IMP

Process View

Mus musculus

20 genes annotated in mouse

negative regulation of protein modification by small protein conjugation or removal

GO:1903321

Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein modification by small protein conjugation or removal"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein modification by small protein conjugation or removal" (in gray)

Name	Description	Probability	Func Analog Organism
Cry2	cryptochrome 2 (photolyase-like)	0.972	Mouse
Clock	circadian locomotor output cycles kaput	0.710
Per2	period homolog 2 (Drosophila)	0.693
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.686
Psen1	presenilin 1	0.385
Ncoa3	nuclear receptor coactivator 3	0.381
Iigp1	interferon inducible GTPase 1	0.251
Skil	SKI-like	0.165
Trp53	transformation related protein 53	0.164
Gbp3	guanylate binding protein 3	0.155	Mouse
Arrb1	arrestin, beta 1	0.155	Human
Gli3	GLI-Kruppel family member GLI3	0.149
Cry1	cryptochrome 1 (photolyase-like)	0.146
Rpgrip1l	Rpgrip1-like	0.133
Shh	sonic hedgehog	0.125	Fly
Axin1	axin 1	0.122
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.120
Usp18	ubiquitin specific peptidase 18	0.108
Lrrk2	leucine-rich repeat kinase 2	0.106
Iqcb1	IQ calmodulin-binding motif containing 1	0.104
Notch1	Notch gene homolog 1 (Drosophila)	0.087
Gdnf	glial cell line derived neurotrophic factor	0.086
Pycard	PYD and CARD domain containing	0.086
Irf9	interferon regulatory factor 9	0.084
Gbp7	guanylate binding protein 7	0.074	Mouse
Hspa8	heat shock protein 8	0.070
Per1	period homolog 1 (Drosophila)	0.059	Mouse
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.058
Hsph1	heat shock 105kDa/110kDa protein 1	0.057
Arrb2	arrestin, beta 2	0.055	Human
Ptrf	polymerase I and transcript release factor	0.054
Stat1	signal transducer and activator of transcription 1	0.054
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.053
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.052
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.051
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.049
Ncstn	nicastrin	0.049
Notch2	Notch gene homolog 2 (Drosophila)	0.047
ND6	NADH dehydrogenase subunit 6	0.045
Wnt3a	wingless-related MMTV integration site 3A	0.045	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.044	Human
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.044
Ifih1	interferon induced with helicase C domain 1	0.043
T	brachyury	0.042
Sox9	SRY-box containing gene 9	0.041
Usp2	ubiquitin specific peptidase 2	0.039
Parp9	poly (ADP-ribose) polymerase family, member 9	0.039
Fgfr2	fibroblast growth factor receptor 2	0.039
Irgm2	immunity-related GTPase family M member 2	0.038
Src	Rous sarcoma oncogene	0.037
Igtp	interferon gamma induced GTPase	0.037
Ifi47	interferon gamma inducible protein 47	0.037
Zfp651	zinc finger protein 651	0.036
Cdk2	cyclin-dependent kinase 2	0.036
Sap18	Sin3-associated polypeptide 18	0.036
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.035
Sgol2	shugoshin-like 2 (S. pombe)	0.034
Ptk2	PTK2 protein tyrosine kinase 2	0.034
Ywhaq	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.034	Yeast
Ret	ret proto-oncogene	0.033
Trim30a	tripartite motif-containing 30A	0.033
Kdm2b	lysine (K)-specific demethylase 2B	0.033
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.033
Pou3f1	POU domain, class 3, transcription factor 1	0.032
Mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.032
Trp73	transformation related protein 73	0.032
Pax8	paired box gene 8	0.032
Efnb2	ephrin B2	0.030
Ric8	resistance to inhibitors of cholinesterase 8 homolog (C. elegans)	0.029
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.029
Gbp6	guanylate binding protein 6	0.027	Mouse
Csnk1e	casein kinase 1, epsilon	0.026
Irgm1	immunity-related GTPase family M member 1	0.026
Rara	retinoic acid receptor, alpha	0.026
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.025
Atg12	autophagy-related 12 (yeast)	0.025
Col2a1	collagen, type II, alpha 1	0.025
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.025
Ptch1	patched homolog 1	0.024
Trim21	tripartite motif-containing 21	0.023	Human
Uba7	ubiquitin-like modifier activating enzyme 7	0.023
Setdb1	SET domain, bifurcated 1	0.023
Gbp2	guanylate binding protein 2	0.023	Mouse
Amh	anti-Mullerian hormone	0.022
Ccne1	cyclin E1	0.022	Fly
Trim25	tripartite motif-containing 25	0.022
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	0.022
Ifi35	interferon-induced protein 35	0.021
Wnt10b	wingless related MMTV integration site 10b	0.021	Mouse
Smad6	MAD homolog 6 (Drosophila)	0.021
Rabep1	rabaptin, RAB GTPase binding effector protein 1	0.021
Fbxl3	F-box and leucine-rich repeat protein 3	0.021
Pax2	paired box gene 2	0.020
Traf6	TNF receptor-associated factor 6	0.020
Porcn	porcupine homolog (Drosophila)	0.020
Aim2	absent in melanoma 2	0.020
Gsk3b	glycogen synthase kinase 3 beta	0.020
Casp1	caspase 1	0.020
Tbx2	T-box 2	0.019
Per3	period homolog 3 (Drosophila)	0.019	Mouse
Wnt4	wingless-related MMTV integration site 4	0.019	Mouse
Hspa1b	heat shock protein 1B	0.019
Fzd10	frizzled homolog 10 (Drosophila)	0.019
Akap8l	A kinase (PRKA) anchor protein 8-like	0.019
