Mus musculus

153 known processes

Pik3ca

phosphatidylinositol 3-kinase, catalytic, alpha polypeptide

(Aliases: p110,p110alpha,MGC161268,6330412C24Rik,caPI3K)

Pik3ca biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
lipid phosphorylation GO:0046834 25 1.000
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 6 1.000
phosphatidylinositol phosphorylation GO:0046854 23 1.000
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.992
cell substrate adhesion GO:0031589 130 0.988
Mouse
cellular response to nutrient levels GO:0031669 64 0.983
regulation of synaptic plasticity GO:0048167 87 0.981
cell matrix adhesion GO:0007160 68 0.980
Mouse
homeostasis of number of cells GO:0048872 210 0.969
Mouse
cell type specific apoptotic process GO:0097285 268 0.968
glycerolipid biosynthetic process GO:0045017 50 0.966
cellular response to starvation GO:0009267 57 0.965
cellular ketone metabolic process GO:0042180 84 0.961
regulation of cellular response to stress GO:0080135 159 0.951
exocytosis GO:0006887 121 0.935
intrinsic apoptotic signaling pathway GO:0097193 132 0.931
regulation of neuronal synaptic plasticity GO:0048168 30 0.930
dna metabolic process GO:0006259 303 0.930
dna alkylation GO:0006305 43 0.928
response to light stimulus GO:0009416 135 0.926
regulation of cell size GO:0008361 72 0.924
regulation of cell motility GO:2000145 236 0.923
response to peptide hormone GO:0043434 127 0.922
autophagy GO:0006914 45 0.911
apoptotic signaling pathway GO:0097190 306 0.910
associative learning GO:0008306 61 0.901
glycerolipid metabolic process GO:0046486 122 0.901
regulation of cell migration GO:0030334 219 0.901
regulation of cellular component size GO:0032535 121 0.900
lymphocyte homeostasis GO:0002260 64 0.898
Mouse
regulation of autophagy GO:0010506 30 0.896
peptidyl serine modification GO:0018209 83 0.894
synaptic transmission GO:0007268 329 0.889
regulation of transferase activity GO:0051338 263 0.884
regulation of mapk cascade GO:0043408 248 0.882
response to starvation GO:0042594 65 0.876
regulation of kinase activity GO:0043549 249 0.875
stem cell differentiation GO:0048863 268 0.869
regulation of cellular ketone metabolic process GO:0010565 66 0.869
myeloid cell differentiation GO:0030099 233 0.865
amine metabolic process GO:0009308 45 0.864
cellular response to organonitrogen compound GO:0071417 145 0.863
intracellular protein transport GO:0006886 204 0.858
leukocyte differentiation GO:0002521 342 0.855
dna modification GO:0006304 50 0.849
t cell differentiation GO:0030217 174 0.847
cellular response to insulin stimulus GO:0032869 78 0.846
organophosphate biosynthetic process GO:0090407 122 0.838
establishment of protein localization to organelle GO:0072594 118 0.837
purine ribonucleotide metabolic process GO:0009150 290 0.835
regulation of hydrolase activity GO:0051336 246 0.834
leukocyte homeostasis GO:0001776 79 0.831
Mouse
response to radiation GO:0009314 165 0.829
macroautophagy GO:0016236 21 0.829
digestive tract morphogenesis GO:0048546 147 0.825
negative regulation of immune system process GO:0002683 209 0.824
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.823
regulation of cellular catabolic process GO:0031329 242 0.823
regulation of peptidyl serine phosphorylation GO:0033135 39 0.821
positive regulation of cell motility GO:2000147 116 0.820
regulation of ras protein signal transduction GO:0046578 114 0.818
guanosine containing compound metabolic process GO:1901068 144 0.813
mitotic cell cycle GO:0000278 195 0.812
regulation of cellular amino acid metabolic process GO:0006521 5 0.811
cellular response to peptide GO:1901653 92 0.806
nucleoside triphosphate catabolic process GO:0009143 205 0.803
neuron apoptotic process GO:0051402 142 0.796
protein autophosphorylation GO:0046777 61 0.790
dna methylation GO:0006306 43 0.789
female gamete generation GO:0007292 74 0.788
