IMP

Process View

Mus musculus

13 genes annotated in mouse

regulation of necrotic cell death

Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of necrotic cell death"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of necrotic cell death" (in gray)

Name	Description	Probability	Func Analog Organism
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.996	Mouse
Ikbkg	inhibitor of kappaB kinase gamma	0.974
Ikbkb	inhibitor of kappaB kinase beta	0.915
Casp8	caspase 8	0.808
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.794
Traf2	TNF receptor-associated factor 2	0.617
Tlr4	toll-like receptor 4	0.613
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.542
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.531
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.500
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.336
Myd88	myeloid differentiation primary response gene 88	0.305
Aim2	absent in melanoma 2	0.259
Ripk3	receptor-interacting serine-threonine kinase 3	0.247
Casp1	caspase 1	0.246	Mouse
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.233	Human Mouse
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.209
Pycard	PYD and CARD domain containing	0.193
Atp6v0d1	ATPase, H+ transporting, lysosomal V0 subunit D1	0.154
Pacsin1	protein kinase C and casein kinase substrate in neurons 1	0.144
Nlrp3	NLR family, pyrin domain containing 3	0.143
Snap25	synaptosomal-associated protein 25	0.131
Hccs	holocytochrome c synthetase	0.125
Sharpin	SHANK-associated RH domain interacting protein	0.118	Mouse
Il18	interleukin 18	0.105
Birc3	baculoviral IAP repeat-containing 3	0.105
Fadd	Fas (TNFRSF6)-associated via death domain	0.103
Cyld	cylindromatosis (turban tumor syndrome)	0.102
Arnt	aryl hydrocarbon receptor nuclear translocator	0.091
Sh3gl2	SH3-domain GRB2-like 2	0.089	Worm
Hif1a	hypoxia inducible factor 1, alpha subunit	0.085
Ap2a2	adaptor protein complex AP-2, alpha 2 subunit	0.077
Stx1a	syntaxin 1A (brain)	0.066
Sult4a1	sulfotransferase family 4A, member 1	0.066
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.063
Stat6	signal transducer and activator of transcription 6	0.063
Stim2	stromal interaction molecule 2	0.063
Traf6	TNF receptor-associated factor 6	0.061
Fkbp8	FK506 binding protein 8	0.052
Kif5a	kinesin family member 5A	0.051	Worm
Ly96	lymphocyte antigen 96	0.049
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.048
Bsn	bassoon	0.047
Itch	itchy, E3 ubiquitin protein ligase	0.047
Ctsl	cathepsin L	0.047
Gbp5	guanylate binding protein 5	0.046
Naip2	NLR family, apoptosis inhibitory protein 2	0.045
Fas	Fas (TNF receptor superfamily member 6)	0.045
Vamp2	vesicle-associated membrane protein 2	0.044
Sncb	synuclein, beta	0.042
Atp6v0b	ATPase, H+ transporting, lysosomal V0 subunit B	0.041
Syp	synaptophysin	0.040
Capns1	calpain, small subunit 1	0.038
Smad5	MAD homolog 5 (Drosophila)	0.037
Rbck1	RanBP-type and C3HC4-type zinc finger containing 1	0.037
Dnm1	dynamin 1	0.037	Worm
Kif5c	kinesin family member 5C	0.036	Worm
Ltbr	lymphotoxin B receptor	0.035
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.035
A230046K03Rik	RIKEN cDNA A230046K03 gene	0.033
Myo6	myosin VI	0.033
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.033
Ncoa2	nuclear receptor coactivator 2	0.031
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.031
Syn1	synapsin I	0.029
Gng3	guanine nucleotide binding protein (G protein), gamma 3	0.029
Casp7	caspase 7	0.029	Mouse
Pfn2	profilin 2	0.029
Il1b	interleukin 1 beta	0.028
Nphs2	nephrosis 2 homolog, podocin (human)	0.028
Pdcd6ip	programmed cell death 6 interacting protein	0.028
