g1 s phase transition GO:0044843 57 0.078
blastocyst development GO:0001824 80 0.078
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.077
response to radiation GO:0009314 165 0.077
Worm
glycoprotein metabolic process GO:0009100 116 0.076
protein alkylation GO:0008213 81 0.076
negative regulation of phosphorylation GO:0042326 166 0.076
cation transport GO:0006812 399 0.076
regulation of cellular ketone metabolic process GO:0010565 66 0.075
Mouse
cellular response to peptide hormone stimulus GO:0071375 92 0.075
Mouse Worm Fly
response to starvation GO:0042594 65 0.075
Fly
response to peptide GO:1901652 136 0.074
Mouse Worm Fly
mitotic g1 dna damage checkpoint GO:0031571 4 0.074
sensory perception GO:0007600 245 0.074
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.074
glial cell apoptotic process GO:0034349 3 0.073
regulation of androgen receptor signaling pathway GO:0060765 3 0.072
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.072
response to oxidative stress GO:0006979 123 0.071
cellular response to organic cyclic compound GO:0071407 87 0.071
positive regulation of kinase activity GO:0033674 155 0.071
carbohydrate biosynthetic process GO:0016051 74 0.071
Mouse
lymphocyte differentiation GO:0030098 242 0.070
positive regulation of ion transport GO:0043270 65 0.070
multicellular organismal homeostasis GO:0048871 164 0.069
gene silencing GO:0016458 38 0.069
maintenance of location GO:0051235 89 0.069
Fly
purine ribonucleotide biosynthetic process GO:0009152 59 0.069
Fly
peptidyl amino acid modification GO:0018193 336 0.069
signal transduction by p53 class mediator GO:0072331 51 0.069
double strand break repair via homologous recombination GO:0000724 21 0.069
positive regulation of binding GO:0051099 49 0.068
negative regulation of protein modification process GO:0031400 163 0.068
methylation GO:0032259 134 0.068
organonitrogen compound biosynthetic process GO:1901566 192 0.068
Fly
somite development GO:0061053 81 0.067
cellular protein catabolic process GO:0044257 155 0.067
t cell activation GO:0042110 289 0.067
regulation of activin receptor signaling pathway GO:0032925 10 0.066
Fly
cyclic nucleotide biosynthetic process GO:0009190 44 0.066
Fly
regulation of cellular amino acid metabolic process GO:0006521 5 0.065
cognition GO:0050890 149 0.064
protein localization to chromatin GO:0071168 3 0.064
epithelial cell proliferation GO:0050673 174 0.063
camp metabolic process GO:0046058 40 0.062
Fly
cellularization GO:0007349 1 0.062
positive regulation of apoptotic signaling pathway GO:2001235 95 0.061
regulation of intracellular transport GO:0032386 159 0.061
regulation of transferase activity GO:0051338 263 0.061
i kappab kinase nf kappab signaling GO:0007249 85 0.060
regulation of apoptotic signaling pathway GO:2001233 197 0.060
positive regulation of proteolysis GO:0045862 85 0.060
protein modification by small protein conjugation GO:0032446 187 0.060
connective tissue development GO:0061448 179 0.059
blood vessel morphogenesis GO:0048514 285 0.059
regulation of system process GO:0044057 200 0.059
regulation of anatomical structure size GO:0090066 178 0.058
Fly
dna recombination GO:0006310 92 0.058
negative regulation of molecular function GO:0044092 258 0.057
regulation of neuron death GO:1901214 134 0.057
Human Zebrafish
protein catabolic process GO:0030163 221 0.057
adaptive immune response GO:0002250 155 0.057
Worm
respiratory tube development GO:0030323 167 0.056
learning GO:0007612 98 0.056
fatty acid biosynthetic process GO:0006633 41 0.056
response to peptide hormone GO:0043434 127 0.056
Mouse Worm Fly
learning or memory GO:0007611 148 0.056
regulation of cellular amine metabolic process GO:0033238 20 0.055
cellular ketone metabolic process GO:0042180 84 0.055
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.055
regulation of neural precursor cell proliferation GO:2000177 70 0.055
regulation of glucose metabolic process GO:0010906 60 0.054
