IMP

Process View

Mus musculus

2 genes annotated in mouse

neural crest formation

The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "neural crest formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "neural crest formation" (in gray)

Name	Description	Probability	Func Analog Organism
Foxc1	forkhead box C1	0.996
Gli3	GLI-Kruppel family member GLI3	0.994
Bmp7	bone morphogenetic protein 7	0.987
Prrx1	paired related homeobox 1	0.985
Fgfr2	fibroblast growth factor receptor 2	0.974
Msx1	homeobox, msh-like 1	0.974
Bmp4	bone morphogenetic protein 4	0.974
Smo	smoothened homolog (Drosophila)	0.962
Rarb	retinoic acid receptor, beta	0.956
Msx2	homeobox, msh-like 2	0.947
Shh	sonic hedgehog	0.945
Pitx2	paired-like homeodomain transcription factor 2	0.889
Runx2	runt related transcription factor 2	0.889
Otx2	orthodenticle homolog 2 (Drosophila)	0.851
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.814
Pax3	paired box gene 3	0.814
Tcfap2a	transcription factor AP-2, alpha	0.776	Zebrafish
Prrx2	paired related homeobox 2	0.774
Eya1	eyes absent 1 homolog (Drosophila)	0.751
Dlx5	distal-less homeobox 5	0.747
Hand1	heart and neural crest derivatives expressed transcript 1	0.732
Tgfb2	transforming growth factor, beta 2	0.727
Tbx1	T-box 1	0.723
Sox9	SRY-box containing gene 9	0.704
Foxc2	forkhead box C2	0.674
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.659
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.552
Gli2	GLI-Kruppel family member GLI2	0.547
Fgfr1	fibroblast growth factor receptor 1	0.530
Alx1	ALX homeobox 1	0.484
Fgf8	fibroblast growth factor 8	0.456
Vangl2	vang-like 2 (van gogh, Drosophila)	0.438
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.428
Zeb1	zinc finger E-box binding homeobox 1	0.408
Hand2	heart and neural crest derivatives expressed transcript 2	0.408
Chrd	chordin	0.360
Ednra	endothelin receptor type A	0.257
Foxg1	forkhead box G1	0.244
Alx4	aristaless-like homeobox 4	0.225
Sox11	SRY-box containing gene 11	0.221
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.219
Sfrp1	secreted frizzled-related protein 1	0.191
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.188
Mn1	meningioma 1	0.177
Fgfr3	fibroblast growth factor receptor 3	0.172
Pbx1	pre B-cell leukemia transcription factor 1	0.163
Bmp2	bone morphogenetic protein 2	0.159
Rarg	retinoic acid receptor, gamma	0.149
Vegfa	vascular endothelial growth factor A	0.140
Pax6	paired box gene 6	0.139
Tbx15	T-box 15	0.130
Meox2	mesenchyme homeobox 2	0.127
Isl1	ISL1 transcription factor, LIM/homeodomain	0.116
Ptch1	patched homolog 1	0.102
Jag1	jagged 1	0.101
Ctnnb1	catenin (cadherin associated protein), beta 1	0.097
Wnt5a	wingless-related MMTV integration site 5A	0.090
Hoxa1	homeobox A1	0.085
Sox2	SRY-box containing gene 2	0.082
Gas1	growth arrest specific 1	0.078
Sfrp2	secreted frizzled-related protein 2	0.077	Mouse
Pax9	paired box gene 9	0.076
Mef2d	myocyte enhancer factor 2D	0.066
Chd7	chromodomain helicase DNA binding protein 7	0.066
Gbx2	gastrulation brain homeobox 2	0.064
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.064
Apaf1	apoptotic peptidase activating factor 1	0.059
Rdh10	retinol dehydrogenase 10 (all-trans)	0.053
Hhat	hedgehog acyltransferase	0.049
Acvr1	activin A receptor, type 1	0.048
