Mus musculus

472 known processes

Smo

smoothened homolog (Drosophila)

(Aliases: bnb,E130215L21Rik,Smoh,smoothened)

Smo biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 1.000
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 1.000
neural crest cell migration involved in autonomic nervous system development GO:1901166 5 1.000
neural tube closure GO:0001843 90 1.000
regionalization GO:0003002 337 1.000
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 1.000
auditory receptor cell fate determination GO:0042668 3 1.000
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072039 4 1.000
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 1.000
anterior commissure morphogenesis GO:0021960 6 1.000
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 1.000
embryonic organ morphogenesis GO:0048562 276 1.000
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.999
embryonic limb morphogenesis GO:0030326 126 0.999
negative regulation of gastrulation GO:2000542 3 0.999
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.999
pyramidal neuron migration GO:0021852 1 0.999
positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 18 0.999
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.999
axial mesodermal cell fate commitment GO:0048322 1 0.998
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.998
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.998
formation of radial glial scaffolds GO:0021943 4 0.998
embryonic skeletal system morphogenesis GO:0048704 91 0.998
Zebrafish
neural tube formation GO:0001841 108 0.997
hindbrain tangential cell migration GO:0021934 2 0.997
trachea formation GO:0060440 3 0.997
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.997
stem cell differentiation GO:0048863 268 0.997
nephron tubule morphogenesis GO:0072078 68 0.997
primary neural tube formation GO:0014020 95 0.997
axis elongation involved in somitogenesis GO:0090245 4 0.997
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.996
mesenchymal cell apoptotic process involved in nephron morphogenesis GO:1901145 4 0.996
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.996
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.995
cardiac right atrium morphogenesis GO:0003213 3 0.995
mitral valve development GO:0003174 4 0.995
regulation of endodermal cell fate specification GO:0042663 2 0.995
appendage morphogenesis GO:0035107 149 0.995
Zebrafish
neuron projection guidance GO:0097485 141 0.995
Zebrafish Rat
regulation of wnt signaling pathway GO:0030111 123 0.995
skeletal system development GO:0001501 356 0.995
Zebrafish
cell proliferation in hindbrain GO:0021534 10 0.994
limb morphogenesis GO:0035108 149 0.994
hindbrain development GO:0030902 128 0.994
embryonic heart tube formation GO:0003144 1 0.994
telencephalon development GO:0021537 186 0.994
locus ceruleus development GO:0021703 1 0.993
lung induction GO:0060492 3 0.993
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072040 4 0.993
regulation of astrocyte differentiation GO:0048710 20 0.993
embryonic skeletal joint morphogenesis GO:0060272 11 0.993
regulation of endodermal cell differentiation GO:1903224 2 0.993
renal vesicle induction GO:0072034 3 0.992
floor plate morphogenesis GO:0033505 3 0.992
Zebrafish
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.992
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 4 0.992
closure of optic fissure GO:0061386 2 0.991
regulation of transcription involved in primary germ layer cell fate commitment GO:0060796 2 0.991
hypophysis morphogenesis GO:0048850 3 0.991
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.991
neural tube patterning GO:0021532 43 0.991
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.990
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.990
embryonic viscerocranium morphogenesis GO:0048703 8 0.990
Zebrafish
negative regulation of endodermal cell differentiation GO:1903225 1 0.989
endodermal cell fate commitment GO:0001711 12 0.989
cardiac atrium morphogenesis GO:0003209 23 0.988
branching involved in ureteric bud morphogenesis GO:0001658 56 0.988
midbrain hindbrain boundary development GO:0030917 9 0.988
