Mus musculus

31 known processes

Ikbke

inhibitor of kappaB kinase epsilon

(Aliases: IKK-i,IKKepsilon,Ikki,AW558201)

Ikbke biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
small gtpase mediated signal transduction GO:0007264 97 0.203
ras protein signal transduction GO:0007265 77 0.203
rho protein signal transduction GO:0007266 32 0.172
immune response regulating signaling pathway GO:0002764 125 0.166
glycosyl compound metabolic process GO:1901657 246 0.165
regulation of innate immune response GO:0045088 91 0.157
Mouse
protein catabolic process GO:0030163 221 0.151
positive regulation of hydrolase activity GO:0051345 148 0.137
Fly
purine ribonucleoside metabolic process GO:0046128 241 0.127
defense response to other organism GO:0098542 197 0.125
Mouse
glycosyl compound catabolic process GO:1901658 206 0.122
positive regulation of programmed cell death GO:0043068 218 0.120
Fly
guanosine containing compound metabolic process GO:1901068 144 0.120
ribose phosphate metabolic process GO:0019693 291 0.119
regulation of rho gtpase activity GO:0032319 58 0.119
cytokine production GO:0001816 319 0.119
Mouse
purine containing compound catabolic process GO:0072523 213 0.119
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.118
ribonucleoside metabolic process GO:0009119 245 0.116
heterocycle catabolic process GO:0046700 280 0.115
regulation of cytokine production GO:0001817 266 0.113
Mouse
positive regulation of nucleotide catabolic process GO:0030813 88 0.109
nucleoside catabolic process GO:0009164 206 0.108
immune effector process GO:0002252 321 0.106
nucleoside triphosphate metabolic process GO:0009141 230 0.105
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.103
positive regulation of cellular amine metabolic process GO:0033240 5 0.100
nucleoside metabolic process GO:0009116 246 0.100
carbohydrate derivative catabolic process GO:1901136 231 0.097
extrinsic apoptotic signaling pathway GO:0097191 126 0.097
activation of immune response GO:0002253 138 0.097
Mouse
purine containing compound metabolic process GO:0072521 311 0.092
nucleoside phosphate catabolic process GO:1901292 222 0.091
positive regulation of cellular catabolic process GO:0031331 148 0.090
gland development GO:0048732 330 0.090
Mouse
organic cyclic compound catabolic process GO:1901361 295 0.089
regulation of cellular catabolic process GO:0031329 242 0.088
regulation of hydrolase activity GO:0051336 246 0.088
Fly
purine nucleotide catabolic process GO:0006195 211 0.083
purine ribonucleotide catabolic process GO:0009154 208 0.081
ribonucleoside triphosphate metabolic process GO:0009199 220 0.080
purine nucleoside metabolic process GO:0042278 241 0.079
activation of innate immune response GO:0002218 56 0.078
Mouse
negative regulation of cytokine production GO:0001818 84 0.076
protein ubiquitination GO:0016567 171 0.075
nucleotide metabolic process GO:0009117 332 0.073
macromolecule catabolic process GO:0009057 281 0.073
innate immune response GO:0045087 157 0.072
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.072
lymphocyte differentiation GO:0030098 242 0.071
cellular response to lipopolysaccharide GO:0071222 77 0.070
regulation of gtp catabolic process GO:0033124 113 0.070
gtp catabolic process GO:0006184 143 0.069
purine nucleoside catabolic process GO:0006152 205 0.067
purine nucleoside triphosphate catabolic process GO:0009146 203 0.066
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.066
ribonucleotide metabolic process GO:0009259 291 0.065
purine nucleotide metabolic process GO:0006163 302 0.065
organonitrogen compound catabolic process GO:1901565 264 0.065
response to molecule of bacterial origin GO:0002237 143 0.064
regulation of cell activation GO:0050865 289 0.064
protein modification by small protein conjugation or removal GO:0070647 207 0.064
nucleotide catabolic process GO:0009166 217 0.063
aromatic compound catabolic process GO:0019439 286 0.062