chemotaxis GO:0006935 247 0.787
Worm
purine nucleoside metabolic process GO:0042278 241 0.783
response to nutrient levels GO:0031667 109 0.783
endocytosis GO:0006897 168 0.780
guanosine containing compound catabolic process GO:1901069 144 0.778
extrinsic apoptotic signaling pathway GO:0097191 126 0.777
lymphocyte differentiation GO:0030098 242 0.776
response to extracellular stimulus GO:0009991 127 0.766
negative regulation of cell proliferation GO:0008285 296 0.765
gastrulation GO:0007369 116 0.762
small gtpase mediated signal transduction GO:0007264 97 0.758
regulation of cell substrate adhesion GO:0010810 73 0.758
Mouse
negative regulation of leukocyte differentiation GO:1902106 51 0.758
digestive tract development GO:0048565 190 0.757
cellular response to radiation GO:0071478 28 0.756
protein kinase b signaling GO:0043491 74 0.754
peptidyl serine phosphorylation GO:0018105 74 0.753
cellular response to external stimulus GO:0071496 88 0.753
nucleoside phosphate biosynthetic process GO:1901293 79 0.750
cellular response to dna damage stimulus GO:0006974 207 0.742
regulation of cellular amine metabolic process GO:0033238 20 0.742
regulation of long term neuronal synaptic plasticity GO:0048169 19 0.739
regulation of leukocyte differentiation GO:1902105 159 0.732
positive regulation of cellular catabolic process GO:0031331 148 0.730
heterocycle catabolic process GO:0046700 280 0.730
blood vessel morphogenesis GO:0048514 285 0.726
nfat protein import into nucleus GO:0051531 6 0.724
developmental maturation GO:0021700 193 0.722
macromolecule methylation GO:0043414 120 0.712
macromolecule catabolic process GO:0009057 281 0.709
cellular response to extracellular stimulus GO:0031668 81 0.707
protein targeting GO:0006605 143 0.706
response to growth factor GO:0070848 198 0.704
regulation of ras gtpase activity GO:0032318 88 0.698
regulation of secretion GO:0051046 274 0.696
protein localization to organelle GO:0033365 185 0.694
myeloid leukocyte differentiation GO:0002573 119 0.694
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.685
lung development GO:0030324 164 0.683
posttranscriptional regulation of gene expression GO:0010608 155 0.679
negative regulation of neuron death GO:1901215 98 0.677
regulation of myeloid leukocyte differentiation GO:0002761 58 0.676
positive regulation of rac protein signal transduction GO:0035022 1 0.670
peptidyl amino acid modification GO:0018193 336 0.669
oogenesis GO:0048477 56 0.667
glycerophospholipid biosynthetic process GO:0046474 32 0.667
multicellular organism growth GO:0035264 161 0.665
positive regulation of ras gtpase activity GO:0032320 65 0.662
mapk cascade GO:0000165 281 0.658
positive regulation of mapk cascade GO:0043410 170 0.656
dendrite development GO:0016358 115 0.653
positive regulation of transcription by galactose GO:0000411 1 0.644
nucleotide catabolic process GO:0009166 217 0.639
regulation of myeloid cell differentiation GO:0045637 96 0.636
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.635
nucleobase containing small molecule metabolic process GO:0055086 352 0.632
glycosyl compound metabolic process GO:1901657 246 0.631
insulin receptor signaling pathway GO:0008286 49 0.625
positive regulation of transferase activity GO:0051347 167 0.624
ribonucleotide metabolic process GO:0009259 291 0.624
cellular amino acid metabolic process GO:0006520 103 0.618
purine nucleotide metabolic process GO:0006163 302 0.616
cellular response to lipid GO:0071396 145 0.616
positive regulation of cellular amine metabolic process GO:0033240 5 0.610
response to organonitrogen compound GO:0010243 246 0.607
respiratory tube development GO:0030323 167 0.605
cellular response to peptide hormone stimulus GO:0071375 92 0.604
organic cyclic compound catabolic process GO:1901361 295 0.601
regulation of apoptotic signaling pathway GO:2001233 197 0.601