heart field specification GO:0003128 6 0.988
negative regulation of chondrocyte differentiation GO:0032331 13 0.988
appendage development GO:0048736 166 0.986
Zebrafish
trachea cartilage morphogenesis GO:0060535 4 0.985
embryonic nail plate morphogenesis GO:0035880 3 0.985
limb development GO:0060173 166 0.984
ventricular zone neuroblast division GO:0021847 3 0.984
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.984
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.984
midbrain hindbrain boundary maturation GO:0021732 1 0.983
epithelial tube formation GO:0072175 130 0.981
Zebrafish
negative regulation of endodermal cell fate specification GO:0042664 1 0.981
tube closure GO:0060606 91 0.981
olfactory bulb interneuron development GO:0021891 7 0.979
mesenchymal cell development GO:0014031 93 0.978
metanephric capsule specification GO:0072267 1 0.978
forebrain regionalization GO:0021871 25 0.976
Zebrafish
endodermal cell fate specification GO:0001714 4 0.976
cerebellum development GO:0021549 77 0.976
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.975
negative regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000160 1 0.975
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.975
mesenchyme development GO:0060485 152 0.975
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.974
kidney morphogenesis GO:0060993 83 0.974
hindlimb morphogenesis GO:0035137 42 0.974
negative regulation of bmp signaling pathway GO:0030514 35 0.973
osteoblast development GO:0002076 17 0.972
regulation of smoothened signaling pathway GO:0008589 58 0.972
gastrulation GO:0007369 116 0.972
epithelial tube morphogenesis GO:0060562 303 0.972
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.971
stem cell development GO:0048864 219 0.971
roof plate formation GO:0021509 1 0.970
bmp signaling pathway involved in heart development GO:0061312 2 0.970
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.970
trophectodermal cellular morphogenesis GO:0001831 3 0.969
neural tube development GO:0021915 160 0.969
pituitary gland development GO:0021983 38 0.967
Zebrafish
morphogenesis of embryonic epithelium GO:0016331 159 0.967
Zebrafish
somitogenesis GO:0001756 69 0.966
negative regulation of astrocyte differentiation GO:0048712 10 0.965
rostrocaudal neural tube patterning GO:0021903 12 0.965
mesenchymal cell proliferation involved in ureteric bud development GO:0072138 3 0.965
forebrain neuron differentiation GO:0021879 52 0.964
central nervous system neuron differentiation GO:0021953 162 0.964
forebrain generation of neurons GO:0021872 63 0.964
metanephric nephron tubule formation GO:0072289 4 0.964
embryonic heart tube anterior posterior pattern specification GO:0035054 3 0.964
endocardial cell differentiation GO:0060956 4 0.964
Zebrafish
ear development GO:0043583 200 0.962
Zebrafish
negative regulation of cell fate specification GO:0009996 4 0.962
neural crest formation GO:0014029 2 0.962
negative regulation of prostatic bud formation GO:0060686 4 0.962
rhombomere morphogenesis GO:0021593 2 0.961
left lung morphogenesis GO:0060460 3 0.961
respiratory system development GO:0060541 190 0.960
negative regulation of neuron differentiation GO:0045665 101 0.959
regulation of intracellular transport GO:0032386 159 0.959
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.959
ossification GO:0001503 216 0.959
inner ear receptor cell differentiation GO:0060113 61 0.959
chondrocyte differentiation GO:0002062 72 0.957
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.956
regulation of bmp signaling pathway GO:0030510 60 0.956
neural crest cell fate commitment GO:0014034 1 0.955
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.954
cell proliferation in midbrain GO:0033278 2 0.954
neuroblast differentiation GO:0014016 2 0.953
forebrain radial glial cell differentiation GO:0021861 4 0.952
diencephalon morphogenesis GO:0048852 6 0.950
central nervous system neuron development GO:0021954 67 0.949
ascending aorta morphogenesis GO:0035910 3 0.949
olfactory lobe development GO:0021988 32 0.948
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.947