Nf1	neurofibromatosis 1	0.019
Mdm4	transformed mouse 3T3 cell double minute 4	0.018
Bmp4	bone morphogenetic protein 4	0.018
Stra8	stimulated by retinoic acid gene 8	0.018
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.018
Use1	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	0.018
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.017
Lhx1	LIM homeobox protein 1	0.017
Hoxd11	homeobox D11	0.017
En1	engrailed 1	0.017
Psenen	presenilin enhancer 2 homolog (C. elegans)	0.017
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.016
Ldb3	LIM domain binding 3	0.016
Mdm2	transformed mouse 3T3 cell double minute 2	0.016
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.016
Cacna1h	calcium channel, voltage-dependent, T type, alpha 1H subunit	0.016
Axin2	axin2	0.016
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.016
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.016
Cct8	chaperonin containing Tcp1, subunit 8 (theta)	0.016
Pias1	protein inhibitor of activated STAT 1	0.016
Btrc	beta-transducin repeat containing protein	0.016
Rnf111	ring finger 111	0.016
Lrp6	low density lipoprotein receptor-related protein 6	0.015
Tcap	titin-cap	0.015
Cacybp	calcyclin binding protein	0.015
Zbtb16	zinc finger and BTB domain containing 16	0.015
Dlg1	discs, large homolog 1 (Drosophila)	0.015
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.015
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.015
Dmd	dystrophin, muscular dystrophy	0.015
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.014	Yeast
Inhbb	inhibin beta-B	0.014
Zkscan3	zinc finger with KRAB and SCAN domains 3	0.014
Chmp2a	chromatin modifying protein 2A	0.014
Bmp7	bone morphogenetic protein 7	0.014
Rnf2	ring finger protein 2	0.014
Cd274	CD274 antigen	0.014
Psmd11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.013
Sox11	SRY-box containing gene 11	0.013
Rtp4	receptor transporter protein 4	0.013
Tbcb	tubulin folding cofactor B	0.013
Ulk2	Unc-51 like kinase 2 (C. elegans)	0.013
Ankrd1	ankyrin repeat domain 1 (cardiac muscle)	0.013
Wdr43	WD repeat domain 43	0.013
Zfp219	zinc finger protein 219	0.013
Psmc5	protease (prosome, macropain) 26S subunit, ATPase 5	0.013
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.013
Plau	plasminogen activator, urokinase	0.013
Ikbke	inhibitor of kappaB kinase epsilon	0.013
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.013
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.013
Sh3bp1	SH3-domain binding protein 1	0.013
Emx2	empty spiracles homolog 2 (Drosophila)	0.013
Sim2	single-minded homolog 2 (Drosophila)	0.013
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.012
Pthlh	parathyroid hormone-like peptide	0.012
Socs1	suppressor of cytokine signaling 1	0.012
Foxm1	forkhead box M1	0.012
Trp63	transformation related protein 63	0.012
Bcl2l10	Bcl2-like 10	0.012
Tgtp2	T-cell specific GTPase 2	0.012
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.012
Bad	BCL2-associated agonist of cell death	0.012
Amhr2	anti-Mullerian hormone type 2 receptor	0.012
Tnip1	TNFAIP3 interacting protein 1	0.012
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.012
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.012
Kcnk4	potassium channel, subfamily K, member 4	0.011
Usp25	ubiquitin specific peptidase 25	0.011
Mixl1	Mix1 homeobox-like 1 (Xenopus laevis)	0.011
Fzd8	frizzled homolog 8 (Drosophila)	0.011
Daxx	Fas death domain-associated protein	0.011
Gbp10	guanylate-binding protein 10	0.011	Mouse
Ihh	Indian hedgehog	0.011	Fly
Gbp9	guanylate-binding protein 9	0.011	Mouse
Irf7	interferon regulatory factor 7	0.011
Irak1	interleukin-1 receptor-associated kinase 1	0.011
Wnt5b	wingless-related MMTV integration site 5B	0.011	Mouse
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.011
Adar	adenosine deaminase, RNA-specific	0.011
Ccne2	cyclin E2	0.011	Fly
Alx4	aristaless-like homeobox 4	0.011
Dnaja1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.011	Human
Fgfr1	fibroblast growth factor receptor 1	0.011
Gli1	GLI-Kruppel family member GLI1	0.011
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.011
Erlin2	ER lipid raft associated 2	0.011
AI462493	expressed sequence AI462493	0.011
Cdx1	caudal type homeobox 1	0.011
Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (yeast)	0.011
Set	SET nuclear oncogene	0.011
Rsad2	radical S-adenosyl methionine domain containing 2	0.011
Smo	smoothened homolog (Drosophila)	0.011
Acta1	actin, alpha 1, skeletal muscle	0.010
Traf2	TNF receptor-associated factor 2	0.010
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.010
Zfp771	zinc finger protein 771	0.010
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.010
Erap1	endoplasmic reticulum aminopeptidase 1	0.010
Vstm2b	V-set and transmembrane domain containing 2B	0.010
Hmga1	high mobility group AT-hook 1	0.010
Hoxd8	homeobox D8	0.010
Fam193b	family with sequence similarity 193, member B	0.010
Zfp335	zinc finger protein 335	0.010
BC006779	cDNA sequence BC006779	0.010
Rel	reticuloendotheliosis oncogene	0.010
Vcp	valosin containing protein	0.010
Myst3	MYST histone acetyltransferase (monocytic leukemia) 3	0.010