|
|
serine phosphorylation of stat protein
|
GO:0042501 |
3 |
1.000
|
|
|
|
positive regulation of antimicrobial peptide production
|
GO:0002225 |
1 |
1.000
|
|
|
|
positive regulation of antibacterial peptide biosynthetic process
|
GO:0006963 |
1 |
1.000
|
|
|
|
antibacterial humoral response
|
GO:0019731 |
8 |
1.000
|
|
|
|
regulation of antibacterial peptide production
|
GO:0002786 |
1 |
1.000
|
|
|
|
negative regulation of necrotic cell death
|
GO:0060547 |
11 |
1.000
|
|
|
|
negative regulation of necroptotic process
|
GO:0060546 |
9 |
1.000
|
|
|
|
positive regulation of interferon beta biosynthetic process
|
GO:0045359 |
3 |
1.000
|
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
4 |
1.000
|
|
|
|
regulation of antibacterial peptide biosynthetic process
|
GO:0002808 |
1 |
1.000
|
|
|
|
antibacterial peptide production
|
GO:0002778 |
2 |
1.000
|
|
|
|
i kappab phosphorylation
|
GO:0007252 |
6 |
1.000
|
Zebrafish |
|
|
regulation of defense response to bacterium
|
GO:1900424 |
3 |
1.000
|
|
|
|
ripoptosome assembly involved in necroptotic process
|
GO:1901026 |
6 |
1.000
|
|
|
|
interferon beta biosynthetic process
|
GO:0045350 |
4 |
1.000
|
|
|
|
negative regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902443 |
3 |
0.999
|
|
|
|
antibacterial peptide biosynthetic process
|
GO:0002780 |
2 |
0.999
|
|
|
|
regulation of interferon beta biosynthetic process
|
GO:0045357 |
4 |
0.999
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.999
|
Human Zebrafish |
|
|
positive regulation of defense response to bacterium
|
GO:1900426 |
1 |
0.998
|
|
|
|
positive regulation of antibacterial peptide production
|
GO:0002803 |
1 |
0.997
|
|
|
|
antimicrobial peptide production
|
GO:0002775 |
2 |
0.997
|
|
|
|
regulation of necroptotic process
|
GO:0060544 |
10 |
0.995
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
28 |
0.993
|
|
|
|
dendritic cell proliferation
|
GO:0044565 |
2 |
0.989
|
|
|
|
positive regulation of antimicrobial peptide biosynthetic process
|
GO:0002807 |
1 |
0.988
|
|
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
3 |
0.987
|
|
|
|
regulation of antimicrobial peptide biosynthetic process
|
GO:0002805 |
1 |
0.984
|
|
|
|
positive regulation of antimicrobial humoral response
|
GO:0002760 |
2 |
0.979
|
|
|
|
antimicrobial peptide biosynthetic process
|
GO:0002777 |
2 |
0.975
|
|
|
|
regulation of necrotic cell death
|
GO:0010939 |
13 |
0.974
|
|
|
|
regulation of defense response
|
GO:0031347 |
233 |
0.970
|
|
|
|
necroptotic process
|
GO:0070266 |
21 |
0.969
|
|
|
|
activation of innate immune response
|
GO:0002218 |
56 |
0.962
|
|
|
|
interferon beta production
|
GO:0032608 |
16 |
0.949
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
45 |
0.911
|
|
|
|
defense response to virus
|
GO:0051607 |
68 |
0.908
|
|
|
|
regulation of defense response to virus by host
|
GO:0050691 |
8 |
0.900
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
58 |
0.898
|
|
|
|
regulation of ripoptosome assembly involved in necroptotic process
|
GO:1902442 |
3 |
0.885
|
|
|
|
peptide metabolic process
|
GO:0006518 |
46 |
0.863
|
|
|
|
positive regulation of defense response to virus by host
|
GO:0002230 |
6 |
0.860
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.860
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.857
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.852
|
|
|
|
defense response to bacterium
|
GO:0042742 |
119 |
0.850
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
54 |
0.849
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.829
|
|
|
|
regulation of antimicrobial peptide production
|
GO:0002784 |
1 |
0.828
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.827
|
|
|
|
regulation of interferon beta production
|
GO:0032648 |
13 |
0.824
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
26 |
0.819
|
|
|
|
activation of immune response
|
GO:0002253 |
138 |
0.815
|
|
|
|
b cell homeostasis
|
GO:0001782 |
34 |
0.813
|
|
|
|
nik nf kappab signaling
|
GO:0038061 |
14 |
0.808
|
|
|
|
type i interferon production
|
GO:0032606 |
29 |
0.808
|
|
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.807
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
306 |
0.790
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
18 |
0.781
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
187 |
0.763
|
|
|
|
necrotic cell death
|
GO:0070265 |
30 |
0.753
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.747
|
|
|
|
positive regulation of interferon beta production
|
GO:0032728 |
8 |
0.744
|
|
|
|
type i interferon biosynthetic process
|
GO:0045351 |
9 |
0.743
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.742
|
|
|
|
sodium ion transport
|
GO:0006814 |
73 |
0.730
|
|
|
|
humoral immune response
|
GO:0006959 |
57 |
0.725
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.724
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.712
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
40 |
0.706
|
|
|
|
transmembrane transport
|
GO:0055085 |
412 |
0.690
|
|
|
|
striated muscle contraction
|
GO:0006941 |
45 |
0.678
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.677
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.677
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.672
|
|
|
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
207 |
