IMP
Process View
marginal zone b cell differentiation
The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "marginal zone b cell differentiation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 1.000 | ||
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 1.000 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 1.000 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 1.000 | ||
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.677 | Mouse | |
| Tnip1 | TNFAIP3 interacting protein 1 | 0.604 | ||
| Bcar1 | breast cancer anti-estrogen resistance 1 | 0.597 | ||
| Bcl3 | B-cell leukemia/lymphoma 3 | 0.529 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.513 | ||
| Tnf | tumor necrosis factor | 0.402 | ||
| Junb | Jun-B oncogene | 0.391 | ||
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.375 | ||
| Cyld | cylindromatosis (turban tumor syndrome) | 0.355 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.330 | ||
| Pxn | paxillin | 0.271 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.219 | ||
| Src | Rous sarcoma oncogene | 0.215 | ||
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.190 | ||
| Bcl6 | B-cell leukemia/lymphoma 6 | 0.167 | ||
| Icam1 | intercellular adhesion molecule 1 | 0.139 | ||
| Zfp36 | zinc finger protein 36 | 0.131 | ||
| Socs3 | suppressor of cytokine signaling 3 | 0.125 | ||
| Prkcd | protein kinase C, delta | 0.123 | ||
| Nfkbiz | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.121 | ||
| 2010106G01Rik | RIKEN cDNA 2010106G01 gene | 0.110 | ||
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.080 | ||
| Fyn | Fyn proto-oncogene | 0.072 | ||
| Asap1 | ArfGAP with SH# domain, ankyrin repeat and PH domain1 | 0.061 | ||
| Vav1 | vav 1 oncogene | 0.059 | ||
| Supv3l1 | suppressor of var1, 3-like 1 (S. cerevisiae) | 0.056 | ||
| Nfkbie | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.056 | Mouse | |
| Birc3 | baculoviral IAP repeat-containing 3 | 0.049 | ||
| Mvp | major vault protein | 0.048 | ||
| Il2rg | interleukin 2 receptor, gamma chain | 0.044 | ||
| Tap2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 0.040 | ||
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.034 | ||
| Rnf19b | ring finger protein 19B | 0.034 | ||
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.034 | ||
| Irf1 | interferon regulatory factor 1 | 0.033 | ||
| Plcg2 | phospholipase C, gamma 2 | 0.031 | ||
| Il4ra | interleukin 4 receptor, alpha | 0.030 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.029 | ||
| Ptpn1 | protein tyrosine phosphatase, non-receptor type 1 | 0.027 | ||
| Pten | phosphatase and tensin homolog | 0.025 | ||
| Ikbke | inhibitor of kappaB kinase epsilon | 0.025 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.023 | ||
| Ltb | lymphotoxin B | 0.022 | ||
| Blnk | B-cell linker | 0.020 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.020 | ||
| Grb2 | growth factor receptor bound protein 2 | 0.020 | ||
| Igh | immunoglobulin heavy chain complex | 0.019 | ||
| Ubc | ubiquitin C | 0.018 | ||
| Prkce | protein kinase C, epsilon | 0.018 | ||
| Dok1 | docking protein 1 | 0.018 | ||
| Cd40 | CD40 antigen | 0.018 | ||
| Pim1 | proviral integration site 1 | 0.017 | ||
| Mcl1 | myeloid cell leukemia sequence 1 | 0.017 | ||
| Lcn2 | lipocalin 2 | 0.016 | ||
| Arid5a | AT rich interactive domain 5A (MRF1-like) | 0.016 | ||
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.016 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.016 | ||
| Abl1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.015 | ||
| Maff | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) | 0.015 | ||
| Sbno2 | strawberry notch homolog 2 (Drosophila) | 0.014 | ||
| Jak3 | Janus kinase 3 | 0.014 | ||
| Zc3h12a | zinc finger CCCH type containing 12A | 0.013 | ||
| Tcirg1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | 0.013 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.012 | ||
| Stk4 | serine/threonine kinase 4 | 0.012 | ||
| Traf3ip2 | TRAF3 interacting protein 2 | 0.012 | ||
| Runx1 | runt related transcription factor 1 | 0.012 | ||
| Csrnp1 | cysteine-serine-rich nuclear protein 1 | 0.011 | ||
| Efhd2 | EF hand domain containing 2 | 0.011 | ||
| Il17ra | interleukin 17 receptor A | 0.011 | ||
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.011 | ||
| Sykb | spleen tyrosine kinase | 0.011 | ||
| Traf6 | TNF receptor-associated factor 6 | 0.011 | ||
| Coro1a | coronin, actin binding protein 1A | 0.010 | ||
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.010 | ||
| Cebpd | CCAAT/enhancer binding protein (C/EBP), delta | 0.010 | ||
| Shisa5 | shisa homolog 5 (Xenopus laevis) | 0.010 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.010 |