Coro1b	coronin, actin binding protein 1B	0.028
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.026
Casp3	caspase 3	0.026	Mouse
Ap1b1	adaptor protein complex AP-1, beta 1 subunit	0.025
Ctsd	cathepsin D	0.025
Gja1	gap junction protein, alpha 1	0.024
Dtna	dystrobrevin alpha	0.023
Eya2	eyes absent 2 homolog (Drosophila)	0.022
Fgl2	fibrinogen-like protein 2	0.022
Spnb3	spectrin beta 3	0.022
Mlkl	mixed lineage kinase domain-like	0.022
Tgfbr1	transforming growth factor, beta receptor I	0.022
Rnf31	ring finger protein 31	0.021
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.021
Il4ra	interleukin 4 receptor, alpha	0.021
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.020
Tubb4	tubulin, beta 4	0.020
Clstn1	calsyntenin 1	0.018
Prnp	prion protein	0.018
Atp5b	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	0.018
Ids	iduronate 2-sulfatase	0.018
Hr	hairless	0.018
Triobp	TRIO and F-actin binding protein	0.017
Cd14	CD14 antigen	0.017
Abcc8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.017
Ptprn	protein tyrosine phosphatase, receptor type, N	0.017
Rit2	Ras-like without CAAX 2	0.017
Vwa5a	von Willebrand factor A domain containing 5A	0.016
Ap2s1	adaptor-related protein complex 2, sigma 1 subunit	0.016
Pcsk1	proprotein convertase subtilisin/kexin type 1	0.015
Plscr1	phospholipid scramblase 1	0.015
Mapk8ip3	mitogen-activated protein kinase 8 interacting protein 3	0.015
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.015
Fth1	ferritin heavy chain 1	0.015
Park2	Parkinson disease (autosomal recessive, juvenile) 2, parkin	0.015
Il1r1	interleukin 1 receptor, type I	0.015
Tnf	tumor necrosis factor	0.014
Map2k4	mitogen-activated protein kinase kinase 4	0.014
Cflar	CASP8 and FADD-like apoptosis regulator	0.014
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.014
Spnb2	spectrin beta 2	0.014
Flii	flightless I homolog (Drosophila)	0.014
Stac2	SH3 and cysteine rich domain 2	0.014
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.014
Ahr	aryl-hydrocarbon receptor	0.014
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.013
Nucks1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.013
Prr13	proline rich 13	0.013
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.013
Syn2	synapsin II	0.013
Cntnap1	contactin associated protein-like 1	0.013
Ap2m1	adaptor protein complex AP-2, mu1	0.013	Worm
Hap1	huntingtin-associated protein 1	0.013
Rab3b	RAB3B, member RAS oncogene family	0.012
Naip5	NLR family, apoptosis inhibitory protein 5	0.012	Mouse
Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	0.012
Col19a1	collagen, type XIX, alpha 1	0.012
Ttc7	tetratricopeptide repeat domain 7	0.012
Gpr37l1	G protein-coupled receptor 37-like 1	0.011
Qk	quaking	0.011
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.011
Syt1	synaptotagmin I	0.011	Worm
Psd	pleckstrin and Sec7 domain containing	0.011
2210415F13Rik	RIKEN cDNA 2210415F13 gene	0.011
Foxp3	forkhead box P3	0.011
Adrbk1	adrenergic receptor kinase, beta 1	0.011
Grb2	growth factor receptor bound protein 2	0.011
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.011
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.011
Snx13	sorting nexin 13	0.010
Gnao1	guanine nucleotide binding protein, alpha O	0.010
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.010
Klf5	Kruppel-like factor 5	0.010
Dpp6	dipeptidylpeptidase 6	0.010
Ppp2r2b	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform	0.010
Cd86	CD86 antigen	0.010
Ticam1	toll-like receptor adaptor molecule 1	0.010
Amph	amphiphysin	0.010
Xiap	X-linked inhibitor of apoptosis	0.010	Mouse