0.667
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.663
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
68 |
0.661
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.656
|
|
|
|
peptide biosynthetic process
|
GO:0043043 |
11 |
0.654
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
21 |
0.649
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.641
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
71 |
0.638
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.631
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.627
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.610
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
103 |
0.605
|
|
|
|
positive regulation of type i interferon production
|
GO:0032481 |
14 |
0.599
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
84 |
0.597
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
57 |
0.590
|
|
|
|
positive regulation of ion transmembrane transporter activity
|
GO:0032414 |
15 |
0.587
|
|
|
|
activation of jnkk activity
|
GO:0007256 |
3 |
0.587
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
147 |
0.584
|
|
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
38 |
0.572
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
33 |
0.567
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.560
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
145 |
0.556
|
|
|
|
regulation of cation channel activity
|
GO:2001257 |
22 |
0.554
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
119 |
0.544
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.535
|
|
|
|
defense response to gram positive bacterium
|
GO:0050830 |
50 |
0.529
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
59 |
0.528
|
|
|
|
mammary gland lobule development
|
GO:0061377 |
22 |
0.519
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.512
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.508
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.503
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
30 |
0.501
|
Human |
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.500
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.474
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.467
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.464
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
77 |
0.458
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.454
|
|
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.450
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
10 |
0.445
|
|
|
|
muscle contraction
|
GO:0006936 |
101 |
0.439
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
13 |
0.429
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.425
|
|
|
|
negative regulation of b cell activation
|
GO:0050869 |
27 |
0.423
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.415
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
25 |
0.412
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
65 |
0.410
|
|
|
|
positive regulation of humoral immune response
|
GO:0002922 |
11 |
0.409
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
61 |
0.404
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
5 |
0.400
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.393
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
26 |
0.392
|
|
|
|
glial cell apoptotic process
|
GO:0034349 |
3 |
0.389
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.389
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.383
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.376
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
42 |
0.372
|
|
|
|
regulation of type i interferon production
|
GO:0032479 |
22 |
0.369
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.367
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.366
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
104 |
0.357
|
|
|
|
negative regulation of interleukin 6 production
|
GO:0032715 |
17 |
0.356
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
111 |
0.347
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
192 |
0.346
|
|
|
|
protein ubiquitination
|
GO:0016567 |
171 |
0.344
|
|
|
|
positive regulation of response to biotic stimulus
|
GO:0002833 |
15 |
0.343
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
62 |
0.336
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
40 |
0.336
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.328
|
|
|
|
lactation
|
GO:0007595 |
25 |
0.328
|
|
|
|
mammary gland alveolus development
|
GO:0060749 |
22 |
0.327
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
189 |
0.325
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
30 |
0.324
|
|
|
|
odontogenesis of dentin containing tooth
|
GO:0042475 |
66 |
0.322
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.321
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.319
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.313
|
|
|
|
positive regulation of protein import into nucleus
|
GO:0042307 |
26 |
0.313
|
|
|
|
mitochondrion organization
|
GO:0007005 |
134 |
0.309
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.305
|
|
|
|
tyrosine phosphorylation of stat1 protein
|
GO:0042508 |
3 |
0.304
|
|
|
|
positive regulation of cation channel activity
|
GO:2001259 |
8 |
0.303
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.300