purine nucleoside triphosphate metabolic process GO:0009144 226 0.062
mapk cascade GO:0000165 281 0.061
nucleobase containing small molecule metabolic process GO:0055086 352 0.060
ribonucleoside triphosphate catabolic process GO:0009203 199 0.059
cellular response to cytokine stimulus GO:0071345 189 0.059
reactive oxygen species metabolic process GO:0072593 84 0.059
guanosine containing compound catabolic process GO:1901069 144 0.059
cellular response to molecule of bacterial origin GO:0071219 83 0.059
positive regulation of innate immune response GO:0045089 80 0.058
Mouse
lymphocyte activation involved in immune response GO:0002285 93 0.057
regulation of ras protein signal transduction GO:0046578 114 0.056
pattern recognition receptor signaling pathway GO:0002221 47 0.054
muscle tissue development GO:0060537 308 0.053
positive regulation of rho gtpase activity GO:0032321 41 0.053
regulation of nucleotide catabolic process GO:0030811 122 0.052
response to lipopolysaccharide GO:0032496 128 0.051
positive regulation of gtpase activity GO:0043547 85 0.049
defense response to virus GO:0051607 68 0.049
cell activation involved in immune response GO:0002263 126 0.049
regulation of cellular component biogenesis GO:0044087 181 0.049
transmembrane transport GO:0055085 412 0.048
Mouse
positive regulation of nucleotide metabolic process GO:0045981 114 0.048
interspecies interaction between organisms GO:0044419 83 0.048
ion transmembrane transport GO:0034220 361 0.048
Mouse
amine metabolic process GO:0009308 45 0.047
ribonucleoside catabolic process GO:0042454 206 0.047
regulation of secretion GO:0051046 274 0.046
t cell activation GO:0042110 289 0.046
membrane organization GO:0061024 245 0.045
negative regulation of protein metabolic process GO:0051248 282 0.045
regulation of establishment of protein localization GO:0070201 181 0.045
regulation of cell adhesion GO:0030155 154 0.044
purine ribonucleotide metabolic process GO:0009150 290 0.044
nucleoside triphosphate catabolic process GO:0009143 205 0.044
protein localization to organelle GO:0033365 185 0.044
gtp metabolic process GO:0046039 144 0.043
purine ribonucleoside catabolic process GO:0046130 205 0.043
cell adhesion GO:0007155 329 0.042
cellular response to dna damage stimulus GO:0006974 207 0.042
Human
regulation of purine nucleotide catabolic process GO:0033121 122 0.042
regulation of defense response GO:0031347 233 0.042
Mouse
cellular protein complex assembly GO:0043623 116 0.041
positive regulation of defense response GO:0031349 124 0.041
Mouse
apoptotic signaling pathway GO:0097190 306 0.041
Human
cytokine biosynthetic process GO:0042089 68 0.041
Mouse
regulation of inflammatory response GO:0050727 147 0.041
regulation of mapk cascade GO:0043408 248 0.041
positive regulation of nucleoside metabolic process GO:0045979 91 0.041
regulation of transferase activity GO:0051338 263 0.041
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.040
regulation of ras gtpase activity GO:0032318 88 0.040
posttranscriptional regulation of gene expression GO:0010608 155 0.040
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.040
immune response activating signal transduction GO:0002757 116 0.040
regulation of cellular amine metabolic process GO:0033238 20 0.039
protein polymerization GO:0051258 57 0.039
positive regulation of protein phosphorylation GO:0001934 242 0.038
regulation of leukocyte proliferation GO:0070663 121 0.038
reactive oxygen species biosynthetic process GO:1903409 8 0.038
cellular amine metabolic process GO:0044106 44 0.038
leukocyte proliferation GO:0070661 172 0.038
Mouse
organophosphate catabolic process GO:0046434 232 0.038
regulation of cell motility GO:2000145 236 0.038
actin filament polymerization GO:0030041 44 0.038
regulation of protein catabolic process GO:0042176 108 0.037
dna metabolic process GO:0006259 303 0.037
regulation of rho protein signal transduction GO:0035023 71 0.037
cellular macromolecule catabolic process GO:0044265 206 0.037