septum primum development GO:0003284 4 0.946
otic placode formation GO:0043049 1 0.946
smoothened signaling pathway GO:0007224 105 0.945
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.944
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.944
tube formation GO:0035148 140 0.944
Zebrafish
non canonical wnt signaling pathway involved in heart development GO:0061341 3 0.942
central nervous system projection neuron axonogenesis GO:0021952 21 0.942
tendon formation GO:0035992 4 0.941
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.940
forebrain anterior posterior pattern specification GO:0021797 5 0.938
axon guidance GO:0007411 141 0.938
Zebrafish Rat
midbrain hindbrain boundary maturation during brain development GO:0022004 1 0.937
stem cell proliferation GO:0072089 117 0.937
positive regulation of transcription by glucose GO:0046016 3 0.937
endochondral bone morphogenesis GO:0060350 50 0.937
regulation of wnt signaling pathway planar cell polarity pathway GO:2000095 10 0.936
positive regulation of tendon cell differentiation GO:2001051 1 0.936
axial mesoderm formation GO:0048320 3 0.935
negative regulation of cartilage development GO:0061037 17 0.934
chondrocyte development GO:0002063 24 0.934
cardiac endothelial cell differentiation GO:0003348 4 0.934
Zebrafish
positive regulation of branching involved in lung morphogenesis GO:0061047 4 0.934
nephrogenic mesenchyme morphogenesis GO:0072134 2 0.934
peripheral nervous system neuron axonogenesis GO:0048936 3 0.932
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.932
cardiac septum development GO:0003279 59 0.931
embryonic skeletal system development GO:0048706 120 0.929
Zebrafish
central nervous system vasculogenesis GO:0022009 3 0.928
oligodendrocyte differentiation GO:0048709 53 0.928
Zebrafish
ureter morphogenesis GO:0072197 4 0.926
embryonic epithelial tube formation GO:0001838 130 0.924
positive regulation of glial cell differentiation GO:0045687 21 0.924
nucleus accumbens development GO:0021768 1 0.923
central nervous system morphogenesis GO:0021551 2 0.922
negative regulation of glial cell proliferation GO:0060253 4 0.921
camera type eye development GO:0043010 266 0.921
Zebrafish
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.920
regulation of myoblast differentiation GO:0045661 29 0.920
spinal cord association neuron differentiation GO:0021527 14 0.917
axial mesodermal cell fate specification GO:0048327 1 0.910
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.909
negative regulation of cell development GO:0010721 169 0.908
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 0.907
forebrain neuron development GO:0021884 30 0.907
regulation of chondrocyte differentiation GO:0032330 33 0.907
forebrain neuroblast division GO:0021873 9 0.906
oculomotor nerve morphogenesis GO:0021622 2 0.905
regulation of planar cell polarity pathway involved in neural tube closure GO:2000167 1 0.905
regulation of transcription from rna polymerase ii promoter involved in forebrain neuron fate commitment GO:0021882 3 0.903
ear morphogenesis GO:0042471 118 0.901
Zebrafish
smoothened signaling pathway involved in ventral spinal cord patterning GO:0021910 7 0.901
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.901
regulation of muscle tissue development GO:1901861 97 0.900
smoothened signaling pathway involved in dorsal ventral neural tube patterning GO:0060831 12 0.899
glomerular mesangial cell development GO:0072144 3 0.898
noradrenergic neuron differentiation GO:0003357 6 0.898
embryonic appendage morphogenesis GO:0035113 126 0.897
growth plate cartilage development GO:0003417 14 0.896
negative regulation of osteoblast differentiation GO:0045668 30 0.896
embryonic heart tube left right pattern formation GO:0060971 5 0.895
astrocyte differentiation GO:0048708 43 0.894
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.894
embryonic heart tube morphogenesis GO:0003143 51 0.893
inner cell mass cellular morphogenesis GO:0001828 1 0.893
formation of primary germ layer GO:0001704 77 0.892
cardiac atrium development GO:0003230 24 0.892