Mouse
response to acid chemical GO:0001101 111 0.054
cell adhesion GO:0007155 329 0.054
signal transduction in absence of ligand GO:0038034 55 0.054
stem cell differentiation GO:0048863 268 0.054
neural precursor cell proliferation GO:0061351 121 0.053
response to organic cyclic compound GO:0014070 198 0.053
chondrocyte differentiation GO:0002062 72 0.053
regulation of hydrolase activity GO:0051336 246 0.052
regulation of cell growth GO:0001558 91 0.052
Fly
organophosphate biosynthetic process GO:0090407 122 0.052
Fly
activin receptor signaling pathway GO:0032924 18 0.052
Fly
heart morphogenesis GO:0003007 178 0.051
b cell activation GO:0042113 161 0.051
cellular carbohydrate metabolic process GO:0044262 119 0.051
Mouse Fly
negative regulation of cell cycle process GO:0010948 69 0.051
Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.050
positive regulation of protein modification process GO:0031401 299 0.050
positive regulation of transferase activity GO:0051347 167 0.050
recombinational repair GO:0000725 21 0.050
cell aging GO:0007569 35 0.049
multicellular organismal aging GO:0010259 24 0.049
Worm Fly
limb development GO:0060173 166 0.049
cellular response to growth factor stimulus GO:0071363 197 0.049
organ growth GO:0035265 117 0.048
g protein coupled receptor signaling pathway GO:0007186 243 0.048
Fly
microtubule based process GO:0007017 236 0.048
Fly
ear development GO:0043583 200 0.047
negative regulation of transferase activity GO:0051348 85 0.047
ossification GO:0001503 216 0.047
mitotic cell cycle checkpoint GO:0007093 31 0.047
Mouse
striated muscle tissue development GO:0014706 293 0.047
response to drug GO:0042493 75 0.047
cyclic purine nucleotide metabolic process GO:0052652 43 0.047
Fly
cellular response to lipid GO:0071396 145 0.047
epithelial tube morphogenesis GO:0060562 303 0.047
response to reactive oxygen species GO:0000302 56 0.047
Mouse
steroid metabolic process GO:0008202 119 0.046
protein modification by small protein conjugation or removal GO:0070647 207 0.046
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.046
Mouse Worm Fly
cellular response to steroid hormone stimulus GO:0071383 33 0.046
oocyte axis specification GO:0007309 2 0.046
response to hypoxia GO:0001666 58 0.045
regulation of kinase activity GO:0043549 249 0.045
palate development GO:0060021 76 0.044
appendage development GO:0048736 166 0.044
Fly
regulation of lipid metabolic process GO:0019216 118 0.044
Worm Fly
regulation of reproductive process GO:2000241 66 0.044
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.043
purine nucleotide metabolic process GO:0006163 302 0.043
Fly
dna damage checkpoint GO:0000077 26 0.043
Mouse
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.042
regulation of chromatin silencing GO:0031935 2 0.042
histone methylation GO:0016571 71 0.042
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.041
ribonucleoside metabolic process GO:0009119 245 0.041
proteoglycan metabolic process GO:0006029 38 0.041
hexose biosynthetic process GO:0019319 39 0.041
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.041
nucleotide metabolic process GO:0009117 332 0.041
Fly
negative regulation of kinase activity GO:0033673 81 0.041
protein glycosylation GO:0006486 55 0.041
mitotic sister chromatid cohesion GO:0007064 1 0.041
regulation of protein import into nucleus translocation GO:0033158 2 0.041
protein localization to membrane GO:0072657 108 0.040
regulation of bmp signaling pathway GO:0030510 60 0.040
myeloid leukocyte differentiation GO:0002573 119 0.040
response to inorganic substance GO:0010035 96 0.040
Mouse
response to steroid hormone GO:0048545 56 0.039
positive regulation of cellular protein catabolic process GO:1903364 34 0.039
immature b cell differentiation GO:0002327 10 0.039
response to insulin GO:0032868 100 0.039
Mouse Worm Fly
nucleocytoplasmic transport GO:0006913 139 0.039