cell type specific apoptotic process GO:0097285 268 0.036
protein localization to nucleus GO:0034504 121 0.036
type i interferon production GO:0032606 29 0.036
Mouse
negative regulation of molecular function GO:0044092 258 0.036
modification dependent macromolecule catabolic process GO:0043632 133 0.036
regulation of cellular amino acid metabolic process GO:0006521 5 0.036
protein modification by small protein conjugation GO:0032446 187 0.035
cellular nitrogen compound catabolic process GO:0044270 280 0.035
positive regulation of gtp catabolic process GO:0033126 85 0.035
positive regulation of type i interferon production GO:0032481 14 0.035
Mouse
nucleocytoplasmic transport GO:0006913 139 0.035
regulation of lymphocyte activation GO:0051249 240 0.035
positive regulation of apoptotic process GO:0043065 217 0.035
Fly
production of molecular mediator of immune response GO:0002440 103 0.035
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.035
response to organic cyclic compound GO:0014070 198 0.035
regulation of proteolysis GO:0030162 164 0.034
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
inorganic ion transmembrane transport GO:0098660 234 0.033
molting cycle GO:0042303 90 0.033
regulation of protein transport GO:0051223 163 0.033
negative regulation of cellular protein metabolic process GO:0032269 247 0.033
muscle cell differentiation GO:0042692 261 0.033
response to organonitrogen compound GO:0010243 246 0.033
negative regulation of phosphate metabolic process GO:0045936 184 0.032
erk1 and erk2 cascade GO:0070371 77 0.032
ribonucleotide catabolic process GO:0009261 208 0.032
cellular amino acid metabolic process GO:0006520 103 0.032
positive regulation of kinase activity GO:0033674 155 0.032
negative regulation of phosphorus metabolic process GO:0010563 184 0.032
regulation of nucleoside metabolic process GO:0009118 130 0.031
regulation of cytokine biosynthetic process GO:0042035 59 0.031
Mouse
peptidyl amino acid modification GO:0018193 336 0.031
Fly
positive regulation of cell death GO:0010942 224 0.031
Fly
positive regulation of transferase activity GO:0051347 167 0.031
myeloid cell differentiation GO:0030099 233 0.031
Mouse
regulation of cell migration GO:0030334 219 0.031
regulation of reactive oxygen species metabolic process GO:2000377 40 0.031
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.031
cellular protein catabolic process GO:0044257 155 0.031
extracellular structure organization GO:0043062 148 0.030
defense response to bacterium GO:0042742 119 0.030
Mouse
regulation of response to biotic stimulus GO:0002831 38 0.030
cellular homeostasis GO:0019725 240 0.030
peptide metabolic process GO:0006518 46 0.030
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.030
positive regulation of cellular component biogenesis GO:0044089 94 0.030
negative regulation of cellular component organization GO:0051129 194 0.030
positive regulation of ras gtpase activity GO:0032320 65 0.030
immunoglobulin production GO:0002377 73 0.029
regulation of type i interferon mediated signaling pathway GO:0060338 7 0.029
regulation of apoptotic signaling pathway GO:2001233 197 0.029
protein targeting GO:0006605 143 0.029
skin development GO:0043588 220 0.029
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.028
dna recombination GO:0006310 92 0.028
b cell activation involved in immune response GO:0002312 50 0.028
regulation of protein complex assembly GO:0043254 83 0.028
cellular response to growth factor stimulus GO:0071363 197 0.028
single organism cell adhesion GO:0098602 156 0.028
negative regulation of phosphorylation GO:0042326 166 0.028
cellular response to lipid GO:0071396 145 0.028
regulation of body fluid levels GO:0050878 162 0.027
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.027
modification dependent protein catabolic process GO:0019941 133 0.027
regulation of protein localization GO:0032880 231 0.027