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.887
olfactory bulb interneuron differentiation GO:0021889 12 0.887
negative regulation of mesodermal cell fate specification GO:0042662 3 0.886
embryonic heart tube development GO:0035050 65 0.886
embryonic skeletal joint development GO:0072498 13 0.885
globus pallidus development GO:0021759 2 0.882
planar cell polarity pathway involved in heart morphogenesis GO:0061346 3 0.882
nephric duct formation GO:0072179 4 0.881
regulation of skeletal muscle fiber development GO:0048742 36 0.880
regulation of establishment of planar polarity involved in neural tube closure GO:0090178 15 0.877
astrocyte fate commitment GO:0060018 4 0.876
branch elongation involved in ureteric bud branching GO:0060681 3 0.873
hindbrain formation GO:0021576 1 0.873
negative regulation of branching involved in ureteric bud morphogenesis GO:0090191 4 0.872
positive regulation of skeletal muscle tissue regeneration GO:0043415 4 0.871
retinal ganglion cell axon guidance GO:0031290 18 0.870
Zebrafish
growth plate cartilage chondrocyte development GO:0003431 3 0.870
cartilage morphogenesis GO:0060536 11 0.870
cerebellum formation GO:0021588 1 0.869
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:0035793 1 0.868
mitral valve morphogenesis GO:0003183 4 0.868
stem cell maintenance GO:0019827 130 0.866
cerebellar granule cell precursor proliferation GO:0021930 10 0.864
cranial suture morphogenesis GO:0060363 8 0.860
orbitofrontal cortex development GO:0021769 2 0.860
rhombomere 3 morphogenesis GO:0021658 2 0.858
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.858
regulation of gliogenesis GO:0014013 50 0.857
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.857
cardiac right ventricle formation GO:0003219 3 0.856
cerebral cortex gabaergic interneuron fate commitment GO:0021893 2 0.856
bone mineralization GO:0030282 54 0.855
negative regulation of glial cell differentiation GO:0045686 21 0.854
primary prostatic bud elongation GO:0060516 2 0.853
axial mesodermal cell differentiation GO:0048321 1 0.851
cardiogenic plate morphogenesis GO:0003142 1 0.851
subpallium development GO:0021544 20 0.851
growth plate cartilage chondrocyte growth GO:0003430 2 0.850
positive regulation of wnt signaling pathway GO:0030177 45 0.849
bmp signaling pathway GO:0030509 93 0.849
mesonephric duct morphogenesis GO:0072180 4 0.848
rhombomere 2 development GO:0021568 2 0.847
cell proliferation in forebrain GO:0021846 30 0.839
oligodendrocyte development GO:0014003 20 0.839
Zebrafish
apoptotic process involved in patterning of blood vessels GO:1902262 6 0.836
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 5 0.835
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.835
mammary placode formation GO:0060596 4 0.835
sinoatrial node cell differentiation GO:0060921 3 0.833
cardiocyte differentiation GO:0035051 87 0.830
Zebrafish
determination of heart left right asymmetry GO:0061371 48 0.829
regulation of canonical wnt signaling pathway GO:0060828 82 0.828
male sex differentiation GO:0046661 109 0.826
cardiac septum morphogenesis GO:0060411 46 0.826
regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000159 1 0.825
mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9 0.825
autonomic nervous system development GO:0048483 43 0.823
Rat
spinal cord dorsal ventral patterning GO:0021513 23 0.820
mesonephric tubule development GO:0072164 94 0.820
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 1 0.819
negative regulation of stem cell maintenance GO:1902455 4 0.816
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 2 0.814
positive regulation of transcription via serum response element binding GO:0010735 1 0.812
substrate dependent cerebral cortex tangential migration GO:0021825 3 0.811
cerebral cortex radial glia guided migration GO:0021801 17 0.808
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 0.808
negative regulation of planar cell polarity pathway involved in neural tube closure GO:2000168 1 0.807
cerebellar purkinje cell granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation GO:0021937 6 0.803