appendage development GO:0048736 166 0.601
regulation of secretion by cell GO:1903530 249 0.599
phospholipid biosynthetic process GO:0008654 36 0.599
cellular lipid metabolic process GO:0044255 323 0.598
positive regulation of cell migration GO:0030335 109 0.597
striated muscle tissue development GO:0014706 293 0.597
cognition GO:0050890 149 0.589
Worm
germ cell development GO:0007281 185 0.584
digestive system development GO:0055123 200 0.584
glycerophospholipid metabolic process GO:0006650 71 0.580
wnt signaling pathway GO:0016055 188 0.579
ribonucleoside catabolic process GO:0042454 206 0.576
stem cell development GO:0048864 219 0.574
response to insulin GO:0032868 100 0.571
cytokine production GO:0001816 319 0.570
purine ribonucleoside metabolic process GO:0046128 241 0.561
regulation of nucleoside metabolic process GO:0009118 130 0.549
cellular macromolecule catabolic process GO:0044265 206 0.548
ras protein signal transduction GO:0007265 77 0.537
cellular protein catabolic process GO:0044257 155 0.528
organelle assembly GO:0070925 177 0.523
protein localization to nucleus GO:0034504 121 0.511
regionalization GO:0003002 337 0.510
phagocytosis GO:0006909 66 0.507
learning or memory GO:0007611 148 0.504
Worm
regulation of protein kinase activity GO:0045859 232 0.504
methylation GO:0032259 134 0.501
t cell activation GO:0042110 289 0.499
positive regulation of protein phosphorylation GO:0001934 242 0.498
ribonucleotide catabolic process GO:0009261 208 0.497
neuron projection guidance GO:0097485 141 0.497
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.496
regulation of metal ion transport GO:0010959 106 0.495
Mouse
regulation of protein transport GO:0051223 163 0.494
positive regulation of jnk cascade GO:0046330 46 0.493
cellular response to light stimulus GO:0071482 19 0.491
negative regulation of fibroblast apoptotic process GO:2000270 6 0.487
olfactory learning GO:0008355 2 0.483
adaptive immune response GO:0002250 155 0.482
purine nucleoside triphosphate catabolic process GO:0009146 203 0.477
stem cell maintenance GO:0019827 130 0.475
b cell activation GO:0042113 161 0.474
Mouse
regulation of protein localization GO:0032880 231 0.472
cellular nitrogen compound catabolic process GO:0044270 280 0.470
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.469
second messenger mediated signaling GO:0019932 73 0.468
rac protein signal transduction GO:0016601 13 0.468
positive regulation of protein modification process GO:0031401 299 0.467
ribose phosphate metabolic process GO:0019693 291 0.465
nuclear transport GO:0051169 139 0.465
cell maturation GO:0048469 127 0.465
positive regulation of protein kinase activity GO:0045860 144 0.463
myeloid cell homeostasis GO:0002262 114 0.461
cyclic nucleotide metabolic process GO:0009187 59 0.461
nucleotide metabolic process GO:0009117 332 0.461
regulation of organ growth GO:0046620 61 0.459
gtp catabolic process GO:0006184 143 0.455
purine ribonucleotide catabolic process GO:0009154 208 0.454
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.450
epithelial cell development GO:0002064 159 0.447
calcium ion homeostasis GO:0055074 127 0.447
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.446
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.442
b cell differentiation GO:0030183 78 0.440
nucleoside catabolic process GO:0009164 206 0.435
ribonucleoside metabolic process GO:0009119 245 0.433
protein modification by small protein conjugation or removal GO:0070647 207 0.433
oocyte axis specification GO:0007309 2 0.432
regulation of system process GO:0044057 200 0.432
regulation of mitotic cell cycle GO:0007346 126 0.431
aromatic compound catabolic process GO:0019439 286 0.429
axon guidance GO:0007411 141 0.427
single organism nuclear import GO:1902593 95 0.427
respiratory system development GO:0060541 190 0.423