regulation of purine nucleotide metabolic process GO:1900542 169 0.027
regulation of kinase activity GO:0043549 249 0.027
lymphocyte proliferation GO:0046651 164 0.026
Mouse
endocytosis GO:0006897 168 0.026
regulation of lymphocyte proliferation GO:0050670 117 0.026
regulation of anatomical structure size GO:0090066 178 0.026
lipid localization GO:0010876 126 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.025
positive regulation of interferon alpha production GO:0032727 4 0.025
regulation of cell cycle GO:0051726 281 0.025
epidermis development GO:0008544 187 0.025
homeostasis of number of cells GO:0048872 210 0.025
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.025
cellular response to biotic stimulus GO:0071216 92 0.025
marginal zone b cell differentiation GO:0002315 2 0.025
alpha beta t cell differentiation GO:0046632 69 0.025
response to radiation GO:0009314 165 0.025
cation transport GO:0006812 399 0.024
Mouse
ear development GO:0043583 200 0.024
leukocyte cell cell adhesion GO:0007159 14 0.024
regulation of myd88 independent toll like receptor signaling pathway GO:0034127 1 0.024
leukocyte activation involved in immune response GO:0002366 126 0.024
skeletal system development GO:0001501 356 0.024
negative regulation of cell proliferation GO:0008285 296 0.023
lymphocyte apoptotic process GO:0070227 54 0.023
i kappab kinase nf kappab signaling GO:0007249 85 0.023
anion transport GO:0006820 177 0.023
organelle assembly GO:0070925 177 0.023
positive regulation of cell activation GO:0050867 158 0.023
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.023
positive regulation of leukocyte proliferation GO:0070665 73 0.023
cation homeostasis GO:0055080 212 0.023
gliogenesis GO:0042063 141 0.023
t cell activation involved in immune response GO:0002286 43 0.022
innate immune response activating signal transduction GO:0002758 50 0.022
interleukin 1 mediated signaling pathway GO:0070498 4 0.022
negative regulation of nervous system development GO:0051961 156 0.022
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.022
actin cytoskeleton organization GO:0030036 220 0.022
Fly
regulation of ion transport GO:0043269 215 0.022
Mouse
toxin transport GO:1901998 38 0.021
response to inorganic substance GO:0010035 96 0.021
toll like receptor signaling pathway GO:0002224 38 0.021
inflammatory response GO:0006954 244 0.021
inorganic cation transmembrane transport GO:0098662 207 0.021
multicellular organismal homeostasis GO:0048871 164 0.021
Fly
protein import GO:0017038 101 0.021
neuron death GO:0070997 154 0.021
regulation of leukocyte differentiation GO:1902105 159 0.021
positive regulation of protein modification process GO:0031401 299 0.021
protein import into nucleus GO:0006606 95 0.021
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.020
positive regulation of lymphocyte activation GO:0051251 140 0.020
b cell apoptotic process GO:0001783 19 0.020
wound healing GO:0042060 157 0.020
organonitrogen compound biosynthetic process GO:1901566 192 0.020
cellular response to organic cyclic compound GO:0071407 87 0.020
leukocyte mediated immunity GO:0002443 174 0.020
regulation of nucleotide metabolic process GO:0006140 169 0.020
cation transmembrane transport GO:0098655 266 0.020
Mouse
negative regulation of immune system process GO:0002683 209 0.019
regulation of interleukin 6 production GO:0032675 55 0.019
protein maturation GO:0051604 176 0.019
nuclear transport GO:0051169 139 0.019
ossification GO:0001503 216 0.019
hair follicle development GO:0001942 85 0.019
embryonic organ morphogenesis GO:0048562 276 0.019
regulation of erk1 and erk2 cascade GO:0070372 71 0.019
epithelial cell development GO:0002064 159 0.019
regulation of organ morphogenesis GO:2000027 144 0.019
jnk cascade GO:0007254 72 0.019
alpha beta t cell activation involved in immune response GO:0002287 31 0.018
activation of rac gtpase activity GO:0032863 2 0.018
interleukin 8 production GO:0032637 4 0.018