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.038
regulation of blood pressure GO:0008217 93 0.038
monocarboxylic acid metabolic process GO:0032787 191 0.038
regulation of protein catabolic process GO:0042176 108 0.038
branching morphogenesis of an epithelial tube GO:0048754 159 0.038
protein maturation GO:0051604 176 0.038
somitogenesis GO:0001756 69 0.038
protein acylation GO:0043543 64 0.037
positive regulation of cellular catabolic process GO:0031331 148 0.037
protein localization to nucleus GO:0034504 121 0.037
positive regulation of behavior GO:0048520 40 0.037
Fly
kidney development GO:0001822 213 0.037
monosaccharide metabolic process GO:0005996 106 0.037
Mouse
nucleobase containing small molecule metabolic process GO:0055086 352 0.037
Fly
cellular response to organonitrogen compound GO:0071417 145 0.037
Mouse Worm Fly
organelle fission GO:0048285 170 0.037
extracellular matrix organization GO:0030198 147 0.037
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.037
mapk cascade GO:0000165 281 0.037
regulation of mitotic cell cycle phase transition GO:1901990 73 0.036
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.036
multicellular organismal signaling GO:0035637 91 0.036
oocyte development GO:0048599 33 0.036
glycosylation GO:0070085 62 0.036
defense response to other organism GO:0098542 197 0.036
Worm
regulation of myeloid leukocyte differentiation GO:0002761 58 0.036
negative regulation of apoptotic signaling pathway GO:2001234 104 0.036
response to low density lipoprotein particle GO:0055098 2 0.036
negative regulation of phosphate metabolic process GO:0045936 184 0.035
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.035
regulation of blood circulation GO:1903522 93 0.035
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.034
regulation of proteolysis GO:0030162 164 0.034
peptidyl lysine modification GO:0018205 77 0.034
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.034
ribonucleotide metabolic process GO:0009259 291 0.034
Fly
macromolecule catabolic process GO:0009057 281 0.033
multicellular organism growth GO:0035264 161 0.033
Worm Fly
heterocycle catabolic process GO:0046700 280 0.033
neuron death GO:0070997 154 0.033
Human Zebrafish
negative regulation of cell size GO:0045792 3 0.033
Fly
urogenital system development GO:0001655 261 0.033
regulation of purine nucleotide metabolic process GO:1900542 169 0.033
negative regulation of cell growth GO:0030308 44 0.033
Fly
activation of adenylate cyclase activity GO:0007190 4 0.033
positive regulation of protein catabolic process GO:0045732 60 0.033
intracellular protein transport GO:0006886 204 0.033
positive regulation of protein binding GO:0032092 29 0.032
regulation of cysteine type endopeptidase activity GO:2000116 65 0.032
protein localization to organelle GO:0033365 185 0.032
long term memory GO:0007616 15 0.032
regulation of cellular component size GO:0032535 121 0.032
Fly
angiogenesis GO:0001525 201 0.032
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 18 0.032
mitochondrion organization GO:0007005 134 0.032
regulation of fatty acid biosynthetic process GO:0042304 12 0.032
pole plasm assembly GO:0007315 2 0.032
negative regulation of hydrolase activity GO:0051346 71 0.032
purine containing compound metabolic process GO:0072521 311 0.032
Fly
alpha amino acid metabolic process GO:1901605 59 0.032
positive regulation of histone methylation GO:0031062 16 0.031
regulation of cell cycle g1 s phase transition GO:1902806 35 0.031
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.031
memory GO:0007613 58 0.031
regulation of transmembrane transport GO:0034762 128 0.031
nucleoside phosphate biosynthetic process GO:1901293 79 0.031
Fly
regulation of cell activation GO:0050865 289 0.031
somatic stem cell maintenance GO:0035019 47 0.031
macromolecule glycosylation GO:0043413 55 0.031
positive regulation of peptidase activity GO:0010952 49 0.031