Lrp6	low density lipoprotein receptor-related protein 6	0.048	Human
Tshz1	teashirt zinc finger family member 1	0.046
Efnb2	ephrin B2	0.044
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.042
Hoxa3	homeobox A3	0.042
Hoxd13	homeobox D13	0.041
Twist2	twist homolog 2 (Drosophila)	0.041
Col2a1	collagen, type II, alpha 1	0.040
Dlx6	distal-less homeobox 6	0.040
Emx1	empty spiracles homolog 1 (Drosophila)	0.040
Ntf3	neurotrophin 3	0.040
Psen1	presenilin 1	0.038
Sox4	SRY-box containing gene 4	0.035
Gja1	gap junction protein, alpha 1	0.034
Gpc3	glypican 3	0.033
Lef1	lymphoid enhancer binding factor 1	0.031
Wnt3a	wingless-related MMTV integration site 3A	0.031
Hoxa2	homeobox A2	0.031
Tbx3	T-box 3	0.027
Nog	noggin	0.027
Bmp5	bone morphogenetic protein 5	0.026
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.026
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.025
Dlx2	distal-less homeobox 2	0.025
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.024
Foxi3	forkhead box I3	0.024
Fgf10	fibroblast growth factor 10	0.023
Emx2	empty spiracles homolog 2 (Drosophila)	0.023
Crebbp	CREB binding protein	0.022
Alx3	aristaless-like homeobox 3	0.022
Otx1	orthodenticle homolog 1 (Drosophila)	0.022
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.022
Mks1	Meckel syndrome, type 1	0.022
Efna4	ephrin A4	0.021
Tgfbr2	transforming growth factor, beta receptor II	0.020
Efs	embryonal Fyn-associated substrate	0.019
Mef2c	myocyte enhancer factor 2C	0.019
Smad5	MAD homolog 5 (Drosophila)	0.018
Gsk3b	glycogen synthase kinase 3 beta	0.018
Pitx1	paired-like homeodomain transcription factor 1	0.018
Gsc	goosecoid homeobox	0.018	Human
Wdr19	WD repeat domain 19	0.018
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.017
Wls	wntless homolog (Drosophila)	0.017
Zic3	zinc finger protein of the cerebellum 3	0.016
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.016
Ece1	endothelin converting enzyme 1	0.016
Sall4	sal-like 4 (Drosophila)	0.016
Pax2	paired box gene 2	0.016
Twist1	twist homolog 1 (Drosophila)	0.016
Ptn	pleiotrophin	0.015
Fbln1	fibulin 1	0.015
Ext1	exostoses (multiple) 1	0.015
Hes1	hairy and enhancer of split 1 (Drosophila)	0.015
Lrp2	low density lipoprotein receptor-related protein 2	0.014
Nrk	Nik related kinase	0.014
Bmper	BMP-binding endothelial regulator	0.014	Zebrafish
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.014
Cdh3	cadherin 3	0.013
Lpar1	lysophosphatidic acid receptor 1	0.013
Pofut1	protein O-fucosyltransferase 1	0.013
En1	engrailed 1	0.012
Kif3a	kinesin family member 3A	0.012
Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	0.012
Fxr1	fragile X mental retardation gene 1, autosomal homolog	0.012
Hoxa13	homeobox A13	0.012
Hmgb1	high mobility group box 1	0.012
Ptk7	PTK7 protein tyrosine kinase 7	0.012
Slc12a2	solute carrier family 12, member 2	0.011
Otud4	OTU domain containing 4	0.011
Cachd1	cache domain containing 1	0.011
Zic2	zinc finger protein of the cerebellum 2	0.011
Rara	retinoic acid receptor, alpha	0.011
Crabp2	cellular retinoic acid binding protein II	0.011
Hoxb4	homeobox B4	0.011
Mecp2	methyl CpG binding protein 2	0.011
Fgfrl1	fibroblast growth factor receptor-like 1	0.011
Grb10	growth factor receptor bound protein 10	0.010
Rcan1	regulator of calcineurin 1	0.010
Lama1	laminin, alpha 1	0.010