protein processing GO:0016485 163 0.018
regulation of actin filament polymerization GO:0030833 38 0.018
positive regulation of cytokine production GO:0001819 174 0.018
Mouse
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.018
positive regulation of apoptotic signaling pathway GO:2001235 95 0.018
establishment of protein localization to organelle GO:0072594 118 0.018
organic hydroxy compound metabolic process GO:1901615 203 0.018
negative regulation of intracellular signal transduction GO:1902532 167 0.018
cytokine production involved in inflammatory response GO:0002534 9 0.018
modification by symbiont of host morphology or physiology GO:0044003 4 0.018
epithelial cell proliferation GO:0050673 174 0.018
Mouse
regulation of nucleocytoplasmic transport GO:0046822 73 0.017
regulation of cd8 positive alpha beta t cell proliferation GO:2000564 1 0.017
regulation of protein processing GO:0070613 96 0.017
compound eye development GO:0048749 1 0.017
response to tumor necrosis factor GO:0034612 26 0.017
anatomical structure homeostasis GO:0060249 145 0.017
Fly
negative regulation of multi organism process GO:0043901 68 0.017
regulation of protein serine threonine kinase activity GO:0071900 157 0.017
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.017
oogenesis GO:0048477 56 0.017
intracellular protein transport GO:0006886 204 0.017
regulation of hormone levels GO:0010817 211 0.017
regulation of cellular component size GO:0032535 121 0.017
positive regulation of protein transport GO:0051222 93 0.017
heart process GO:0003015 94 0.017
positive regulation of cell development GO:0010720 237 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.017
stem cell differentiation GO:0048863 268 0.017
female gamete generation GO:0007292 74 0.017
nuclear import GO:0051170 95 0.017
positive regulation of cytokine biosynthetic process GO:0042108 40 0.017
Mouse
spermatogenesis GO:0007283 284 0.017
rna interference GO:0016246 2 0.017
regulation of protein kinase activity GO:0045859 232 0.017
regulation of multi organism process GO:0043900 111 0.017
regulation of cellular ketone metabolic process GO:0010565 66 0.017
stem cell development GO:0048864 219 0.016
interferon beta biosynthetic process GO:0045350 4 0.016
Mouse
ubiquitin dependent protein catabolic process GO:0006511 129 0.016
protein secretion GO:0009306 111 0.016
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.016
organic anion transport GO:0015711 137 0.016
positive regulation of cell projection organization GO:0031346 95 0.016
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.016
circulatory system process GO:0003013 197 0.016
sensory perception of mechanical stimulus GO:0050954 107 0.016
negative regulation of apoptotic signaling pathway GO:2001234 104 0.016
wnt signaling pathway GO:0016055 188 0.016
leukocyte differentiation GO:0002521 342 0.016
Mouse
vacuole organization GO:0007033 38 0.016
positive regulation of jnk cascade GO:0046330 46 0.016
g protein coupled receptor signaling pathway GO:0007186 243 0.016
negative regulation of cellular amine metabolic process GO:0033239 1 0.016
myeloid leukocyte differentiation GO:0002573 119 0.016
Mouse
myeloid leukocyte activation GO:0002274 83 0.016
bone remodeling GO:0046849 53 0.016
cellular ketone metabolic process GO:0042180 84 0.015
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.015
leukocyte migration GO:0050900 124 0.015
lateral inhibition GO:0046331 1 0.015
regulation of protein targeting GO:1903533 61 0.015
regulation of organelle organization GO:0033043 289 0.015
Fly
amide transport GO:0042886 138 0.015
blood circulation GO:0008015 195 0.015
oocyte axis specification GO:0007309 2 0.015
sensory perception GO:0007600 245 0.015
positive regulation of mapk cascade GO:0043410 170 0.015
regulation of translation GO:0006417 71 0.015
microtubule cytoskeleton organization GO:0000226 157 0.015
Fly
regulation of interferon beta biosynthetic process GO:0045357 4 0.015
Mouse