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.299
|
|
|
|
positive regulation of cytokine production involved in immune response
|
GO:0002720 |
19 |
0.297
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
61 |
0.296
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.293
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.292
|
|
|
|
regulation of humoral immune response
|
GO:0002920 |
22 |
0.289
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.288
|
|
|
|
body fluid secretion
|
GO:0007589 |
53 |
0.283
|
|
|
|
odontogenesis
|
GO:0042476 |
78 |
0.273
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
30 |
0.272
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
143 |
0.271
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.265
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
77 |
0.260
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
189 |
0.258
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.249
|
|
|
|
cellular response to nitric oxide
|
GO:0071732 |
4 |
0.247
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.245
|
|
|
|
muscle system process
|
GO:0003012 |
141 |
0.244
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.244
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.243
|
|
|
|
positive regulation of sodium ion transport
|
GO:0010765 |
13 |
0.240
|
|
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
2 |
0.236
|
|
|
|
skeletal system development
|
GO:0001501 |
356 |
0.236
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.235
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
65 |
0.234
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.227
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
128 |
0.226
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
70 |
0.226
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.225
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
64 |
0.224
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
198 |
0.224
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
77 |
0.224
|
|
|
|
antimicrobial humoral response
|
GO:0019730 |
11 |
0.219
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.218
|
|
|
|
leukocyte homeostasis
|
GO:0001776 |
79 |
0.213
|
|
|
|
jak stat cascade
|
GO:0007259 |
42 |
0.211
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.210
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.209
|
|
|
|
positive regulation of transmembrane transport
|
GO:0034764 |
29 |
0.209
|
|
|
|
regulation of cellular amide metabolic process
|
GO:0034248 |
10 |
0.208
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.207
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.206
|
|
|
|
positive regulation of ion transmembrane transport
|
GO:0034767 |
24 |
0.205
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
47 |
0.203
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.203
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
34 |
0.202
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.198
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.198
|
|
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
10 |
0.197
|
|
|
|
cell cell recognition
|
GO:0009988 |
44 |
0.197
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.197
|
|
|
|
positive regulation of neuron death
|
GO:1901216 |
28 |
0.195
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
106 |
0.195
|
Human |
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.195
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.187
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.187
|
|
|
|
regulation of anion transport
|
GO:0044070 |
27 |
0.186
|
|
|
|
mammary gland epithelial cell proliferation
|
GO:0033598 |
24 |
0.186
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
162 |
0.186
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.184
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.182
|
|
|
|
interleukin 6 production
|
GO:0032635 |
58 |
0.182
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.178
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
6 |
0.178
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
50 |
0.176
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
61 |
0.176
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
46 |
0.174
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
28 |
0.174
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.172
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.171
|
|
|
|
response to drug
|
GO:0042493 |
75 |
0.168
|
|
|
|
regulation of sodium ion transport
|
GO:0002028 |
29 |
0.168
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.167
|
|
|
|
activation of mapkk activity
|
GO:0000186 |
15 |
0.167
|
|
|
|
necroptotic signaling pathway
|
GO:0097527 |
3 |
0.166
|
|
|
|
positive regulation of activation of membrane attack complex
|
GO:0001970 |
2 |
0.166
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.161
|
|
|
|
activation of mapk activity
|
GO:0000187 |
59 |
0.160
|
|
|
|
positive regulation of t cell mediated immunity
|
GO:0002711 |
24 |
0.158
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.157
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.154
|
|
|
|
single organism nuclear import
|
GO:1902593 |
95 |
0.151
|
|
|
|
interleukin 8 production
|
GO:0032637 |
4 |
0.151
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
