IMP
Process View
i kappab phosphorylation
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "i kappab phosphorylation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Ikbkg | inhibitor of kappaB kinase gamma | 1.000 | Zebrafish | |
| Chuk | conserved helix-loop-helix ubiquitous kinase | 0.989 | Mouse | |
| Ikbkb | inhibitor of kappaB kinase beta | 0.980 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.980 | ||
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.939 | Fly | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.917 | Fly | |
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.887 | Fly | |
| Psen1 | presenilin 1 | 0.869 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.512 | ||
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.422 | ||
| Psen2 | presenilin 2 | 0.343 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.328 | ||
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.307 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.214 | ||
| Tnf | tumor necrosis factor | 0.208 | ||
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.186 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.184 | ||
| Il10 | interleukin 10 | 0.162 | ||
| Traf6 | TNF receptor-associated factor 6 | 0.145 | ||
| Jag1 | jagged 1 | 0.134 | ||
| Dll4 | delta-like 4 (Drosophila) | 0.095 | ||
| Cd44 | CD44 antigen | 0.094 | ||
| Egfl7 | EGF-like domain 7 | 0.092 | ||
| Msr1 | macrophage scavenger receptor 1 | 0.080 | ||
| Il1rn | interleukin 1 receptor antagonist | 0.076 | ||
| Ldlr | low density lipoprotein receptor | 0.076 | ||
| Tax1bp1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.067 | ||
| Rnf31 | ring finger protein 31 | 0.060 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.055 | ||
| Orm2 | orosomucoid 2 | 0.049 | ||
| Il6 | interleukin 6 | 0.049 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.039 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.038 | ||
| Sykb | spleen tyrosine kinase | 0.034 | ||
| Birc3 | baculoviral IAP repeat-containing 3 | 0.033 | ||
| Ncoa3 | nuclear receptor coactivator 3 | 0.033 | ||
| Il1r1 | interleukin 1 receptor, type I | 0.031 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.030 | ||
| Spp1 | secreted phosphoprotein 1 | 0.029 | ||
| Hspa1b | heat shock protein 1B | 0.029 | ||
| Dll1 | delta-like 1 (Drosophila) | 0.029 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.029 | ||
| Tank | TRAF family member-associated Nf-kappa B activator | 0.022 | ||
| Rab5a | RAB5A, member RAS oncogene family | 0.022 | ||
| Ptf1a | pancreas specific transcription factor, 1a | 0.022 | ||
| Ticam1 | toll-like receptor adaptor molecule 1 | 0.021 | ||
| Pten | phosphatase and tensin homolog | 0.020 | ||
| Wsb1 | WD repeat and SOCS box-containing 1 | 0.019 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.019 | ||
| Casp1 | caspase 1 | 0.019 | ||
| Nos2 | nitric oxide synthase 2, inducible | 0.019 | ||
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.019 | ||
| Lair1 | leukocyte-associated Ig-like receptor 1 | 0.018 | ||
| C3 | complement component 3 | 0.018 | ||
| Casp8 | caspase 8 | 0.016 | ||
| Src | Rous sarcoma oncogene | 0.016 | ||
| Plec | plectin | 0.015 | ||
| Siglec1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.014 | ||
| Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.013 | ||
| Pparg | peroxisome proliferator activated receptor gamma | 0.013 | ||
| Cd33 | CD33 antigen | 0.012 | ||
| Mib1 | mindbomb homolog 1 (Drosophila) | 0.012 | ||
| Cd14 | CD14 antigen | 0.012 | ||
| Foxo1 | forkhead box O1 | 0.012 | ||
| Klf13 | Kruppel-like factor 13 | 0.012 | ||
| Klra2 | killer cell lectin-like receptor, subfamily A, member 2 | 0.011 | ||
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.011 | ||
| Azi2 | 5-azacytidine induced gene 2 | 0.011 | ||
| Plcd1 | phospholipase C, delta 1 | 0.011 | ||
| Nr2f2 | nuclear receptor subfamily 2, group F, member 2 | 0.010 | ||
| Traf3ip2 | TRAF3 interacting protein 2 | 0.010 |