regulation of neuron apoptotic process GO:0043523 122 0.422
embryonic skeletal system development GO:0048706 120 0.421
learning GO:0007612 98 0.415
muscle cell differentiation GO:0042692 261 0.414
purine nucleotide catabolic process GO:0006195 211 0.409
osteoclast differentiation GO:0030316 62 0.408
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.407
cellular response to abiotic stimulus GO:0071214 56 0.403
cellular amine metabolic process GO:0044106 44 0.402
skeletal muscle organ development GO:0060538 163 0.401
epithelial tube morphogenesis GO:0060562 303 0.399
metal ion homeostasis GO:0055065 189 0.398
Mouse
regulation of proteolysis GO:0030162 164 0.395
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.390
response to metal ion GO:0010038 47 0.386
Worm
cell adhesion GO:0007155 329 0.385
Mouse
genetic imprinting GO:0071514 27 0.384
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.380
embryonic hemopoiesis GO:0035162 23 0.371
response to peptide GO:1901652 136 0.370
purine nucleoside catabolic process GO:0006152 205 0.369
organonitrogen compound catabolic process GO:1901565 264 0.369
positive regulation of apoptotic process GO:0043065 217 0.367
regulation of erk1 and erk2 cascade GO:0070372 71 0.364
reactive oxygen species metabolic process GO:0072593 84 0.360
visual learning GO:0008542 44 0.360
positive regulation of peptidyl serine phosphorylation GO:0033138 25 0.359
cellular response to hormone stimulus GO:0032870 150 0.359
skeletal system development GO:0001501 356 0.359
regulation of cell cycle GO:0051726 281 0.358
sensory organ morphogenesis GO:0090596 242 0.357
cytoplasmic transport GO:0016482 234 0.356
regulation of lipid metabolic process GO:0019216 118 0.356
positive regulation of intracellular transport GO:0032388 70 0.354
positive regulation of cell death GO:0010942 224 0.352
cellular ion homeostasis GO:0006873 165 0.352
Mouse
ion transmembrane transport GO:0034220 361 0.351
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.351
glycosyl compound catabolic process GO:1901658 206 0.349
positive regulation of cytokine production GO:0001819 174 0.349
establishment of vesicle localization GO:0051650 81 0.347
b cell homeostasis GO:0001782 34 0.347
Mouse
cellular response to acid chemical GO:0071229 68 0.346
neurotransmitter secretion GO:0007269 62 0.345
establishment of organelle localization GO:0051656 122 0.343
activation of adenylate cyclase activity GO:0007190 4 0.343
body morphogenesis GO:0010171 45 0.342
positive regulation of programmed cell death GO:0043068 218 0.342
regulation of protein stability GO:0031647 52 0.339
purine nucleoside triphosphate metabolic process GO:0009144 226 0.337
regulation of membrane potential GO:0042391 192 0.337
purine containing compound metabolic process GO:0072521 311 0.335
negative regulation of cell cycle GO:0045786 123 0.335
response to transforming growth factor beta GO:0071559 88 0.331
hyperosmotic response GO:0006972 4 0.330
regulation of establishment of protein localization GO:0070201 181 0.329
regulation of purine nucleotide metabolic process GO:1900542 169 0.328
ribose phosphate biosynthetic process GO:0046390 59 0.328
negative regulation of protein modification process GO:0031400 163 0.326
positive regulation of growth GO:0045927 104 0.326
positive regulation of apoptotic signaling pathway GO:2001235 95 0.325
regulation of organelle organization GO:0033043 289 0.324
microtubule based process GO:0007017 236 0.322
oocyte differentiation GO:0009994 35 0.322
regulation of ion transport GO:0043269 215 0.321
Mouse
neuron death GO:0070997 154 0.320
skeletal system morphogenesis GO:0048705 203 0.320
cellular response to organic cyclic compound GO:0071407 87 0.318
muscle tissue development GO:0060537 308 0.314
metencephalon development GO:0022037 89 0.311
nucleocytoplasmic transport GO:0006913 139 0.309
cellular metal ion homeostasis GO:0006875 151 0.307