84 |
0.150
|
|
|
|
interleukin 5 secretion
|
GO:0072603 |
2 |
0.149
|
|
|
|
lymph node development
|
GO:0048535 |
18 |
0.149
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.149
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.149
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.149
|
|
|
|
regulation of immunoglobulin secretion
|
GO:0051023 |
12 |
0.148
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
271 |
0.147
|
|
|
|
response to acid chemical
|
GO:0001101 |
111 |
0.147
|
|
|
|
myeloid dendritic cell activation
|
GO:0001773 |
25 |
0.143
|
|
|
|
morphogenesis of an epithelial sheet
|
GO:0002011 |
27 |
0.141
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.140
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
90 |
0.140
|
|
|
|
muscle tissue development
|
GO:0060537 |
308 |
0.140
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
68 |
0.137
|
Human |
|
|
protein maturation
|
GO:0051604 |
176 |
0.137
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
129 |
0.136
|
|
|
|
autophagy
|
GO:0006914 |
45 |
0.136
|
|
|
|
regulation of interferon gamma production
|
GO:0032649 |
57 |
0.133
|
|
|
|
protein homooligomerization
|
GO:0051260 |
43 |
0.133
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.133
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
69 |
0.131
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
52 |
0.131
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.130
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
25 |
0.128
|
|
|
|
ripoptosome assembly
|
GO:0097343 |
6 |
0.128
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
34 |
0.125
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
70 |
0.124
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
142 |
0.123
|
|
|
|
positive regulation of transporter activity
|
GO:0032411 |
17 |
0.122
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
34 |
0.121
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
50 |
0.120
|
|
|
|
t cell cytokine production
|
GO:0002369 |
10 |
0.118
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
77 |
0.117
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.115
|
|
|
|
signal transduction in absence of ligand
|
GO:0038034 |
55 |
0.115
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.112
|
|
|
|
positive regulation of interleukin 6 production
|
GO:0032755 |
37 |
0.110
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
89 |
0.109
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
87 |
0.108
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.108
|
Human |
|
|
positive regulation of secretion
|
GO:0051047 |
130 |
0.108
|
|
|
|
t cell activation involved in immune response
|
GO:0002286 |
43 |
0.108
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
65 |
0.108
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
62 |
0.106
|
|
|
|
angiogenesis
|
GO:0001525 |
201 |
0.106
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
133 |
0.105
|
|
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.104
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.103
|
|
|
|
anion transport
|
GO:0006820 |
177 |
0.103
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
106 |
0.102
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
11 |
0.100
|
|
|
|
amide biosynthetic process
|
GO:0043604 |
16 |
0.099
|
|
|
|
digestive system development
|
GO:0055123 |
200 |
0.098
|
|
|
|
somatic diversification of immunoglobulins involved in immune response
|
GO:0002208 |
36 |
0.098
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.098
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
55 |
0.098
|
|
|
|
rhythmic process
|
GO:0048511 |
174 |
0.098
|
|
|
|
nuclear transport
|
GO:0051169 |
139 |
0.095
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
76 |
0.094
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.093
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.092
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
45 |
0.092
|
|
|
|
response to steroid hormone
|
GO:0048545 |
56 |
0.091
|
|
|
|
activation induced cell death of t cells
|
GO:0006924 |
10 |
0.091
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
159 |
0.090
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.089
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
3 |
0.089
|
|
|
|
cellular response to acid chemical
|
GO:0071229 |
68 |
0.087
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.086
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
39 |
0.086
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
98 |
0.086
|
|
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.085
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
34 |
0.085
|
|
|
|
keratinocyte differentiation
|
GO:0030216 |
48 |
0.082
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
85 |
0.082
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.082
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.081
|
|
|
|
l amino acid transport
|
GO:0015807 |
32 |
0.081
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.080
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
48 |
0.079
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.079
|
|
|
|
positive regulation of nucleocytoplasmic transport
|
GO:0046824 |
30 |
0.079
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.079