left lung development GO:0060459 4 0.802
negative regulation of glomerular mesangial cell proliferation GO:0072125 1 0.799
atrial septum primum morphogenesis GO:0003289 3 0.799
negative regulation of transcription from rna polymerase ii promoter by glucose GO:0000433 1 0.798
positive regulation of nervous system development GO:0051962 221 0.797
positive regulation of ureteric bud formation GO:0072107 3 0.796
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.796
foregut regionalization GO:0060423 3 0.796
clara cell differentiation GO:0060486 4 0.795
transforming growth factor beta receptor signaling pathway involved in primitive streak formation GO:0090010 1 0.795
endocardial cushion development GO:0003197 26 0.792
cerebellar granule cell differentiation GO:0021707 9 0.791
embryonic hindlimb morphogenesis GO:0035116 32 0.791
forebrain development GO:0030900 302 0.790
myotube differentiation GO:0014902 105 0.790
cochlea morphogenesis GO:0090103 22 0.789
negative regulation of immature t cell proliferation GO:0033087 3 0.788
morphogenesis of a branching epithelium GO:0061138 193 0.787
cell migration in hindbrain GO:0021535 16 0.785
determination of left right asymmetry in lateral mesoderm GO:0003140 5 0.780
regulation of heart morphogenesis GO:2000826 22 0.779
regulation of branching involved in ureteric bud morphogenesis GO:0090189 22 0.778
muscle fiber development GO:0048747 76 0.772
regulation of osteoblast differentiation GO:0045667 67 0.772
tendon cell differentiation GO:0035990 4 0.772
ventricular septum morphogenesis GO:0060412 27 0.771
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.769
negative regulation of axon extension GO:0030517 19 0.768
lateral mesoderm morphogenesis GO:0048369 3 0.765
primitive streak formation GO:0090009 10 0.762
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.762
noradrenergic neuron development GO:0003358 3 0.758
regulation of vascular wound healing GO:0061043 2 0.757
regulation of mesodermal cell fate specification GO:0042661 5 0.756
establishment of planar polarity involved in nephron morphogenesis GO:0072046 1 0.752
myelination in peripheral nervous system GO:0022011 19 0.750
positive regulation of odontogenesis GO:0042482 4 0.749
odontogenesis GO:0042476 78 0.748
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.748
negative regulation of ossification GO:0030279 49 0.747
urogenital system development GO:0001655 261 0.742
negative regulation of smoothened signaling pathway GO:0045879 25 0.742
glomerulus vasculature morphogenesis GO:0072103 6 0.741
vascular wound healing GO:0061042 3 0.741
protein import into nucleus GO:0006606 95 0.741
olfactory bulb development GO:0021772 30 0.740
mesenchymal stem cell maintenance involved in nephron morphogenesis GO:0072038 7 0.739
embryonic eye morphogenesis GO:0048048 29 0.738
paraxial mesodermal cell differentiation GO:0048342 2 0.734
lung development GO:0030324 164 0.734
face morphogenesis GO:0060325 29 0.733
amine metabolic process GO:0009308 45 0.731
regulation of lens epithelial cell proliferation GO:2001109 1 0.729
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development GO:0061310 1 0.727
telencephalon regionalization GO:0021978 14 0.727
frontal suture morphogenesis GO:0060364 2 0.726
biomineral tissue development GO:0031214 64 0.725
renal capsule specification GO:0072130 1 0.721
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.720
inhibition of neuroepithelial cell differentiation GO:0002085 2 0.719
cell proliferation in external granule layer GO:0021924 10 0.714
positive regulation of neuroblast proliferation GO:0002052 19 0.713
embryonic digit morphogenesis GO:0042733 56 0.711
specification of organ position GO:0010159 3 0.709
regulation of glial cell differentiation GO:0045685 41 0.708
carbon catabolite repression of transcription GO:0045013 1 0.705
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.705
embryonic olfactory bulb interneuron precursor migration GO:0021831 2 0.704
brain morphogenesis GO:0048854 32 0.703
negative regulation of epithelial cell proliferation GO:0050680 64 0.700
