IMP

Process View

Mus musculus

1 genes annotated in mouse

atrioventricular bundle cell differentiation

The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "atrioventricular bundle cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "atrioventricular bundle cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Pitx2	paired-like homeodomain transcription factor 2	1.000
Shh	sonic hedgehog	0.999
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.998
Fgfr2	fibroblast growth factor receptor 2	0.997
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.993
Tbx3	T-box 3	0.992
Hoxa1	homeobox A1	0.990
Eya1	eyes absent 1 homolog (Drosophila)	0.980
Foxg1	forkhead box G1	0.972
Foxc2	forkhead box C2	0.969
Tcfap2a	transcription factor AP-2, alpha	0.968
Foxc1	forkhead box C1	0.968
Pax3	paired box gene 3	0.965
Pitx1	paired-like homeodomain transcription factor 1	0.963
Tbx5	T-box 5	0.957	Mouse
Bmp4	bone morphogenetic protein 4	0.945
Otx2	orthodenticle homolog 2 (Drosophila)	0.938
Chd7	chromodomain helicase DNA binding protein 7	0.931
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.927
Prrx1	paired related homeobox 1	0.923
Pax2	paired box gene 2	0.914
Sox9	SRY-box containing gene 9	0.888
Gli3	GLI-Kruppel family member GLI3	0.876
Hand2	heart and neural crest derivatives expressed transcript 2	0.870
Fgf8	fibroblast growth factor 8	0.865
Jag1	jagged 1	0.822
Dlx5	distal-less homeobox 5	0.821
Msx1	homeobox, msh-like 1	0.800
Hand1	heart and neural crest derivatives expressed transcript 1	0.745
Vangl2	vang-like 2 (van gogh, Drosophila)	0.681
Fgf10	fibroblast growth factor 10	0.677
Scn5a	sodium channel, voltage-gated, type V, alpha	0.668
Rarg	retinoic acid receptor, gamma	0.626
Chrd	chordin	0.574
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.570
Smo	smoothened homolog (Drosophila)	0.562
Tbx1	T-box 1	0.547	Mouse
Fgfr3	fibroblast growth factor receptor 3	0.517
Sox2	SRY-box containing gene 2	0.508
Fgfr1	fibroblast growth factor receptor 1	0.479
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.428
Rarb	retinoic acid receptor, beta	0.416
Alx1	ALX homeobox 1	0.400
Tbx4	T-box 4	0.388	Mouse
Hoxa3	homeobox A3	0.372
Runx2	runt related transcription factor 2	0.353
Gsc	goosecoid homeobox	0.297
Lrp6	low density lipoprotein receptor-related protein 6	0.291
Vegfa	vascular endothelial growth factor A	0.282
Rxra	retinoid X receptor alpha	0.248
Gbx2	gastrulation brain homeobox 2	0.247
Isl1	ISL1 transcription factor, LIM/homeodomain	0.245
Lmx1a	LIM homeobox transcription factor 1 alpha	0.244
Bmp7	bone morphogenetic protein 7	0.242
Gata3	GATA binding protein 3	0.225
Ednra	endothelin receptor type A	0.225
Lef1	lymphoid enhancer binding factor 1	0.225
Zeb1	zinc finger E-box binding homeobox 1	0.218
Hoxa2	homeobox A2	0.214
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.202
Zic3	zinc finger protein of the cerebellum 3	0.193
Msx2	homeobox, msh-like 2	0.189
Gja5	gap junction protein, alpha 5	0.180
Gata4	GATA binding protein 4	0.173
Prrx2	paired related homeobox 2	0.161
Ece1	endothelin converting enzyme 1	0.152
Wnt3a	wingless-related MMTV integration site 3A	0.139
Hoxd3	homeobox D3	0.136
Tgfb2	transforming growth factor, beta 2	0.135
Sall4	sal-like 4 (Drosophila)	0.135