cellular response to tumor necrosis factor GO:0071356 21 0.015
positive regulation of proteolysis GO:0045862 85 0.015
Fly
adult behavior GO:0030534 135 0.015
regulation of cell projection assembly GO:0060491 38 0.015
nitrogen compound transport GO:0071705 271 0.015
response to oxygen levels GO:0070482 62 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.015
mesodermal cell migration GO:0008078 4 0.015
cytokine mediated signaling pathway GO:0019221 115 0.015
protein localization to membrane GO:0072657 108 0.015
steroid metabolic process GO:0008202 119 0.015
engulfment of apoptotic cell GO:0043652 3 0.014
forebrain development GO:0030900 302 0.014
regulation of protein maturation GO:1903317 96 0.014
regulation of map kinase activity GO:0043405 120 0.014
regulation of lymphocyte differentiation GO:0045619 107 0.014
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.014
cellular metal ion homeostasis GO:0006875 151 0.014
memory GO:0007613 58 0.014
regulation of actin filament based process GO:0032970 99 0.014
membrane tubulation GO:0097320 4 0.014
synaptic transmission GO:0007268 329 0.014
regulation of defense response to virus by host GO:0050691 8 0.014
fat cell differentiation GO:0045444 160 0.014
positive regulation of antimicrobial peptide production GO:0002225 1 0.014
sensory organ morphogenesis GO:0090596 242 0.014
positive regulation of organelle organization GO:0010638 128 0.014
regulation of alpha beta t cell differentiation GO:0046637 35 0.014
maintenance of location GO:0051235 89 0.014
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.014
positive regulation of lymphocyte proliferation GO:0050671 70 0.014
dendritic spine maintenance GO:0097062 4 0.014
organelle localization GO:0051640 179 0.014
neuron apoptotic process GO:0051402 142 0.014
regulation of protein ubiquitination GO:0031396 52 0.014
male gamete generation GO:0048232 285 0.014
t cell proliferation GO:0042098 120 0.013
regulation of response to wounding GO:1903034 189 0.013
mesenchymal cell development GO:0014031 93 0.013
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.013
regulation of neuron differentiation GO:0045664 281 0.013
negative regulation of protein modification process GO:0031400 163 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.013
regulation of antimicrobial humoral response GO:0002759 3 0.013
response to decreased oxygen levels GO:0036293 59 0.013
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.013
cellular chemical homeostasis GO:0055082 215 0.013
t helper 2 cell differentiation GO:0045064 12 0.013
positive regulation of protein catabolic process GO:0045732 60 0.013
negative regulation of proteolysis GO:0045861 74 0.013
t cell differentiation in thymus GO:0033077 77 0.013
negative regulation of protein modification by small protein conjugation or removal GO:1903321 20 0.013
leukocyte apoptotic process GO:0071887 71 0.013
regulation of antimicrobial peptide production GO:0002784 1 0.013
regulation of t cell proliferation GO:0042129 92 0.013
positive regulation of t cell activation GO:0050870 101 0.013
cytoplasmic transport GO:0016482 234 0.013
antimicrobial peptide biosynthetic process GO:0002777 2 0.013
homotypic cell cell adhesion GO:0034109 28 0.013
positive regulation of phospholipase activity GO:0010518 3 0.013
myotube differentiation GO:0014902 105 0.013
regulation of cellular response to stress GO:0080135 159 0.013
regulation of actin filament length GO:0030832 45 0.013
myeloid dendritic cell differentiation GO:0043011 16 0.013
ear morphogenesis GO:0042471 118 0.013
regulation of neuron death GO:1901214 134 0.013
response to light stimulus GO:0009416 135 0.012
regulation of cd8 positive alpha beta t cell activation GO:2001185 3 0.012
cellular response to nitric oxide GO:0071732 4 0.012
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.012
single organism nuclear import GO:1902593 95 0.012
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.012