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.078
|
|
|
|
regulation of cd8 positive alpha beta cytotoxic t cell extravasation
|
GO:2000452 |
2 |
0.077
|
|
|
|
cellular response to inorganic substance
|
GO:0071241 |
37 |
0.077
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
50 |
0.076
|
|
|
|
positive regulation of neuron apoptotic process
|
GO:0043525 |
25 |
0.076
|
|
|
|
immunoglobulin secretion
|
GO:0048305 |
17 |
0.075
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
82 |
0.075
|
|
|
|
protein targeting
|
GO:0006605 |
143 |
0.074
|
|
|
|
response to amino acid
|
GO:0043200 |
37 |
0.073
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.072
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.071
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
151 |
0.071
|
|
|
|
response to fatty acid
|
GO:0070542 |
8 |
0.070
|
|
|
|
execution phase of apoptosis
|
GO:0097194 |
19 |
0.070
|
|
|
|
ossification
|
GO:0001503 |
216 |
0.069
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.068
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
19 |
0.068
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
8 |
0.068
|
|
|
|
positive regulation of protein oligomerization
|
GO:0032461 |
4 |
0.068
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.068
|
|
|
|
protein oligomerization
|
GO:0051259 |
67 |
0.067
|
|
|
|
nuclear import
|
GO:0051170 |
95 |
0.067
|
|
|
|
interleukin 6 biosynthetic process
|
GO:0042226 |
12 |
0.066
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
53 |
0.066
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.065
|
|
|
|
organic acid transport
|
GO:0015849 |
101 |
0.064
|
|
|
|
organelle localization
|
GO:0051640 |
179 |
0.064
|
|
|
|
negative regulation of protein localization to nucleus
|
GO:1900181 |
23 |
0.064
|
|
|
|
transcription factor import into nucleus
|
GO:0042991 |
26 |
0.063
|
|
|
|
positive regulation of multi organism process
|
GO:0043902 |
26 |
0.063
|
|
|
|
regulation of protein import into nucleus translocation
|
GO:0033158 |
2 |
0.062
|
|
|
|
cellular response to amino acid stimulus
|
GO:0071230 |
29 |
0.062
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.062
|
|
|
|
response to interleukin 12
|
GO:0070671 |
2 |
0.061
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.061
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
0.061
|
|
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.061
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
3 |
0.060
|
|
|
|
embryonic skeletal system development
|
GO:0048706 |
120 |
0.059
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.058
|
|
|
|
regulation of protein processing
|
GO:0070613 |
96 |
0.058
|
|
|
|
cell division
|
GO:0051301 |
120 |
0.058
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
93 |
0.058
|
|
|
|
positive regulation of cellular amide metabolic process
|
GO:0034250 |
5 |
0.056
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
130 |
0.056
|
|
|
|
regulation of alpha beta t cell proliferation
|
GO:0046640 |
18 |
0.056
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
133 |
0.056
|
|
|
|
negative regulation of inflammatory response
|
GO:0050728 |
61 |
0.055
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.055
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
49 |
0.055
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
0.054
|
|
|
|
t cell selection
|
GO:0045058 |
34 |
0.054
|
|
|
|
positive regulation of protein import into nucleus translocation
|
GO:0033160 |
1 |
0.054
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.053
|
|
|
|
somatic recombination of immunoglobulin genes involved in immune response
|
GO:0002204 |
36 |
0.053
|
|
|
|
hair follicle development
|
GO:0001942 |
85 |
0.053
|
|
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.053
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
23 |
0.052
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
145 |
0.052
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.051
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
96 |
0.051
|
|
|
|
b cell mediated immunity
|
GO:0019724 |
71 |
0.051
|
|
|
|
cellular response to type i interferon
|
GO:0071357 |
10 |
0.050
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
139 |
0.050
|
|
|
|
detection of stimulus
|
GO:0051606 |
84 |
0.050
|
|
|
|
protein deacetylation
|
GO:0006476 |
32 |
0.050
|
|
|
|
carboxylic acid transport
|
GO:0046942 |
100 |
0.050
|
|
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
67 |
0.049
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
27 |
0.049
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.049
|
|
|
|
peptidyl lysine acetylation
|
GO:0018394 |
45 |
0.049
|
|
|
|
negative regulation of inflammatory response to antigenic stimulus
|
GO:0002862 |
10 |
0.049
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
62 |
0.049
|
|
|
|
lipid localization
|
GO:0010876 |
126 |
0.049
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.048
|
|
|
|
positive regulation of interleukin 8 production
|
GO:0032757 |
2 |
0.048
|
|
|
|
bone development
|
GO:0060348 |
120 |
0.048
|
|
|
|
positive regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042511 |
1 |
0.048
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.048
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.048
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