hexose metabolic process GO:0019318 98 0.031
Mouse
muscle cell differentiation GO:0042692 261 0.031
Fly
protein ubiquitination GO:0016567 171 0.030
posttranscriptional regulation of gene expression GO:0010608 155 0.030
Human
mitochondrion degradation GO:0000422 3 0.030
positive regulation of programmed cell death GO:0043068 218 0.030
Human Worm
dna integrity checkpoint GO:0031570 28 0.030
Mouse
cellular response to antibiotic GO:0071236 4 0.030
regulation of dna templated transcription in response to stress GO:0043620 9 0.030
Worm
lateral inhibition GO:0046331 1 0.030
cartilage development GO:0051216 140 0.030
modification dependent macromolecule catabolic process GO:0043632 133 0.030
sensory organ morphogenesis GO:0090596 242 0.030
Fly
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.030
positive regulation of macroautophagy GO:0016239 3 0.029
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 24 0.029
multi multicellular organism process GO:0044706 109 0.029
positive regulation of bmp signaling pathway GO:0030513 23 0.029
developmental maturation GO:0021700 193 0.029
cellular response to hormone stimulus GO:0032870 150 0.029
Mouse Worm Fly
regulation of membrane potential GO:0042391 192 0.029
regulation of ion transmembrane transport GO:0034765 119 0.029
positive regulation of cellular amine metabolic process GO:0033240 5 0.029
protein kinase b signaling GO:0043491 74 0.029
oxidation reduction process GO:0055114 342 0.029
Fly
insulin secretion GO:0030073 89 0.029
cellular chemical homeostasis GO:0055082 215 0.028
segmentation GO:0035282 93 0.028
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.028
microtubule cytoskeleton organization GO:0000226 157 0.028
Fly
regulation of nucleotide biosynthetic process GO:0030808 34 0.028
regulation of protein binding GO:0043393 60 0.028
modification dependent protein catabolic process GO:0019941 133 0.028
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.028
skeletal system morphogenesis GO:0048705 203 0.028
single organism cell adhesion GO:0098602 156 0.028
chromatin organization GO:0006325 206 0.028
regulation of sterol transport GO:0032371 17 0.028
female gamete generation GO:0007292 74 0.027
oocyte maturation GO:0001556 18 0.027
regulation of chromosome organization GO:0033044 83 0.027
nuclear division GO:0000280 158 0.027
male sex differentiation GO:0046661 109 0.027
chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8 0.027
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.027
positive regulation of cell cycle GO:0045787 92 0.027
associative learning GO:0008306 61 0.027
regulation of mapk cascade GO:0043408 248 0.027
b cell differentiation GO:0030183 78 0.027
neuron apoptotic process GO:0051402 142 0.027
Human Zebrafish
positive regulation of epithelial cell proliferation GO:0050679 68 0.026
protein autophosphorylation GO:0046777 61 0.026
regulation of microtubule polymerization GO:0031113 7 0.026
intracellular receptor signaling pathway GO:0030522 74 0.026
regulation of peptidase activity GO:0052547 96 0.026
ovulation GO:0030728 15 0.026
membrane organization GO:0061024 245 0.026
regulation of ion transport GO:0043269 215 0.026
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.026
cytokine mediated signaling pathway GO:0019221 115 0.026
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.026
dendrite development GO:0016358 115 0.026
Fly
regulation of endopeptidase activity GO:0052548 89 0.026
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.026
gluconeogenesis GO:0006094 39 0.026
Mouse
lipid biosynthetic process GO:0008610 179 0.026
Worm
cellular lipid metabolic process GO:0044255 323 0.025
embryonic digit morphogenesis GO:0042733 56 0.025
midbrain development GO:0030901 35 0.025
germ line stem cell division GO:0042078 2 0.025
adult locomotory behavior GO:0008344 91 0.025
central nervous system neuron differentiation GO:0021953 162 0.025
wnt signaling pathway GO:0016055 188 0.025