cardioblast migration to the midline involved in heart field formation GO:0060975 1 0.700
sensory organ morphogenesis GO:0090596 242 0.695
Zebrafish Fly
cartilage development GO:0051216 140 0.695
Zebrafish
renal inner medulla development GO:0072053 3 0.695
cellular ketone metabolic process GO:0042180 84 0.693
pancreatic pp cell fate commitment GO:0003329 2 0.692
cellular response to lipid GO:0071396 145 0.689
regulation of secretion GO:0051046 274 0.688
mesenchymal cell differentiation GO:0048762 107 0.688
subpallium neuron fate commitment GO:0060163 2 0.688
canonical wnt signaling pathway GO:0060070 130 0.687
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.684
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 3 0.684
ventricular cardiac muscle cell differentiation GO:0055012 17 0.683
retinal bipolar neuron differentiation GO:0060040 5 0.683
metanephric comma shaped body morphogenesis GO:0072278 1 0.682
wnt signaling pathway involved in heart development GO:0003306 8 0.681
gliogenesis GO:0042063 141 0.681
cardiac chamber development GO:0003205 108 0.680
regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000161 1 0.680
positive regulation of stem cell proliferation GO:2000648 59 0.679
forebrain morphogenesis GO:0048853 17 0.677
synapse organization GO:0050808 125 0.676
negative regulation of t cell proliferation GO:0042130 38 0.675
neural fold formation GO:0001842 7 0.675
regulation of cartilage development GO:0061035 44 0.673
sertoli cell fate commitment GO:0060010 1 0.673
cerebral cortex tangential migration GO:0021800 7 0.672
pericardium development GO:0060039 16 0.670
regulation of nephron tubule epithelial cell differentiation GO:0072182 9 0.668
regulation of ureteric bud formation GO:0072106 3 0.667
spinal cord development GO:0021510 81 0.666
positive regulation of cell proliferation in bone marrow GO:0071864 2 0.664
regulation of mesenchymal cell proliferation involved in ureter development GO:0072199 3 0.663
bmp signaling pathway involved in mesodermal cell fate specification GO:0060803 1 0.663
regulation of cellular component biogenesis GO:0044087 181 0.662
regulation of somitogenesis GO:0014807 6 0.661
regulation of neuron maturation GO:0014041 5 0.660
positive regulation of vascular wound healing GO:0035470 1 0.654
lateral mesoderm formation GO:0048370 3 0.654
ureteric bud morphogenesis GO:0060675 62 0.653
prostate gland morphogenesis GO:0060512 32 0.653
cell type specific apoptotic process GO:0097285 268 0.648
pyramidal neuron development GO:0021860 8 0.648
regulation of protein targeting GO:1903533 61 0.648
spinal cord motor neuron differentiation GO:0021522 35 0.648
Zebrafish
epithelial to mesenchymal transition GO:0001837 47 0.647
positive regulation of cell development GO:0010720 237 0.646
retina development in camera type eye GO:0060041 119 0.645
Zebrafish
regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000150 1 0.643
embryonic camera type eye development GO:0031076 36 0.642
Zebrafish
positive regulation of lens epithelial cell proliferation GO:2001111 1 0.641
regulation of cellular ketone metabolic process GO:0010565 66 0.640
positive regulation of bone mineralization GO:0030501 12 0.640
response to growth factor GO:0070848 198 0.640
inner ear morphogenesis GO:0042472 101 0.639
Zebrafish
heart morphogenesis GO:0003007 178 0.637
hindbrain morphogenesis GO:0021575 46 0.634
digestive tract morphogenesis GO:0048546 147 0.634
Zebrafish
optic vesicle morphogenesis GO:0003404 2 0.633
kidney development GO:0001822 213 0.633
regulation of establishment of planar polarity GO:0090175 28 0.632
blood vessel morphogenesis GO:0048514 285 0.631
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferation GO:0044343 1 0.625
positive regulation of cell motility GO:2000147 116 0.625
canonical wnt signaling pathway involved in neural crest cell differentiation GO:0044335 1 0.619
muscle tissue development GO:0060537 308 0.619
lateral motor column neuron migration GO:0097477 3 0.611
cellular response to growth factor stimulus GO:0071363 197 0.611
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.605
forebrain ventricular zone progenitor cell division GO:0021869 6 0.602