Mouse
monosaccharide metabolic process GO:0005996 106 0.306
organophosphate catabolic process GO:0046434 232 0.306
response to uv GO:0009411 44 0.305
purine containing compound catabolic process GO:0072523 213 0.305
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.304
muscle adaptation GO:0043500 39 0.303
gland development GO:0048732 330 0.297
cellular homeostasis GO:0019725 240 0.297
Mouse
actin cytoskeleton organization GO:0030036 220 0.289
nuclear import GO:0051170 95 0.288
axonogenesis GO:0007409 274 0.282
connective tissue development GO:0061448 179 0.282
positive regulation of proteolysis GO:0045862 85 0.281
cyclic nucleotide biosynthetic process GO:0009190 44 0.279
translation GO:0006412 93 0.279
carbon catabolite activation of transcription GO:0045991 4 0.275
mitotic cell cycle process GO:1903047 159 0.275
positive regulation of organelle organization GO:0010638 128 0.275
response to inorganic substance GO:0010035 96 0.273
Worm
regulation of cell adhesion GO:0030155 154 0.268
Mouse
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.267
protein catabolic process GO:0030163 221 0.266
ameboidal type cell migration GO:0001667 128 0.266
regulation of exocytosis GO:0017157 61 0.264
regulation of vesicle mediated transport GO:0060627 139 0.263
leukocyte activation involved in immune response GO:0002366 126 0.258
negative regulation of zinc ion transmembrane transport GO:0071583 2 0.257
Mouse
ubiquitin dependent protein catabolic process GO:0006511 129 0.255
organ growth GO:0035265 117 0.254
maintenance of location GO:0051235 89 0.252
g protein coupled receptor signaling pathway GO:0007186 243 0.250
cell division GO:0051301 120 0.250
Mouse
jnk cascade GO:0007254 72 0.250
ribonucleoside triphosphate metabolic process GO:0009199 220 0.248
regulation of jnk cascade GO:0046328 62 0.248
lipid biosynthetic process GO:0008610 179 0.248
adherens junction organization GO:0034332 28 0.242
regulation of neuron death GO:1901214 134 0.240
epidermal growth factor receptor signaling pathway GO:0007173 28 0.239
regulation of muscle tissue development GO:1901861 97 0.238
embryonic organ morphogenesis GO:0048562 276 0.238
spermatogenesis GO:0007283 284 0.235
positive regulation of ras protein signal transduction GO:0046579 13 0.235
camp metabolic process GO:0046058 40 0.235
modification dependent protein catabolic process GO:0019941 133 0.235
carbohydrate derivative biosynthetic process GO:1901137 183 0.234
visual behavior GO:0007632 45 0.233
gonad development GO:0008406 141 0.232
epithelial cell proliferation GO:0050673 174 0.231
cation homeostasis GO:0055080 212 0.230
Mouse
nucleoside phosphate catabolic process GO:1901292 222 0.229
nitrogen compound transport GO:0071705 271 0.228
cerebellum development GO:0021549 77 0.227
regulation of translation GO:0006417 71 0.225
cell cell junction organization GO:0045216 72 0.224
immune effector process GO:0002252 321 0.223
microtubule cytoskeleton organization GO:0000226 157 0.221
carbon catabolite regulation of transcription GO:0045990 4 0.221
generation of precursor metabolites and energy GO:0006091 103 0.218
camp biosynthetic process GO:0006171 31 0.217
negative regulation of cellular catabolic process GO:0031330 47 0.216
regulation of rac protein signal transduction GO:0035020 19 0.215
response to alcohol GO:0097305 48 0.215
erk1 and erk2 cascade GO:0070371 77 0.215
regulation of cytokine production GO:0001817 266 0.215
regulation of actin filament based process GO:0032970 99 0.214
development of primary sexual characteristics GO:0045137 143 0.214
divalent inorganic cation homeostasis GO:0072507 138 0.213
Mouse
nucleoside triphosphate metabolic process GO:0009141 230 0.213
negative regulation of myeloid cell differentiation GO:0045638 38 0.213
circadian rhythm GO:0007623 114 0.212
negative regulation of apoptotic signaling pathway GO:2001234 104 0.211