104 |
0.047
|
|
|
|
binding of sperm to zona pellucida
|
GO:0007339 |
34 |
0.047
|
|
|
|
inositol phosphate catabolic process
|
GO:0071545 |
4 |
0.046
|
|
|
|
embryonic organ morphogenesis
|
GO:0048562 |
276 |
0.046
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
52 |
0.046
|
|
|
|
embryonic skeletal system morphogenesis
|
GO:0048704 |
91 |
0.046
|
|
|
|
positive regulation of fever generation by positive regulation of prostaglandin secretion
|
GO:0071812 |
2 |
0.046
|
|
|
|
protein heterooligomerization
|
GO:0051291 |
14 |
0.046
|
|
|
|
defense response to gram negative bacterium
|
GO:0050829 |
28 |
0.045
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.045
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
46 |
0.045
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.045
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.045
|
|
|
|
immunoglobulin production
|
GO:0002377 |
73 |
0.045
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
6 |
0.044
|
|
|
|
organic anion transport
|
GO:0015711 |
137 |
0.044
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
36 |
0.044
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.043
|
|
|
|
regulation of autophagy
|
GO:0010506 |
30 |
0.043
|
|
|
|
positive regulation of alpha beta t cell differentiation
|
GO:0046638 |
28 |
0.043
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
54 |
0.043
|
|
|
|
regulation of cytokine secretion involved in immune response
|
GO:0002739 |
4 |
0.042
|
|
|
|
amino acid transport
|
GO:0006865 |
61 |
0.042
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.042
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
70 |
0.042
|
|
|
|
muscle cell development
|
GO:0055001 |
133 |
0.042
|
|
|
|
segment specification
|
GO:0007379 |
15 |
0.042
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.042
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
122 |
0.042
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
15 |
0.042
|
|
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
4 |
0.041
|
|
|
|
mammary gland epithelium development
|
GO:0061180 |
65 |
0.041
|
|
|
|
regulation of epidermis development
|
GO:0045682 |
33 |
0.041
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
44 |
0.041
|
|
|
|
regulation of interleukin 13 secretion
|
GO:2000665 |
2 |
0.040
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.040
|
|
|
|
heart growth
|
GO:0060419 |
45 |
0.040
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
52 |
0.039
|
|
|
|
b cell apoptotic process
|
GO:0001783 |
19 |
0.039
|
|
|
|
protein complex localization
|
GO:0031503 |
19 |
0.039
|
|
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
15 |
0.039
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
116 |
0.039
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
61 |
0.038
|
|
|
|
fatty acid derivative transport
|
GO:1901571 |
14 |
0.038
|
|
|
|
acetylcholine secretion neurotransmission
|
GO:0014055 |
2 |
0.038
|
|
|
|
appendage development
|
GO:0048736 |
166 |
0.038
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.038
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.038
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
40 |
0.038
|
|
|
|
nucleic acid phosphodiester bond hydrolysis
|
GO:0090305 |
49 |
0.038
|
|
|
|
positive regulation of autophagy
|
GO:0010508 |
9 |
0.037
|
|
|
|
regulation of action potential
|
GO:0098900 |
4 |
0.037
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
57 |
0.037
|
|
|
|
positive regulation of interferon alpha production
|
GO:0032727 |
4 |
0.037
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
43 |
0.037
|
|
|
|
positive regulation of cell cycle process
|
GO:0090068 |
61 |
0.037
|
|
|
|
cellularization
|
GO:0007349 |
1 |
0.037
|
|
|
|
natural killer cell activation
|
GO:0030101 |
44 |
0.037
|
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.036
|
|
|
|
positive regulation of synaptic growth at neuromuscular junction
|
GO:0045887 |
1 |
0.036
|
|
|
|
regulation of interleukin 6 biosynthetic process
|
GO:0045408 |
11 |
0.036
|
|
|
|
somite specification
|
GO:0001757 |
4 |
0.036
|
|
|
|
t cell homeostasis
|
GO:0043029 |
35 |
0.036
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
73 |
0.036
|
|
|
|
acetylcholine transport
|
GO:0015870 |
2 |
0.036
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
323 |
0.036
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.036
|
|
|
|
hepatocyte apoptotic process
|
GO:0097284 |
11 |
0.036
|
|
|
|
segmentation
|
GO:0035282 |
93 |
0.035
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.035
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
26 |
0.035
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
74 |
0.035
|
|
|
|
phagocytosis
|
GO:0006909 |
66 |
0.035
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.035
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.035
|
|
|
|
circadian rhythm
|
GO:0007623 |
114 |
0.035
|
|
|
|
positive regulation of angiogenesis
|
GO:0045766 |
46 |
0.035
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.035
|
|
|
|
regulation of transcription factor import into nucleus
|
GO:0042990 |
24 |
0.035
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
197 |
0.034
|
|
|
|
digestive tract development
|
GO:0048565 |
190 |
0.034
|
|
|
|
response to glucocorticoid
|
GO:0051384 |
20 |
0.034
|
|