Pax9	paired box gene 9	0.127
Otx1	orthodenticle homolog 1 (Drosophila)	0.123
Bdnf	brain derived neurotrophic factor	0.097
Ntf3	neurotrophin 3	0.096
Bmp5	bone morphogenetic protein 5	0.094
Smad6	MAD homolog 6 (Drosophila)	0.089
Hmx3	H6 homeobox 3	0.084
Ighmbp2	immunoglobulin mu binding protein 2	0.080
Dlx2	distal-less homeobox 2	0.079
Wt1	Wilms tumor 1 homolog	0.078
Emx2	empty spiracles homolog 2 (Drosophila)	0.072
Lrp5	low density lipoprotein receptor-related protein 5	0.070
Irx3	Iroquois related homeobox 3 (Drosophila)	0.070
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.067
Nog	noggin	0.064
Trp63	transformation related protein 63	0.062
Gli2	GLI-Kruppel family member GLI2	0.062
Myf5	myogenic factor 5	0.061
Sox11	SRY-box containing gene 11	0.061
Efnb2	ephrin B2	0.060
Pou5f1	POU domain, class 5, transcription factor 1	0.057
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.054
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.054
Gata6	GATA binding protein 6	0.054
Hoxa13	homeobox A13	0.053
Rara	retinoic acid receptor, alpha	0.049
Nodal	nodal	0.048
Dll4	delta-like 4 (Drosophila)	0.048
Tcf21	transcription factor 21	0.047
T	brachyury	0.042	Mouse
Hoxb3	homeobox B3	0.042
Nanog	Nanog homeobox	0.041
Acvr1	activin A receptor, type 1	0.040
En1	engrailed 1	0.039
Mn1	meningioma 1	0.039
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.038
Lhx1	LIM homeobox protein 1	0.037
Meox2	mesenchyme homeobox 2	0.036
Tcfcp2l1	transcription factor CP2-like 1	0.035
Col13a1	collagen, type XIII, alpha 1	0.035
Cxadr	coxsackie virus and adenovirus receptor	0.033
Mecom	MDS1 and EVI1 complex locus	0.033
Ptk7	PTK7 protein tyrosine kinase 7	0.032
Gata2	GATA binding protein 2	0.031
Rnf2	ring finger protein 2	0.030
Sall1	sal-like 1 (Drosophila)	0.030
Hoxb1	homeobox B1	0.030
Alx4	aristaless-like homeobox 4	0.030
Wnt5a	wingless-related MMTV integration site 5A	0.029
Mesp1	mesoderm posterior 1	0.029
Ptch1	patched homolog 1	0.029
Bmp2	bone morphogenetic protein 2	0.028
Hoxb4	homeobox B4	0.028
Shox2	short stature homeobox 2	0.028
Pbx1	pre B-cell leukemia transcription factor 1	0.027
Noto	notochord homolog (Xenopus laevis)	0.026
Hoxd1	homeobox D1	0.026
Pou4f3	POU domain, class 4, transcription factor 3	0.025
Gata5	GATA binding protein 5	0.024
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.022
Emx1	empty spiracles homolog 1 (Drosophila)	0.022
Prdm6	PR domain containing 6	0.021
Bnc1	basonuclin 1	0.021
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.021
Fgf3	fibroblast growth factor 3	0.021
Fgfrl1	fibroblast growth factor receptor-like 1	0.020
Pax7	paired box gene 7	0.020
Pou4f2	POU domain, class 4, transcription factor 2	0.020
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.020
Hoxa10	homeobox A10	0.019
Foxi3	forkhead box I3	0.019
Foxf1a	forkhead box F1a	0.019
Twist2	twist homolog 2 (Drosophila)	0.019
Gja1	gap junction protein, alpha 1	0.019
Hoxa11	homeobox A11	0.018
Alx3	aristaless-like homeobox 3	0.018
Tgfbr2	transforming growth factor, beta receptor II	0.018
Irx5	Iroquois related homeobox 5 (Drosophila)	0.018
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.017
Hoxd11	homeobox D11	0.017
Myf6	myogenic factor 6	0.017
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.017