negative regulation of protein metabolic process GO:0051248 282 0.211
leukocyte mediated immunity GO:0002443 174 0.210
stress activated protein kinase signaling cascade GO:0031098 81 0.208
regulation of chemotaxis GO:0050920 53 0.208
Worm
purine ribonucleoside catabolic process GO:0046130 205 0.205
regulation of lipid kinase activity GO:0043550 14 0.205
establishment or maintenance of cell polarity GO:0007163 86 0.200
negative regulation of phosphorylation GO:0042326 166 0.200
cell chemotaxis GO:0060326 81 0.196
cation transport GO:0006812 399 0.196
Mouse
actin filament bundle assembly GO:0051017 40 0.195
striated muscle cell development GO:0055002 125 0.195
regulation of nucleotide metabolic process GO:0006140 169 0.195
inorganic ion transmembrane transport GO:0098660 234 0.195
Mouse
cell fate commitment GO:0045165 210 0.194
carbohydrate metabolic process GO:0005975 230 0.194
regulation of cytoskeleton organization GO:0051493 122 0.193
regulation of gtp catabolic process GO:0033124 113 0.193
positive regulation of protein transport GO:0051222 93 0.192
regulation of reactive oxygen species metabolic process GO:2000377 40 0.191
mitotic sister chromatid cohesion GO:0007064 1 0.190
regulation of cytoplasmic transport GO:1903649 112 0.190
ribonucleoside triphosphate catabolic process GO:0009203 199 0.189
negative regulation of mitotic cell cycle GO:0045930 58 0.188
regulation of camp metabolic process GO:0030814 30 0.187
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 14 0.185
regulation of cell activation GO:0050865 289 0.184
limb development GO:0060173 166 0.184
positive regulation of kinase activity GO:0033674 155 0.183
carbohydrate derivative catabolic process GO:1901136 231 0.182
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.181
positive regulation of cellular protein catabolic process GO:1903364 34 0.181
regulation of cellular protein catabolic process GO:1903362 61 0.180
male sex differentiation GO:0046661 109 0.178
cd4 positive alpha beta t cell activation GO:0035710 45 0.178
ventricular cardiac myofibril assembly GO:0055005 3 0.178
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.178
lipid modification GO:0030258 65 0.176
protein import into nucleus GO:0006606 95 0.174
protein modification by small protein conjugation GO:0032446 187 0.172
regulation of purine nucleotide catabolic process GO:0033121 122 0.169
transition metal ion transport GO:0000041 38 0.168
Mouse
leukocyte migration GO:0050900 124 0.167
positive regulation of defense response GO:0031349 124 0.167
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.166
genitalia development GO:0048806 37 0.165
protein acylation GO:0043543 64 0.164
alpha beta t cell differentiation GO:0046632 69 0.164
erythrocyte differentiation GO:0030218 88 0.162
negative regulation of neuron apoptotic process GO:0043524 92 0.161
cellular response to biotic stimulus GO:0071216 92 0.160
embryonic limb morphogenesis GO:0030326 126 0.160
regulation of protein targeting GO:1903533 61 0.159
regulation of synapse structural plasticity GO:0051823 4 0.157
regulation of innate immune response GO:0045088 91 0.156
negative regulation of intracellular signal transduction GO:1902532 167 0.155
cellular carbohydrate metabolic process GO:0044262 119 0.151
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.151
negative regulation of organ growth GO:0046621 17 0.150
i kappab kinase nf kappab signaling GO:0007249 85 0.150
cellular divalent inorganic cation homeostasis GO:0072503 127 0.149
Mouse
protein ubiquitination GO:0016567 171 0.149
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.148
male gamete generation GO:0048232 285 0.145
regulation of intracellular protein transport GO:0033157 82 0.144
nucleotide biosynthetic process GO:0009165 78 0.143
nucleoside monophosphate metabolic process GO:0009123 85 0.142