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.025
enucleate erythrocyte differentiation GO:0043353 8 0.025
negative regulation of b cell differentiation GO:0045578 4 0.025
nitrogen compound transport GO:0071705 271 0.025
regulation of histone modification GO:0031056 56 0.025
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.025
exocytosis GO:0006887 121 0.025
regulation of cellular catabolic process GO:0031329 242 0.025
Fly
response to nitric oxide GO:0071731 4 0.024
Mouse
mesenchyme development GO:0060485 152 0.024
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.024
Mouse
divalent inorganic cation transport GO:0072511 178 0.024
myeloid cell differentiation GO:0030099 233 0.024
Human
cell activation involved in immune response GO:0002263 126 0.024
meiotic cell cycle GO:0051321 122 0.024
lipid localization GO:0010876 126 0.024
Fly
notch signaling pathway GO:0007219 71 0.024
blastocyst growth GO:0001832 23 0.024
response to retinoic acid GO:0032526 56 0.024
cellular response to cytokine stimulus GO:0071345 189 0.024
transcription from rna polymerase iii promoter GO:0006383 3 0.024
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 7 0.024
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.023
regulation of lymphocyte apoptotic process GO:0070228 41 0.023
cellular response to radiation GO:0071478 28 0.023
regulation of insulin receptor signaling pathway GO:0046626 21 0.023
Fly
negative regulation of epithelial cell proliferation GO:0050680 64 0.023
embryonic hemopoiesis GO:0035162 23 0.023
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.023
ion transmembrane transport GO:0034220 361 0.023
energy homeostasis GO:0097009 15 0.023
response to ionizing radiation GO:0010212 42 0.023
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 18 0.023
hormone mediated signaling pathway GO:0009755 23 0.023
chondroitin sulfate biosynthetic process GO:0030206 5 0.023
regulation of metal ion transport GO:0010959 106 0.022
regulation of stem cell differentiation GO:2000736 50 0.022
histone modification GO:0016570 159 0.022
positive regulation of hydrolase activity GO:0051345 148 0.022
positive regulation of chromosome segregation GO:0051984 4 0.022
regulation of secretion GO:0051046 274 0.022
regulation of adaptive immune response GO:0002819 90 0.022
Worm
purine nucleoside triphosphate metabolic process GO:0009144 226 0.022
regulation of somitogenesis GO:0014807 6 0.022
cellular response to reactive nitrogen species GO:1902170 5 0.022
Mouse
sensory perception of pain GO:0019233 47 0.022
alpha beta t cell differentiation GO:0046632 69 0.022
gland development GO:0048732 330 0.022
myeloid cell homeostasis GO:0002262 114 0.022
Human
sequestering of calcium ion GO:0051208 18 0.022
activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 3 0.022
morphogenesis of a branching epithelium GO:0061138 193 0.022
tissue homeostasis GO:0001894 115 0.022
chromatin silencing at rdna GO:0000183 3 0.021
dendritic cell cytokine production GO:0002371 3 0.021
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.021
Mouse
cytokine production GO:0001816 319 0.021
erk1 and erk2 cascade GO:0070371 77 0.021
negative regulation of ossification GO:0030279 49 0.021
regulation of cell migration GO:0030334 219 0.021

Foxo3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.851
disease of anatomical entity DOID:7 0 0.851
disease of cellular proliferation DOID:14566 0 0.632
hematopoietic system disease DOID:74 0 0.163
cancer DOID:162 0 0.132
organ system cancer DOID:0050686 0 0.110
disease of metabolism DOID:0014667 0 0.094
gastrointestinal system cancer DOID:3119 0 0.060
immune system cancer DOID:0060083 0 0.052
inherited metabolic disorder DOID:655 0 0.048
hematologic cancer DOID:2531 0 0.030
acquired metabolic disease DOID:0060158 0 0.029
lymphatic system disease DOID:75 0 0.028
endocrine system disease DOID:28 0 0.025
reproductive organ cancer DOID:193 0 0.023