programmed necrotic cell death GO:0097300 28 0.012
natural killer cell proliferation GO:0001787 3 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.012
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
regulation of actin cytoskeleton organization GO:0032956 84 0.012
morphogenesis of a polarized epithelium GO:0001738 37 0.012
regulation of cell killing GO:0031341 40 0.012
positive regulation of secretion GO:0051047 130 0.012
camera type eye development GO:0043010 266 0.012
regulation of system process GO:0044057 200 0.012
positive regulation of antimicrobial humoral response GO:0002760 2 0.012
regulation of intracellular protein transport GO:0033157 82 0.012
oocyte construction GO:0007308 2 0.012
actin polymerization or depolymerization GO:0008154 54 0.012
regulation of intracellular transport GO:0032386 159 0.012
regulation of interferon gamma production GO:0032649 57 0.012
negative regulation of defense response GO:0031348 77 0.012
regulation of cell cycle process GO:0010564 160 0.012
positive regulation of cell motility GO:2000147 116 0.012
regulation of cell growth GO:0001558 91 0.012
tissue remodeling GO:0048771 102 0.011
oxidation reduction process GO:0055114 342 0.011
negative regulation of cell development GO:0010721 169 0.011
protein polyubiquitination GO:0000209 33 0.011
cell fate commitment GO:0045165 210 0.011
regulation of cell projection organization GO:0031344 206 0.011
heart contraction GO:0060047 93 0.011
negative regulation of leukocyte differentiation GO:1902106 51 0.011
stress activated protein kinase signaling cascade GO:0031098 81 0.011
organelle fission GO:0048285 170 0.011
response to growth factor GO:0070848 198 0.011
regulation of membrane potential GO:0042391 192 0.011
citrate metabolic process GO:0006101 3 0.011
retina development in camera type eye GO:0060041 119 0.011
positive regulation of cell adhesion GO:0045785 80 0.011
protein autophosphorylation GO:0046777 61 0.011
Fly
dephosphorylation GO:0016311 129 0.011
regionalization GO:0003002 337 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.011
organic acid transport GO:0015849 101 0.011
inner ear morphogenesis GO:0042472 101 0.011
regulation of defense response to fungus GO:1900150 1 0.011
endomembrane system organization GO:0010256 147 0.011
syncytium formation GO:0006949 43 0.011
regulation of myd88 dependent toll like receptor signaling pathway GO:0034124 2 0.011
protein kinase b signaling GO:0043491 74 0.011
single organismal cell cell adhesion GO:0016337 131 0.011
regulation of peptidase activity GO:0052547 96 0.011
Fly
cellular amide metabolic process GO:0043603 58 0.011
regulation of interleukin 8 production GO:0032677 3 0.011
regulation of cell shape GO:0008360 39 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.011
Fly
response to peptide GO:1901652 136 0.011
cell adhesion mediated by integrin GO:0033627 18 0.011
apical constriction GO:0003383 4 0.011
regulation of cellular protein catabolic process GO:1903362 61 0.011
defense response to protozoan GO:0042832 25 0.011
antimicrobial peptide production GO:0002775 2 0.011
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.011
t cell differentiation involved in immune response GO:0002292 30 0.010
cellularization GO:0007349 1 0.010
amino acid transport GO:0006865 61 0.010

Ikbke disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 0 0.105
disease of anatomical entity DOID:7 0 0.105
musculoskeletal system disease DOID:17 0 0.105
connective tissue disease DOID:65 0 0.105
immune system disease DOID:2914 0 0.060
bone remodeling disease DOID:0080005 0 0.020
osteopetrosis DOID:13533 0 0.020
osteosclerosis DOID:4254 0 0.020
nervous system disease DOID:863 0 0.020
disease of metabolism DOID:0014667 0 0.019
disease of cellular proliferation DOID:14566 0 0.017
cancer DOID:162 0 0.017
primary immunodeficiency disease DOID:612 0 0.014
organ system cancer DOID:0050686 0 0.012
gastrointestinal system cancer DOID:3119 0 0.011