response to amphetamine GO:0001975 16 0.142
cyclic purine nucleotide metabolic process GO:0052652 43 0.141
positive regulation of stress activated mapk cascade GO:0032874 48 0.140
protein import GO:0017038 101 0.140
erbb signaling pathway GO:0038127 32 0.140
response to drug GO:0042493 75 0.139
oocyte construction GO:0007308 2 0.139
lymphocyte proliferation GO:0046651 164 0.137
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.137
regulation of nucleotide catabolic process GO:0030811 122 0.135
hematopoietic progenitor cell differentiation GO:0002244 143 0.134
purine nucleotide biosynthetic process GO:0006164 65 0.134
regulation of anatomical structure size GO:0090066 178 0.134
regulation of cell cycle phase transition GO:1901987 77 0.133
leukocyte apoptotic process GO:0071887 71 0.133
cell growth GO:0016049 130 0.133
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.132
formation of primary germ layer GO:0001704 77 0.131
phosphatidylinositol mediated signaling GO:0048015 41 0.130
regulation of mitotic cell cycle phase transition GO:1901990 73 0.130
regulation of intracellular transport GO:0032386 159 0.130
tor signaling GO:0031929 21 0.129
regulation of osteoclast differentiation GO:0045670 36 0.128
positive regulation of autophagy GO:0010508 9 0.128
negative regulation of transmembrane transport GO:0034763 15 0.127
Mouse
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.126
positive regulation of lyase activity GO:0051349 11 0.126
mesenchyme morphogenesis GO:0072132 32 0.126
regulation of ion transmembrane transport GO:0034765 119 0.126
Mouse
cellular chemical homeostasis GO:0055082 215 0.125
Mouse
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.125
negative regulation of autophagy GO:0010507 9 0.125
regulation of protein catabolic process GO:0042176 108 0.125
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.124
thymus development GO:0048538 41 0.123
inositol lipid mediated signaling GO:0048017 41 0.123
cell fate determination GO:0001709 32 0.122
divalent inorganic cation transport GO:0072511 178 0.121
regulation of cellular response to growth factor stimulus GO:0090287 82 0.121
modification dependent macromolecule catabolic process GO:0043632 133 0.120
regulation of jak stat cascade GO:0046425 34 0.120
neural tube development GO:0021915 160 0.120
regulation of erbb signaling pathway GO:1901184 16 0.120
lymphocyte apoptotic process GO:0070227 54 0.119
organonitrogen compound biosynthetic process GO:1901566 192 0.119
muscle contraction GO:0006936 101 0.118
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.118
regulation of canonical wnt signaling pathway GO:0060828 82 0.117
nucleoside metabolic process GO:0009116 246 0.117
negative regulation of homeostatic process GO:0032845 71 0.116
protein processing GO:0016485 163 0.116
regulation of lymphocyte differentiation GO:0045619 107 0.116
regulation of protein serine threonine kinase activity GO:0071900 157 0.115
regulation of homeostatic process GO:0032844 182 0.114
detection of mechanical stimulus GO:0050982 27 0.114
myeloid leukocyte activation GO:0002274 83 0.113
calcium mediated signaling GO:0019722 46 0.113
negative regulation of ras protein signal transduction GO:0046580 18 0.113
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.112
positive regulation of leukocyte differentiation GO:1902107 86 0.112
regulation of macroautophagy GO:0016241 12 0.111
organelle localization GO:0051640 179 0.111

Pik3ca disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.994
Human
cancer DOID:162 0 0.978
Human
organ system cancer DOID:0050686 0 0.936
Human
large intestine cancer DOID:5672 0 0.601
Human
colon cancer DOID:219 0 0.601
Human
gastrointestinal system cancer DOID:3119 0 0.601
Human
intestinal cancer DOID:10155 0 0.601
Human
colorectal cancer DOID:9256 0 0.601
Human
endocrine gland cancer DOID:170 0 0.291