Dlx6	distal-less homeobox 6	0.017
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.017
Lhx9	LIM homeobox protein 9	0.017
Tbx20	T-box 20	0.017	Mouse
Xirp1	xin actin-binding repeat containing 1	0.017
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.016
Dnahc11	dynein, axonemal, heavy chain 11	0.016
Pds5a	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.016
Hoxb2	homeobox B2	0.016
Wnt1	wingless-related MMTV integration site 1	0.016
Foxi1	forkhead box I1	0.016
Rdh10	retinol dehydrogenase 10 (all-trans)	0.016
Hes1	hairy and enhancer of split 1 (Drosophila)	0.016
Ripply3	ripply3 homolog (zebrafish)	0.016
Foxa1	forkhead box A1	0.015
Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	0.015
Nkx3-2	NK3 homeobox 2	0.015
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.015
Ryr2	ryanodine receptor 2, cardiac	0.015
Myo6	myosin VI	0.015
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.015
Defb10	defensin beta 10	0.015
Egfr	epidermal growth factor receptor	0.014
Tnfrsf25	tumor necrosis factor receptor superfamily, member 25	0.014
Hoxa4	homeobox A4	0.014
Tbx15	T-box 15	0.014	Mouse
Satb2	special AT-rich sequence binding protein 2	0.014
Bmper	BMP-binding endothelial regulator	0.014
Acvr2b	activin receptor IIB	0.014
Hmx2	H6 homeobox 2	0.014
BC020535	cDNA sequence BC020535	0.014
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.014
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.013
Pax1	paired box gene 1	0.013
Zic1	zinc finger protein of the cerebellum 1	0.013
Nkd1	naked cuticle 1 homolog (Drosophila)	0.013
Pcdh1	protocadherin 1	0.013
Irx4	Iroquois related homeobox 4 (Drosophila)	0.013
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.013
Fbn2	fibrillin 2	0.012
Atoh8	atonal homolog 8 (Drosophila)	0.012
Foxf2	forkhead box F2	0.012
Hoxb5	homeobox B5	0.012
Cd8b1	CD8 antigen, beta chain 1	0.012
Hes5	hairy and enhancer of split 5 (Drosophila)	0.012
Tead1	TEA domain family member 1	0.012
Hoxd9	homeobox D9	0.012
Rybp	RING1 and YY1 binding protein	0.012
Gzmk	granzyme K	0.012
Zic2	zinc finger protein of the cerebellum 2	0.012
Mkl2	MKL/myocardin-like 2	0.012
Cd274	CD274 antigen	0.012
Socs1	suppressor of cytokine signaling 1	0.012
Zfpm2	zinc finger protein, multitype 2	0.012
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.011
Notch1	Notch gene homolog 1 (Drosophila)	0.011
Osr1	odd-skipped related 1 (Drosophila)	0.011
Olig3	oligodendrocyte transcription factor 3	0.011
Kdr	kinase insert domain protein receptor	0.011
Myo7a	myosin VIIA	0.011
Hoxb6	homeobox B6	0.011
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.011
Hoxd8	homeobox D8	0.011
Sox17	SRY-box containing gene 17	0.011
Notch2	Notch gene homolog 2 (Drosophila)	0.011
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.011
Asb12	ankyrin repeat and SOCS box-containing 12	0.011
Mnx1	motor neuron and pancreas homeobox 1	0.011
Foxh1	forkhead box H1	0.011
Mks1	Meckel syndrome, type 1	0.010
Axin2	axin2	0.010
Nkd2	naked cuticle 2 homolog (Drosophila)	0.010
Zfp503	zinc finger protein 503	0.010
Asb10	ankyrin repeat and SOCS box-containing 10	0.010
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.010
Col2a1	collagen, type II, alpha 1	0.010
Sox4	SRY-box containing gene 4	0.010
Tbx2	T-box 2	0.010	Mouse