metanephric nephron tubule morphogenesis GO:0072282 7 0.601
cardiac ventricle development GO:0003231 83 0.599
Zebrafish
regulation of cardioblast differentiation GO:0051890 3 0.598
wound healing spreading of cells GO:0044319 8 0.597
cell proliferation involved in metanephros development GO:0072203 9 0.597
muscular septum morphogenesis GO:0003150 4 0.596
positive regulation of cartilage development GO:0061036 18 0.591
cellular response to cholesterol GO:0071397 2 0.589
hippocampus development GO:0021766 52 0.589
mammary gland morphogenesis GO:0060443 54 0.589
paraxial mesodermal cell fate commitment GO:0048343 2 0.588
renal vesicle development GO:0072087 17 0.586
regulation of odontogenesis GO:0042481 18 0.584
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification GO:0021913 4 0.584
mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis GO:0072309 3 0.581
metencephalon development GO:0022037 89 0.579
organ growth GO:0035265 117 0.579
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.579
cranial nerve development GO:0021545 41 0.577
Rat
digestive system development GO:0055123 200 0.575
regulation of cell cycle GO:0051726 281 0.574
Fly
commitment of multipotent stem cells to neuronal lineage in forebrain GO:0021898 3 0.571
nephron morphogenesis GO:0072028 69 0.570
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.570
endoderm development GO:0007492 45 0.569
regulation of bone mineralization GO:0030500 31 0.568
branching morphogenesis of an epithelial tube GO:0048754 159 0.567
lung field specification GO:0060424 3 0.564
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.563
atrioventricular bundle cell differentiation GO:0003167 1 0.562
negative regulation of cell cycle GO:0045786 123 0.562
Fly
negative regulation of cardiac muscle tissue development GO:0055026 8 0.561
skeletal system morphogenesis GO:0048705 203 0.560
Zebrafish
metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136 2 0.560
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000081 1 0.556
glomerular mesangial cell differentiation GO:0072008 3 0.555
pallium development GO:0021543 120 0.553
somatic motor neuron differentiation GO:0021523 6 0.551
Zebrafish
oocyte axis specification GO:0007309 2 0.550
carbohydrate homeostasis GO:0033500 128 0.549
metanephros morphogenesis GO:0003338 24 0.548
regulation of mapk cascade GO:0043408 248 0.548
subpallium cell proliferation in forebrain GO:0022012 1 0.544
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 9 0.544
negative regulation of epidermis development GO:0045683 9 0.541
bone morphogenesis GO:0060349 78 0.537
positive regulation of smoothened signaling pathway GO:0045880 23 0.537
cellular response to organic cyclic compound GO:0071407 87 0.536
heart induction GO:0003129 2 0.535
glial cell differentiation GO:0010001 131 0.535
lateral mesodermal cell differentiation GO:0048371 3 0.534
myotube cell development GO:0014904 60 0.532
nephron epithelium morphogenesis GO:0072088 68 0.530
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.529
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.528
endocardial cushion formation GO:0003272 13 0.528
cloacal septation GO:0060197 2 0.522
regulation of gastrulation GO:0010470 16 0.522
rhombomere 3 development GO:0021569 4 0.519
paraxial mesoderm morphogenesis GO:0048340 10 0.518
regulation of epithelial cell proliferation involved in lung morphogenesis GO:2000794 5 0.515
determination of left right symmetry GO:0007368 80 0.515
regulation of oligodendrocyte differentiation GO:0048713 23 0.515
spemann organizer formation GO:0060061 2 0.514
photoreceptor cell fate commitment GO:0046552 2 0.514
craniofacial suture morphogenesis GO:0097094 10 0.512
lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 2 0.512
branching involved in labyrinthine layer morphogenesis GO:0060670 9 0.507
chondrocyte hypertrophy GO:0003415 4 0.505

Smo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.985
musculoskeletal system disease DOID:17 0 0.985
connective tissue disease DOID:65 0 0.985
bone development disease DOID:0080006 0 0.801
bone disease DOID:0080001 0 0.801